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Sandoz Ag patents


Recent patent applications related to Sandoz Ag. Sandoz Ag is listed as an Agent/Assignee. Note: Sandoz Ag may have other listings under different names/spellings. We're not affiliated with Sandoz Ag, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Sandoz Ag-related inventors


Asymmetric bisamidation of malonic ester derivatives

The present invention relates to processes, process steps and intermediates useful in the asymmetric bisamidation of malonic ester derivatives wherein the new processes, process steps and intermediates are, for example, useful in the preparation of asymmetric malonic acid bisanilides such as cabozantinib.. . ... Sandoz Ag

Form c of avibactam sodium

The present invention relates to crystalline form c of avibactam sodium and to a process for its preparation. The invention also concerns a pharmaceutical composition comprising form c and one or more antibacterial agents, wherein at least one antibacterial agent is a beta-lactam antibiotic. ... Sandoz Ag

Pharmaceutical composition containing rifaximin alpha & delta

The present invention relates to a pharmaceutical composition containing rifaximin in the form of two different polymorphs as well as a method of preparing the same.. . ... Sandoz Ag

Synthesis of phosphoramidates

A process for preparing a nucleoside phosphoramidate, in particular to a process for preparing sofosbuvir, wherein a phosphoramidate derivative is used as starting material.. . ... Sandoz Ag

Method for the purification of g-csf

. . The present invention relates to a method for obtaining recombinant granulocyte-colony stimulating factor (g-csf), comprising at least one cation exchange chromatography and at least one hydrophobic interaction chromatography, wherein said two chromatographic steps are immediately consecutive in optional order. In particular, the present invention relates to a method for purifying g-csf from a mixture of g-csf and other proteins, comprising two cation exchange chromatography steps which are conducted before and after a hydrophobic interaction chromatography, respectively.. ... Sandoz Ag

Constitutive yeast llp promotor-based expression systems

The present invention belongs to the field of biotechnology, recombinant protein production, molecular biology, microbiology and microbial genetics. It provides a modified eukaryotic cell that is modified to the effect that the modified eukaryotic cell is not able to provide an ssn6-like related protein or an ssn6-like protein that exerts its wildtype function and/or wildtype activity, the amount of ssn6-like related protein or of ssn6-like protein being present in the modified eukaryotic cell differs from the amount of ssn6-like related protein or of ssn6-like protein being present in its wildtype form, and/or essentially no ssn6-like related protein or ssn6-like protein is present in the modified cell. ... Sandoz Ag

Penicillin retard composition for intramuscular injection

The present invention is directed to an injection syringe comprising an injectable composition, the composition comprising a penicillin, salt or prodrug thereof, one or more pharmaceutically acceptable excipients, and water, wherein the composition is free of a preservative agent. In other aspects, the invention relates to a process for producing the injection syringe, and a kit comprising the injection syringe.. ... Sandoz Ag

Method for producing a recombinant protein of interest

Disclosed is a method for producing a recombinant protein of interest, characterised in by the following steps: (a) providing a fusion protein comprising an npro autoprotease moiety and a protein of interest moiety in inclusion bodies, (b) solubilising the fusion protein in the inclusion bodies by subjecting the inclusion bodies to a solubilisation buffer containing a detergent and wherein the solubilisation buffer contains no chaotropes or chaotropes in a concentration of less than 1.5 m urea (c) refolding the solubilised fusion protein and (d) allowing the fusion protein to be cleaved by the npro autoprotease moiety under kosmotropic conditions, wherein the recombinant protein of interest is cleaved from the fusion protein, and (e) recovering the protein of interest.. . ... Sandoz Ag

Pharmaceutical compositions comprising ledipasvir and sofosbuvir

The present invention relates to novel pharmaceutical compositions comprising ledipasvir and sofosbuvir as well as to methods for their preparation.. . ... Sandoz Ag

Pharmaceutical composition containing crystalline macitentan

The present invention relates to an oral solid dosage form, in particular a tablet, comprising macitentan free base polymorphic form i.. . ... Sandoz Ag

An apparatus and method for producing a flow profile

A method for generating a flow profile of an inhalation device is described. The method comprises the step of measuring acoustic emissions induced by inhalation flow through the inhalation device. ... Sandoz Ag

Flibanserin hydrate

The present invention relates to a hydrate of flibanserin, a process for its preparation and to a pharmaceutical composition comprising the hydrate. The invention further relates to the use of said pharmaceutical composition as a medicament in particular for the treatment of hypoactive sexual desire disorder (hsdd).. ... Sandoz Ag

Sequence variants

Amino acid residue misincorporations are necessarily found in sequence variants at low concentrations in admixture with expressed polypeptides, resulting from one or more base mismatches within codons susceptible to amino acid residue misincorporation during transcription and/or translation. The invention provides a method of optimizing the coding sequences of a polynucleotide that encodes a polypeptide, wherein at least one codon is susceptible to amino acid residue misincorporation. ... Sandoz Ag

Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines

The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1h-pyrazolo[3,4-d]pyrimidine of formula (i), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.. ... Sandoz Ag

11/16/17 / #20170326153

Pharmaceutical composition consisting of ceftaroline fosamil acetic acid solvate particles arginine particles, both having a specific particle size distribution

The invention relates to a pharmaceutical composition consisting of ceftaroline fosamil acetic acid solvate and arginine, both having a specific particle size distribution, wherein said pharmaceutical composition is stable and does not segregate into an inhomogeneous mixture.. . ... Sandoz Ag

09/14/17 / #20170258761

Pharmaceutical compositions comprising canagliflozin

The present invention belongs to the field of pharmaceutical industry and relates to a dry pharmaceutical composition comprising canagliflozin, as well as to a process for preparing the same. Such dry pharmaceutical composition is useful as a medicament, especially for the normalization of plasma glucose levels.. ... Sandoz Ag

09/07/17 / #20170253900

Method for producing a recombinant protein on a manufacturing scale

A method for producing a protein of interest on a manufacturing scale is based on integration, by homologous recombination, of the dna encoding the protein of interest into a bacterial cell's genome at a pre-selected site. The manufacturing scale production of recombinant proteins is in the fed-batch mode, semi-continuous or in a chemostat.. ... Sandoz Ag

08/17/17 / #20170233330

Process for the preparation of 3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-phenol

A process for the preparation of a compound of formula (i) and of a acid salt (t) wherein r1 is selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, r2 and r3, are, independently of each other, selected from the group consisting of alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, r4, r5, r6 and r7, are independently of each other, selected from the group consisting of h, alkyl, aryl, cycloalkyl, heteroalkyl, heteroaryl and heterocycloalkyl, and wherein the acid salt is a 2,3-ditoluoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid salt, 2,3-dianisoyl tartaric acid salt, 2,3-dibenzoyl tartaric acid mono(dimethylamide) salt or a mixture of two or more thereof, wherein the tartaric acid salt (t) of the compound of formula (i) contains at least 90% by weight of the tartaric salt of the compound of formula (ia) based on the total weight of the acid salt of the compound of formula (i).. . ... Sandoz Ag

08/17/17 / #20170231969

Pharmaceutical compositions of edoxaban

Edoxaban is factor x inhibitor useful for the treatment or the prevention of thrombosis or embolism. A pharmaceutical composition comprising edoxaban, or a pharmaceutically acceptable salt thereof, a water soluble vinylpyrrolidone polymer selected from the group consisting of povidone and copovidone, and a cellulose ether, and not comprising a sugar alcohol, having good dissolution and bioavailability is provided. ... Sandoz Ag

08/03/17 / #20170218006

Synthesis of phosphoramidates

A process for the preparation of a compound of formula (i) including all isomers, stereoisomers, enantiomers and diastereomers thereof (i), and salts thereof; the process comprising providing a mixture comprising a compound of formula (ii) and a compound of formula (iii) subjecting the mixture provided in a) to reaction conditions in the presence of one or more lewis acids to the mixture provided in a), obtaining a mixture comprising the compound of formula (i).. . ... Sandoz Ag

08/03/17 / #20170217947

Novel route of synthesis for the preparation of suvorexant

The present invention relates to a process for the preparation of a compound of formula (a), further, the present invention relates to the respective compound (a) as such and to its use in the preparation of antifungal agent.. . ... Sandoz Ag

08/03/17 / #20170216211

Aqueous granulation process for amorphous poorly water soluble drugs

The invention relates to an aqueous granulation process for preparing granules comprising an amorphous poorly water soluble active pharmaceutical ingredient, a particular polymer and a particular surfactant. The invention also refers to a process for preparing tablets comprising said granules. ... Sandoz Ag

06/15/17 / #20170166570

Preparation of ertapenem intermediates

The present invention relates to the preparation of compounds, in particular to the preparation of compounds which may be used as intermediates for the preparation of antibiotics, preferably carbapenem antibiotics, more preferably ertapenem, and salts thereof.. . ... Sandoz Ag

04/13/17 / #20170100422

Solid composition comprising amorphous sofosbuvir

A solid composition comprising sofosbuvir and at least one pharmaceutically acceptable matrix compound wherein at least 99 weight-% of the sofosbuvir comprised in the composition are present in amorphous form, at least 99 weight-% of the solid composition consist of the sofosbuvir and the at least one matrix compound, and wherein the solid composition contains the sofosbuvir in an amount of at least 55 weight-% based on the combined weight of the sofosbuvir and the at least one matrix compound.. . ... Sandoz Ag

02/02/17 / #20170027873

Solid dispersion comprising an orexin receptor antagonist

A solid dispersion comprising suvorexant or a salt thereof in amorphous form and at least one pharmaceutically acceptable matrix compound, wherein the matrix compound is (i) a polymer and wherein the solid dispersion contains the suvorexant or salt thereof in an 5 amount of at least 50 weight-% based on the combined weight of the suvorexant or salt thereof and the at least one matrix compound, or (ii) a silicon-based inorganic adsorbent.. . ... Sandoz Ag








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