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Sanofi patents


Recent patent applications related to Sanofi. Sanofi is listed as an Agent/Assignee. Note: Sanofi may have other listings under different names/spellings. We're not affiliated with Sanofi, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Sanofi-related inventors


Purification of respiratory syncytial virus

Disclosed herein are methods for the purification of respiratory syncytial virus (rsv) particles from a host cell culture comprising treating the host cell culture with an endonuclease, filtering the material to remove cellular debris and/or aggregated material, applying the material to a core bead chromatography resin, and recovering the purified rsv particles. Also disclosed herein are pharmaceutical compositions comprising purified rsv.. ... Sanofi

Battery disconnection circuit

The invention is related to an apparatus comprising a switch configured to variably connect a device circuit of an electronic device to a battery, a cutout control circuit connected to the switch and comprising a supply power input and a cutout activation input, wherein the cutout control circuit is configured to turn the switch on when a supply voltage is connected to the supply power input. The invention is further related to a drug delivery device for delivering at least one drug agent comprising an apparatus of the aforementioned kind, a charging connector for a drug deliver device of the aforementioned kind, and a method for manufacturing a drug delivery device of the aforementioned kind.. ... Sanofi

Medicament dosage determination

A data collection device includes a camera and a processing arrangement configured to capture at least two images of a medicament dose indicator of a medicament delivery device in each of the at least two images the processing arrangement identifies a displayed dosage using a first character identification technique, in each of the at least two images, determines whether the displayed dosages in the images are different and, if not, identifies at least one character in the images using a second character identification technique and determines the medicament dosage amount indicated by the medicament dose indicator based thereon. The first character recognition technique may be, for example, an optical pattern recognition or correlation, may be less computationally intensive than the second character recognition technique, for example, an optical character recognition (ocr). ... Sanofi

Multispecific binding molecules having specificity to dystroglycan and laminin-2

. . . . . . Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.. ... Sanofi

Azetidine compounds as grp119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders

The present disclosure relates to azetidine compounds. The azetidine compounds are gpr119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. ... Sanofi

Coding system for a drug delivery device and drug delivery device

A coding system for a drug reservoir, where the drug reservoir is intended for use with a reservoir holder of a drug delivery device. The coding system includes a collar fitted around the drug reservoir. ... Sanofi

Assembly for a drug delivery device and drug delivery device

An assembly for a drug delivery device (1) comprises a housing (5), a rotation member (15), a drive member (16) and at least one correction member (7). The rotation member (15) is adapted to be rotated with respect to the housing (5) in a first rotational direction for delivering a dose of a drug (11). ... Sanofi

Sensor, cartridge and drug delivery device

The present disclosure relates to a sensor for measuring at least one physical or chemical parameter of a cartridge or syringe filled with a liquid substance. In further aspects, the disclosure relates to a cartridge equipped with such a sensor as well as to a drug delivery device equipped with such a cartridge, wherein the sensor comprises: a planar flexible foil arrangeable to an outer circumference of a barrel of the cartridge or syringe, at least a first and a second measuring electrode arranged on said foil, at least a first and a second contact electrode arranged on said foil, and a processor arranged on said foil and connected to the first and to the second measuring electrodes, wherein the first contact electrode and the second contact electrode are connected to the processor.. ... Sanofi

Fgf21 compound / glp-1r agonist combinations with optimized activity ratio

The present invention relates to combinations, pharmaceutical compositions and fusion molecules comprising an fgf21 (fibroblast growth factor 21) compound and a glp-1r (glucagon-like peptide-1 receptor) agonist with optimized glp-1r agonist/fgf21 compound activity ratio. It further relates to their use as medicaments, in particular for the treatment of obesity, being overweight, metabolic syndrome, diabetes mellitus, diabetic retinopathy, hyperglycemia, dyslipidemia, non-alcoholic steatohepatitis (nash) and/or atherosclerosis.. ... Sanofi

Pharmaceutical composition for treating a metabolic syndrome

The invention is directed to a pharmaceutical composition containing at least one fgf-21 (fibroblast growth factor 21) compound, at least one glp-1r (glucagon-like peptide-1 receptor) agonist and optionally at least one anti-diabetic drug and/or at least one dpp-4 (dipeptidyl peptidase-4) inhibitor for the treatment of at least one metabolic syndrome and/or atherosclerosis, in particular diabetes, dyslipidemia, obesity and/or adipositas.. . ... Sanofi

Housing and drug delivery device herewith

. . The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and a housing for such a device. The housing for the drug delivery device comprises an outer housing, a housing insert, which is rotationally constrained to the outer housing and guided axially movable relative to the outer housing, and a cartridge holder. ... Sanofi

Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123

. . The present invention concerns antibody-like binding protein specifically binding to cd3 and binding specifically to at least one further antigen, for example cd123. The present invention also concerns antibody-like binding protein specifically binding to cd123 and binding specifically to at least one further antigen. ... Sanofi

Methods for treating pain using antibodies to kallidin and des-arg10-kallidin

The invention provides antibodies that specifically bind to kallidin or des-arg10-kallidin. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-kallidin or des-arg10-kallidin antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. ... Sanofi

Sensor device for a drug delivery device

A sensor device to be attached to a drug delivery device includes an array of conducting elements each forming part of a respective resonant circuit and each operable to have a signal applied to it. The drug delivery device has a first movable element supporting a conductive region, which is configured to move along a path parallel to a longitudinal axis of the drug delivery device. ... Sanofi

08/02/18 / #20180214640

Auto-injector

An auto-injector comprising an elongate housing containing a syringe. The housing having an orifice intended to be applied against an injection site. ... Sanofi

08/02/18 / #20180214637

Drug delivery device

The present disclosure relates to a drug delivery device having a case adapted to retain a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament from the medicament container, and at least one feedback mechanism that is in operative connection with the plunger. The feedback mechanism includes a collar, a needle shroud, and a control spring biasing the needle shroud in a distal direction relative to the collar. ... Sanofi

08/02/18 / #20180214542

Humanized cxcr3 antibodies with depleting activity and methods of use thereof

Provided are humanized cxcr3 antibodies and methods of using the antibodies to treat cxcr3-associated disorders such as type 1 diabetes mellitus (t1d), particularly new-onset t1d, and psoriasis. In certain embodiments, the anti-cxcr3 antibodies are humanized anti-human cxcr3 antibodies with enhanced effector function against cells expressing cxcr3 on their surface. ... Sanofi

07/26/18 / #20180207367

Cap and cap removal device

A cap removal device for removing and retaining a plurality of caps from a drug delivery device includes a body having a plurality of recesses. Each of the plurality of recesses comprises a shape corresponding to a shape of one of the plurality of caps and each recess is provided with an engagement member adapted to engage a cap. ... Sanofi

07/26/18 / #20180207364

Dose setting mechanism for priming a drug delivery device

A method and system for providing a drug delivery device. The drug delivery device comprises a dose setting mechanism comprising a spindle and a cartridge holder coupled to the dose setting mechanism. ... Sanofi

07/19/18 / #20180200457

Drug delivery device with load indicator

A drug delivery device includes a piston rod which extends along a longitudinal axis of the drug delivery device, wherein the piston rod is adapted to apply an axial load in the distal direction to a cartridge bung in order to dispense a medicament contained in the cartridge. In order to improve the convenience of the injection process and to mitigate the risk of underdosing due to a blocked needle a cartridge bung load indicator is provided, located at the distal end of the piston rod and adapted to abut against the cartridge bung, wherein the cartridge bung load indicator comprises an indicator element that audibly, tangibly and/or visually indicates a load state of the piston rod to the user.. ... Sanofi

07/19/18 / #20180200453

Drug delivery device with protective needle cap control and device activation mechanism

A drug delivery device includes an outer body receiving a cartridge with a needle, a needle cap adapted to be coupled to the outer body and to cover the needle and a control mechanism for activating the drug delivery device. The control mechanism includes a control element received within the outer body and axially and/or rotationally movable relative to the outer body between an initial position, a first activating position, and a second activating position. ... Sanofi

07/19/18 / #20180200445

Detent mechanism

A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. ... Sanofi

07/19/18 / #20180200370

Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine

A liquid composition comprising a glp-1 agonist or/and a pharmacologically tolerable salt thereof, an insulin or/and a pharmacologically tolerable salt thereof, and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin where appropriate.. . ... Sanofi

07/12/18 / #20180193568

Drug delivery device

Drug delivery device comprising a housing retaining a primary drug delivery assembly for the delivery of a primary medicament with a primary dose setting member configured to rotate in a helical movement to set a dose of the primary medicament and a secondary drug delivery assembly for the delivery of a secondary medicament. A dose dial is movable between a first position and a second position in axial direction and is rotationally constrained with respect to the housing when moved from the first position into the second position and is rotationally constrained to the primary dose setting member in the second position for setting a dose of the primary medicament. ... Sanofi

07/12/18 / #20180193447

Concomitant dengue and yellow fever vaccination

The present invention relates to a yellow fever (yf) vaccine for use in a method for inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said yellow fever vaccine to a human subject together with a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4. This invention also pertains to a tetravalent dengue vaccine which comprises a live attenuated dengue virus of each of serotypes 1 to 4 for use in a method of inducing a protective immune response against yellow fever, wherein said method comprises concomitantly administering said tetravalent dengue vaccine to a human subject together with a yellow fever (yf) vaccine.. ... Sanofi

07/05/18 / #20180185589

Cap assembly for covering a needle shield and method for assembling the cap assembly

The disclosure refers to a cap assembly for covering a needle shield of an injection device, the cap assembly comprising: a collar, and a cap with a sheath and a bottom, wherein the collar is movable along a longitudinal direction relative to the sheath from an unlocked position not engaging the sheath towards a locked position, force-lockingly engaging the sheath, thereby locking the sheath to the needle shield.. . ... Sanofi

07/05/18 / #20180185585

Drug delivery device

The disclosure relates to a drug delivery device, comprising: an outer needle sleeve; a cartridge containing a dosage of a medicament and sealed with a sealing element that is arranged across an open distal end of the cartridge; a cartridge carrier adapted to hold the cartridge; a needle hub adapted to hold a double ended hollow needle; an inner needle sleeve arranged between the needle hub and the cartridge carrier; a removable cap coupled to the inner needle sleeve and adapted to cover and seal the needle; and a first locking mechanism adapted to lock the inner needle sleeve against axial movement in the proximal direction with respect to the cartridge carrier in an initial state, wherein in the initial state, the needle is spaced from the cartridge in the distal direction, and wherein the first locking mechanism is releasable by a rotational movement of the cap with respect to the outer needle sleeve.. . ... Sanofi

07/05/18 / #20180185450

Exendin-4 derivatives as dual glp1/glucagon agonists

The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.. . ... Sanofi

06/28/18 / #20180177948

Drive mechanism for a medication delivery device and medication delivery device

A drive mechanism for a medication delivery device is presented having a housing, a rotation member that rotates in a first direction with respect to the housing during setting of a dose of a medication and rotates in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction. The device also has a piston rod that is displaced in a distal direction with respect to the housing for delivering the dose, a drive member which follows rotational movement of the rotation member in the second direction during delivery of the dose, and a stop member which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose.. ... Sanofi

06/28/18 / #20180177947

Auto-injector

Described is an injection device for administering a dose of a medicament (m) comprising a carrier adapted to contain a syringe having a hollow injection needle and a stopper, a drive spring, a plunger adapted to forward load of the drive spring to the stopper, and a noise component adapted to generate an audible and/or tactile feedback by impacting a component of the injection device when the stopper is located at a proximal end of the syringe. In a first state, a resilient arm on the plunger is maintained in engagement with the noise component by the carrier. ... Sanofi

06/28/18 / #20180177861

Methods of use of influenza vaccine for prevention of pneumonia

This application relates to the field of prevention of pneumonia by administration of a high-dose influenza vaccine.. . ... Sanofi

06/21/18 / #20180172701

Antibody epitope

. . It has been demonstrated that certain compounds bind to tnf and stabilise a conformation of trimeric tnf that binds to the tnf receptor. Antibodies which selectively bind to complexes of such compounds with tnf superfamily members are disclosed. ... Sanofi

06/21/18 / #20180169352

Auto-injector

An auto-injector for administering a dose of a liquid medicament (m) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. ... Sanofi

06/21/18 / #20180169349

Shroud lock

A shroud lock for locking a position of a needle shroud relative to a housing of an autoinjector, includes a shroud beam arranged on the needle shroud and biased radially outwards, a stop arranged within the housing, a recess arranged proximal of the stop, and a cap coupled to the housing and adapted to prevent distal translation of the needle shroud relative to the housing. At least a portion of the shroud beam is within the recess when the cap is in place and, the shroud beam abuts the stop after the needle shroud is locked relative to the housing of the autoinjector. ... Sanofi

06/21/18 / #20180169342

Drug delivery device

The disclosure relates to a drug delivery device including a plunger disposed within a case and an audible indicator that comprises a resilient element. Thee plunger is slidable from a proximal position to a distal position within the case and the resilient element is in a first configuration when the plunger is in the proximal position, such that the resilient element is deflected radially outwards to a second configuration during movement of the plunger from the proximal position towards the distal position. ... Sanofi

06/21/18 / #20180169338

Syringe support and autoinjector

The disclosure relates to a syringe support for supporting an axial position of a syringe relative to a housing of an autoinjector. The syringe support includes a supporting beam arranged on the syringe support and biased radially inwards. ... Sanofi

06/14/18 / #20180162914

Methods of optimizing nucleotide sequences encoding engineered influenza proteins

. . . . The disclosure provides methods for generating an optimized nucleotide sequence encoding an engineered influenza structural protein and the optimized nucleotide sequences obtained therefrom. The optimized nucleotide sequences can be used in a reverse genetics system to facilitate the rescue of infectious influenza virus containing the engineered structural proteins and/or enhance viral titers. ... Sanofi

06/14/18 / #20180162809

Ror gamma (rory) modulators

The present invention relates to compounds according to formula i: or a pharmaceutically acceptable salt thereof. The compounds can be used as inhibitors of rory and are useful for the treatment of rory mediated diseases such as autoimmune and inflammatory diseases.. ... Sanofi

06/14/18 / #20180161517

Drug delivery device

Disclosed is a drug delivery device having an adapter configured for mounting a needle hub and a flange portion configured for cooperating with an orifice of a cap, the cap is configured to cover the adapter, and a latch mechanism configured for releasably engaging a detent or recess in a surface portion of the cap. In addition, the latch mechanism is configured to turn into an inoperable state when a needle hub is mounted to the adapter.. ... Sanofi

06/14/18 / #20180161510

Drug delivery device

Drug delivery device comprising a housing retaining a primary drug delivery assembly for the delivery of a primary medicament with a primary dose setting member configured to rotate in a helical movement to set a dose of the primary medicament and a secondary drug delivery assembly for the delivery of a secondary medicament. A dose dial is movable between a first position and a second position in axial direction and is rotationally constrained with respect to the housing when moved from the first position into the second position and is rotationally constrained to the primary dose setting member in the second position. ... Sanofi

06/14/18 / #20180161508

Drug delivery device with audible indicator spring

The disclosure relates to a drug delivery device comprising a case adapted to hold a medicament container, a plunger disposed within the case and slidable from a proximal position into a distal position for delivering a medicament (m) from the medicament container, an audible indicator that is arranged within a case pocket lateral to the plunger and that is in operative connection with the plunger, the audible indicator comprises at least one indicator spring and at least one locking element, wherein the indicator spring is biased by the locking element, and the indicator spring relaxes due to a release of the locking element by a movement of the plunger.. . ... Sanofi

06/14/18 / #20180161505

Injection device and a supplemental device configured for attachment thereto

A supplemental device configured for attachment to an injection device, the supplemental device comprising: a camera configured to generate camera output indicative of a scene viewable by the camera, and to be located on an optical path with a surface of an injection device attached to the supplemental device in use; a light source having an emission spectrum and configured to illuminate the surface with light within the emission spectrum in use; and a filter configured to be located on the optical path between the camera and the surface in use, the filter being substantially opaque to light across the entire emission spectrum of the light source and substantially transparent to light of at least one frequency outside the emission spectrum of the light source.. . ... Sanofi

06/14/18 / #20180161504

Syringe support and autoinjector

The invention relates to a syringe support (15, 15′) for supporting an axial position of a syringe (3) relative to a housing (2) of an autoinjector (1), wherein the syringe support (15, 15′) comprises:—a projecting portion (15.3) which projects from the syringe support (15, 15′) in a distal direction (d) and—a flexible portion (15.1) which axially adjoins the projecting portion (15.3) and which is adapted to axially bias the syringe (3) in the distal direction (d) within the housing (2). The invention further relates to an autoinjector (1).. ... Sanofi

06/14/18 / #20180161500

Drug delivery device

Disclosed herein is a drug delivery device with a primary drug delivery assembly for the delivery of a primary medicament, with a primary dose setting member; and a secondary drug delivery assembly for the delivery of a secondary medicament with a secondary dose setting member. A dose dial is rotationally constrained with respect to the housing in a first axial position and is rotationally constrained to the primary dose setting member in a second axial position. ... Sanofi

06/07/18 / #20180155450

Dual variable region antibody-like binding proteins having cross-over binding region orientation

. . . . The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a cross-over orientation. The invention also provides methods for making such antigen-like binding proteins.. ... Sanofi

06/07/18 / #20180155407

Compounds as peptidic glp1/glucagon/gip receptor agonists

The present invention relates to trigonal glp-1/glucagon/gip receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.. . ... Sanofi

06/07/18 / #20180155406

Compounds as peptidic trigonal glp1/glucagon/gip receptor agonists

The present invention relates to trigonal glp-1/glucagon/gip receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as for reduction of excess food intake.. . ... Sanofi

06/07/18 / #20180154089

Audible indicator

The disclosure relates to an audible indicator in combination with a drug delivery device having a resilient force member capable of resting in either of two states. In a biased state, the resilient force member is biased and stores energy and in a relaxed state, the resilient force member is relaxed. ... Sanofi

06/07/18 / #20180154086

Data collection apparatus for attachment to an injection device

A data collection device comprises: a first portion having one or more features configured for attaching of the first portion to a dosage knob of an injection device; a second portion rotatably coupled with the first portion, wherein at least part of the second portion is movable axially relative to the first portion; a sensor arrangement configured to detect rotation of the first portion relative to the second portion; and a processor arrangement configured to, based on said detected movement, determine a medicament amount expelled by the injection device, wherein the coupling arrangement is configured to provide a non-permanent coupling between the first portion and the dosage knob of the injection device.. . ... Sanofi

06/07/18 / #20180154085

Audible indicator for a drug delivery device

The disclosure relates to a drug delivery device, comprising a mechanical audible indicator capable of producing an audible signal with a volume of at least 100 db.. . ... Sanofi

06/07/18 / #20180154078

Audible indicator

The disclosure relates to an audible indicator for use with a drug delivery device comprising a bistable resilient force member capable of residing in two states. In a biased state, the resilient force member is biased and stores energy in a relaxed state, the resilient force member is relaxed. ... Sanofi

06/07/18 / #20180154010

Multivalent meningococcal polysaccharide-protein conjugate vaccine

The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. ... Sanofi

05/31/18 / #20180149502

Flow rate sensor

. . . . The disclosure relates to a flow rate sensor for determining a flow rate of a liquid within a tube, the flow rate sensor comprising at least one coil arranged in the vicinity of the tube in such a manner that an eddy current in the liquid due to the liquid's flowing affects an impedance of the coil.. . ... Sanofi

05/31/18 / #20180147354

Pressure container for driving a medical device

The present disclosure relates to a portable pressure container for driving a medical device. The container includes a pressure housing confining an interior volume and a pressure outlet extending through the pressure housing. ... Sanofi

05/31/18 / #20180147353

Auto-injector

Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament (m), the housing having a distal end (d) and a proximal end (p) with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end (p), operate the syringe to supply the dose of medicament (m), and retract the syringe with the needle after delivering the medicament (m). ... Sanofi

05/31/18 / #20180147350

Arrangement for detecting a position of a plunger

The invention relates to an arrangement for detecting a position of a plunger (4) relative to a bung (3) in a drug cartridge (1), comprising a proximity sensor (5) located close to a distal end (6) of the plunger (4) facing the bung (3) and aligned to receive light reflected by the bung (3).. . ... Sanofi

05/24/18 / #20180142032

Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof

. . Antibodies are provided which specifically bind human and macaca fascicularis lysosomal-associated membrane protein 1 (lamp1) proteins and immunoconjugates comprising said antibodies conjugated or linked to a growth inhibitory agent. Pharmaceutical compositions comprising antibodies or immunoconjugates of the invention and use of the antibodies or immunoconjugates for the treatment of cancer are also provided, as well as lamp1 antibodies, isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies and the use of said antibody as a diagnostic tool. ... Sanofi

05/24/18 / #20180140782

Autoinjector and method of assembling

The disclosure further relates to an autoinjector and a method of assembling the autoinjector. A syringe carrier is disclosed comprising a housing adapted to receive a syringe. ... Sanofi

05/24/18 / #20180140781

Syringe carrier for an autoinjector and method of assembling

A syringe carrier includes a housing adapted to receive a syringe having a needle encapsulated by a removable protective needle sheath, and two or more flexible arms protruding inwards in a relaxed state and adapted to couple with the syringe in a mounted position. The flexible arms are adapted to deflect radially outwards in a pre-assembled position of the syringe in the syringe carrier. ... Sanofi

05/24/18 / #20180140779

Pen-type drug injection device with iris style quick coupling for piston rod resetting

A pen-type drug injection device is disclosed which comprises a housing having a longitudinal axis, a threaded piston rod, a guide member for guiding the piston rod in a drug dispense operation, and a cartridge holder for receiving a cartridge, wherein the cartridge holder is detachable from the housing and wherein the guide member comprises an iris type aperture defined by a plurality of threaded pivotable segments. The drug delivery device is configured such that the aperture increases in diameter when the cartridge holder is being detached from the housing, such that the piston rod is free of the threaded engagement with the guide member and can be reset or pushed back to its initial position, and decreases in diameter when the cartridge holder is attached, such that the threads on segments reengage the piston rod.. ... Sanofi

05/17/18 / #20180133290

Insulin glargine/lixisenatide fixed ratio formulation

. . The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin glargine or/and a pharmaceutically acceptable salt thereof, wherein the compound (b) and compound (a) are present in a fixed ratio.. . ... Sanofi

05/10/18 / #20180127511

Ca6 antigen-specific cytotoxic conjugate and methods of using the same

Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the ca6 glycotope. ... Sanofi

05/10/18 / #20180127487

Anti-chikv antibodies and uses thereof

The present invention concerns antibodies and antigen-binding fragments of antibodies which specifically bind to and neutralize chikungunya virus (chikv) and which are engineered to develop therapeutics in order to treat chikv disease or prevent chikv infection. The invention also relates to pharmaceutical compositions comprising antibodies of the invention and the use of the antibodies for the prevention and treatment of chikv disease.. ... Sanofi

05/10/18 / #20180126087

Drug delivery device and retaining member for a drug delivery device

A drug delivery device includes a housing, a mechanical assembly which is at least partially accommodated in the housing and a retaining member for retaining the mechanical assembly in the housing wherein the retaining member is engaged with the housing such that the device is configured to be damaged when the mechanical assembly or parts thereof are forcefully separated from the housing.. . ... Sanofi

05/10/18 / #20180126069

Injection system

Described is a medicament cartridge comprising a housing having open proximal and distal ends, a first coupling mechanism, and a syringe slidably disposed in the housing. The syringe includes a needle and has a retracted position in which the needle is covered by the housing and an extended position in which the needle is exposed. ... Sanofi

05/10/18 / #20180125981

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

05/10/18 / #20180125961

Neisseria meningitidis trypsin-like serine protease polypeptides and compositions thereof

The present invention relates to novel polypeptides derived from neisseria meningitidis proteins, in particular auto-transporters of the trypsin-like serine protease subclass, such as iga1p, app and ausi, and their use in immunogenic compositions i.a., vaccine compositions for the prevention and/or treatment of meningococcal infections. In particular, it provides fragments of iga1p, app and ausi and polypeptides comprising or consisting of these fragments and fusions thereof, which may be used in immunogenic compositions, for example vaccine compositions.. ... Sanofi

05/10/18 / #20180125960

Meningitidis vaccines comprising subtilinases

The present invention relates to novel polypeptides derived from meningitis proteins, in particular auto-transporters of the subtilinase subclass, and their use in vaccines and vaccine compositions for the prevention and/or treatment of meningitis and meningococcal infections.. . ... Sanofi

05/10/18 / #20180125959

Compositions comprising n. meningitidis proteins

The invention relates to immunogenic compositions comprising at least two neisseria meningitidis (nm) protein antigens selected from the group consisting of a trypsin-like serine protease auto-transporter antigen such as igai p, app or ausi antigen, a nalp antigen and a tbpb antigen. Preferably, the composition of the invention comprises (i) the trypsin-like serine protease auto-transporter antigen and (ii) the nalp antigen and/or tbpb antigen.. ... Sanofi

05/10/18 / #20180125945

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

05/10/18 / #20180125944

Stabilized pharmaceutical formulations of insulin aspart

Stabilized pharmaceutical formulations of insulin aspart are disclosed.. . ... Sanofi

05/10/18 / #20180125943

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

05/03/18 / #20180119111

Icp0-mediated enhanced expression system

Methods and compositions for increasing the production of recombinant proteins by introducing icp0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.. ... Sanofi

05/03/18 / #20180117244

Flexible container for an injection device

The present disclosure relates to a flexible container for an injection device including a flexible bag having an interior volume to be filled with a liquid medicament, an outlet located at a first end of the bag, and a contraction member connected to the bag to displace a second end of the bag located opposite to the first end towards the first end.. . ... Sanofi

04/12/18 / #20180100019

Humanized anti-cxcr5 antibodies, derivatives thereof and their use

. . The present invention relates to humanized antibodies that specifically bind to cxcr5 and can, for example, inhibit cxcr5 function. The invention also includes uses of the antibodies to treat or prevent cxcr5 related diseases or disorders.. ... Sanofi

04/12/18 / #20180099097

Drug delivery device with tamper-evident closure

The present invention relates to a drug delivery device for dispensing of a dose of a medicament, comprising a housing to accommodate a cartridge being at least partially filled with a medicament, wherein the housing comprises a dispensing end with an access opening which is closed by a tamper-evident closure.. . ... Sanofi

04/12/18 / #20180099084

Device and method for determining information related to a medical device

The invention relates to an apparatus (2, 3), comprising a mating unit (20-1, 20-2) for releasably attaching the apparatus (2) to a medical device (1) or for releasably receiving at least a part of the medical device (1). The apparatus (2, 3) further comprises one or more optical sensors (25, 26) and/or one or more acoustical sensors (27) for determining information related to a condition and/or use of the medical device (1). ... Sanofi

04/05/18 / #20180093046

Autoinjector with an inner plunger which disengages the outer plunger to retract the syringe carrier

Described is an autoinjector comprising a case, a chassis slidably arranged in the case, a syringe carrier operably coupled to the chassis, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. ... Sanofi

04/05/18 / #20180093042

Sensor and sensor assembly for capacitive determination of a filling level

The present disclosure relates to a sensor for a capacitive determination of a filling level of a cartridge filled with a liquid substance. The sensor comprises a planar flexible foil arrangeable to an outer circumference of a tubular shaped barrel of the cartridge. ... Sanofi

04/05/18 / #20180092965

Treatment type 2 diabetes mellitus patients

A pharmaceutical combination for use in glycemic control in a type 2 diabetes mellitus patient, said combination comprising (i) lixisenatide or/and a pharmaceutically acceptable salt thereof, (ii) insulin glargine or/and a pharmaceutically acceptable salt thereof, and (iii) optionally metformin or/and a pharmaceutically acceptable salt thereof.. . ... Sanofi

03/29/18 / #20180086799

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

03/29/18 / #20180085537

Drug delivery device and predetermined breaking member for a drug delivery device

A drug delivery device comprises a housing and a mechanical assembly, which is at least partially accommodated in the housing. The mechanical assembly comprises a predetermined breaking member, which is configured to be damaged when forcefully separated from the housing.. ... Sanofi

03/29/18 / #20180085528

Dosing mechanism and drug delivery device

This disclosure refers to a dosing mechanism for use in a drug delivery device implementing a dialing mode and a dispensing mode, wherein the dosing mechanism comprises a dose button, a housing and a determination unit. The dose button is activatable by the user for dose dispense, causing displacement of an indicating element connected to the housing from a first position to a second position. ... Sanofi

03/22/18 / #20180080592

Coded cartridge holder and fastener enabled by cartridge size

. . A coded cartridge holder for use with a drug delivery device is provided. The cartridge holder includes a fastener that becomes operative based in part on a length of a cartridge or a diameter of the cartridge. ... Sanofi

03/22/18 / #20180079119

Housing and drug delivery device herewith and method for producing a housing

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a housing for such a device. The housing comprises a twin-shot injection moulded casing with at least one window and at least one interface for engaging a further component part of the drug delivery device. ... Sanofi

03/22/18 / #20180078717

Medical device and method for limiting the use of the medical device

A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. ... Sanofi

03/22/18 / #20180078603

Methods for treating severe atopic dermatitis by administering an il-4r inhibitor

The present invention provides methods for treating moderate-to-severe or severe atopic dermatitis (ad). The methods of the present invention comprise administering to a subject in need thereof one or more doses of an interleukin-4 receptor (il-4r) inhibitor such as an anti-il-4r antibody. ... Sanofi

03/22/18 / #20180078496

Article of manufacture comprising aflibercept or ziv-aflibercept

Article of manufacture comprising a packaging material, a polypeptide of seq id no:1, aflibercept or ziv-aflibercept or a biosimilar thereof, and a label comprising a printed statement which informs a prospective user of adverse events or adverse reactions.. . ... Sanofi

03/15/18 / #20180071460

Resettable drug delivery device

The present disclosure is generally directed to a resettable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The drug delivery device comprises a housing, a cartridge holder releasably attached to the distal end of the housing, a piston rod engaging a housing insert and a drive member, a dose setting member guided within the housing to allow rotation of the dose setting member during dose setting and dose dispensing, a clutch for rotationally coupling the drive member and the dose setting member, and a locking element which is rotationally constrained to the housing and is axially movable relative to the housing between a proximal dose setting position and a distal resetting position.. ... Sanofi

03/08/18 / #20180064884

Sealed needle assembly for medicament delivery device

. . . . The disclosure relates to a needle assembly adapted to couple with a medicament delivery device including a needle having a proximal tip and a distal tip, a needle hub coupled to the needle, a body adapted to engage the needle hub, a removable needle cap adapted to cover the distal tip, and a removable sealing element. The sealing element is adapted to seal an open proximal end of a compartment of the body, including the proximal tip, in such a manner that the proximal tip is housed in a sealed environment before use of the needle. ... Sanofi

03/01/18 / #20180057597

Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123

The present invention concerns antibody-like binding protein specifically binding to cd3 and binding specifically to at least one further antigen, for example cd123. The present invention also concerns antibody-like binding protein specifically binding to cd123 and binding specifically to at least one further antigen. ... Sanofi

03/01/18 / #20180057567

Multispecific antibodies facilitating selective light chain pairing

Provided herein are multispecific antibodies, e.g. Bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. ... Sanofi

03/01/18 / #20180057539

Multimerization of recombinant protein by fusion to a sequence from lamprey

The present invention relates to polymerized recombinant proteins, to recombinant nucleic acids coding for the polymerized recombinant proteins, to expression cassettes comprising the recombinant nucleic acids, to host cells transformed by the expression cassettes and to a method for multimerizing a recombinant protein. The polymerized proteins of the invention may be used in pharmaceutical or immunogenic compositions. ... Sanofi

03/01/18 / #20180056008

Drug delivery device

A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. ... Sanofi

03/01/18 / #20180055994

Method of priming a medical pump

A method of priming a medical pump is disclosed. The method includes providing a medical pump comprising a chamber, a first plunger element and, a second plunger element. ... Sanofi

02/22/18 / #20180050161

Drug delivery device

The disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing having a proximal end and an opposite distal end, a dose setting member rotatable relative to the housing during dose setting and during dose dispensing, and an axially compressible torsion spring which is rotationally and axially constrained with a first end to the housing. ... Sanofi

02/22/18 / #20180050160

Drug delivery device

The disclosure refers to an injection device for automatic spring driven injection of a liquid drug by which doses of an individual size can be set by a user. The injection device comprises a housing defining an interior space and having a longitudinal window, a rotatable dose dial axially retained in relation to the housing, a rotatable scale drum carrying indicia for indicating the size of the set dose, wherein the scale drum is functionally coupled to the dose dial to rotate when the dose dial is rotated to set a dose, a sliding element provided with a sliding window, which sliding element is adapted to slide axially in relation to the housing during dose setting, and through which sliding window the indicia carried by the scale drum is visible. ... Sanofi

02/22/18 / #20180050155

Drug delivery device

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing and at least two separate component parts, wherein for example at least one of these component parts performs a movement relative to the housing during dose setting and for example at least one of these component parts performs a movement relative to the housing during dose dispensing, and wherein the relative movement of the at least two separate component parts with respect to each other during dose setting differs from the relative movement of the at least two separate component parts with respect to each other during dose dispensing. ... Sanofi

02/15/18 / #20180047392

Methods and systems for modifying operational data of an interaction process or of a process for determining an instruction

It is inter alia disclosed to perform at least one of operating an interaction process with a user of the medical apparatus and determining, based on a representation of at least one instruction given by the user, at least one instruction operable by the medical apparatus. Therein, the at least one of the operating and the determining at least partially depends on operational data. ... Sanofi

02/15/18 / #20180043104

Sensor arrangement for an injection device

The disclosure relates to a sensor arrangement for an injection device to determine an axial position of at least one device component of the injection device inside a housing of the injection device. The sensor arrangement includes an elongated member located inside the housing, extending in an axial direction and having at least a first section and a second section of different magnetization. ... Sanofi

02/08/18 / #20180037619

Novel proteins specific for pyoverdine and pyochelin

. . The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

02/08/18 / #20180037618

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Acruginosa. ... Sanofi

02/08/18 / #20180036483

Drive mechanisms suitable for use in drug delivery devices

A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. ... Sanofi

02/08/18 / #20180036411

Stable formulation of insulin glulisine

An aqueous pharmaceutical formulation comprising 200-1000 u/ml of insulin glulisine.. . ... Sanofi

02/08/18 / #20180036339

Meningococcal vaccine based on lipooligosaccharide (los) originating from modified neisseria meningitidis strains of immunotype l6

The invention especially relates to multivalent vaccine compositions that can treat or prevent at least 60, preferably 75% of infections caused by neisseria meningitidis especially of serogroup b. To this end, the invention in particular provides a lipooligosaccharide (lqs) of n. ... Sanofi

02/01/18 / #20180030156

Antibodies that bind il-4 and/or il-13 and their uses

The present invention relates to novel humanized anti-il-4 and il-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to il-4 and il-13. The invention also includes uses of the antibodies to treat or prevent il-4 and/or il-13 mediated diseases or disorders, including allergic asthma and dermatitis.. ... Sanofi

02/01/18 / #20180030101

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

02/01/18 / #20180028760

Supplemental device for removable attachment to a medicament injection device

The disclosure provides a supplemental device configured for removable attachment to a medicament injection device. The supplemental device includes a display, a processor arrangement, at least one memory, and an image-capturing component. ... Sanofi

02/01/18 / #20180028759

Injection device with supplementary device

The present invention relates to a supplementary device for a manually operable injection device, the supplementary device comprising: a body (300) having at least one engaging member (340) to releasably mount the body (300) to the injection device (1) in a specific position (p) on an outside surface (106) of the injection device (1), at least one indicator (350; 370; 380) located on the body (300) and having a shape or contour to overlap or to align with a mark (150; 160; 170; 180) on the outside surface (106) of the injection device (1) when the body (300) is in or near the specific position (p).. . ... Sanofi

02/01/18 / #20180028757

Drive mechanism for an injection device

The present invention relates to a drive mechanism for an injection device for setting and dispensing of a dose of a medicament, the drive mechanism comprising:—a tubular shaped housing component (12, 45) extending in an axial direction (z) and comprising an inner thread (46),—a tubular shaped display member (80) having an outer thread (81) engaged with the inner thread (46), and—a dose member (90) axially displaceable between a dose setting position (s) and a dose dispensing position relative to the display member (80),—wherein the display member (80) comprises at least one blocking member (87) on its outer circumference to axially engage with a blocking structure (18) on an inside facing sidewall portion (12a) of the housing component (12, 45) to block an axial displacement of the dose member (90) from the dose setting position (s) towards the dose dispensing position.. . ... Sanofi

02/01/18 / #20180028637

Toxoid, compositions and related methods

The disclosure relates to generally to the field of toxin inactivation. More specifically, it relates to clostridial toxins, methods of inactivating these toxins and compositions (e.g., vaccines) comprising toxoids (e.g., produced by these methods). ... Sanofi

02/01/18 / #20180028400

Container for a liquid medicament

The present disclosure relates to a container for a liquid medicament that includes a wall structure with at least one flexible portion and confining an inner volume filled with the liquid medicament and an elongated extraction tube having at least a first portion and a second portion that are separated from each other along the tube and which are located inside the inner volume. The extraction tube is radially collapsible when exposed to a compressive force above a predefined threshold, and the first portion, which is located at a distal end of the extraction tube, is less resistive against radial collapsing than the second portion.. ... Sanofi

01/25/18 / #20180022817

Anti-ceacam5 antibodies and uses thereof

The present invention discloses antibodies which bind human and macaca fascicularis ceacam5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The invention also discloses immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the invention. ... Sanofi

01/25/18 / #20180022814

Specific anti-cd38 antibodies for treating human cancers

The present disclosure concerns an antibody that specifically binds cd38 which is capable of killing a cd38+ cell by induction of apoptosis, antibody-dependent cell-mediated cytotoxicity (adcc), and complement-dependent cytotoxicity. The disclosed antibody may be used as a medicament or in the making of a medicament, wherein the antibody is to be administered to a human subject in a safe therapeutic dose of about 20 mg/kg or below. ... Sanofi

01/25/18 / #20180022713

Heteroaryl compounds and uses thereof

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.. . ... Sanofi

01/25/18 / #20180021520

Magnifying device for a medicament injection device

The present disclosure relates to a magnifying device attachable to an injection device. The magnifying device includes a frame having a distal end and having a proximal end opposite to the distal end and further has a receptacle extending from the distal end towards the proximal end. ... Sanofi

01/25/18 / #20180021518

Trigger mechanism and drug delivery device herewith

The present disclosure is generally directed to a trigger mechanism for initiating dispensing doses of a medicament from a drug delivery device. The trigger mechanism includes a trigger element movable in a first direction relative to a counter element. ... Sanofi

01/18/18 / #20180017531

Method and arrangement for acoustically testing the mechanical integrity of a cartridge

The present invention relates to a method of testing the mechanical integrity of a cartridge (10) containing a medicament and being arranged inside a drug delivery device (20). The invention also relates to a testing arrangement and to a respective drug delivery device, wherein the method comprises the steps of: acoustically stimulating the cartridge (10), measuring of the cartridge's (10) acoustic response (60) to the acoustic stimulation (32), comparing the acoustic response (60) with a standard response (62) of an intact cartridge (10), and determining the mechanical integrity of the cartridge (10) on the basis of the comparison.. ... Sanofi

01/11/18 / #20180008783

Assembly for a drug delivery device

An assembly for a drug delivery device is proposed, the assembly comprising: a housing; a clutch member; and a drive member, wherein one of the clutch member and the drive member is provided with at least one deflectable feature and the other one of the clutch member and the drive member is provided with at least one interaction feature, the clutch member and the drive member are movable relative to one another between a first relative position and a second relative position, in the first relative position, the clutch member and/or the drive member is rotatable relative to the housing, in the second relative position, the deflectable feature is arranged to prevent rotation of the clutch member and/or of the drive member relative to the housing, and wherein the deflectable feature and the interaction feature are arranged such that, when the clutch member and the drive member are moved relative to one another from the first relative position into the second relative position, the deflectable feature and the interaction feature mechanically interact in order to deflect the deflectable feature.. . ... Sanofi

01/11/18 / #20180008782

Method for assembling a drug delivery device and drug delivery device

A method for assembling a drug delivery device that includes mounting a cartridge with a bung, the mechanism, the plunger and the spring within a housing such that a spring biases a plunger in a dispensing direction and that a drum and/or the release member is attached to the plunger attaching a tool with torque measurement capability to the drum or a release member of a dose mechanism in a state where at least one housing part is detached from further housing part; setting a dose by rotating the dose setting member in a first direction, activating a trigger and monitoring the torque applied to the drum or the release member; releasing the trigger upon detection of a predetermined change in the torque measured by the tool; and releasing the tool and closing the housing.. . ... Sanofi

01/11/18 / #20180008781

Drug delivery device with a drive mechanism

The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a drug delivery device. The mechanism comprises a housing having a longitudinal axis defined by a compartment for receiving a cartridge, a plunger suitable for acting on a bung of a cartridge retained in the housing, a strained pressure spring arranged between the housing and the plunger, a retaining member coupled to the plunger, and a release member operable between a first state, in which the release member constrains the retaining member to the housing, and a second state, in which the release member is movable relative to the housing.. ... Sanofi

01/11/18 / #20180008778

Data collection device for attachment to an injection device

A data collection device (20) for attachment to an injection device (1), such as an injector pen, comprises a sensor arrangement (26) to detect movement of a movable (70) of the injection device (1) relative to the data collection device (20) during delivery of a medicament by the injection device (1), and a processor arrangement (23) configured to, based on said detected movement, determine a medicament dosage administered by the injection device (1). The processor arrangement (23) may monitor the time that has elapsed since the medicament dosage was administered, and control a display (22) to show the medicament dosage (22a) and elapsed 22 time to provide a memory aid to the user. ... Sanofi

01/11/18 / #20180008707

Stable liquid formulation for monoclonal antibodies

The present invention concerns stable pharmaceutical compositions for monoclonal antibodies, for example igg antibodies. The invention further relates to medicaments and treatments using the pharmaceutical compositions of the invention. ... Sanofi

01/04/18 / #20180001027

Supplemental device for attachment to a pen injector and determination of a set dose amount using optical incremental encoder

A data collection device comprises at least two optical sensors configured to detect tick marks of a medicament dose indicator of the medicament delivery device in their respective detection areas, and a processing arrangement configured to determine a current medicament dosage programmed into said medicament delivery device based on a count of the tick marks that pass through the detection areas of the optical sensors during programming of said medicament dosage into said medicament delivery device. A direction of travel of the tick marks may be identified, to determine whether the programmed dosage is increasing or decreasing. ... Sanofi

01/04/18 / #20180001026

Auto-injector

An auto-injector for administering a dose of a liquid medicament (m) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. ... Sanofi

01/04/18 / #20180001019

Pre-filled drug cartridge with stopper partially protruding from it for facilitating priming

Disclosed is a combination of an infusion set consisting of infusion tubing and needle connected to a drug cartridge, the latter comprising a cylindrical body of inner diameter and having an open rear end, wherein a stopper is slidably disposed within the body. In an initial state after the cartridge has been filled, the stopper is partially disposed within the body such that the stopper protrudes from the rear end of the body by a distance. ... Sanofi

01/04/18 / #20180000920

Pharmaceutical compositions containing clostridium difficile toxoids a and b

This invention relates to compositions including clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.. ... Sanofi

01/04/18 / #20180000902

Prevention of hypoglycaemia in diabetes mellitus type 2 patients

A method for the prevention of hypoglycaemia in diabetes mellitus type 2 comprising administering (a) despro36exendin-4(1-39)-lys6-nh2 or/and a pharmaceutically acceptable salt thereof, and (b) a sulfonyl urea or/and a pharmaceutically acceptable salt thereof, to a subject in need thereof.. . ... Sanofi

12/28/17 / #20170369440

Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

. . A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as fexofenadine.. ... Sanofi

12/28/17 / #20170368263

Sensor for use with a drug delivery device

An optical decoding system including an optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device and a processor configured to: (i) cause the optical sensor to capture images of the first and second rotatable components at least at the beginning and end of a medicament dose dispensing process; (ii) determine a rotational position of both the first and second rotatable components in each of the captured images; and (iii) determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by the dose setting and dispensing mechanism of the drug delivery device.. . ... Sanofi

12/28/17 / #20170368256

Drug delivery device with electromagnetic drive unit

The disclosure relates to a drug delivery device having a drive unit includes a stator comprising a plurality of coils consecutively arranged in an axial direction, and an armature axially movable within the stator, the armature including a number of magnets and pole shoes consecutively arranged in the axial direction. A respective pole shoe is arranged between respectively neighbouring magnets. ... Sanofi

12/28/17 / #20170368164

Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza

The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized h1n1 influenza hemagglutinin (ha) polypeptides. Co-administration of the optimized h1n1 influenza hemagglutinin (ha) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple h1n1 influenza virus strains, including both seasonal and pandemic strains.. ... Sanofi

12/21/17 / #20170361038

Assembly for a drug delivery device

The present disclosure concerns an assembly for a drug delivery device (1)comprising a housing (3), a first abutment surface (64), a second abutment surface (21), and a detachable member (7) which is detachable from the housing (3) and attachable to the housing (3), wherein the assembly is configured such that, during detachment of the detachable member (7) from the housing (3) for an nth time, n being a predetermined number, the first abutment surface (64) is brought into abutment with the second abutment surface (21), wherein the assembly is configured such that, when the first abutment surface (64) abuts with the second abutment surface (21), the detachable member (7) is enabled to be reattached to the housing (3) and, afterwards, the detachable member (7) is prevented from being detached from the housing (3).. . ... Sanofi

12/21/17 / #20170361035

Lock out member with different cross sections

An apparatus is presented comprising a lock out member configured to be implemented into a medical device, in particular a dispense interface, attachable to a second medical device, in particular a main body, wherein said lock out member is configured to prevent a second attachment of said medical device to said second medical device, wherein said lock out member has at least a first area with a first cross-sectional area, wherein said lock out member has at least a second area having a second cross-sectional area smaller than the first cross-sectional area, such that an electric resistance is defined between opposite ends of the lockout member and wherein said lock out member, at least in the second area, is made of a conductive material.. . ... Sanofi

12/21/17 / #20170360923

Novel immunogenic formulations comprising linear or branched polyacrylic acid polymer adjuvants

The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. ... Sanofi

12/14/17 / #20170354784

Packaging for pre-filled drug cartridges with peg for pushing cartridge stopper for priming purposes

Disclosed is a packaging for a number of pre-filled drug cartridges comprising a body to which an infusion set with tubing and needle can be fitted, the body having an open rear end, wherein a stopper is slidably disposed within the body, wherein a peg is arranged on the packaging, the peg having a height which is such that when a cartridge is being put on the peg with the rear end and pushed against it until the rear end abuts a surface of the packaging, the stopper is moved within the body by such a distance that a predetermined volume of a medicament is displaced from the cartridge for priming the cartridge and infusion set.. . ... Sanofi

12/14/17 / #20170354570

Medicament delivery device

The disclosure relates to a medicament delivery device, comprising a medicament cartridge adapted to contain a medicament and a stopper slidably arranged within the cartridge. The stopper-comprises a rigid body that is enclosed partially by a soft sealing component.. ... Sanofi

12/07/17 / #20170348480

Needle interface

The invention relates to a needle interface (2) for connecting a hollow needle (3) having a proximal tip (3.1) to a medicament reservoir (1), the needle interface (2) comprising an inner ring (5) fixed to a reservoir wall (4) of the reservoir (1) and an outer ring (6) attachable to the needle (3), wherein one of the inner ring (5) and the outer ring (6) comprises at least one magnet (6.1) and wherein the other one of the inner ring (5) and the outer ring (6) comprises a magnetisable material (5.1) or a magnet (6.1).. . ... Sanofi

11/30/17 / #20170343550

Novel anti-cd38 antibodies for the treatment of cancer

Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to cd38, are capable of killing cd3830 cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (adcc), and/or complement-dependent cytotoxicity (cdc). Said antibodies and fragments thereof may be used in the treatment of tumors that express cd38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic rnyelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autoimmune and inflammatory diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. ... Sanofi

11/30/17 / #20170342389

Novel cytochrome p450 polypeptide with increased enzyme activity

The present invention pertains to an isolated p450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to seq id no: 1, wherein said sequence comprises a threonine at position corresponding to position 225 and/or an aspartic acid mutation at position corresponding to position 289. The invention also concerns an isolated nucleic acid comprising a sequence encoding said enzyme, a vector comprising said nucleic acid, and a host cell containing said nucleic acid or said vector. ... Sanofi

11/30/17 / #20170340835

Drug delivery device with variable piston force

The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.. ... Sanofi

11/30/17 / #20170340834

Drive mechanism and drug delivery device herewith

The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. A handheld injection device for selecting and dispensing a number of user variable doses of a medicament. ... Sanofi

11/30/17 / #20170340833

Drug delivery device comprising a prism

The present invention relates to a drug delivery device comprising a dose setting member (70) for setting user variable doses of a medicament and a display for indicating the dose set by the dose setting member (70). The display comprises a number wheel (100), which is rotationally coupled to the dose setting member (70) and is provided with a series of markings on its outer circumference, and at least one prism (90) deviating the image of the markings of the number wheel (100), e.g. ... Sanofi

11/30/17 / #20170340832

Pen-type injector

The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. ... Sanofi

11/30/17 / #20170340826

Pen-type drug injection device and optical dose value decoding system with additional sensor to distinguish between dose dialling and dose delivery mode

An optical decoding system comprising: a first optical sensor configured to be directed at a first rotatable component of a drug delivery device; a second optical sensor configured to be directed at a second rotatable component of a drug delivery device; and a processor configured to: receive signals from the first optical sensor, wherein the signals from the first optical sensor represent encoded dosage values present on the first rotatable component; receive signals from the second optical sensor, wherein the signals from the second optical sensor represent whether the second rotatable component is rotating or not; and to determine from the received signals whether the drug delivery device is in a drug dose dialling mode or a drug dose delivery mode.. . ... Sanofi

11/30/17 / #20170340806

Medical apparatus package

A package for components of a medical apparatus comprising a plurality of panels defining a container having an interior space. A first component of the medical apparatus is disposed within the interior space. ... Sanofi

11/30/17 / #20170340515

Pharmaceutical compositions comprising human antibodies to pcsk9

The present invention relates to pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (pcsk9), to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (pcsk9) expression or activity causes an impact by administration of pcsk9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase (hmg-coa reductase). The present invention further relates to pcsk9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which pcsk9 expression or activity causes an impact. ... Sanofi

11/23/17 / #20170335292

Novel selection marker for cell transfection and protein production

The present invention is within the field of industrial protein production. The invention provides a novel expression system using dihydroorotate dehydrogenase (dhodh) as a selection marker in combination with leflunomide or a metabolite thereof, notably for use in mammalian cell lines. ... Sanofi

11/23/17 / #20170333557

Methods for treating atopic dermatitis by administering an il-4r antagonist

The present invention provides methods for treating atopic dermatitis (ad). Also provided are methods for improving one or more ad-associated parameter(s), and methods for decreasing the level of at least one ad-associated biomarker in a subject in need thereof. ... Sanofi

11/16/17 / #20170326304

Assembly for a drug delivery device and drug delivery device

. . An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. ... Sanofi








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