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Somalogic Inc patents


Recent patent applications related to Somalogic Inc. Somalogic Inc is listed as an Agent/Assignee. Note: Somalogic Inc may have other listings under different names/spellings. We're not affiliated with Somalogic Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Somalogic Inc-related inventors


Cardiovascular risk event prediction and uses thereof

Methods and computer methods used to assess an individual for the prediction of risk of developing a cardiovascular (cv) event over a 1 to 5 year period are provided. The methods employ at least two biomarkers selected from mmp12, angiopoietin-2, complement c7, cardiac troponin i, angiopoietin-related protein 4, ccl18/parc, alpha-1-antichymotrypsin complex, gdf11 and alpha-2-antiplasmin, or gdf11 in combination with fstl3. ... Somalogic Inc

Multiaptamer target detection

Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first aptamer and the second aptamer comprise c-5 pyrimidine modification schemes that are different, and methods of making and using such compositions.. . ... Somalogic Inc

Multiplexed analyses of test samples

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. In one embodiment, a test sample is contacted with an aptamer that includes a tag and has a specific affinity for a target molecule. ... Somalogic Inc

Method for generating aptamers with improved off-rates

The present disclosure describes improved selex methods for producing aptamers that are capable of binding to target molecules and improved photoselex methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior selex and photoselex methods. ... Somalogic Inc

Tuberculosis biomarkers and uses thereof

The present application includes biomarkers, methods, devices, reagents, systems, and kits for the detection, treatment and diagnosis of tuberculosis (tb). In one aspect, the present application includes the identification of biomarkers that can be used alone or in various combinations for the detection of tb, including those set forth in tables 1, 2, 4, 5, and 8 to 12. ... Somalogic Inc

5-position modified pyrimidines and their use

The present disclosure relates to the field of nucleic acid chemistry, specifically to 5-position modified uridines as well as phosphoramidite and triphosphate derivatives thereof. The present disclosure also relates to methods of making and using the same.. ... Somalogic Inc

Pancreatic cancer biomarkers and uses thereof

The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and pancreatic cancer specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or pancreatic cancer specifically. ... Somalogic Inc

Nucleic acid compounds for binding growth differentiation factor 8

Described herein are aptamers capable of binding to growth differentiation factor 8 (gdf8) protein; compositions comprising a gdf8 binding aptamer; and methods of making and using the same.. . ... Somalogic Inc

Aptamers and diagnostic methods for detecting the egf receptor

The present invention provides aptamers that specifically bind to the egf receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3′ cap. ... Somalogic Inc

Aptamers to pdgf and vegf and their use in treating pdgf and vegf mediated conditions

Aptamers that bind pdgf and aptamers that bind vegf are provided. In addition, aptamer constructs comprising a pdgf aptamer and a vegf aptamer are provided. ... Somalogic Inc

Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders

Aptamers having improved stability against nucleases that bind pdgf and aptamers that bind vegf are provided. In addition, aptamer constructs comprising a pdgf aptamer and a vegf aptamer are provided. ... Somalogic Inc

Nonalcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash) biomarkers and uses thereof

Methods, compositions, and kits for determining whether a subject has non-alcoholic fatty liver disease (nafld) are provided. Methods, compositions, and kits for determining whether a subject has non-alcoholic steatosis are also provided. ... Somalogic Inc

Multiplexed analyses of test samples

The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer) where the aptamer-aptamer interactions are significantly reduced or eliminated while maintaining the aptamer-target interaction.. ... Somalogic Inc

Nucleic acid compounds for binding to complement component 3 protein

Described herein are aptamers capable of binding to human complement component 3 (c3) protein; compositions comprising a c3 binding aptamer with a c3-protein; and methods of making and using the same.. . ... Somalogic Inc

05/18/17 / #20170137819

Method for generating aptamers with improved off-rates

The present disclosure describes improved selex methods for producing aptamers that are capable of binding to target molecules and improved photoselex methods for producing photoreactive aptamers that are capable of both binding and covalently crosslinking to target molecules. Specifically, the present disclosure describes methods for producing aptamers and photoaptamers having slower dissociation rate constants than are obtained using prior selex and photoselex methods. ... Somalogic Inc

02/23/17 / #20170051337

Method of detecting a microorganism in a sample by a fluorescence based detection method

The present invention relates to a method of detecting a microorganism, in particular staphylococcus aureus, in a sample, comprising the steps of a) incubating the sample with a slow off-rate modified aptamer (somamer) comprising a fluorescent label, b) optionally washing the sample, c) analyzing the sample by a fluorescence-based detection method. The invention further relates to a slow off-rate modified aptamer comprising a fluorescent label, wherein the somamer comprises a nucleotide sequence specific for staphylococcus aureus, its use for detecting staphylococcus aureus cells in a sample, and to a microarray or biosensor and a kit comprising at least one of such somamers comprising a fluorescent label.. ... Somalogic Inc








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