Real Time Touch



new TOP 200 Companies filing patents this week

new Companies with the Most Patent Filings (2010+)




Real Time Touch

The Cleveland Clinic Foundation patents


Recent patent applications related to The Cleveland Clinic Foundation. The Cleveland Clinic Foundation is listed as an Agent/Assignee. Note: The Cleveland Clinic Foundation may have other listings under different names/spellings. We're not affiliated with The Cleveland Clinic Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Cleveland Clinic Foundation-related inventors


Motion-assisted systems, devices and methods for minimizing obstruction of medical devices

. . A device for minimizing obstruction in a medical device that carries fluids includes a housing defining a channel configured to receive and secure a section of the medical device such that the section of the medical device extends coaxially with a central longitudinal axis of the channel. The device also includes components supported in the housing, including a motor, wherein the components are configured to be operated to impart motion to the housing and the attached medical device. ... The Cleveland Clinic Foundation

Automated centerline extraction method and generation of corresponding analytical expression and use thereof

A computer implemented method for determining a centerline of a three-dimensional tubular structure is described. The method includes providing an edge-detected data set of voxels that characterize a boundary of the tubular structure according to a three-dimensional voxel data set for the tubular structure. ... The Cleveland Clinic Foundation

Model-based surgical planning and implant placement

Systems and methods are provided for model-based surgical planning. A surgical planning system can include a prescreening tool configured to provide an initial classification of a set of patients according to a pelvic tilt, measured as a position of a pelvis of the patient relative to the position of a spine of the patient, in a plurality of body positions. ... The Cleveland Clinic Foundation

Mouse model of retinal degeneration

The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (amd). ... The Cleveland Clinic Foundation

Endoluminal prosthesis having multiple branches or fenestrations and methods of deployment

A branched and fenestrated prosthesis may include a main tubular graft body including a proximal end opening, a distal end opening, a lumen, and a sidewall. A branch may extend from the sidewall and may include a first end opening, a second end opening, and a lumen. ... The Cleveland Clinic Foundation

Methods and systems for treating acute heart failure by neuromodulation

Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. ... The Cleveland Clinic Foundation

Ultrafiltration membrane, device, bioartificial organ, and related methods

The present invention relates to ultrafiltration. In particular, the present invention provides nanoporous membranes having pores for generating in vitro and in vivo ultrafiltrate, devices and bioartificial organs utilizing such nanoporous membranes, and related methods (e.g., diagnostic methods, research methods, drug screening). ... The Cleveland Clinic Foundation

Flagellin related polypeptides and uses thereof

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.. . ... The Cleveland Clinic Foundation

Use of epineural sheath grafts for neural regeneration and protection

Described herein is conduit material that causes minimal inflammatory reaction, and serves as a structural guide for regenerating nerve tissue (e.g., axons). Thus, the invention is directed to methods of treating a nerve injury in an individual in need thereof. ... The Cleveland Clinic Foundation

System and method for assisting with attachment of a stock implant to a patient tissue

A guide for assisting with attachment of a stock prosthetic implant to a patient tissue includes a lower guide surface configured to contact an upper implant surface of the stock prosthetic implant when a lower implant surface of the stock prosthetic implant contacts the patient tissue. An upper guide surface is accessible to a user when the lower guide surface is in contact with the upper implant surface. ... The Cleveland Clinic Foundation

Composition and method to enhance expression of human defensin 2

Compositions and methods are provided for enhancing the expression of human beta defensin 2 (hbd2) in human colon epithelium cells. The method comprises orally administering a composition comprising hyaluronan, where said hyaluronan has a molecular weight within the range of about 35 kda.. ... The Cleveland Clinic Foundation

Systems and methods for peripheral vascular cannulation

Systems and method for peripheral cannulation are provided. Systems include cannulas defining fenestrations that can be exposed or occluded by a cover slip to selectively expose fenestrations to blood flow in an artery or vein.. ... The Cleveland Clinic Foundation

Method and device for selectively providing irrigation fluid to a target patient tissue site

A continuous-flow hemostatic device is provided for selectively providing irrigation fluid to a target patient tissue site. The continuous-flow hemostatic device includes a compression ring and a handle. ... The Cleveland Clinic Foundation

Reinforced tissue graft

A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.. ... The Cleveland Clinic Foundation

03/15/18 / #20180070949

Apparatus and method for assisting in hemostasis of a vessel

A hemostatic vessel band is provided. The hemostatic vessel band has a membrane. ... The Cleveland Clinic Foundation

03/01/18 / #20180059111

Methods and compositions for detection of cowden syndrome (cs) and cs-like syndrome

In one aspect, the invention is directed to a method of detecting cowden syndrome (cs) or cs-like syndrome in an individual comprising detecting the presence of a mutated succinate dehydrogenase b (sdhb), mutated succinate dehydrogenase d (sdhd) or combination thereof in the individual, wherein detection of a mutated sdhb, sdhd or a combination thereof indicates that the individual is positive for cs or cs-like syndrome. In another aspect, the invention is directed to a method of determining whether an individual is at risk for developing cowden syndrome (cs) or cs-like syndrome comprising detecting the presence of a mutated succinate dehydrogenase b (sdhb), mutated succinate dehydrogenase d (sdhd) or combination thereof in the individual, wherein detection of a mutated sdhb, sdhd or a combination thereof indicates that the individual is at risk for developing for cs or cs-like syndrome. ... The Cleveland Clinic Foundation

02/15/18 / #20180042915

Treatment of retinopathy of prematurity (rop)

Disclosed herein are methods of treating retinopathy of prematurity (rop) in a premature and/or low birth weight infant in need thereof, comprising administering to the infant an effective amount of a compound represented by structural formula i, structural formula ia or structural formula ii described herein, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of inhibiting the destruction of retinal blood vessels in a premature and/or low birth weight infant in need thereof, comprising administering to the infant an effective amount of a compound represented by structural formula i, structural formula ia or structural formula ii, or a pharmaceutically acceptable salt thereof. ... The Cleveland Clinic Foundation

02/08/18 / #20180036019

System and method for association of a guiding aid with a patient tissue

A guide for placing a landmark(s) in a patient tissue comprises a central portion defining at least one guiding bore configured to receive and guide a tool for placing the at least one landmark in the patient tissue. Extended portions project away from the central portion, each of the extended portions having respective lower base surfaces contoured to mate with the patient tissue, at least the respective lower base surfaces being customized as a function of preoperative imaging of the patient tissue, whereby the guide is specific to the patient.. ... The Cleveland Clinic Foundation

02/01/18 / #20180033338

System of preoperative planning and provision of patient-specific surgical aids

A method for assisting a user with surgical implementation of a preoperative plan includes generating a physical native tissue model of a native patient tissue. The physical native tissue model includes at least one primary patient tissue area including a surface of interest, at least one secondary patient tissue area including no surfaces of interest, and a base surface for engaging a supporting structure. ... The Cleveland Clinic Foundation

02/01/18 / #20180028807

Stereo-thermo-lesioning to treat a patient's neurological condition

This disclosure relates to using stereo-thermo-lesioning (stl) to create lesions at one or more locations in the patient's nervous system at the patient's bedside without general anesthesia. A method that uses stl to treat a patient's neurological condition includes: using a plurality of stereotactically-implanted thermo-coupled multi-contact electrodes to record conduction data within a predetermined theoretical zone of activity within the patient's neurological tissue; detecting abnormal neurological activity of a neurological condition within the conduction data and localize a portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity; creating a lesion at the portion of the predetermined theoretical zone of activity that is responsible for a primary organization of the abnormal neurological activity using at least one contact of the plurality of thermo-coupled multi-contact electrodes.. ... The Cleveland Clinic Foundation

01/25/18 / #20180023146

3.beta-hydroxysteroid dehydrogenase in steroid dependent disease

Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a biological sample from the subject, determining if the hsd3b1(1245c) gene or 3βhsd1(367t) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the hsd3b1(1245c) gene or 3βhsd1(367t) protein is expressed is also described.. ... The Cleveland Clinic Foundation

01/18/18 / #20180014952

Frame structures, stent grafts incorporating the same, and methods for extended aortic repair

One aspect of the present disclosure can include a frame structure adapted for use with a stent graft. The frame structure can include a scallop region and a z-form region. ... The Cleveland Clinic Foundation

12/21/17 / #20170362331

Cd6 antibody for treatment of t-cell mediated diseases or disorders

A method of treating a t-cell mediated disease in a subject by administering to the subject a therapeutically effective amount of an antibody or fragment thereof that specifically binds to cd6 is described. Humanized antibodies useful for the method are also described.. ... The Cleveland Clinic Foundation

12/07/17 / #20170348000

Surgical fixation assemblies, systems and kits

. . Surgical stapling devices including surgical fastening assemblies, surgical fastening devices, surgical fastening kits, and surgical fastening systems are provided. Surgical fastening assemblies include staples that provide a redundant approach and have prongs that are retroflexed onto the back of opposing staples or provide a rivet based compression. ... The Cleveland Clinic Foundation

12/07/17 / #20170347921

Systems and methods for monitoring a depth of neuromuscular blockade

One aspect of the present disclosure relates to a system for monitoring a diaphragmatic twitch response. The diaphragmatic twitch response can be used to determine a depth of neuromuscular blockade. ... The Cleveland Clinic Foundation

11/30/17 / #20170344721

Method and device for displaying predicted volume of influence

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (dbs) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. ... The Cleveland Clinic Foundation

11/23/17 / #20170336425

Pip2 as a marker for hdl function and cardiovascular disease risk

Provided herein are compositions, systems, kits, and methods for detecting cardiovascular disease, risk of cardiovascular disease, and/or reverse cholesterol transport potential in a subject based on the levels of pip2 phospholipid in the subject.. . ... The Cleveland Clinic Foundation

11/23/17 / #20170333714

Implantable temporary nerve conduction blocking method and system

Systems and methods of reducing pain after surgery in the thoracic or abdominal region and managing chronic nerve pain in the thoracic or abdominal region are provided. Such methods involve an electrode assembly that has a proximal portion and a distal portion with the distal portion including a plurality of electrodes. ... The Cleveland Clinic Foundation

11/23/17 / #20170333046

Method and apparatus for substantially blocking bloodflow through a dissected aorta

An implantable expandable device includes an occluding surface oriented substantially in a transverse plane. The occluding surface is bounded by a lateral occluding surface edge and a medial occluding surface edge. ... The Cleveland Clinic Foundation

11/16/17 / #20170325978

Twin bifurcated stent graft

A stent graft has a tubular body with a first bifurcation with first and second legs extending from the bifurcation. One of the legs has a further bifurcation to define a side arm. ... The Cleveland Clinic Foundation

11/16/17 / #20170325935

Tendon repair apparatus and method

A tendon repair apparatus includes a tendon bridge having oppositely disposed proximal and distal bridge ends spaced longitudinally apart by a bridge body. A plurality of engagement legs is provided. ... The Cleveland Clinic Foundation

11/09/17 / #20170319692

Anti-ar agent and radiation therapy for androgen receptor positive cancer

Provided herein are compositions, systems, kits, and methods for treating cancer in a subject with androgen receptor positive cancer cells by sensitizing such cancer cells with anti-androgen receptor therapy (e.g., enzalutamide or anti-androgen antibody), and then treating with radiation therapy.. . ... The Cleveland Clinic Foundation

10/05/17 / #20170281945

Nerve stimulation to promote neuroregeneration

Temporary or sub-threshold electrical stimulation to promote recovery of a damaged or injured nerve. Methods include promoting neuroregeneration of a nerve iatrogenically injured during a medical procedure performed on a target site of a patient's body. ... The Cleveland Clinic Foundation

09/28/17 / #20170274210

System and method for treating obstructive sleep apnea

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. ... The Cleveland Clinic Foundation

09/21/17 / #20170266435

Lead assemblies with adjustable contacts

One aspect of the present disclosure relates to lead assemblies for stimulating tissue. The lead assemblies can include lead bodies that are slidably coupled to each other and include one or more contacts that are moveably disposed within the slits of the lead bodies. ... The Cleveland Clinic Foundation

09/21/17 / #20170266233

Il-9 secreting cd8+ tc9 cells and method of treating cancer

A method of producing a population of cd8+ tc9 lymphocytes is provided including priming a population of naïve cd8+ t cells by contacting the population of naïve cd8+ t cells with an immunogenic peptide, in the presence of a tc9 supportive environment, thereby producing a population of cd8+ tc9 lymphocytes which secrete il-9. Purified populations of cd8+tc9 cells are also disclosed herein, as are method for their use in the treatment of cancer in a subject.. ... The Cleveland Clinic Foundation

09/21/17 / #20170266208

Treating and preventing disease with tma and tmao lowering agents

Provided herein are compositions, systems, and methods for treating a disease, such as kidney and/or cardiovascular disease, with an agent that reduces the production of trimethylamine (tma) or trimethylamine-n-oxide (tmao) in a subject. In certain embodiments, the agent is: i) 3,3-dimethyl-1-butanol (dmb) or a dmb derivative or related compound, ii) acetylsalicylic acid or derivative thereof (e.g., with an enteric coating for delivery to the colon and/or cecum); iii) a flavin monooxygenase 3 (fmo3) inhibitor; iv) a gut tma lyase inhibitor; v) an antibiotic or antimicrobial; vi) a probiotic or prebiotic; vii) an antiplatelet agent; or viii) a tma and/or tmao sequestering agent.. ... The Cleveland Clinic Foundation

09/21/17 / #20170266002

Method for implanting a cardiovascular valve

A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. ... The Cleveland Clinic Foundation

09/14/17 / #20170258740

Treatment and prevention of cardiovascular disease and thrombosis

Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (cvd), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of tma in the gut, such as 3,3-dimethyl-1-butanol (dmb) or other compounds represented by formula i or as shown in figs. ... The Cleveland Clinic Foundation

09/07/17 / #20170252145

Endoluminal prosthesis with steerable branch

. . An endoluminal prosthesis may include a tubular main graft body including a sidewall and proximal and distal ends. A first stent may be positioned near the proximal end of the main graft body. ... The Cleveland Clinic Foundation

08/17/17 / #20170235910

Systems and methods for remote monitoring of non-critically ill hospitalized patients

Described herein is a system for remote monitoring of non-critically ill hospitalized patients. The system can include a graphical user interface displaying a representation of the patient census. ... The Cleveland Clinic Foundation

08/17/17 / #20170231953

Hydrazone modulators of cannabinoid receptors

Hydrazone compounds which modulate cannabinoid receptors are presented. Pharmaceutical compositions containing these compounds, methods of using these compounds as modulators of cannabinoid receptors and processes for synthesizing these compounds are also described herein.. ... The Cleveland Clinic Foundation

08/03/17 / #20170216545

Reversible airway device and related method for ventilating a subject

One aspect of the present disclosure relates to a reversible airway device for ventilating a subject. The airway device can comprise a laryngeal tube, an endotracheal tube, and a sealing mechanism. ... The Cleveland Clinic Foundation

08/03/17 / #20170216013

Thoracic aorta stent graft with access region

A stent graft (2) for placement in the thoracic arch of a patient has a first tubular body portion (6) with a first lumen therein for placement in the ascending aorta of a patient and a second tubular body portion (8) to extend along the thoracic arch and down the descending aorta. The second tubular body portion is of a lesser diameter than the first tubular body portion. ... The Cleveland Clinic Foundation

07/27/17 / #20170210746

Substituted thioxanthenone autophagy inhibitors

Autophagy inhibitors useful for the treatment of cancer and other diseases are described. The autophagy inhibitors are a compound of formula: i wherein r1 is a group selected from lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; r2 and r3 are h or a group selected from cycloalkyl, lower alkyl, lower alkyl amide, lower alkyl ester, lower alkyl ketone, and lower alkyl ether; r4 is a heteroaryl group; and l is a —(ch2)n—x—(ch2)n— group, wherein n is 1, 2, 3, or 4, x is absent, o, s, or n—r5, wherein r5 is h or a lower alkyl group, or a pharmaceutically acceptable salt thereof.. ... The Cleveland Clinic Foundation

07/27/17 / #20170209132

System, method, and apparatus for assisting with submucosal dissections

Systems, methods, and apparatuses for assisting with submucosal dissections include a retraction strip body. The retraction strip body is formed at least partially from a deformable material. ... The Cleveland Clinic Foundation

07/13/17 / #20170199207

Methods for predicting and treating myocardial damage

A method for predicting myocardial damage in a subject having or at risk of cardiac disease includes determining a level of apolipoprotein ai (apoai) and a level of coenzyme q10 (coq10) in the subject and comparing the determined levels of apoa1 and coq10 to control levels.. . ... The Cleveland Clinic Foundation

07/13/17 / #20170198023

Compounds and methods of modulating angiogenesis

A pharmaceutical composition includes a synthetic peptide consisting of about 10 to about 50 amino acids and having an amino acid sequence substantially homologous to consecutive amino acids of a portion of the cytoplasmic doman of at least one of αvβ3 integrin or vegfr2 that includes a tyrosine residue, the amino acid sequence of the peptide including a phosphorylated tyrosine residue or a γ-carboxyglutamic acid residue that is substituted for a corresponding tyrosine residue of the portion of the cytoplasmic domain of αvβ3 integrin or vegfr2.. . ... The Cleveland Clinic Foundation

07/13/17 / #20170196454

Monitoring severity and duration of aberrant physiological parameters during a procedure

Systems and methods are provided for monitoring a patient during a procedure. A physiological parameter of a patient is monitored during a procedure at an associated sensor. ... The Cleveland Clinic Foundation

07/06/17 / #20170191910

Method, computing device and system for collecting exhaled breath

Various methods, computing devices, and systems for collecting breath from a subject are described. In one aspect, a method for collecting breath from a subject includes capturing a target sample from an exhaled breath of a subject having a target concentration of a target volatile organic compound (voc). ... The Cleveland Clinic Foundation

06/22/17 / #20170178010

Clinical decision support systems and methods

Systems and methods facilitate decision support based on dynamic expression data stored in memory. The dynamic expression data includes a plurality of expressions, each expression representing a different condition that varies as a function of one or more variables. ... The Cleveland Clinic Foundation

06/15/17 / #20170165059

Apparatus and method for repairing the function of a diseased valve

An apparatus for repairing the function of a diseased valve includes a tubular first support member which is expandable to a first average diameter and has oppositely disposed proximal and distal first support member ends. A tubular second support member is spaced axially apart from the first support member and is expandable to a second average diameter that is smaller than the first average diameter. ... The Cleveland Clinic Foundation

06/08/17 / #20170161894

Automated lesion segmentation from mri images

Systems and methods are provided for automated segmentation of lesions within a region of interest of a patient. At least one magnetic resonance imaging (mri) image of the region of interest is produced. ... The Cleveland Clinic Foundation

06/08/17 / #20170156582

Automated clinical evaluation of the eye

Systems and methods are provided for evaluating an eye of a patient. A first imager interface receives a first image of at least a portion of the eye generated via a first imaging modality, and a second imager interface receives a second image of at least a portion of the eye generated via a second imaging modality. ... The Cleveland Clinic Foundation

06/01/17 / #20170150978

System and method for association of a guiding aid with a patient tissue

A patient tissue includes a primary patient tissue area and an anatomically differentiated bordering secondary patient tissue area. An apparatus is at least partially customized responsive to preoperative imaging of the patient tissue. ... The Cleveland Clinic Foundation

06/01/17 / #20170150924

Registration of head impact detection assembly

Systems and methods are provided for registering a sensor assembly, implemented on a base apparatus, to a desired location associated with a head of a user. A position of a reference point on the base apparatus is determined relative to an external anatomical landmark of the user. ... The Cleveland Clinic Foundation

05/18/17 / #20170137495

Timp3 as vegf inhibitor

Polypeptides or proteins comprising tissue inhibitor of mettaloproteinases-3 (timp3) or variants of timp3 can be used to substantially inhibit vascular endothelial growth factor (vegf) binding to vegf receptor-2 (vegfr2/kdr/flk-1)) without substantially inhibiting vegf binding to vegf receptor 1 (vegfr1/flt-1).. . ... The Cleveland Clinic Foundation

05/11/17 / #20170128533

Protection against apoptosis from ionizing radiation

The use and screening of modulators of apoptosis is disclosed. The modulators may be, for example, modulator of nf-κb activity. ... The Cleveland Clinic Foundation

05/11/17 / #20170128220

Humeral joint replacement component

A humeral prosthetic head has a non-spherical articulation surface coupled with an intermediate component connecting the head and the humerus, the intermediate component connected to the epiphysis, metaphysis, or diaphysis, or to one or more additional components connected to the humerus. The intermediate portion provides for axial and angular offset of the head with respect to a connection to the humerus, using a curvilinear tapered engagement.. ... The Cleveland Clinic Foundation

04/27/17 / #20170117916

Systems and methods for automated electrical element addressing

The present disclosure relates generally to automating the task of assignment of labels to identify electrical elements (e.g., electrode contacts, electrodes including a plurality of electrode contacts, and/or non-addressable electrical elements, like wires). A system that can automate the task of assignment of labels can include an electrical element, a microelectronic circuit associated with the electrical element, and an acquisition system. ... The Cleveland Clinic Foundation

04/27/17 / #20170115280

Affinity probes for defining protein-lipid contacts

Provided herein are activatable and taggable lipid probes, and method of use thereof. In particular, the probes described herein find use in the identification of protein-lipid interactions.. ... The Cleveland Clinic Foundation

04/20/17 / #20170106190

System and method for treating obstructive sleep apnea

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. ... The Cleveland Clinic Foundation

04/20/17 / #20170105394

Mouse model of retinal degeneration

The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (amd). ... The Cleveland Clinic Foundation

03/23/17 / #20170080051

Flagellin related polypeptides and uses thereof

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.. . ... The Cleveland Clinic Foundation

03/16/17 / #20170071647

Guide for assisting with arrangement of a stock instrument with respect to a patient tissue

A guide and a stock instrument in combination. The stock instrument includes a guide interacting feature, a lower instrument surface to abut the patient tissue and an upper instrument surface for contacting the guide. ... The Cleveland Clinic Foundation

03/02/17 / #20170056154

Pre-loaded multiport delivery device

. . A pre-loaded stent graft delivery device and stent graft, the stent graft delivery device. The stent graft has at least one fenestration or side arm and the fenestration is preloaded with an indwelling guide wire. ... The Cleveland Clinic Foundation

02/23/17 / #20170051353

Diagnosis of cowden and cowden-like syndrome by detection of decreased killin expression

A method of diagnosing cowden syndrome (cs) and cowden-like syndrome (cls) is described. The method includes diagnosing cs and cls in a subject by identifying a decrease in expression of the killin gene, or by identifying hypermethylation of the killin promoter region. ... The Cleveland Clinic Foundation

02/23/17 / #20170049856

Sdf-1 delivery for treating advanced ischemic cardiomyopathy

Provided herein are methods of treating a cardiomyopathy in a subject by administering directly to, or expressing locally in, a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of sdf-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or new york heart association (nyha) functional classification. Methods of treating subjects with advanced ischemic cardiomyopathy are further disclosed herein.. ... The Cleveland Clinic Foundation

02/16/17 / #20170042619

System and method for model-based surgical planning

The present disclosure relates to model-based surgical planning. One aspect of the present disclosure relates to a surgical planning tool that can be implemented on a computer to be used for model-based surgical planning. ... The Cleveland Clinic Foundation

02/09/17 / #20170036014

Methods and systems for treating acute heart failure by neuromodulation

Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. ... The Cleveland Clinic Foundation

02/02/17 / #20170028175

System and method for wound healing

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. ... The Cleveland Clinic Foundation

01/19/17 / #20170013890

Method and garment for assisting a wearer with regulating body temperature

A temperature-regulating garment is provided for assisting a user with regulating body temperature. A garment body has first and second major garment body edges. ... The Cleveland Clinic Foundation








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



###

This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. Freshpatents.com is not affiliated or associated with The Cleveland Clinic Foundation in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for The Cleveland Clinic Foundation with additional patents listed. Browse our Agent directory for other possible listings. Page by FreshPatents.com

###