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The General Hospital Corporation patents


Recent patent applications related to The General Hospital Corporation. The General Hospital Corporation is listed as an Agent/Assignee. Note: The General Hospital Corporation may have other listings under different names/spellings. We're not affiliated with The General Hospital Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The General Hospital Corporation-related inventors


 new patent  Antagonistic anti-tumor necrosis factor receptor superfamily antibodies

. . Antagonistic tnfr superfamily polypeptides, such as antibodies and antigen-binding fragments thereof, and the use of these polypeptides to inhibit the proliferation of regulatory t cells (t-regs). For example, antibodies of the invention include antagonistic tnfr2 antibodies and antigen-binding fragments thereof, and can be used to suppress the t-reg-mediated deactivation of tumor reactive t-lymphocytes, as well as to treat a wide variety of cancers and infectious diseases.. ... The General Hospital Corporation

 new patent  Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

 new patent  Methods and agents for treating alzheimer's disease

The present disclosure provides compositions and methods useful for treating or preventing diseases or disorders where beta amyloid accumulation or aggregation contributes to the pathology or symptomology of the disease, for example alzheimer's disease.. . ... The General Hospital Corporation

 new patent  Method and apparatus for damage and removal of fat

Exemplary embodiments of method and apparatus are provided for damaging and/or removing portions of subcutaneous fatty tissue while leaving the overlying dermal layer of the skin substantially undamaged. One or more hollow needles can be provided that include an arrangement within the lumen configured to retain or damage portions of fatty tissue that enter the lumen. ... The General Hospital Corporation

Field of view increase in magnetic resonance imaging using nonlinear gradients and generalized iterative reconstruction

A method for increasing field of view (fov) in magnetic resonance imaging includes determining linear field gradients of associated with a gradient coil of a magnetic resonance (mr) scanner and using the mr scanner to acquire a k-space dataset representative of a patient using a plurality of readout gradient amplitudes. An extended fov image is generated based on the k-space dataset using an iterative reconstruction process to solve a forward model that incorporates a measurement of gradient distortion as a deviation from the linear field gradients.. ... The General Hospital Corporation

Methods for diagnosis and prognosis of epithelial cancers

The present invention is based on the discovery that three proteins, cystatin b, chaperonin 10, and profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. ... The General Hospital Corporation

Red blood cell dynamics for administering treatment for iron-deficiency anemia

Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. ... The General Hospital Corporation

Tal-tet1 fusion proteins and methods of use thereof

Fusion proteins comprising a dna binding domain, e.g., a tal effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in dna, and methods of use thereof.. . ... The General Hospital Corporation

Compounds for the treatment of obesity and methods of use thereof

Pentacyclic triterpene weight loss agents are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the weight loss agents, or pharmaceutically acceptable salts or prodrugs thereof, in combination with one or more pharmaceutically acceptable excipients. ... The General Hospital Corporation

Flow rate measurement and control of infusion devices

An infusion apparatus includes a housing and a chamber configured to be connected to the housing. The apparatus further includes a weight sensor coupled to a load connector connected to the housing and an optical sensor disposed in the housing. ... The General Hospital Corporation

Combination therapies for the treatment of alzheimer's disease and related disorders

The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout.. ... The General Hospital Corporation

Combination therapies for the treatment of alzheimer's disease and related disorders

The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout.. ... The General Hospital Corporation

Combination therapies for the treatment of alzheimer's disease and related disorders

The present invention relates to combination therapies for treating alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits ab peptide polymerization; is an anti-inflammatory; improves cognitive function, mood, or social behavior; is associated with tau or alpha-synuclein; or regulates amyloid peptide washout.. ... The General Hospital Corporation

Corneal fillers for correction of ametropia

A method for treating hyperopia or presbyopia in a patient, the method comprising making a cut deep in the patient's cornea to create a two-dimensional slit adjacent to and generally parallel to an anterior surface of the cornea and injecting a liquid or semi-solid transparent filler material into the deep cut in an amount sufficient to flatten the posterior surface of the cornea to increase the refractive power of the cornea by a predetermined correction of up to about 5 diopters due to the physical flattening of the posterior surface of the cornea, wherein the transparent filler material comprises a refractive index of about 1.3 to about 1.6, and forms a corneal implant with a lenticular shape within the cornea.. . ... The General Hospital Corporation

06/14/18 / #20180164395

Method and apparatus for accelerated magnetic resonance imaging

. . In a method for controlling a radio-frequency transmitter of a magnetic resonance imaging apparatus to apply an inversion pulse to a sample magnetization, in a multi-shot readout phase, a gradient system of the magnetic resonance imaging apparatus is controlled to apply a steady-state gradient echo readout sequence having at least one first phase-encoding gradient along a first direction, at least one second phase-encoding gradient along a second direction, and a sequence of readout gradients along a readout direction. In the multi-shot readout phase, the gradient system is controlled to apply first ac gradients along the first direction and at least partly contemporaneously with readout gradients of the sequence of readout gradients, and the gradient system is controlled to apply second ac gradients along the second direction and at least partly contemporaneously with the readout gradients of the sequence of readout gradients.. ... The General Hospital Corporation

06/14/18 / #20180161775

Sorting particles in a microfluidic device

A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel.. . ... The General Hospital Corporation

06/14/18 / #20180161480

High temperature melting

The present invention relates to methods for making wear and oxidation resistant polymeric materials by high temperature melting. The invention also provides methods of making medical implants containing cross-linked antioxidant-containing tough and ductile polymers and materials used therewith also are provided.. ... The General Hospital Corporation

06/14/18 / #20180161411

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

06/14/18 / #20180161370

Methods for expansion or depletion of t-regulatory cells

The invention features methods of producing compositions enriched in tregs and methods for treating immunological disorders using these compositions. The invention also features methods for producing compositions enriched in lymphocytes and depleted of tregs and the use of these compositions in the treatment of proliferative disorders.. ... The General Hospital Corporation

06/14/18 / #20180161272

Liposomal nanoconstructs and methods of making and using the same

Provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a strained cyclooctyne moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. Also provided herein is a liposome comprising: a) a conjugate comprising a lysophospholipid and a photosensitizer; b) a first derivatized phospholipid comprising a first phospholipid and a targeting moiety; c) a second derivatized phospholipid comprising a second phospholipid and a polyethylene glycol polymer; and d) a cationic or anionic lipid. ... The General Hospital Corporation

06/14/18 / #20180160965

Systems and methods for an actively controlled optical imaging device

Systems and methods for a tethered optical imaging probe configured to be integrated into an optical system for medical diagnosis are provided. In one configuration, the present disclosure provides a tethered optical imaging probe including a motor arranged within a swallowable capsule. ... The General Hospital Corporation

06/07/18 / #20180158376

System and method for a wearable medical simulator

A system and method for providing a medical simulation system that adds high-fidelity features to manikin simulators and standardized patients. The medical simulation system includes wearable components that contain modules for simulating pulses, heart and lung sounds, and breathing motion. ... The General Hospital Corporation

06/07/18 / #20180156882

Systems and methods for efficient magnetic resonance fingerprinting scheduling

A system and method is provided for estimating quantitative parameters of a subject using a magnetic resonance system. The method includes using a neural network, estimating acquisition parameters that are selected to direct a magnetic resonance system to generate a plurality of different signal evolutions that elicit discrimination between different quantitative parameters in a desired number of repetition time (tr) periods. ... The General Hospital Corporation

06/07/18 / #20180156778

Autoantigens for diagnosis of rheumatoid arthritis

Disclosed herein are methods of diagnosing rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with n-acetylglucosamine-6-sulfatase and/or filamin-a, wherein immunological reactivity of the subject to one or more of n-acetylglucosamine-6-sulfatase or filamin-a, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.. ... The General Hospital Corporation

06/07/18 / #20180155778

Systems and methods for epigenetic sequencing

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. ... The General Hospital Corporation

06/07/18 / #20180155777

Systems and methods for epigenetic sequencing

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. ... The General Hospital Corporation

06/07/18 / #20180153975

Shared neoantigens

Disclosed herein in one aspect is a pharmaceutical composition comprising a plurality of neoantigenic peptides and a pharmaceutically acceptable carrier, each neoantigenic peptide comprising a tumor-specific neoepitope capable of binding to an hla protein in a subject, each tumor-specific neoepitope comprising a tumor-specific mutation present in a tumor, wherein (a) the composition comprises neoantigenic peptides comprising tumor-specific mutations present in at least 1% of subjects in a population of subjects suffering from cancer; (b) the composition comprises neoantigenic peptides comprising tumor-specific neoepitopes which bind to hla proteins present in at least 5% of subjects in the population; and (c) the composition comprises at least one neoantigenic peptide capable of eliciting an immune response against a tumor present in at least 5% of the subjects in the population of subjects suffering from cancer.. . ... The General Hospital Corporation

06/07/18 / #20180153921

Tau modulators and methods and compositions for delivery thereof

The present disclosure is in the field of diagnostics and therapeutics for alzheimer's disease.. . ... The General Hospital Corporation

05/31/18 / #20180148694

Oncolytic virus therapy for resistant tumors

Disclosed herein is a recombinant oncolytic virus comprising a nucleic acid sequence encoding tumor necrosis factor-related apoptosis-inducing ligand (trail). One such oncolytic virus is ohsv. ... The General Hospital Corporation

05/31/18 / #20180146876

Systems and methods for analyzing electrophysiological data from patients undergoing medical treatments

Systems and methods for analyzing electrophysiological signals acquired from a subject are provided. In some aspects, a method includes receiving electrophysiological signals acquired from a subject using one or more sensors, and assembling a set of time-series data using the acquired electrophysiological signals. ... The General Hospital Corporation

05/24/18 / #20180142284

Multiplex analysis of gene expression in individual living cells

The technology as disclosed herein relates to methods, compositions and kits for multiplex measuring levels of expression of target rna species (e.g., mrna and non-coding rnas) in single, living cells. Aspects of the invention relate to, in part, a duplex-binding protein which is labeled with a fret dye, and a rna-binding probe, which comprises a spectrally paired fret dye and specifically hybridizes to a target rna. ... The General Hospital Corporation

05/24/18 / #20180140863

System and method for phototherapy for preventing or treating carbon monoxide poisoning

Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin.. ... The General Hospital Corporation

05/24/18 / #20180140719

Self assembling molecules for targeted drug delivery

Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.. ... The General Hospital Corporation

05/24/18 / #20180140457

System and method for surgical support mat

A device to secure a patient during a surgery on an operating table. The device includes: a central cushioning mat to be positioned between the patient and the operating table when the patient is placed on the device. ... The General Hospital Corporation

05/24/18 / #20180140316

Method and apparatus for tissue grafting and copying

Exemplary embodiments of apparatus and method for obtaining one or more portions of biological tissue (“micrografts”) to form grafts are provided. For example, a hollow tube can be inserted into tissue at a donor site, and a pin provided within the tube can facilitate controlled removal of the micrograft from the tube. ... The General Hospital Corporation

05/24/18 / #20180140244

Muscle power detection device and method for muscle power classification

A muscle power detection device and a muscle power detection method for detecting and classifying a muscle power status of a subject are provided. The muscle power detection device includes an inertia measurement unit, a pressure detection unit and a processing unit. ... The General Hospital Corporation

05/24/18 / #20180140218

Method for recording diagnostic measurement data of a head of an examination object in head imaging via a magnetic resonance device

A method is proposed for recording diagnostic measurement data of a head of an examination object in head imaging via a magnetic resonance device. The method comprises performing an overview scan of the head of the examination object, wherein overview measurement data is acquired in the overview scan and performing various diagnostic scans of the head of the examination object based on the acquired overview measurement data, wherein diagnostic measurement data is acquired in the various diagnostic scans.. ... The General Hospital Corporation

05/17/18 / #20180136237

Compositions and methods for detecting and/or treating inflammation

The present disclosure relates to assays and methods for the detection of renal inflammation by measuring the level of p2y14 and/or udp-glucose in a sample from a subject, such as a urine sample. The present disclosure also relates to methods for the treatment of renal inflammation by administering a p2y14 inhibitor.. ... The General Hospital Corporation

05/17/18 / #20180133467

System and method for using concomittant fields to control peripheral nerve stimulation (pns) in mri image encoding

A system and method for assessing peripheral nerve stimulation (pns). The system receives an imaging pulse sequence to be applied to at least a region of interest (roi) of a subject arranged in the imaging system, the imaging pulse sequence identifying coil parameters related to at least one coil. ... The General Hospital Corporation

05/10/18 / #20180127834

Predicting breast cancer treatment outcome

Methods and compositions are provided for the identification of expression signatures in er+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to treatment with tamoxifen or another antiestrogen agent against breast cancer the signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with breast cancer with tamoxifen or another antiestrogen agent against breast cancer. Additional methods and compositions are provided for predicting responsiveness to tamoxifen or another antiestrogen agent against breast cancer in cases of breast cancer by use of three biomarkers. ... The General Hospital Corporation

05/10/18 / #20180127748

Methods relating to the prevention and treatment of drug resistance

Described herein are methods, assays, and compositions relating to the treatment and/or prevention of drug-resistance, e.g, by inhibiting the activity of kdm4a-like enzymes.. . ... The General Hospital Corporation

05/03/18 / #20180120555

Multi-bandwidth spectrally encoded endoscope

An apparatus comprising at least: a first waveguide; a second waveguide; and a diffractive element. The first waveguide guides a first band of onto the diffractive element such that the first band is diffracted at an mth non-zero order over a first range of angles. ... The General Hospital Corporation

05/03/18 / #20180120319

Methods for diagnosis and prognosis of epithelial cancers

The present invention is based on the discovery that three proteins, cystatin b, chaperonin 10, and profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to methods for facilitating diagnosis of cancers of epithelial origin by monitoring the presence of these markers in biological samples. ... The General Hospital Corporation

05/03/18 / #20180119148

Regulation of mir-33 micrornas in the treatment of cholesterol-related disorders

Compositions comprising nucleic acid sequences that target mir-33 micrornas are described, together with uses of the same in the treatment of cholesterol-related disorders.. . ... The General Hospital Corporation

05/03/18 / #20180117593

Systems and methods for particle focusing in microchannels

Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. ... The General Hospital Corporation

05/03/18 / #20180117155

Anti-fugetactic agent and anti-cancer agent combination therapy and compositions for the treatment of cancer

The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.. . ... The General Hospital Corporation

05/03/18 / #20180117079

Methods and compositions for bowel cleansing before a medical procedure

Described are kits, food compositions and methods for cleaning the bowel, e.g., in preparation for a medical procedure, e.g., a diagnostic or treatment procedure, such as an endoscopic or surgical procedure, or radiologic imaging such as ct colography.. . ... The General Hospital Corporation

05/03/18 / #20180117006

Anti-fugetactic agent and immunotherapy agent combination therapy and compositions for the treatment of cancer

The invention described herein relates to methods and compositions for treating cancer in a patient, or a tumor cell, by administering an effective amount of an anti-fugetactic agent and an immunotherapy agent.. . ... The General Hospital Corporation

05/03/18 / #20180117005

Compositions for the treatment of cancer

The invention described herein relates to compositions for treating cancer in a patient, or a tumor cell, by administering an effective amount of amd3100 over a period of time.. . ... The General Hospital Corporation

05/03/18 / #20180116912

Stomach tube for preventing aspiration

The present invention discloses a stomach tube for preventing aspiration, comprising: a control circuit, an air pump, a ph sensor and a stomach tube provided with an air sack, wherein the air pump is in communication with the air sack, the ph sensor is arranged on an inner wall of the stomach tube at a distance of 40 cm away from a foretooth, and the control circuit is connected to the air pump and the ph sensor, respectively. The stomach tube of the present invention uses the ph sensor and the pressure sensor to monitor the ph value of the esophagus and the pressure of the air sack in real time, so as to accurately detect the occurrence of stomach esophagus regurgitation each time in advance, thereby avoiding the possibility of aspiration caused by regurgitation and the recessive pneumonia caused thereby; meanwhile, the present invention adopts a real-time control manner to automatically start the expansion of the air sack, thereby avoiding the damage to the esophageal mucosa caused by the long-time compression of the air sack on the esophagus, and reducing the substernal discomfort of a user. ... The General Hospital Corporation

05/03/18 / #20180116809

Prosthesis and method for using prosthesis to facilitate deep knee flexion

The present invention provides a femoral prosthesis for a femur which can enable or allow deep knee flexion without creating excessive tension in the ligamentous structure of the knee. The femoral prosthesis includes an internal non-articulating surface, an external articulating surface, a medial condyle and a lateral condyle. ... The General Hospital Corporation

04/19/18 / #20180103998

Method and apparatus for dermatological treatment and tissue reshaping

The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled patterns. ... The General Hospital Corporation

04/19/18 / #20180103861

System and method for non-invasively monitoring intracranial pressure

A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, the method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. ... The General Hospital Corporation

04/12/18 / #20180100908

Systems and methods for slice dithered enhanced resolution simultaneous multislice magnetic resonance imaging

Systems and methods for simultaneously acquiring high-resolution images of a subject from multiple different slice locations using magnetic resonance imaging (“mri”) are described. The present invention overcomes the aforementioned drawbacks by providing method for producing a plurality of images of a subject with a magnetic resonance imaging (“mri”) system. ... The General Hospital Corporation

04/12/18 / #20180100201

Tumor and microenvironment gene expression, compositions of matter and methods of use thereof

This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also relates to methods of diagnosing, prognosing and/or staging of tumors, tissues and cells, and provides compositions and methods of modulating expression of genes and gene networks of tumors, tissues and cells, as well as methods of identifying, designing and selecting appropriate treatment regimens. ... The General Hospital Corporation

04/12/18 / #20180099037

Anti-fugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

04/12/18 / #20180099036

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

04/12/18 / #20180099035

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

04/12/18 / #20180099034

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

04/05/18 / #20180094292

Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same

The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.. ... The General Hospital Corporation

04/05/18 / #20180094232

Methods for the cryopreservation of mammalian cells

Manufactured capillary tubes can include: a tubular member; and a coating applied partially covering the tubular member, the coating defining a window where the tubular member is free of the coating. Kits containing and methods related to the capillary tubes can be used for the cryopreservation of cells.. ... The General Hospital Corporation

03/29/18 / #20180088025

Method and system for integrated mutliplexed photometry module

Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. ... The General Hospital Corporation

03/29/18 / #20180087104

Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)

Unbiased, genomewide and highly sensitive methods for detecting mutations, e.g., off-target mutations, induced by engineered nucleases.. . ... The General Hospital Corporation

03/29/18 / #20180085389

Agents and methods for treating pancreatic ductal adenocarcinomas

It has been discovered that nad+-dependent histone deacetylase sirt6 is critical for suppression of pdac by con trolling the expression of lin28b, which is a negative regulator of let-7 microrna. Specifically, sirt6 loss results in histone hyperacetylation at the lin28b promoter, myc recruitment, and pronounced induction of lin28b and downstream let-7 target genes, hmga2, igf2bp1, and igf2bp3. ... The General Hospital Corporation

03/29/18 / #20180085024

System and method for magnetic resonance angiography using hyperpolarized fluid

Systems and methods are provided for performing a medical imaging. The system includes a main magnet system configured to generate a main static magnetic field about at least a region of interest (rod of a subject arranged in the main magnet system. ... The General Hospital Corporation

03/15/18 / #20180075706

Eluting matrix and uses thereof

. . Cxcl12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.. . ... The General Hospital Corporation

03/15/18 / #20180072811

Anti-cspg4 reagents and methods of treating cancer

Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e.g., cars), that specifically bind to cspg4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or car-t-cells that specifically bind to cspg4 positive cancer cells are also provided.. ... The General Hospital Corporation

03/15/18 / #20180072790

Hemojuvelin fusion proteins and uses thereof

The present invention provides a hemojuvelin (hjv) fusion protein (e.g., a human hjv.fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a hjv fusion protein to a patient in need thereof. ... The General Hospital Corporation

03/15/18 / #20180071279

Methods and compositions for treating degenerative and ischemic disorders

Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (oxphos) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. ... The General Hospital Corporation

03/15/18 / #20180070932

Apparatus, method and computer-accessible medium for obtaining tissue sample

Apparatus and method can be provided for obtaining at least one anatomical sample. For example, it is possible to provide and insert a housing into a body or provided on a hydrated anatomical structure. ... The General Hospital Corporation

03/15/18 / #20180070831

System and method for monitoring absolute blood flow

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. ... The General Hospital Corporation

03/15/18 / #20180070830

Systems and methods for time-resolved diffuse correlation spectroscopy

The present disclosure generally relates to improvements to systems and methods for measuring the dynamic properties of scattering particles within a medium, including fluid flow. Specifically, the present disclosure relates to systems and methods for time-resolved diffuse correlation spectroscopy. ... The General Hospital Corporation

03/08/18 / #20180067049

Plasmonic nanoparticle immunoassay method

A method for detecting a target cell surface molecule and classifying cell types in a fluid sample. The method involves the addition of a reagent to the fluid sample. ... The General Hospital Corporation

03/08/18 / #20180066315

Clinical predictors of weight loss

Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and a level of gene expression, and performing a first metabolic procedure if the genetic indicator is present, or performing an alternative second metabolic procedure if the genetic indicator is absent. ... The General Hospital Corporation

03/01/18 / #20180057889

Digital analysis of circulating tumor cells in blood samples

This disclosure relates to new assay methods for analysis of circulating tumor cells (ctcs) in blood samples for detection, e.g., early detection, and/or monitoring of disease, e.g., cancer. The methods provide ultra-high sensitivity and specificity, and include the use of microfluidic isolation of ctcs and digital detection of rna derived from the ctcs.. ... The General Hospital Corporation

03/01/18 / #20180057838

Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins

Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to modulate expression of genes of interest. Engineered zinc-finger transcription factors that interact with engineered promoters constitute synthetic and regulatable expression systems which facilitate the modulation of gene expression as desired.. ... The General Hospital Corporation

03/01/18 / #20180055953

Atherosclerosis imaging agents and methods of using the same

Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. ... The General Hospital Corporation

03/01/18 / #20180055922

Compositions and methods of identifying tumor specific neoantigens

The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the invention provides a method of identifying tumor specific neoantigens that alone or in combination with other tumor-associated peptides serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor responses.. ... The General Hospital Corporation

03/01/18 / #20180055781

Therapeutic nanoparticles and methods of use thereof

Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-rna identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell (e.g., mir-10b) or a sequence within an mrna encoding a pro-apoptotic protein that is covalently linked to the nanoparticle. Also provided are pharmaceutical compositions containing these therapeutic nanoparticles. ... The General Hospital Corporation

02/22/18 / #20180051342

Prostate cancer survival and recurrence

The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to prostate cancer. In particular, the disclosure is based on the identities of genes that are correlated with patient survival and prostate cancer recurrence. ... The General Hospital Corporation

02/22/18 / #20180051069

Compositions and methods for treating allergic inflammation

Compositions and methods are provided that relate to inhibiting and/or reducing glycosylation of ige for the treatment of allergic and atopic disorders. These compositions and methods are based, in part, on the discovery that glycosylation of ige is a requirement for initiation of the allergic cascade and that a single n-linked site in the c?3 domain of mouse and human ige, occupied by an oligomannose structure, specifically n394 of the c?3 domain of human ige is required for the conformational integrity of the ige.. ... The General Hospital Corporation

02/22/18 / #20180050069

Intestinal microbe therapy, composition therefor and method for preparing the same

The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome or related diseases thereof.. . ... The General Hospital Corporation

02/15/18 / #20180044413

Use of mip-1beta inhibitors for improving angiogenesis to reduce tissue ischemia and rescue diabetic vascular disease in diabetes mellitus

The present invention relates to a use of mip-1β inhibitor for promoting angiogenesis in diabetes mellitus patients so as to improve tissue ischemia in damaged area and to prevent diabetic vasculopathy.. . ... The General Hospital Corporation

02/15/18 / #20180044389

Compositions for regulating iron homeostasis and methods of using same

The present invention relates to hemojuvelin-igg fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods of using these fusion proteins for the regulation of iron homeostasis and the treatment of diseases related to iron homeostasis.. . ... The General Hospital Corporation

02/15/18 / #20180042819

Systems and methods for self-detection positioning of nasogastric tubes, feeding tubes, or other tubes

A systems and methods for determining a position of a medical tube within a patient is provided. In one example, systems and methods are provided for a self- detection positioning system that is capable of determining a location of a distal end of a medical tube placed within a patient, and notifying a physician of the location of the distal end of the medical tube.. ... The General Hospital Corporation

02/08/18 / #20180039328

Biomedical system variably configured based on estimation of information content of input signals

Computationally efficient procedure for estimating modulation depth from multivariate data. Neural interface system utilizing such procedure to rank neural signals and select optimal channel subset for inclusion in the neural decoding algorithm. ... The General Hospital Corporation

02/08/18 / #20180036552

System and method for photo-dynamic procedure

A problem of incomplete inhibition of harmful cells/bacteria and short duration of time, after the photodynamic treatment, during which such cells may re-grow, is solved by exposing the target bacteria with a multi-component photosensitizer material formed by adding a predetermined potentiating chemical to a conventional single-component photosensitizer at the target, prior to irradiating the target with light. The multi-component photosensitizer is effectuated by forming a mix of the two chemical compositions or by sequential exposure of the bacteria to a single-component photosensitizer and the potentiating chemical of choice.. ... The General Hospital Corporation

02/08/18 / #20180036029

Method and apparatus for tissue grafting

Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to facilitate separation of the micrografts from the surrounding tissue. ... The General Hospital Corporation

02/08/18 / #20180035874

Apparatus and method for fixation to endoscope accessories

A probe coupling apparatus can be provided which can include, e.g., at least two opposing edges, one of the edges being configured to receive a tip of a probe. The exemplary apparatus can also include an orifice provided between the edges and a portion provided between the opposing edges and extending along the orifice. ... The General Hospital Corporation

02/01/18 / #20180031667

System and method for magnetic resonance fingerprinting in the presence of inhomogeneous magnetic fields

Systems and methods for magnetic resonance fingerprinting (“mrf”) using highly differentiated trajectories that optimize differentiation between magnetic resonance signal patterns as a function of relaxation time(s) and static magnetic field homogeneity are described. Using the optimized acquisition parameters, mrf can be performed in the presence of inhomogeneous magnetic fields. ... The General Hospital Corporation

02/01/18 / #20180030425

Variants of crispr from prevotella and francisella 1 (cpf1)

Engineered crispr from prevotella and francisella 1 (cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics.. . ... The General Hospital Corporation

02/01/18 / #20180028685

Methods and gene therapy constructs for treating gm2 gangliosidoses

Disclosed are novel gene therapy constructs containing both hexa and hexb genes to treat gm2 gangliosidoses, including sandhoff disease and tay-sach's disease. Also described are co-treatments using chaperone and anti-inflammatory agents to enhance the effects of gene therapy.. ... The General Hospital Corporation

02/01/18 / #20180028659

Compositions and methods comprising energy absorbing materials for follicular delivery

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. ... The General Hospital Corporation

02/01/18 / #20180028253

Method and apparatus for dermatological hypopigmentation

Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or 0.5 mm, and a distance between these frozen regions can be greater than about 3 times the width of the regions. ... The General Hospital Corporation

01/25/18 / #20180023142

Micrornas in neurodegenerative disorders

Provided herein are methods of treating a neurodegenerative disorder such as amyotrophic lateral sclerosis (als) or multiple sclerosis (ms) that include administering to a subject at least one inhibitory nucleic acid that decreases the level or activity of microrna has-mir-155.. . ... The General Hospital Corporation

01/25/18 / #20180023133

Systems and methods for epigenetic sequencing

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. ... The General Hospital Corporation

01/25/18 / #20180021594

Volumetric modulated arc therapy (vmat) with non-coplanar trajectories

A method includes determining a set of candidate beam directions. The radiation therapy method further includes selecting a sub-set of non-coplanar beam directions of interest from the set of candidate beam directions based on a fluence optimization using a beam angle selection algorithm. ... The General Hospital Corporation

01/25/18 / #20180021087

Method and apparatus for tissue expansion

Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such that small gaps that can heal quickly can be formed when the tissue is stretched. ... The General Hospital Corporation

01/18/18 / #20180017778

Spectrally encoded probe with multiple diffraction orders

A spectrally encoded endoscopic probe. The probe has a light guiding component, a light focusing component, and a grating component. ... The General Hospital Corporation

01/18/18 / #20180015186

Compositions and methods for in vivo imaging

This document relates to compounds useful for targeting parp1. Also provided herein are methods for using such compounds to detect and image cancer cells.. ... The General Hospital Corporation

01/11/18 / #20180012515

Medical simulation apparatus

Systems and methods for simulating medical procedures are provided. In one example, systems and methods are provided for a neck simulator that presents realistic interactions with the neck during medical procedures, including injections, such as may be performed during a laryngeal injection.. ... The General Hospital Corporation

01/11/18 / #20180010965

Spectrally-encoded endoscopy techniques, apparatus and methods

Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. ... The General Hospital Corporation

01/11/18 / #20180008838

Devices, systems, and methods for inducing dermal blood vessel leakage

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject.. ... The General Hospital Corporation

01/11/18 / #20180008823

System and method for stimulating hair growth

A system and method are provided for stimulating hair growth of a user. The system includes a stimulating unit in communication with a control unit. ... The General Hospital Corporation

01/11/18 / #20180008500

Method and apparatus for dermatological treatment

Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.. ... The General Hospital Corporation

01/04/18 / #20180003481

Devices, systems, methods and storage mediums using full range optical coherence tomography

One or more devices, systems, methods and storage mediums for performing continuously, full range optical coherence tomography (oct) without losing a-lines are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes (e.g., common path probes), catheters, endoscopes, phase shift units (e.g., galvanometer scanner) and bench top systems. ... The General Hospital Corporation

01/04/18 / #20180002398

Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy

Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. ... The General Hospital Corporation

01/04/18 / #20180000886

Prevention and treatment of itch with an mrgpr antagonist

Embodiments described herein relates to compositions and methods of preventing and/or treating itch in a subject using a therapeutically effective amount of a mrg receptor antagonist. E.g., a tripeptide qwf. ... The General Hospital Corporation

01/04/18 / #20180000406

Non-invasive visualization and quantification of natural pigments

A system for visualizing melanin present in tissue can include an imaging system to record a signal based on a presence of melanin in tissue and a display device to display an image based on the signal. A first laser source can emit a stokes pulse train and a second laser source can emit a pump pulse train. ... The General Hospital Corporation

12/28/17 / #20170369939

Rapid quantitative detection of single nucleotide polymorphisms or somatic variants and methods to identify malignant neoplasms

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of locked nucleic acids into probes that are complementary to a mutant allele of the target sequence to increase specificity. ... The General Hospital Corporation

12/28/17 / #20170369839

Isolated human lung progenitor cells and uses thereof

Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial in the art and at present, methods for isolating and using adult lung stem cells from humans lack reproducibility. ... The General Hospital Corporation

12/28/17 / #20170368202

Optical sensor conjugates for detecting reactive oxygen and/or reactive nitrogen species in vivo

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.. . ... The General Hospital Corporation

12/28/17 / #20170367581

Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. ... The General Hospital Corporation

12/21/17 / #20170362311

Methods and compositions for regulating iron homeostasis by modulation of bmp-6

Modulation of iron homeostasis by regulating bmp-6 activity is provided. Methods of using bmp-6 and bmp-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. ... The General Hospital Corporation

12/21/17 / #20170362266

Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions

The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated n-azido galactosamine ac4galnaz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ecm) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated n-azido galactosamine ac4galnaz) to the mammal. ... The General Hospital Corporation

12/21/17 / #20170360967

Collagen targeted imaging probes

Disclosed herein are collagen-targeted imaging agents for positron emission tomography and related imaging methods using the collagen-targeted imaging agents. The collagen-targeted imaging agent is a cyclic polypeptide comprising a cyclic main body, wherein the cyclic main body comprises at least one s—s bond; at least two branches, wherein each of the at least two branches comprises at least three amino acids; and a linker, wherein the linker is capable of linking an imaging reporter.. ... The General Hospital Corporation

12/14/17 / #20170356054

Biomarkers of cancer

Methods for diagnosing cancer based on detecting the presence of increased levels of expression of satellite repeats and/or line-1.. . ... The General Hospital Corporation

12/14/17 / #20170354317

Spectrally encoded endoscopic probe having a fixed fiber

Exemplary apparatus, systems, methods of making, and methods of using a configuration in an optical arrangement for spectrally encoded endoscopy (see) probe can be provided. For example, the probe can comprise a fixed guiding portion and a rotatable dispersive portion.. ... The General Hospital Corporation

12/07/17 / #20170350896

Diagnosis and monitoring treatement of prostate cancer

Provided herein are assays and methods related to determining a ratio of expression levels of psa/psma or determining the expression level of psma in circulating tumor cells for diagnosis and/or for the purpose of monitoring treatment efficacy for prostate cancers that are likely hormone resistant.. . ... The General Hospital Corporation

12/07/17 / #20170349540

Histone deacetylase inhibitors

Provided herein are brain penetrant histone deacetylase (hdac) inhibitors useful for treating diseases or disorders associated with hdac. An exemplary hdac inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. ... The General Hospital Corporation

12/07/17 / #20170348437

Compounds, systems, and methods for monitoring and treating a surface of a subject

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. ... The General Hospital Corporation

11/30/17 / #20170343539

Nucleic acid constructs and methods for labeling and detecting nucleosomal dna modifications

Embodiments disclosed herein provide methods for identifying cell-type-specific nucleosomal dna modifications. The methods leverage nucleosomal dna barcoding and pool-and-split multiplexing to provide high-throughout, quantitative profiling of nucleosomal dna states. ... The General Hospital Corporation

11/30/17 / #20170342398

Microfluidic droplet encapsulation

Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. ... The General Hospital Corporation

11/30/17 / #20170342151

Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof

Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (cspg4) and, in particular, chimeric and humanized anti-cspg4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of cspg4-related diseases, in particular, melanoma.. ... The General Hospital Corporation

11/30/17 / #20170340736

Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof

Provided herein are compositions containing photoactivatable caged tamoxifen and tamoxifen derivative molecules. Also provided are kits containing one of these compositions and a light source. ... The General Hospital Corporation

11/23/17 / #20170336395

Methods and compositions for treating amyloid deposits

The present disclosure provides methods of determining a-beta in a mammal before and after treatment of an amyloid disorder, comprising obtaining a first blood sample from the mammal; administering to the mammal a treatment for an amyloid disorder; obtaining a second blood sample from the mammal; quantifying a level of a-beta in the first blood sample and in the second blood sample; and determining the level of a-beta in the mammal before and after treatment of the amyloid disorder.. . ... The General Hospital Corporation

11/23/17 / #20170335324

Methods for treating neurodegenerative diseases

Methods for treating, and for identifying novel treatments for, neurodegenerative diseases, as well as animal and cellular models. The present disclosure shows that age dependent accumulation of genomic lesions leads to the production of rna molecules within neurons that mimic viruses and intrinsically activate innate immune signaling, which triggers neurodegeneration. ... The General Hospital Corporation

11/23/17 / #20170335317

Methods for modulating atrx-dependent gene repression

Methods and compositions for modulation of the activity of alpha thalassemia/mental retardation syndrome x-linked (atrx), e.g., modulation of dna-atrx or rna-atrx interactions, and methods for identifying and using compounds that modulate dna-atrx or rna-atrx interactions, as well as the compounds themselves.. . ... The General Hospital Corporation

11/23/17 / #20170334804

F-18 labeled tracer and methods of manufacture

A method of producing a radiofluorinated compound comprising the steps of forming a reaction mixture comprising a reactant having a formula of r—y and a radiofluorinating agent having a formula of r′—18f; and contacting the reaction mixture with microwave radiation to achieve a temperature of between 100° c. And 250° c. ... The General Hospital Corporation

11/23/17 / #20170333540

Compositions and methods for the prevention and treatment of autoimmune conditions

The methods include selectively reducing or expanding t cells according to the antigenic specificity of the t cells. Therefore, the present invention can be used to reduce or eliminate pathogenic t cells that recognize autoantigens, such as beta cell specific t cells. ... The General Hospital Corporation

11/16/17 / #20170328971

Method for simultaneous time-interleaved multislice magnetic resonance imaging

Methods for reducing scan time in magnetic resonance imaging (“mri”), particularly when imaging three-dimensional image volumes, using a simultaneous time-interleaved multislice (“stims”) acquisition are described. The unused time in each repetition time (“tr”) period is exploited to provide an additional reduction in encoding time for a three-dimensional acquisition (e.g., a 3d whole brain coverage). ... The General Hospital Corporation

11/16/17 / #20170327823

Selective reactivation of genes on the inactive x chromosome

Methods and compositions for selectively reactivating genes on the inactive x chromosome (xi) in a locus-specific manner, e.g., genes associated with x-linked diseases, e.g., rett syndrome, factor viii or ix deficiency, fragile x syndrome, duchenne muscular dystrophy, and pnh, in heterozygous females.. . ... The General Hospital Corporation

11/16/17 / #20170327806

Engineered crispr-cas9 nucleases with altered pam specificity

Engineered crispr-cas9 nucleases with altered and improved pam specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.. . ... The General Hospital Corporation

11/16/17 / #20170327805

Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing

Methods for increasing specificity of rna-guided genome editing, e.g., editing using crispr/cas9 systems.. . ... The General Hospital Corporation

11/16/17 / #20170327481

Compounds for the treatment of mycobacterial infections

The invention relates to compounds of formula i or a pharmaceutically acceptable salt, ester or prodrug thereof:. . ... The General Hospital Corporation

11/16/17 / #20170326293

Syringe infusion pump

An infusion apparatus for use with a syringe includes a housing enclosing a drivetrain. The drivetrain includes a pinion, spur gears, and a worm gear. ... The General Hospital Corporation

11/16/17 / #20170326273

Human airway stem cells in lung epithelial engineering

Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with tenascin-c and/or fibrillin 2.. ... The General Hospital Corporation

11/16/17 / #20170326244

Biotin complexes for treatment and diagnosis of alzheimer's disease

Described herein are compositions and methods for treating or imaging alzheimer's disease (ad). The compositions comprise a biotin moiety and a sirna moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. ... The General Hospital Corporation

11/16/17 / #20170326171

Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells

A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. ... The General Hospital Corporation

11/09/17 / #20170322279

Multi-shot echo planar imaging using reordered segments and rf excitation pulse phase and slice profiles matched across interleaves

Described here are systems and methods for producing images with a magnetic resonance imaging (“mri”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“epi”) technique. In particular, a fast low angle excitation echo planar imaging technique (“fleet”) using variable flip angle (“vfa”) radio frequency (“rf”) excitation pulses that are specifically designed to have a flat magnitude and phase profile across a slice for a range of different flip angles.. ... The General Hospital Corporation

11/09/17 / #20170322079

Simple monolithic optical element for forward-viewing spectrally encoded endoscopy

Exemplary spectrally encoded probes are provided having forward view capabilities. These probes are configured such that the detection element comprises a plurality of light collecting components, where the distal ends at least partially surround the illumination element and the proximal ends form a linear array that is optically connected to a dispersive component.. ... The General Hospital Corporation

11/09/17 / #20170321217

Antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene and using method thereof

This present invention discloses an antisense oligonucleotide for splicing adjustment of mutant dopa decarboxylase gene which is complementary to seq id no: 1. This antisense oligonucleotide can modulate alternative splicing site of mutant dopa decarboxylase gene. ... The General Hospital Corporation

11/09/17 / #20170319676

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides fugetactic agents and methods for the use thereof in enhancing an immune response.. ... The General Hospital Corporation

11/09/17 / #20170319517

Methods, compositions, and kits for treating pain and pruritis

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quarternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.. ... The General Hospital Corporation

11/09/17 / #20170319378

Treatment systems for removing heat from subcutaneous lipid-rich cells and treatment systems for affecting subcutaneous lipid-rich cells

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.. ... The General Hospital Corporation

11/09/17 / #20170319071

System, apparatus and method for utilizing optical dispersion for fourier-domain optical coherence tomography

An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation so as to provide at least one second electro-magnetic radiation. ... The General Hospital Corporation

10/26/17 / #20170307607

A method for diagnosing primary biliary cirrhosis (pbc) using novel autoantigens

Methods and compositions are described for the diagnosis of primary biliary cirrhosis. Novel autoantigens are described for use in assays which employ test samples from individuals.. ... The General Hospital Corporation

10/26/17 / #20170307595

Methods and devices to study metabolism

Methods and devices to screen test compounds, e.g., study metabolism of test compounds, e.g., a pro-drug, by one cell, e.g., a hepatocyte, and the effect of metabolism of the test compound by the first cell on a second cell, e.g., a cancer cell, are described.. . ... The General Hospital Corporation

10/26/17 / #20170307488

System and method for multiplexed affinity purification of proteins and cells

In accordance with an embodiment of the invention, there is provided a method for: a) high-throughput, multiplexed, affinity-based separation of proteins—especially low abundance proteins—from complex biological mixtures such as serum; and b) high-throughput, multiplexed, affinity-based separation of cells—especially rare cells—from complex biological mixtures such as blood or blood fractions. The separation of proteins or cells is achieved based on differential binding to affinity-capture beads of different sizes and then sorting the protein-bound or cell-bound beads using the concept of centrifugal-induced dean migration in a spiral microfluidic device. ... The General Hospital Corporation

10/26/17 / #20170305866

Histone deacetylase 6 selective inhibitors for the treatment of bone disease

This invention relates to methods for treating bone disease associated with osteoclast activation using hdac6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.. . ... The General Hospital Corporation








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