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The Johns Hopkins University patents
Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.
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Rasal1 is a major tumor suppressor gene in thyroid cancer
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for treating thyroid cancer. ... The Johns Hopkins University
Certain embodiments are directed to methods and compounds for inhibiting smn-nat, the natural antisense transcript of smn. Such methods and compounds are useful for increasing expression of smn in cells and animals. ... The Johns Hopkins University
P75ntr antagonists and treatment of acute and chronic cardiac disease
The present invention provides 75 kd transmembrane neurotrophin receptor (p75ntr) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.. ... The Johns Hopkins University
Compositions and methods to improve nanoparticle distribution within the brain interstitium
Improved distribution can be achieved by delivering nanoparticles possessing non-adhesive surfaces via ced in a hyperosmolar infusate solution. This delivery strategy minimizes the hindrances imposed by the brain extracellular matrix and reduces the concentration of therapeutic that is confined within perivascular spaces.. ... The Johns Hopkins University
Particles, compositions and methods for ophthalmic and/or other applications
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. ... The Johns Hopkins University
High energy fiber laser amplifier with reduced optical linewidth
Example apparatuses and methods are provided that improve laser performance or decrease the frequency or severity of the occurrence of stimulated brillouin scattering. One example is a laser device that may include a seed laser configured to generate an optical output, a pattern generator configured to generate a modulation pattern, and a phase modulator configured to apply a modulation scheme to the optical output based on the modulation pattern. ... The Johns Hopkins University
Methods for bioanalysis of 6-diazo-5-oxo-l-norleucine (don) and other glutamine antagonists
The presently disclosed subject matter provides methods for quantifying levels of glutamine antagonists, such as 6-diazo-5-oxo-l-norleucine (don), including such glutamine antagonists resulting from in vivo conversion of ester prodrugs of such glutamine antagonists, in a biological sample.. . ... The Johns Hopkins University
Salicylic acid-based polymeric cest contrast agents targeting prostate-specific membrane antigen, pharmaceutical composition comprising the same and methods of use thereof are disclosed.. . ... The Johns Hopkins University
Compositions and methods for enhancing transport through mucus
The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.. ... The Johns Hopkins University
Targeting the m2-tumor associated macrophage for cancer therapy
The present invention features methods of directly targeting specific cell surface receptors on the m2 macrophage for antibody or nanoparticle directed therapy.. . ... The Johns Hopkins University
Therapeutic electrospun fiber compositions
The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. ... The Johns Hopkins University
Systems for quantifying clinical skill
A system quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user.. . ... The Johns Hopkins University
Compositions and methods for treating solid tumors
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid tumors. ... The Johns Hopkins University
Fast x-y axis bright pupil tracker
The present invention provides for very fast detection of gaze direction using retro-reflected light from the ocular fundus that is cost-efficient, small, and portable. These eye trackers are useful in many areas of science and technology, including but not limited to remote control, space, defense, medical and psycho-physiological applications, to identify for example subtle neurologic deficits that occur with cerebellar or vestibular disorders, parkinson's disease, strokes, traumatic brain injury, possible concussions during sports matches, some forms of reading disability, or simply fatigue or inebriation. ... The Johns Hopkins University
Devices for and methods of treatment of metabolic syndromes
Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. ... The Johns Hopkins University
Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (psma) and uses thereof
The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. ... The Johns Hopkins University
Psma-binding agents and uses thereof
Prostate-specific membrane antigen (psma) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. ... The Johns Hopkins University
Constant power adaptive power system
An adaptive power system for powering a dynamically changing load may include an energy storage device, a bi-directional current source, and compensation circuitry. The bi-directional current source may be electrically connected between the energy storage device and a power distribution bus of a power distribution system. ... The Johns Hopkins University
Apparatus for translation of gps signals to facilitate asset tracking
A method for facilitating real time tracking of an airborne asset via downlink of gps signals that are usable for determining asset location information from the asset to a ground station may include receiving a first gps signal and a second gps signal at a device disposed on the airborne asset and combining the first and second gps signals to form combined signal responsive to filtration and amplification of the first and second gps signals. The method may further include employing an overlay analog translation to convert the combined signal into a composite signal at a different frequency than the combined signal, generating a pilot carrier frequency for association with the composite signal, and amplifying the composite signal prior to transmission via the downlink from the airborne asset to the ground station. ... The Johns Hopkins University
Personalized tumor biomarkers
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (pare), which can identify translocations in solid tumors. ... The Johns Hopkins University
Composition and method for treatment of metabolic disorders
The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic disorders. ... The Johns Hopkins University
Tissue-derived scaffolds for corneal reconstruction
The present invention relates to methods for treating a corneal disease such as, for example, corneal blindness, or the refractive power of a cornea by generating a vitrified decellularized corneal inlay.. . ... The Johns Hopkins University
System for hand rehabilitation
Provided is a system for hand rehabilitation comprising an enclosure comprising a top surface and a bottom surface opposite the top surface; a wrist support attached to the top surface and configured to support and rigidly hold a wrist in position with respect to the top surface; a finger retention support arranged on the top surface, sized to accommodate at least a fingertip, and arranged to allow the finger to exert forces on the finger retention support in any direction; a sensor housed within the enclosure and in communication with the finger retention support, the sensor configured to detect and convert forces exerted by the finger on the finger retention support in multiple degrees of freedom into an electrical signal; and a processor in electrical communication with the sensor and configured to receive the electrical signal and provide feedback to a user.. . ... The Johns Hopkins University
Microbiome identification and use in diagnosis of head and neck squamous cell cancer
. . . . Methods for analyzing the bacterial microbiome of a subject and triaging the subject into treatment for head and neck squamous cell cancer from a saliva or tissue sample are provided. The methods also provide means for differentiation of different cancer patient cohorts from the bacterial microbiome of a subject.. ... The Johns Hopkins University
Hybrid cyclic libraries and screens thereof
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. ... The Johns Hopkins University
Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines for imaging fractalkine receptor (cx3cr1)
Radiofluorinated 7-amino-5-thio-thiazolo[4,5-d]pyrimidines targeting fractalkine receptor (cx3cr1) are disclosed. Methods of imaging cx3cr1-expressing tumors or cells also are disclosed.. ... The Johns Hopkins University
Mucus penetrating particles with high molecular weight and dense coatings
Mucus penetrating particles (mpps) include one or more core polymers, one or more therapeutic, prophylactic and/or diagnostic agents; and one or more surface modifying agents. The surface modifying agents coat the surface of the particle in a sufficient density to enhance the diffusion of the modified nanoparticles throughout the mucosa, relative to equivalent nanoparticles that are not surface modified. ... The Johns Hopkins University
Biomarkers of myocardial injury
The present invention relates to the field of myocardial injury. More specifically, the present invention provides methods and compositions useful in the diagnosis, prognosis and/or assessment of myocardial injury. ... The Johns Hopkins University
Compositions and methods for detecting pancreatic cancer
Provided herein are methods of detecting pancreatic cancer in a subject, the method comprising measuring in a sample from the subject a level of ca19-9 polysaccharide relative to a reference, and a level of a polynucleotide or polypeptide of at least one marker selected from the group consisting of: opn, mia, ceacam-1, mic-1, spon1, hsp27, postn, and lgals3bp relative to a reference, wherein an increased level of the ca19-9 polysaccharide relative to a reference and an increased level of the polynucleotide or polypeptide relative to a reference indicates presence of pancreatic cancer in the subject.. . ... The Johns Hopkins University
Alternative splice variant patterns of human telomerase reverse transcriptase (htert) in thyroid tumors to distinguish benign from malignant
This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of tert (telomerase reverse transcriptase) mrna which lacks the β sequence and the amount of tert mrna in the sample which comprises the β sequence, wherein a preponderance (e.g., at least about 55%) of tert mrna in the sample which comprises the β sequence indicates that the tumor is malignant, and wherein a preponderance of tert mrna which lacks the β sequence indicates that the tumor is not malignant.. . ... The Johns Hopkins University
Three-dimensional vascular network assembly from induced pluripotent stem cells
Early vascular cells (evcs), including endothelial cells and pericytes, are generated from hipscs. Unlike the isolated endothelial progenitor cells, the differentiated ecs mature and are functional. ... The Johns Hopkins University
Rehabilitation and training gaming system to promote cognitive-motor engagement description
Provided is a rehabilitation and training gaming system that can comprise a mechanism of detecting user inputs, such as a camera, joystick, force sensor, position sensor, inertial sensor, robotic interface, bioelectrical signal sensor, etc., computing unit(s) for processing inputs and generating outputs, and a computer-rendered object that is at least partially controlled by the user's inputs in a physics-driven manner. The physics-driven manner involves the computer-rendered object responding to user inputs in a manner which is both continuous and time-dependent, including but not limited to: a viscosity relationship, where the velocity, or rate of change, of a property of the computer-rendered object is proportional to the user's input, or an inertial relationship, where the acceleration, or second time derivative, of a property of the computer-rendered object is proportional to the user's input.. ... The Johns Hopkins University
Compositions and methods related to characterizing proviral reservoirs
In some aspects, the invention relates to methods for determining the proportion of intact, hypermutated, deleted, and/or defective proviruses in a sample of nucleic acids, e.g., a sample obtained from a subject. The subject may be a human subject. ... The Johns Hopkins University
Tissue ablation and assessment system and method of use thereof
The present disclosure provides a system with an innovative electrode designed as an rf/microwave antenna as well as methods to monitor/assess biological tissue and perform surgical procedures.. . ... The Johns Hopkins University
Methods and compositions for correlating genetic markers with prostate cancer risk
The present invention provides a method of identifying a subject as having an increased risk of developing prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of developing prostate cancer.. . ... The Johns Hopkins University
Compositions and methods of rna analysis
The present disclosure relates to compositions and methods of rna analysis. In particular, the present disclosure provides a method of rna analysis that includes obtaining a sample, applying one or more multi-partite probes to the sample, where each of the one or more multi-partite probes includes at least two sub-probes, annealing at least one of the applied one or more multi-partite probes to at least one target nucleic acid within the sample, and ligating the at least two sub-probes associated with the at least one annealed multi-partite probe to create a target nucleic acid proxy that can be detected.. ... The Johns Hopkins University
Avibactam and carbapenems antibacterial agents
Described are methods of treating or preventing a bacterial infection by administering an antibacterial agent comprising a β-lactamase inhibitor and one or more carbapenem to a subject.. . ... The Johns Hopkins University
Measuring medication response using wearables for parkinson's disease
An embodiment in accordance with the present invention includes a smartphone based platform that can be used to objectively and remotely measure aspects related to pd (e.g., voice, balance, dexterity, gait, and reaction time), activities of daily living, and pd medicine response. The present invention includes a unified pd-specific remote monitoring platform that incorporates both active and passive tests to provide high frequency monitoring of symptoms and activities of daily living related to pd and medicine response. ... The Johns Hopkins University
Head-mounted indirect opthalmoscope camera
The present invention is directed to an indirect ophthalmoscopic system for imaging of the ocular fundus including a headband configured to hold a digital imaging device and a plus eyepiece lens in front of an eye of the examiner, with the plus eyepiece lens positioned in between the digital imaging device and the examiner's eye, such that the examiner is focused upon the display of the digital imaging device. The aperture of the digital imaging device receives light reflected from the ocular fundus of the patient's eye, emanating from the patient's pupil. ... The Johns Hopkins University
Inhibiting ctrp5 action to improve insulin resistance associated with obesity and type 2 diabetes
The presently disclosed subject matter relates to methods of improving insulin sensitivity in cells, tissues, and subjects, as well as methods of reducing insulin resistance, improving glucose homeostasis, reducing hepatic tryglyceride levels, reducing food intake, and treating metabolic disorders, such as those occurring in individuals who are obese, diabetic, and/or have hepatic steatosis.. . ... The Johns Hopkins University
Compositions and methods for the expression of crispr guide rnas using the h1 promoter
The presently disclosed subject matter provides compositions and methods for the expression of crispr guide rnas using the h1 promoter. In particular, compositions and methods are provided for the use of the h1 promoter to express crispr guide rna (grna) with altered specificity of the 5′ nucleotide, as well as use of the h1 promoter sequence as a bidirectional promoter to express cas9 nuclease and the grna simultaneously. ... The Johns Hopkins University
Marrow infiltrating lymphocytes (mils) as a source of t-cells for chimeric antigen receptor (car) thereapy
In some embodiments, marrow-infiltrating lymphocytes (“mils”) comprising a chimeric antigen receptor (“car”) are provided. In some aspects, the embodiments relate to a method for making a recombinant mil, comprising obtaining bone marrow comprising mils; and transfecting, transforming, or transducing the mils with a nucleic acid encoding a chimeric antigen receptor. ... The Johns Hopkins University
Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods
The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of n-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (tad), for improving the detection limit of maldi-ms. ... The Johns Hopkins University
Biomarkers for ovarian cancer ctap3-related proteins
The present invention provides a protein-based biomarker that is useful qualifying ovarian cancer status to a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. ... The Johns Hopkins University
Method and device for sacral nerve stimulation
The present invention provides a method and device for sacral nerve stimulation (sns) for treatment of disease, such as inflammatory disease. The sns therapy is automatically adjusted in response to detection of physiological data from the patient.. ... The Johns Hopkins University
Engineering synthetic brain penetrating gene vectors
A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged peg, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. ... The Johns Hopkins University
Transport peptides for transcellular delivery of biological and therapeutic agents
Transport peptides with extraordinary ability to effectively transcellular transport cargo(s) across biological barriers have been identified. While the cargo itself shows a very limited ability to cross the biological barrier, the conjugated form with the transport peptide of the present invention enhances the rate of cargo transport across a biological barrier by approximately 30 times.. ... The Johns Hopkins University
Method and system for a natural language processing using data streaming
System and methods for obtaining frequent terms in a set of data is provided. The method comprises obtaining the set of data comprising a stream of terms; analyzing the stream of terms using a modified data streaming generator to find a set of frequent terms; forming a dictionary of terms based on the set of most frequent terms; identifying one or more of the set of frequent terms in the set of data; and analyzing the one or more of the set of frequent terms in the set of data to determine a context and/or structure based on neighboring terms in the set of data; providing a visualization toot for the interactions with the frequent terms and the application at hand.. ... The Johns Hopkins University
Sterile connection luer access device
A luer access device (lad) and a method of attaching the same are provided to create a sterile fluid-flow path. The lad includes a female luer connector that has an internal female split septum disposed at a proximal end thereof and is coupled to an internal surface of the lad. ... The Johns Hopkins University
Extracellular matrix (ecm) mixture and ecm scaffolds made with same
An extracellular matrix (ecm) mixture and ecm scaffolds made with same are disclosed. The ecm mixture can comprise from about 5% to about 85% by weight of ecm material and from about 15% to about 95% by weight of a polymer material, such as, but not limited to, a biodegradable polyester. ... The Johns Hopkins University
Targeted structure-specific particulate delivery systems
Provided are targeted structure-specific particulate-based delivery systems comprising: a nanoparticle; a peg polymer coating on the surface of the nanoparticle; a targeting moiety conjugated on a surface of the nanoparticle and configured to promote specific binding to a cell surface molecule expressed by a target cell; and a biologically active agent in or on the nanoparticle, wherein the biologically active agent is selected to enhance a desired response in a target cell intracellularly or extracellularly. Methods of treating a disease or disorder administering the delivery system are contemplated.. ... The Johns Hopkins University
Immune checkpoint chimeric antigen receptors therapy
In some aspects, the embodiments relate to compositions and methods related to chimeric transmembrane proteins. The chimeric transmembrane proteins may comprise the extracellular domain of an inhibitory receptor, and an intracellular signaling domain that can activate an immune response.. ... The Johns Hopkins University
N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors and uses thereof
N-substituted hydroxamic acids with carbon-based leaving groups as efficient hno donors are disclosed. Pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions also are disclosed.. ... The Johns Hopkins University
Device and method to treat esophageal disorders
Described are devices for treating disease in subjects wherein the devices include a sponge comprising a hydrogel, extracellular vesicles (evs), and an agent. Methods of using the devices to treat or prevent disease such as esophageal adenocarcinoma are also described.. ... The Johns Hopkins University
Compositions of nucleic acid-containing nanoparticles for in vivo delivery
Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (peg) polymer having an average molecular weight less than 1 kda, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.. ... The Johns Hopkins University
Multicomponent degradable cationic polymers
Degradable polymers were synthesized that self-assemble with dna to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. ... The Johns Hopkins University
Minimally invasive focused ultrasound (mifus) for brain surgery
Hifu (high-intensity focused ultrasound) sometimes fus or mifus is a highly precise medical procedure using high-intensity focused ultrasound to heat and destroy pathogenic tissue rapidly in the brain for neurosurgical purposes, by causing coagulation necrosis. Here we have described a system that uses specially designed micro-transducer heads that are placed inside the later ventricles for the purposes of mifus lesioning of brain targets under real time mri, endoscopic and doppler guidance. ... The Johns Hopkins University
Machine learning approach to beamforming
An embodiment according to the present invention includes a method for a machine-learning based approach to the formation of ultrasound and photoacoustic images. The machine-learning approach is used to reduce or remove artifacts to create a new type of high-contrast, high-resolution, artifact-free image. ... The Johns Hopkins University
Head and neck squamous cell carcinoma assays
We queried dna from saliva or plasma of 93 hnscc patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor dna. When both plasma and saliva were tested, tumor dna was detected in 96% (95% ci, 84% to 99%) of 47 patients. ... The Johns Hopkins University
Methods for increasing the infectivity of viruses
Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. ... The Johns Hopkins University
Derivation of endothelial cells from mammalian pluirpotent stem cells
This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (pscs) into endothelial cells (ecs) in vitro, by plating a single-cell suspension of pscs onto a suitable surface such as type iv collagen and culturing the cells with vegf after which ecs can be harvested. A preferred embodiment of the method first cultures the cells without vegf and then sequentially cultures the cells with vegf. ... The Johns Hopkins University
Device and method for analysis of tissue constructs
The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.. . ... The Johns Hopkins University
Contrast agent and associated methods
Example substances and methods relating to contrast agents are provided. An example method includes combining a surface active protein, a stabilizer, and a dispersion media to form a solution. ... The Johns Hopkins University
Lipid-based drug carriers for rapid penetration through mucus linings
Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more peg-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. ... The Johns Hopkins University
Methods for enhancing antigen-specific immune responses
Described herein are methods comprising administering to a mammalian subject an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at least one immunogenic antigen, thereby enhancing the antigen specific immune response relative to administration of the immunogenic antige alone. Methods and kits for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. ... The Johns Hopkins University
Drug combinations for the treatment of hiv
Provided herein are effective latency-reversing agent (lra) combinations of drugs for the reversal of hiv-1 latency. Such methods utilize, for example, the combination of a protein kinase c agonist and a bromodomain inhibitor combine to reverse latency or a nfκb activator combined with histone deacetylase inhibitors to reverse latency. ... The Johns Hopkins University
Sustained delivery of therapeutic agents to an eye compartment
Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or iop after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.. ... The Johns Hopkins University
Liposome compositions encapsulating modified cyclodextrin complexes and uses thereof
The invention provides liposome compositions comprising liposomes encapsulating cyclodextrins that both bear ionizable functional groups, such as on their solvent-exposed surfaces, and encompass therapeutic agents, as well as uses thereof.. . ... The Johns Hopkins University
Personalized computational modeling of atrial fibrosis to guide catheter ablation of atrial fibrillation
Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (af) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. ... The Johns Hopkins University
Optimizing diagnostics for galactofuranose containing antigens
Disclosed herein are methods of detecting microbial infection in mammalian subjects comprising treatment of a sample and detection of galactofuranose (galf)-containing antigenic components utilizing monoclonal antibodies. The methods disclosed provide for pretreatment of biological samples, such as urine samples, to maximize detection of galf antigens and improvement of sensitivity of galf antigen detection assays. ... The Johns Hopkins University
Genomic alterations in the tumor and circulation of pancreatic cancer patients
Pancreatic adenocarcinoma has the worst overall mortality of any solid tumor, with only 7% of patients surviving after 5 years. To evaluate the clinical implications of genomic alterations in this low cellularity tumor type, we deeply sequenced the genomes of 101 enriched pancreatic adenocarcinomas from patients who underwent potentially curative resections and used non-invasive approaches to examine tumor specific mutations in the circulation of these patients. ... The Johns Hopkins University
Method and device for non-invasive anatomical and systemic cooling and neuroprotection
The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. ... The Johns Hopkins University
Method of epigenetic analysis for determining clinical genetic risk
The present invention provides a method for identifying a subject having or at risk of having a metabolic disease, such as diabetes or obesity. The invention is based on an approach to identify candidate genes involved in metabolic diseases, such as obesity and type 2 diabetes (t2d) through epigenetic mechanisms. ... The Johns Hopkins University
Synthetic enhancement of the t-cell armamentarium as an anti-cancer therapy
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for using synthetically enhanced t-cells to treat cancer. ... The Johns Hopkins University
Use of uap inhibitors to inhibit flux through the hexosamine biosynthetic pathway
Disclosed are uap inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.. . ... The Johns Hopkins University
Compositions and methods for therapy of prostate cancer using drug combinations to target polyamine biosynthesis and related pathways
Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine salvage pathway in prostate of the individual and ii) a polyamine analogue. ... The Johns Hopkins University
Novel fluoride prenatal dietary supplement
The presently disclosed subject matter provides compositions, kits, and methods for administering a prenatal dietary supplement comprising at least about 3 mg of bioavailable fluoride to a pregnant woman.. . ... The Johns Hopkins University
Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
Novel nucleic acid vectors comprising sequences encoding (a) an antigen, (b) a signal peptide, and (c) a heat shock protein, are disclosed, as are methods for using such vectors to induce antigen-specific immune responses and to treat tumors.. . ... The Johns Hopkins University
Empowering additive manufacturing metals and alloys against localized three-dimensional corrosion
Functionalized metallic feedstock and three-dimensional articles formed therefrom via an additive manufacturing process are provided. The functionalized metallic feedstock includes a plurality of discrete metallic substrates including a first metallic substrate having a first surface area, in which at least a portion of the first surface area comprises a functionalizing agent selected to render the first metallic substrate resistant to corrosion.. ... The Johns Hopkins University
Shape memory particles for biomedical uses
The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. ... The Johns Hopkins University
Superlattice structures for thermoelectric devices
Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. ... The Johns Hopkins University
Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence lrrfstapfafidindvinf, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. ... The Johns Hopkins University
Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase ix and uses thereof
Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase ix with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase ix-expressing cells or tumors also are disclosed.. ... The Johns Hopkins University
Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products
The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.. ... The Johns Hopkins University
Compositions and methods to accelerate resolution of acute lung inflammation
The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an il-4 polypeptide or fragment thereof possessing cytokine activity or an il-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. ... The Johns Hopkins University
Methods and compositions for treating schizophrenia
The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2a (sv2a) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In some embodiments, the methods and the compositions are for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania).. ... The Johns Hopkins University
Manipulator device and therapeutic and diagnostic methods
Dexterous manipulation devices are provided having an end effector enabling large curvature with a diameter of 1 mm or less that can articulate about an axis in a working space of about or less than 4 mm by 4 mm. Preferred devices are robotically actuated and controlled and can be used for a variety of therapeutic and diagnostic applications.. ... The Johns Hopkins University
Pre-symptomatic diagnosis of a viral illness
A method for a pre-symptomatic diagnosis of a viral illness includes obtaining a biological sample with a peripheral blood mononuclear cell from a subject. The method further includes stimulating the biological sample, where the stimulation of the biological sample includes adding to the biological sample a predetermined amount of antigen configured to trigger a t-cell ifn-γ response in the biological sample and a predetermined amount of reagent configured to capture the t-cell ifn-γ response. ... The Johns Hopkins University
Diagnostic biomarkers and therapeutic targets for pancreatic cancer
We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. ... The Johns Hopkins University
Mutations of the pik3ca gene in human cancers
Phosphatidylinositol 3-kinases (pi3ks) are known to be important regulators of signaling pathways. To determine whether pi3ks are genetically altered in cancers, we analyzed the sequences of the pi3k gene family and discovered that one family member, pik3ca, is frequently mutated in cancers of the colon and other organs. ... The Johns Hopkins University
Small molecule compounds targeting pbx1 transcriptional complex
In accordance with one or more embodiments, the present invention provides a compound of formulas i, ii, and iii, for use in methods of inhibition of pbx1-dna interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.. . ... The Johns Hopkins University
Patient-specific virtual intervention laboratory to prevent stroke
The present application relates to systems and methods for performing a computerized cardiac simulation for at least one of diagnosis, risk assessment or treatment planning including: receiving, by a computer, a plurality of three-dimensional cardiac images of a subject's heart such that each three-dimensional cardiac image corresponds to a different phase of a single cardiac cycle of the subject's heart; modeling structure, using the computer, of the left atrium of the subject as a function of time using the plurality of three-dimensional cardiac images of the subject's heart; modeling blood flow, using the computer, within, into and out of the left atrium of the subject as a function of time using computational fluidic dynamics and using structure of said left atrium obtained from at least one of said plurality of three-dimensional cardiac images or said modeling structure of said left atrium; simulating at least one of time dependent structural function or time-dependent blood flow of said left atrium using results from said modeling structure and said modeling blood flow for a selected period of time; and providing information to a user from said simulating for use in at least one of diagnosis, risk assessment or treatment planning for a physiological effect related to function of said left atrium of the subject.. . ... The Johns Hopkins University
Catheter ultrasound transmission element (cute) catheter
An embodiment in accordance with the present invention provides a precise catheter tracking system, active ultrasound pattern injection system (auspis). Auspis establishes ultrasonic communication between any ultrasound external probe and internal catheter (cute catheter). ... The Johns Hopkins University
A non-invasive bio-fluid detector and portable sensor-transmitter-receiver system
The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic pdas such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as pdas including, but not limited to, cell phones.. ... The Johns Hopkins University
Autoimmune antibodies for use in inhibiting cancer cell growth
The present disclosure provides, among other things, compositions (e.g., autoantibodies) that inhibit the growth, viability, or mobility of (invasion by) a cancer cell. Also provided are applications, such as therapeutic and diagnostic methods, in which the agents are useful, as well as screening methods for identifying autoantibodies useful in the applications.. ... The Johns Hopkins University
Geometric biopsy plan optimization
The present invention is directed to a method for calculating tumor detection probability of a biopsy plan and for generating a 3d biopsy plan that maximizes tumor detection probability. A capsule shaped volume is modeled to represent the volume that a biopsy core may sample. ... The Johns Hopkins University
Automated system for measurement of spatial-cognitive abilities
Described are systems for spatial cognitive ability assessment wherein a subject is able to manipulate one or more object(s) that is monitored by a device for recording motion attached to the object(s), the subject, or both that is able to generate motion electronic data. Also described are methods for assessing spatial cognitive ability.. ... The Johns Hopkins University
Systems and methods for simulation prediction of targets for catheter ablation of left atrial flutter in patients with atrial structural remodeling
A computer-implemented method for non-invasively identifying ablation locations in atrial tissue, can include: receiving three-dimensional imaging data representing atrial tissue of a left atrial flutter (lafl) subject; generating a subject-specific model of the at least one of the atrial tissue from the three-dimensional imaging data; estimating tissue fiber orientations in the atrial tissue; assigning the estimated tissue fiber orientations to the subject-specific model of the atrial tissue; conducting simulations of lafl using the subject-specific model to identify regions of slow conduction of a propagating wave within an atrial tissue region of the atrial tissue; a critical isthmus of a rotational wavefront within the atrial tissue region; or a region based on a minimum cut in a flow network; and identifying at least one ablation location in the atrial tissue region based on the identified regions of slow conduction, the critical isthmus, or the minimum cut.. . ... The Johns Hopkins University
Apparatus and method for implementing network deception
An example apparatus configured to perform network deception may include processing circuitry configured to generate virtual instances of decoy resources residing within a defined host network for presentation to cyber attackers, control at least one software defined network switch to monitor network traffic directed to real and decoy resources of the defined host network, and route network traffic based on detected interactions with the decoy resources. The decoy resources may have differing levels of decoy fidelity, where decoy fidelity indicates a difficulty for a cyber attacker to determine that the resource is a decoy. ... The Johns Hopkins University
Method and apparatus for analysis and classification of high dimensional data sets
A method executable via operation of configured processing circuitry may include constructing a mutual information graph for categorical data with respect to observed attributes of a plurality of entities described in terms of respective ones of the observed attributes by the categorical data, determining a clique tree correlating attributes having at least a threshold level of mutual dependence among the observed attributes, and determining a normality rating for an entity relative to the plurality of entities based on the clique tree.. . ... The Johns Hopkins University
Dna methylation markers for metastatic prostate cancer
The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. ... The Johns Hopkins University
Novel monoclonal antibody inhibitors targeting potassium channel kcnk9
The presently disclosed subject matter relates to antibodies, antibody fragments or derivatives thereof, which specifically bind to and/or interact with at least one epitope of the extracellular domain of the mammalian kcnk9 potassium channel, and to nucleic acid molecules encoding the same, as well as to vectors comprising said nucleic acid molecules. The presently disclosed subject matter provides methods for the preparation of said antibodies, antibody fragments or derivatives thereof, as well as pharmaceutical compositions, diagnostic compositions, and kits comprising the same. ... The Johns Hopkins University
Methods of inducing vascular morphogensis
Novel hydrogels that can serve as 3d hypoxic microenvironments are disclosed. Oxygen controllable, hypoxia-inducible hydrogels (hi hydrogels) are composed of a phenolic agent and polymer backbone, which can form hydrogel networks via oxygen consumption in an enzyme-mediated crosslinking reaction. ... The Johns Hopkins University
Anti-viral azide containing compounds
Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. ... The Johns Hopkins University
Patterning devices using fluorinated compounds
. . A method for producing a spatially patterned structure includes forming a layer of a material on at least a portion of a substructure of the spatially patterned structure, forming a barrier layer of a flourinated material on the layer of material to provide an intermediate structure, and exposing the intermediate structure to at least one of a second material or radiation to cause at least one of a chemical change or a structural change to at least a portion of the intermediate structure. The barrier layer substantially protects the layer of the material from chemical and structural changes during the exposing. ... The Johns Hopkins University
Cell egress and invasion inhibitors and their use as antiparasitical agents
The present invention provides cell egress and invasion inhibitors and their use as antiparasitical agents.. . ... The Johns Hopkins University
Hla-restricted epitopes encoded by somatically mutated genes
Mutant epitopes encoded by cancer genes are virtually always located in the interior of cells, making them invisible to conventional antibodies. We generated single chain variable fragments (scfvs) specific for mutant peptides presented on the cell surface by human leukocyte antigen (hla) molecules. ... The Johns Hopkins University
Method and device for treating cardiac arrhythmias
The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (ac) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. ... The Johns Hopkins University
Labeled inhibitors of prostate specific membrane antigen (psma) biological evaluation, and use of imaging agents
The prostate-specific membrane antigen (psma) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mtc/re-labeled compounds were prepared by attaching known tc/re chelating agents to an amino-functionalized psma inhibitor with or without a variable length linker moiety. ... The Johns Hopkins University
Immunogenic fusion proteins for the treatment of cancer
Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.. ... The Johns Hopkins University
Optical detection system
An active optical detection system includes an optical transmitter configured to transmit light in a signal pattern and an optical receiver configured to receive light and determine a correlation between the received light and the signal pattern. The correlation of the received light and the signal pattern is indicative of range to an object.. ... The Johns Hopkins University
Enrichment of nucleic acids by complimentary capture
Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from body fluids such as cyst fluids. ... The Johns Hopkins University
Anti-h7cr antibodies
Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the b7-h7 counter-receptor, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.. . ... The Johns Hopkins University
Systems and methods for patient-specific modeling of the heart for prediction of targets for catheter ablation of ventricular tachycardia in patients with implantable cardioverter defibrillators
A system, computer-readable medium and method can include receiving three-dimensional imaging data of a subject's heart, the subject having an icd, wherein the icd causes an imaging artifact in the three-dimensional imaging data that includes regions that are free of the artifact and regions that are affected by the artifact; segmenting the regions that are free of the artifact into a plurality of normal tissue regions and remodeled tissue regions for the subject; extrapolating from the regions that are free of the artifact to provide extrapolated three-dimensional imaging data corresponding to the regions that are affected by the artifact; and simulating at least one of electrophysiological or electromechanical activity of the subject's heart using the segmented and extrapolated three-dimensional imaging data, the simulating including providing a preselected alteration of electrophysiological or electromechanical behavior of the subject's heart for a target of said subject-specific cardiac ablation procedure.. . ... The Johns Hopkins University
Tissue characterization based on machine learning in medical imaging
Tissue is characterized using machine-learnt classification. The prognosis, diagnosis or evidence in the form of a similar case is found by machine-learnt classification from features extracted from frames of medical scan data. ... The Johns Hopkins University
Trichoplusia ni piggybac transposases with reduced integration activity
The present invention is directed to nucleic acid and amino acid sequences of a novel piggybac transposase enzymes created by modifying the transposase of trichoplusia ni. The piggybac transposases of the present invention are functionally active or hyperactive for excision and have decreased integration activity compared to wild type trichoplusia ni piggybac transposase enzyme. ... The Johns Hopkins University
Bone harvesting
Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula including a cutting surface positioned at or adjacent the distal end, the cutting surface being oriented at an angle, the angle being greater than 90 degrees relative to the longitudinal axis of the cannula, and the harvested bone is adapted to move from a position adjacent to the cutting surface through the cannula into the bone receptacle. ... The Johns Hopkins University
Apparatus and method for computational workflow management
Apparatuses and methods for performing computational workflow management are provided. An example apparatus may include processing circuitry. ... The Johns Hopkins University
Anti-h7cr antibodies
Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the b7-h7 counter-receptor, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.. . ... The Johns Hopkins University
Assay for telomere length regulators
The present invention provides an assay that identifies genes required for telomerase-dependent telomere elongation by measuring the de novo telomere addition at a single chromosome.. . ... The Johns Hopkins University
Compositions and methods for ophthalmic and/or other applications
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. ... The Johns Hopkins University
Point source image blur mitigation
Apparatuses and methods for point source image blur mitigation are provided. An example method may include receiving, from an imaging detector, a plurality of pixel signals associated with respective pixels of an image over a stare time, and determining a trajectory of a point source within the image due to relative angular motion of the point source across a plurality of pixels of the image. ... The Johns Hopkins University
Method for manufacturing a low-profile intercranial device and the low-profile intercranial device manufactured thereby
A low-profile intercranial device including a low-profile static cranial implant and a functional neurosurgical implant. The low-profile static cranial implant and the functional neurosurgical implant are virtually designed and interdigitated prior to physical assembly of the low-profile intercranial device.. ... The Johns Hopkins University
68ga-labeled nota-chelated psma-targeted imaging and therapeutic agents
Psma-targeted pet/spect agents for imaging psma-positive cancer and or tumor neovasculature and psma-targeted radiotherapeutic agent for the treatment of psma-positive cancer or tumor neovasculature are disclosed. Methods of imaging psma expressing tumors, or cells and kits also are disclosed.. ... The Johns Hopkins University
Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels
The present invention provides compounds of formula i or a salt, solvate, or stereoisomer thereof, wherein x is h, or an electron withdrawing group such as a halogen, nh2, no2, so2, cn, or a c1-c6 alkyl group; alk is c1-c3 alkyl; r1 is h, c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups; and r2, is c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups. Pharmaceutical compositions comprising these compounds and/or rufinamide are also provided. ... The Johns Hopkins University
Composite material for tissue restoration
A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. ... The Johns Hopkins University
Compositions and methods for sensitizing cells to trail-induced apoptosis
The present invention comprises pegylated trail peptides and their use in conjunction with various trail sensitizing agents in tumor homing nanoparticle formulations for use in the treatment of cancer in a subject.. . ... The Johns Hopkins University
Neuromodulation device
The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. ... The Johns Hopkins University
Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells
Antigen-specific t cells, including nave t cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining t cell reactivity with a library of candidate peptide antigens.. ... The Johns Hopkins University
Interactive user interfaces for minimally invasive telesurgical systems
In one embodiment of the invention, a a minimally invasive surgical system is disclosed. The system configured to capture and display camera images of a surgical site on at least one display device at a surgeon console; switch out of a following mode and into a masters-as-mice (mam) mode; overlay a graphical user interface (gui) including an interactive graphical object onto the camera images; and render a pointer within the camera images for user interactive control. ... The Johns Hopkins University
Device and method to measure ventricular arterial coupling and vascular performance
A device for measuring a ventricular-arterial coupling of a subject includes first and second inputs. The first input receives signals from a plurality of electrocardiogram sensors that are coupled to the subject at a plurality of first locations. ... The Johns Hopkins University
Compact endoscope design for three-dimensional surgical guidance
The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3d endoscopic technique to conduct high resolution 3d imagery for use in surgical guidance system. The present invention is directed to an fpp endoscopic imaging setup which provides a wide field of view (fov) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. ... The Johns Hopkins University
Compositions and methods for enhancing an immune response
The disclosure features compounds comprising an antigen portion, a soluble major histocompatibility complex (mhc) molecule portion (e.g., all or an antigen-binding portion of a soluble mhc class i molecule), and a dynamic anchor portion (e.g., an agent, such as annexin v, that binds to phosphatidylserine). The featured compounds are useful for a variety of therapeutic applications, including, e.g., enhancing a t cell response to an antigen of interest or enhancing a t cell-driven immune response by a subject to an antigen of interest (e.g., a cancer antigen or a microbial antigen).. ... The Johns Hopkins University
Device for magnetic stimulation of the vestibular system
The present invention is directed to a magnetic vestibular stimulation (mvs) system for rehabilitation of subjects with vestibular and balance disorders. The magnetic vestibular stimulation system includes a magnet and a cooling system. ... The Johns Hopkins University
Cvs transplantation for treatment of bacterial vaginosis
Methods and materials for treating bacterial vaginosis (“bv”) are provided. Cervicovaginal secretions (“cvs”) from a woman with lactobacillus crispatus-dominated (>50%) vaginal microbiota is transplanted to women with bv as a method for restoring beneficial vaginal microbial communities and/or increasing resistance to sexually transmitted disease. ... The Johns Hopkins University
Local delivery forms of acriflavine for treating tumors
Local delivery formulations of the antineoplastic and microbicide agent acriflavine, and methods of making and using thereof are significantly more efficacious at increasing the median survival of subjects with proliferative disease than systemic administrations of acriflavine. The local delivery formulations of acriflavine show a dose-dependent increase in the median survival of subjects. ... The Johns Hopkins University
Targeting liver nuclear receptors as a treatment for wilson disease
The present invention relates to the field of wilson disease. More specifically, the present invention provides methods and compositions useful for treating wilson disease by targeting liver nuclear receptors. ... The Johns Hopkins University
A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides
The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or nmp) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (snapps) range in size from about 500 daltons to about 3000 daltons. ... The Johns Hopkins University
Methods and systems for generating, validating and using monoclonal antibodies
Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.. ... The Johns Hopkins University
Extracellular vesicles for agent delivery
The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. ... The Johns Hopkins University
Peptide/particle delivery systems
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.. ... The Johns Hopkins University
Method and device for statistical tissue sampling using microdevices
The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. ... The Johns Hopkins University
Extremity imaging apparatus for cone beam computed tomography
An apparatus for cone beam computed tomography can include a support structure, a scanner assembly coupled to the support structure for controlled movement in at least x, y and z orientations, the scanner assembly can include a dr detector configured to move along at least a portion of a detector path that extends at least partially around a scan volume with a distance d1 that is sufficiently long to allow the scan volume to be positioned within the detector path; a radiation source configured to move along at least a portion of a source path outside the detector path, the source path having a distance d2 greater than the distance d1, the distance d2 being sufficiently long to allow adequate radiation exposure of the scan volume for an image capture by the detector; and a first gap in the detector path.. . ... The Johns Hopkins University
Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (cgc) under isotonic conditions. ... The Johns Hopkins University
Mebendazole polymorph for treatement and prevention of tumors
Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. ... The Johns Hopkins University
Inhibition of yap for breaking tumor immune tolerance
Yes-associated protein (yap), a downstream co-activator of the hippo pathway, is highly expressed in the treg cell subset, and is critical to maintain its suppressive activity. Originally discovered in drosophila melanogaster, the hippo signaling pathway is a major regulator of cellular growth and proliferation in mammals. ... The Johns Hopkins University
Optical imaging system and method of making and using the same
An optical imaging system for interfacing with a separate examination apparatus and methods of making and using the same are disclosed. The optical imaging system can include an imaging housing including a housing enclosure and a housing receptor plate, a subject support mount, a cart including an extendable arm, an optical arrangement including an optical source, a cantilever mirror system, and the housing enclosure, and a detection optical path providing optical communication between the cantilever mirror system and an optical detector. ... The Johns Hopkins University
Compounds and methods for treatment and prevention of flavivirus infection
The present invention concerns the use of compounds for the treatment or prevention of flavivirus infections, such as zika virus infections. Aspects of the invention include methods for treating or preventing flavivirus virus infection, such as zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting flavivirus infections such as zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing flavivirus infections, such zika virus infections.. ... The Johns Hopkins University
Methods and compositions for improving cognitive function
The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2a (sv2a) inhibitor and an acetylcholinesterase inhibitor (achei) or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In particular, it relates to the use of a combination of an sv2a inhibitor and an achei in treating a central nervous system disorder with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (mci), dementia, alzheimer's disease (ad), prodromal ad, post traumatic stress disorder (ptsd), schizophrenia, amyotrophic lateral sclerosis (als), and cancer-therapy-related cognitive impairment.. ... The Johns Hopkins University
Methods for characterizing and treating cognitive impairment in aging and disease
This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging.. ... The Johns Hopkins University
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