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The Johns Hopkins University patents (2015 archive)


Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Johns Hopkins University-related inventors


12/31/15 / #20150380651

Patterning devices using fluorinated compounds

A method for producing a spatially patterned structure includes forming a layer of a material on at least a portion of a substructure of the spatially patterned structure, forming a barrier layer of a fluorinated material on the layer of material to provide an intermediate structure, and exposing the intermediate structure to at least one of a second material or radiation to cause at least one of a chemical change or a structural change to at least a portion of the intermediate structure. The barrier layer substantially protects the layer of the material from chemical and structural changes during the exposing. ... The Johns Hopkins University

12/31/15 / #20150376691

Rapid aneuploidy detection

Massively parallel sequencing of cell-free, maternal plasma dna was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies. Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with pcr employing a single primer pair. ... The Johns Hopkins University

12/31/15 / #20150376622

Influenza-activated constructs and methods of use thereof

The presently disclosed subject matter provides a novel approach for the treatment, prevention, and diagnosis of cap-snatching virus infections, particularly all classes of human influenza, including pandemic influenza. The methods involve the use of constructs for rna-interference (rnai).. ... The Johns Hopkins University

12/31/15 / #20150374723

Anti-viral azide containing compounds

Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. ... The Johns Hopkins University

12/24/15 / #20150370496

Hardware-enforced prevention of buffer overflow

An apparatus having processing circuitry configured to execute applications involving access to memory may include a cpu and a cache controller. The cpu may be configured to access cache memory for execution of an application. ... The Johns Hopkins University

12/24/15 / #20150369738

Red fluorescent aldehyde dehydrogenase (aldh) substrate

A detectable substrate for aldehyde dehydrogenase (aldh) can be used for selecting cells that express aldh. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.. ... The Johns Hopkins University

12/24/15 / #20150368652

Treatment of neuropathic pain

The present invention relates to the field of neurology. More specifically, the present invention provides methods and composition useful for treating neuropathic pain. ... The Johns Hopkins University

12/24/15 / #20150368408

Cellulose hydrogel compositions and contact lenses for corneal applications

The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high oxygen permeability, high biocompatibility, high tensile strength and desirable thermal stability. The present invention further provides a process for preparing a cellulose hydrogel comprising (i) a step of activating cellulose, in which the activating step comprises contacting the cellulose with a solvent to activate the cellulose for a time duration from about 2 hours to about 30 hours; (ii) substantially dissolving the activated cellulose to form a solution; and (iii) gelling the solution to form a gel, in which the gelling step comprises allowing the solution to gel in an environment comprising a relative humidity from about 30% to about 80% at 35° c.. ... The Johns Hopkins University

12/24/15 / #20150368211

Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels

The present invention provides compounds of formula i or a salt, solvate, or stereoisomer thereof, wherein x is h, or an electron withdrawing group such as a halogen, nh2, no2, so2, cn, or a c1-c6 alkyl group; alk is c1-c3 alkyl; r1 is h, c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups; and r2, is c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups. Pharmaceutical compositions comprising these compounds and/or rufinamide are also provided. ... The Johns Hopkins University

12/24/15 / #20150366991

Antigen-specific t cell redirectors

This disclosure describes compositions and methods for selectively recruiting antigen-specific t cells and re-direct them to kill targeted cells, particularly tumor cells. This approach permits selective engagement of specific effector cell populations and, by using nanoparticles, overcomes the geometric limitations associated with previous approaches.. ... The Johns Hopkins University

12/17/15 / #20150361507

Tert promoter mutations in gliomas and a subset of tumors

We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (≧15%) frequencies of tert promoter mutations. The nine tert-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type). ... The Johns Hopkins University

12/17/15 / #20150361492

Safe sequencing system

The identification of mutations that are present in a small fraction of dna templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. ... The Johns Hopkins University

12/17/15 / #20150361088

Two-carbon linked artemisinin-derived trioxane dimers

Two-carbon linked artemisinin-derived trioxane dimers and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.. . ... The Johns Hopkins University

12/17/15 / #20150359866

Treatment of cervical and related neoplasias with topical immunomodulators

The present invention provides methods for treating cervical and related hpv-associated neoplasias in subjects who are hpv16 negative comprising administering to the patient an effective amount of an immunomodulator, such as a toll-like receptor agonist to the site of the lesions two or more times over a period of weeks to achieve regression of the neoplasia in the patient. Methods comprising the use of the immunomodulator with additional biological agents are also provided.. ... The Johns Hopkins University

12/17/15 / #20150359776

Treatment of drug abuse by preventing gapdh nitrosylation

The present invention relates to the field of drug abuse. More specifically, the present invention provides methods and compositions for treating drug abuse by preventing gapdh nitrosylation. ... The Johns Hopkins University

12/17/15 / #20150359605

Ultrasound-detectable markers, ultrasound system, and methods for monitoring vascular flow and patency

An ultrasound-detectable marker, ultrasound system, and methods for monitoring vascular flow and patency are disclosed. The ultrasound-detectable marker comprises one or more resorbable polymers, one or more non-resorbable polymers, one or more non-polymeric materials, or any combinations thereof. ... The Johns Hopkins University

12/10/15 / #20150356712

Model-based tomographic reconstruction with correlated measurement noise

The present invention is directed to a novel tomographic reconstruction framework that explicitly models the covariance of the measurements in the forward model using a mean measurement model and a noise model. This more accurate model can result in improved image quality, increased spatial resolution, and enhanced detectability—in particular, for imaging scenarios where there are features on the order of the correlation length in the projection data. ... The Johns Hopkins University

12/10/15 / #20150355114

A spectral response effects (sre) compensation method for photon counting detectors (pcds)

An embodiment in accordance with the present invention provides a new sr compensation (src) method, using a more efficient conjugate gradient method. In this method, the first and second derivatives are directly calculated analytically. ... The Johns Hopkins University

12/10/15 / #20150354939

Optical coherence tomography systems and methods with magnitude and direction tracking of transverse motion

An optical coherence tomography (oct) system having magnitude and direction of motion detection has a light source, and a scanning system arranged in an optical path of the light source. The scanning system is configured to scan an illumination beam of light in a spatial pattern around each of a plurality of points of interest of an object under observation for a corresponding plurality of instants of time in which each of the plurality of points of interest are displaced from each other due to motion of at least one of the oct system or the object under observation. ... The Johns Hopkins University

12/10/15 / #20150353354

System and method for precision transport, positioning, and assembling of longitudinal nano-structures

A method for assembling multi-component nano-structures that includes dispersing a plurality of nano-structures in a fluid medium, and applying an electric field having an alternating current (ac) component and a direct current (dc) component to the fluid medium containing the plurality of nano-structures. The electric field causes a first nano-structure from the plurality of nano-structures to move to a predetermined position and orientation relative to a second nano-structure of the plurality of nano-structures such that the first and second nano-structures assemble into a multi-component nano-structure.. ... The Johns Hopkins University

12/10/15 / #20150351724

Real time ultrasound thermal dose monitoring system for tumor ablation therapy

An interventional system with real-time ablation thermal dose monitoring includes an interventional tool, an ultrasound transmitter at least one of attached to or integral with the interventional tool, an ultrasound receiver configured to receive ultrasound signals from the ultrasound transmitter after at least one of transmission through or reflection from a region of tissue while under an ablation procedure and to provide detection signals, and a signal processing system configured to communicate with the ultrasound receiver to receive the detection signals and to calculate, based on the detections signals, a thermal dose delivered to the region of tissue in real time during the ablation procedure.. . ... The Johns Hopkins University

12/03/15 / #20150344970

Personalized tumor biomarkers

Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (pare), which can identify translocations in solid tumors. ... The Johns Hopkins University

12/03/15 / #20150344965

Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants

The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related diseases or disorders.. . ... The Johns Hopkins University

12/03/15 / #20150344437

Pyrazolone derivatives as nitroxyl donors

The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.. ... The Johns Hopkins University

12/03/15 / #20150342695

Multi-force sensing surgical instrument and method of use for robotic surgical systems

A multi-force sensing instrument includes a tool that has a tool shaft having a distal end and a proximal end, a strain sensor arranged at a first position along the tool shaft, at least one of a second strain sensor or a torque-force sensor arranged at a second position along the tool shaft, the second position being more towards the proximal end of the tool shaft than the first position, and a signal processor configured to communicate with the strain sensor and the at least one of the second strain sensor or the torque-force sensor to receive detection signals therefrom. The signal processor is configured to process the signals to determine a magnitude and position of a lateral component of a force applied to the tool shaft when the position of the applied force is between the first and second positions.. ... The Johns Hopkins University

11/26/15 / #20150337121

Multifunctional tunable biomaterials for tissue engineering

The present invention provides a multifunctional biomaterial comprising one or more biocompatible polymers and one or more α-cyclodextrin molecules having a plurality of hydroxyl groups capable of being chemically substituted with another functional group or moiety to form a pseudopolyrotaxane structure. The multifunctional biomaterials of the present invention provide synthetic 2d or 3d biomaterial scaffolds and nanofibers that can be decorated with multiple chemical functionalities without altering the base network. ... The Johns Hopkins University

11/26/15 / #20150336904

Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels

The present invention provides compounds of formula i which are capable of inhibition of the activation of hnav1.1 or hnav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. ... The Johns Hopkins University

11/26/15 / #20150335788

Stem cell-impregnated therapeutic patch

A therapeutic patch includes at least one layer of a nanofiber fabric and at least one of a plurality of stem cells or a plurality of stem cell-derived paracrine factors embedded in the nanofiber fabric. The therapeutic patch is produced such that the nanofiber fabric is formed of a nanofiber web.. ... The Johns Hopkins University

11/26/15 / #20150335718

Preservation and reconstitution of cell-free protein expression systems

A method of preserving a cell-free protein expression system includes preserving a cell extract with a first non-reducing sugar alcohol to provide a preserved cell extract, preserving a reaction buffer with a second non-reducing sugar alcohol to provide a preserved reaction buffer, and preserving an energy source, so that the cell extract, the reaction buffer, and the energy source are preserved separately.. . ... The Johns Hopkins University

11/19/15 / #20150328337

Protection from oxidative damage by gene transfer by glutamate cysteine ligase and glutathione synthase

An isolated polynucleotide encoding human glutamate cysteine ligase and human glutathione synthase, as well as expression constructs, vectors and pharmaceutical compositions comprising the same, are provided herein. Methods for use of these compositions in the treatment oxidative stress related diseases, including, for example, atherosclerosis, parkinson's disease, heart failure, myocardial infarction, alzheimer's disease, diabetes, chronic lung disease, diseases associated with mitochondrial dysfunction, diseases associated with chronic inflammation, retinitis pigmentosa, wet age related macular degeneration, dry age related macular degeneration, diabetic retinopathy, lebers optic neuropathy, and optic neuritis are also provided.. ... The Johns Hopkins University

11/12/15 / #20150323478

System and method for phase-contrast x-ray imaging

A differential phase contrast x-ray imaging system includes an x-ray illumination system, a beam splitter arranged in a radiation path of the x-ray illumination system, and a detection system arranged in a radiation path to detect x-rays after passing through the beam splitter.. . ... The Johns Hopkins University

11/12/15 / #20150321343

Adjustable stiffness morphable manipulator

Compliant manipulators are provided, in which the manipulators include a plurality of slideably interlocked filaments each having a proximate end and a distal end. The interlocked filaments can be formed from a flexible material. ... The Johns Hopkins University

11/12/15 / #20150321021

Method and device for treating cardiac arrhythmias

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (ac) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. ... The Johns Hopkins University

11/12/15 / #20150320862

Process for making iron oxide nanoparticle preparations for cancer hyperthermia

Iron oxide nanoparticle compositions, methods of preparing the nanoparticles using high gravity controlled precipitation (hgcp), and methods of using the nanoparticles are disclosed.. . ... The Johns Hopkins University

11/12/15 / #20150320798

Use of post-transplant cyclophosphamide treated allogeneic marrow infiltrating lymphocytes to augment anti-tumor immunity

The present invention relates to the field of cancer therapy. More specifically, the present invention provides methods and compositions useful for augmenting anti-tumor immunity. ... The Johns Hopkins University

11/05/15 / #20150319188

Canonical network isolator component

A method for isolating a computer platform includes receiving a service request from an external requestor via a network at processing circuitry associated with a hardware barrier between the computer platform and the network, causing the service request to be loaded into a first buffer having a dual port connection to a corresponding second buffer of the computer platform, providing an indication to the computer platform to indicate the service request is loaded into the first buffer to be pulled into the second buffer of the computer platform, responsive to processing of the service request by the computer platform, receiving a message indicating a response loaded in the second buffer has been pushed to the first buffer, and communicating the response to the external requestor. The buffers form the only access point to the computer platform. ... The Johns Hopkins University

11/05/15 / #20150317504

System for lightweight image processing

An embodiment in accordance with the present invention provides a system and method for image analysis and processing. The present invention provides a software package for processing afm data. ... The Johns Hopkins University

11/05/15 / #20150316554

Diagnostic biomarkers and therapeutic targets for pancreatic cancer

We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. ... The Johns Hopkins University

11/05/15 / #20150315771

Sudsy water fixture

A sudsy water fixture and methods is disclosed, wherein the sudsy water fixture is a fixture for mixing soap and water. In particular aspects, the presently disclosed fixture comprises a soap canister, an aspirator, a supply line, a shutoff valve, and a soap infusion valve. ... The Johns Hopkins University

11/05/15 / #20150315589

Methods of inhibiting cancer stem cells with hmga1 inhibitors

The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with hmga1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using hmga1 inhibitors.. ... The Johns Hopkins University

11/05/15 / #20150315275

Anti-human b7-h4 antibodies and their uses

Anti-human b7-h4 antibody “6h3”, antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immmospecifically binding to b7-h4, and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases are disclosed. In preferred embodiments, the molecules are used to retard or prevent tumor growth, inhibit tumor-mediated suppression, eliminate tumors and/or deplete or block the activity of tumor-associated macrophages (“tams”) so as to alter their activity and/or decrease tam-mediated immune suppression.. ... The Johns Hopkins University

11/05/15 / #20150314625

High resolution laser labeling of microscopic glass slides and histological sections

The present invention is directed to a device and a laser, eye-safe method for laser marking slides for use in conjunction with a light microscope. The device is an attachment for a light microscope that allows the operator to make marks on preparations of biological tissues or other materials placed on a glass slide or between a glass slide and a cover slip. ... The Johns Hopkins University

11/05/15 / #20150313876

Methods and compositions for treating schizophrenia

The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2a (sv2a) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs, and prodrugs thereof. The methods and the compositions can be used for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania).. ... The Johns Hopkins University

10/29/15 / #20150307592

Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer sonogram models and age-related macular degeneration models are disclosed. ... The Johns Hopkins University

10/29/15 / #20150306184

Tumor-specific delivery of therapeutic agents via liposomase/us

Clostridium novyi is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with c. ... The Johns Hopkins University

10/29/15 / #20150306066

Treatment of human cytomegalovirus by modulating wnt

The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for treating human cytomegalovirus using wnt pathway modulators. ... The Johns Hopkins University

10/29/15 / #20150305822

Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography

A surgical evaluation and guidance system for use in extravascular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically coupled to the optical coherence tomography engine; and a signal processing and display system adapted to communicate with the optical coherence tomography engine to receive imaging signals therefrom. An optical coherence tomography vessel probe for use in extravascular evaluation and guidance of fluid vessel surgeries, includes a probe body having a proximal end and a distal end; an optical relay system disposed within the probe body; and a vessel adapter at least one of attached to or integral with the probe body at the distal end of the probe body, wherein the vessel adapter defines a groove that is configured to accept one of a fluid vessel and a lymphaticovenous vessel.. ... The Johns Hopkins University

10/29/15 / #20150305761

Motion-compensated micro-forceps system and method

A motion-compensated micro-forceps system, including a manually-operable micro-forceps assembly having a plurality of moveable grasping elements; a motor assembly operatively connected to the plurality of moveable grasping elements; an optical detection system having an optical fiber attached to the manually-operable micro-forceps assembly at a fixed axial distance relative to a distal-most end of the plurality of moveable grasping elements; and a motor controller configured to communicate with the optical detection system and the motor assembly to provide motion compensation of the plurality of moveable grasping elements of the manually-operable micro-forceps, wherein the optical detection system is configured to output a signal for the determination of a distance of the plurality of moveable grasping elements of the micro-forceps to a target during operation, and wherein the motor controller is configured to provide feedback control signals to the motor assembly for motion compensation for both hand tremor and for hand-action-induced motions.. . ... The Johns Hopkins University

10/22/15 / #20150302197

Apparatus and method for identifying similarity via dynamic decimation of token sequence n-grams

An apparatus for identifying related code variants or text samples includes processing circuitry configured to execute instructions for receiving query binary code, processing the query binary code to generate one or more query code fingerprints comprising compressed representations of respective functional components of the query binary code, generating token sequence n-grams of the fingerprints, hashing the n-grams, partitioning samples by length to compare selected samples based on length, and identifying similarity via dynamic decimation of token sequence n-grams.. . ... The Johns Hopkins University

10/22/15 / #20150299807

Genomic classifiers for non-invasive identification of high grade prostate cancer with metastatic potential

The present invention relates to the field of biomarkers. More specifically, the present invention provides methods and compositions useful for diagnosing and/or prognosing prostate cancer. ... The Johns Hopkins University

10/22/15 / #20150299791

Dna methylation biomarkers of post-partum depression risk

The present invention relates to the field of post-partum depression. More specifically, the present invention relates to the use of biomarkers to diagnose post-partum depression or predict a risk thereof. ... The Johns Hopkins University

10/22/15 / #20150297784

Imidated biopolymer adhesive and hydrogel

Biologically compatible polymers carry an imide and can be used as an adhesive, a hydrogel or both. A second biologically compatible polymer reactive with the imidated polymer can be used therewith to seal openings.. ... The Johns Hopkins University

10/22/15 / #20150297531

Nanoparticle formulations with enhanced mucosal penetration

Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (mpp). Hypotonic formulations markedly increased the rate at which drugs and mpp reached the epithelial surface, including deep into the vaginal folds. ... The Johns Hopkins University

10/22/15 / #20150297404

Fiber optic distal sensor controlled micro-manipulation systems and methods

A motion-compensated cutting system includes a hand-held tool body, and an actuator connected to the tool body. A shaft of the actuator is movable relative to the tool body so that a distal end of a cutting implement attached to the shaft is axially movable relative to the tool body. ... The Johns Hopkins University

10/22/15 / #20150297177

Robot assisted ultrasound system

According to some embodiments of the invention, a robot-assisted ultrasound system includes a first ultrasound probe, a robot comprising a manipulator arm having a tool end, and a second ultrasound probe attached to the tool end of the manipulator arm. The robot-assisted ultrasound system further includes a robot control system configured to control at least one of a position or a pose of the second ultrasound probe based on a contemporaneous position and pose of the first ultrasound probe, and an ultrasound processing and display system configured to communicate with at least one of the first and second ultrasound probes to receive and display an ultrasound image based on the first and second ultrasound probes acting in conjunction with each other.. ... The Johns Hopkins University

10/22/15 / #20150297007

System and method for providing eating assistance to those with physical limitations

The present invention is directed to a system and method for method to facilitate self-feeding for those with physical limitations that can easily loaded with food and is usable anywhere. The system includes a specially designed utensil called a ploon, which is a hybrid of a spoon and a plate. ... The Johns Hopkins University

10/22/15 / #20150296758

Humanized transgenic single nucleotide polymorphism animal systems

The present invention relates to the field of transgenic animals. More specifically, the present invention provides methods and composition related to humanized transgenic single polymorphism non-human animal systems. ... The Johns Hopkins University

10/01/15 / #20150276761

Methods for diagnosing pulmonary hypertension

Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. ... The Johns Hopkins University

10/01/15 / #20150276746

Biomarkers for aggressive prostate cancer

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing aggressive prostate cancer. ... The Johns Hopkins University

10/01/15 / #20150275315

Protein tyrosine phosphatase mutations in cancers

Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (ptps) and kinases (ptks), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine phosphatase gene superfamily in human cancers identified 83 somatic mutations in six ptps (ptprf, ptprg, ptprt, ptpn3, ptpn13, ptpn14), affecting 26% of colorectal cancers and a smaller fraction of lung, breast and gastric cancers. ... The Johns Hopkins University

10/01/15 / #20150275310

Methods and compositions for detecting internal tandem duplication mutations

The present invention relates to the field of diagnostics methods and compositions. More specifically, the present invention provides methods for detecting internal tandem duplication (itd) mutations. ... The Johns Hopkins University

10/01/15 / #20150273071

Bioreducible poly (beta-amino ester)s for sirna delivery

Degradable polymers were synthesized that self-assemble with nucleic acids, proteins, hydrophobic drugs, and other small molecules to form particles that are effective for delivery into a cell, tissue and/or organism either in vitro or in vivo. The presently disclosed polymers demonstrate differential cell-type specificity, an ability to promote endosomal escape to protect the cargos from degradation and enhance delivery to the cytoplasm, and/or bioreducibility, which enables triggered intracellular drug release to be tuned to promote optimal delivery to the target cell type. ... The Johns Hopkins University

10/01/15 / #20150272900

Layer-by-layer approach to co-deliver dna and sirna via aunps: a potential platform for modifying release kinetics

A layer-by-layer (lbl) system, which alternately ionically complexes anionic aunps to two unique cationic polymers (disuifide-reducible and hydrolytically degradable) and two anionic nucleic acids, is disclosed.. . ... The Johns Hopkins University

09/24/15 / #20150267243

Inducible reconstitution and real-time quantitative kinetic system for the study of intramembrane enzymes

The present invention relates to the field of enzymes. More specifically, the present invention provides an inducible reconstitution and real-time quantitative kinetic system for the study of intramembrane enzymes. ... The Johns Hopkins University

09/24/15 / #20150265656

Human endocrine progenitors from adult pancreatic tissue

The present invention relates to the field of progenitor cells. More specifically, the present invention provides compositions and methods for isolating endocrine progenitor cells from pancreatic tissue. ... The Johns Hopkins University

09/24/15 / #20150265354

Mri-safe robot for transrectal prostate biopsy

An mri safe robot for guiding transrectal prostate biopsy comprises a support arm, a robot body operatively connected to the support arm and a transrectal biopsy device operatively connected to the robot body. The transrectal biopsy device includes an endorectal extension and a biopsy needle device, the endorectal extension including an mri coil for mri imaging of the prostate. ... The Johns Hopkins University

09/24/15 / #20150265144

System and method for detecting and classifying severity of retinal disease

A method of detecting, and classifying severity of, a retinal disease using retinal images includes at least one of receiving, retrieving or generating reference data that includes information concerning occurrences of key image features for each of a plurality of retinal disease and disease severity conditions; receiving a retinal image of an individual; processing the retinal image of the individual to identify occurrences of each of a plurality of distinguishable image features throughout at least a region of interest of the retinal image; identifying which ones of the identified occurrences of the plurality of distinguishable image features of the retinal image of the individual correspond to the key image features of the reference data; calculating, based on the identifying, a number of occurrences of each of the key image features in the retinal image of the individual; and determining at least one of a likelihood of a presence of a retinal disease or a likelihood of developing a retinal disease based on a comparison of the number of occurrences of each of the key image features in the retinal image of the individual to the reference data.. . ... The Johns Hopkins University

09/17/15 / #20150262500

Method and device for training a user to sight read music

An embodiment in accordance with the present invention provides a method and system for training a student to sight-read music. The method includes displaying a measure of music having at least a first and second phrase of notes. ... The Johns Hopkins University

09/17/15 / #20150262390

Information propagation in prior-image-based reconstruction

A framework, comprising techniques, process(es), device(s), system(s), combinations thereof, or the like, to analyze propagation of information in prior-image-based reconstruction by decomposing the estimation into distinct components supported by a current data acquisition and by a prior image. Such decomposition can quantify contributions from prior data and current data as a spatial map and/or can trace specific features in an image to a source of at least some of such features.. ... The Johns Hopkins University

09/17/15 / #20150258344

Method and device for treating cardiac arrhythmias

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (ac) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. ... The Johns Hopkins University

09/17/15 / #20150258061

Compositions and methods for treatment of neurodegenerative disease

Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.. . ... The Johns Hopkins University

09/17/15 / #20150257675

Methods and apparatus for accelerated, motion-corrected high-resolution mri employing internal detectors or mri endoscopy

A method of internal mri employing at least one active internal mri detector located within a sample of interest. The method includes applying an mri pulse sequence to the sample of interest. ... The Johns Hopkins University

09/10/15 / #20150252438

Agents for reversing epigenetic silencing of genes

The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (mbd) proteins with methylated genomic dna. Also provided are methods for reactivating silenced genes having cpg island hypermethylation along with methods for treatment and prevention of diseases, such as cancer and sickle cell anemia, by administering an agent that modulates methyl-binding domain (mbd) protein-mediated transcriptional repression, thereby increasing gene transcription to prevent or treat disease. ... The Johns Hopkins University

09/10/15 / #20150252415

Arid1b and neuroblastoma

Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases), genome-wide rearrangement analyses (32 cases), and targeted analyses of specific genomic loci (40 cases) using massively parallel sequencing to determine the genetic basis for neuroblastoma. ... The Johns Hopkins University

09/10/15 / #20150252285

Methods for extraction of lipids from wet algal biomass

The present invention provides novel methods for extraction of lipids from intact or lysed microorganisms in aqueous culture using a partially water soluble cosolvent with, or without a second organic solvent, and/or pressurized co2 in the extraction methods. Such a process can also be implemented at a much larger industrial scale, where the economics of scale based capital expenditures costs distributed over much higher volume production as well as increased equipment efficiency would significantly improve production rates and lower costs.. ... The Johns Hopkins University

09/10/15 / #20150250906

Bacteria-specific labeled substrtates as imaging biomarkers to diagnose, locate, and monitor infections

The methods of the present invention exploit unique biochemical pathways present within infectious organisms to develop small molecule metabolic tracers. Labeled substrates created using these inventive methods were created. ... The Johns Hopkins University

09/10/15 / #20150250881

Multicomponent degradable cationic polymers

Degradable polymers were synthesized that self-assemble with dna to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. ... The Johns Hopkins University

09/10/15 / #20150250747

Compositions and methods for treating obesity and obesity-related conditions

The present invention relates to the field of obesity. More specifically, the present invention provides methods and compositions useful in treating obesity and obesity-associated conditions. ... The Johns Hopkins University

09/03/15 / #20150246144

Labeled inhibitors of prostate specific membrane antigen (psma) biological evaluation, and use of imaging agents

The prostate-specific membrane antigen (psma) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mtc/re-labeled compounds were prepared by attaching known tc/re chelating agents to an amino-functionalized psma inhibitor with or without a variable length linker moiety. ... The Johns Hopkins University

08/27/15 / #20150241437

Isobaric aldehyde-reactive tags for and analysis of glycans using same

Highly specific and novel methods for analyzing glycans and proteoglycans are provided. Uses of the information generated by the inventive methods for diagnosis and treatment are also disclosed.. ... The Johns Hopkins University

08/27/15 / #20150239945

Compositions and methods for increasing the expression and signalling of proteins on cell surfaces

The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. ... The Johns Hopkins University

08/27/15 / #20150239739

Bent carbon nanotubes and methods of production

A method of producing carbon nanotubes includes directing a flow of a gas over a substrate to provide growth of at least one carbon nanotube in a carbon-nanotube-growth region of the substrate; applying an electric field to the carbon-nanotube-growth region of the substrate after the at least one carbon nanotube has begun to grow in the carbon-nanotube-growth region, the electric field being substantially in a first direction in the carbon-nanotube-growth region; and changing the electric field at a preselected time to be substantially in a second direction in the carbon-nanotube-growth region during growth of the at least one carbon nanotube. The second direction is different from the first direction resulting in a bend substantially at a selected position of the at least one carbon nanotube, the method of producing carbon nanotubes providing the production of the at least one carbon nanotube having at least one bend substantially at a selected position along the at least one carbon nanotube.. ... The Johns Hopkins University

08/27/15 / #20150238511

Synergistic antiviral compositions comprising a viral attachment inhibitor, an integration inhibitor, and a proviral transcription inhibitor, and their use

Compounds, compositions and methods for the treatment of hiv/hsp/hpv, in particular, compositions and methods for a 3 part combination therapy for hiv/hsv/hpv, comprising a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor. The therapy is advantageous for the treatment of hiv infection, and is also effective for hsv and hpv infection. ... The Johns Hopkins University

08/27/15 / #20150238465

Novel, protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair

Provided herein is a novel mitochondrial angiotensin ii type 1 and type 2 at1r and at2r receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues. ... The Johns Hopkins University

08/20/15 / #20150233903

Solid phase glycan and glycopeptide analysis and microfluidic chip for glycomic extraction, analysis and methods for using same

Highly specific and novel solid phase methods for analyzing glycans and proteoglycans using a solid phase system are provided. The present invention also provides an integrated apparatus and methods of use which comprises a high-throughput glycan isolation and reverse-phase liquid chromatography (rplc) for on-chip glycan extraction, modification and separation. ... The Johns Hopkins University

08/20/15 / #20150231239

Compositions and methods for rendering tumor cells susceptible to cd8+ t cell-mediated killing

The present invention provides an immunoconjugate having the formula: t-c-en-c-fcn or t-c-fcn-c-en; wherein, t is a single chain variable portion fragment of a monoclonal antibody (scfv) directed to a target protein, polypeptide, or fragment thereof, which is highly expressed on cancer cells; e is two or more foreign immunogenic cd8+ t cell antigenic epitopes; c is a peptide or polypeptide fragment thereof, capable of being cleaved by a specific protease; and fc is two or more fc portions of an igg antibody. Nucleic acid sequences encoding the same and vectors containing said nucleic acid sequences are also provided. ... The Johns Hopkins University

08/13/15 / #20150225430

Inhibitors of dxp synthase and methods of use thereof

Novel inhibitors of dxp synthase and methods of use thereof are disclosed.. . ... The Johns Hopkins University

08/13/15 / #20150224170

Methods of inhibiting alphavirus replication and treating alphavirus infection

The invention provides methods of inhibiting alphavirus replication and treating alphavirus infection.. . ... The Johns Hopkins University

08/13/15 / #20150223903

Method and system for transcranial photoacoustic imaging for guiding skull base surgeries

The present invention is directed to a method and system for photoacoustic imaging for guiding medical procedures. A transducer is placed near the site of the procedure. ... The Johns Hopkins University

08/06/15 / #20150222596

Secure layered iterative gateway

In methods and a device for mitigating against cyber-attack on a network, a distributed intermediary device is placed into a network between computers or network nodes of the network to mitigate cyber-attacks between the computers or nodes of a network from remote systems. Threats are assessed by utilizing internal information assurance mechanisms of the device to detect such cyber-attacks without requiring external modification of the software and/or hardware of the computers or nodes of the network to be protected. ... The Johns Hopkins University

08/06/15 / #20150220706

Tailored rapid interactive mobile messaging (trimm) for weight management

An embodiment in accordance with the present invention provides a system and a method for facilitating a user to meet a self-selected goal. The user enrolls in the program and receives a tailored series of motivational text messages. ... The Johns Hopkins University

08/06/15 / #20150220593

Apparatus and method for aligning token sequences with block permutations

A method of determining matching between at least a first sample comprising a sequence of tokens a and a second sample comprising a sequence of tokens b may include, for monotonically decreasing values of n, performing operations including recording a subset sa of n-grams of a in a hash table la, such that a value of each n-gram determines an index in la and a location of each respective n-gram in a is recorded as the value in la, recording a subset sb of n-grams of b in a hash table lb, such that a value of each n-gram determines an index in lb and a location of each respective n-gram in b is recorded as the value in lb, for each location l that is occupied in both la and lb, examining a region in a centered on la(l) and a region in b centered on lb(l), and reporting a largest matching region aligning la(l) with lb(l) that does not include already-matched tokens in a or b and marking the largest matching region as matched.. . ... The Johns Hopkins University

08/06/15 / #20150218156

Inhibitors of d-amino acid oxidase

D-amino acid oxidase (daao) inhibitors and methods of their use, either alone or in combination with d-serine or d-alanine, to facilitate allosteric activation of nmda receptor-mediated neurotransmission and methods of their use as therapeutic agents for treating a subject afflicted with one or more cognitive-disorders, such as schizophrenia, including subjects suffering from negative symptoms and cognitive impairments, post-traumatic stress disorder (ptsd), or pain, are disclosed.. . ... The Johns Hopkins University

08/06/15 / #20150217030

Method for coating a medical device with a conformal hydrogel

Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a ph of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.. ... The Johns Hopkins University

07/30/15 / #20150215707

Pblg based planar microphones

A piezoelectric, poly (γ-benzyl-α,l-glutamate) (“pblg”) planar microphone, and method for construction thereof, are disclosed. The microphone includes at least a polyester film, a piezoelectric, hot pressed poly (γ-benzyl-α,l-glutamate) (“hppblg”) layer, and an aluminum coating for the hppblg layer. ... The Johns Hopkins University

07/30/15 / #20150212098

Diagnostic assay for alzheimer's disease

The present invention relates to the field of alzheimer's disease (ad). More specifically, the present invention provides methods and compositions useful in diagnosing and assessing ad. ... The Johns Hopkins University

07/30/15 / #20150209580

Implantable vestibular prosthesis

An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.. ... The Johns Hopkins University

07/30/15 / #20150209527

Fiber optic distal sensor controlled drug injector

A motion-compensated injector system includes a handheld tool having a hollow shaft with a distal end for insertion into tissue of a subject. The system also includes an optical coherence tomography-based optical detection system having an optical fiber with a distal end at a fixed distance from the distal end of the hollow shaft, and an optical sensor to receive a signal from the optical fiber. ... The Johns Hopkins University

07/30/15 / #20150209381

On01910.na enhances chemotherapeutic agent activity in drug-resistant tumors

The invention includes compositions and methods of treatment of cancers susceptible to treatment with nucleotide analog chemotherapeutic agent, including cancers in which nucleotide analog resistant tumors have developed, including identifying a subject having cancer susceptible to treatment with a nucleotide analog chemotherapeutic agent and a mitotic disruptor/polo-like kinase (pik) pathway inhibitor to a subject; and monitoring the subject for a reduction of stabilization of at least one sign or symptom of cancer.. . ... The Johns Hopkins University

07/30/15 / #20150209304

Methods for inhibition of bnip3 and prevention and treatment of ischemia reperfusion injury by tetra-o-methyl nordihydroguaiaretic acid

Provided herein are methods for prevention and treatment of ischemia-reperfusion (ir) injury in the cardiac myocytes of a subject, by administration to the subject, a compound of formula i, or a salt, solvate, or stereoisomer thereof, in a sufficient amount either prior to, or during and/or after an ischemic event to mitigate or prevent ir injury to the cardiac tissue. Pharmaceutical compositions including the compound of formula i, or a salt, solvate, or stereoisomer thereof, and/or at least one additional therapeutic agent, are also provided.. ... The Johns Hopkins University

07/30/15 / #20150209299

Drug-eluting medical devices

A medical device includes a plurality of drug-eluting nanofibers directly or indirectly located over an outer surface of the medical device, or utilized independently as a tissue engineering scaffold. The plurality of drug-eluting nanofibers include one or more therapeutic agents. ... The Johns Hopkins University

07/16/15 / #20150199811

Methods and systems for psychophysical assessment of number-sense acuity

Featured are methods and systems for psychophysical assessment of number-sense acuity. Such methods include determining at least a display time based on participant related information (e.g., age) and selecting images for viewing by the participant based on the participant related information, the selected images having a complexity appropriate for the participant. ... The Johns Hopkins University

07/16/15 / #20150198768

Fiber optic circuit breaker

An optical circuit breaker includes a main optical transmission path including an optical coupler, a delay line and a protection device, and a parallel protection path configured to receive a tapped portion of a signal provided to the main optical transmission path and generate a reference signal based on the tapped portion. The protection device may be configured to be triggered to prevent an overpower condition from passing through the optical circuit breaker responsive to the reference signal exceeding a user selectable threshold. ... The Johns Hopkins University

07/16/15 / #20150198609

Human autoantibodies specific for pad3 which are cross-reactive with pad4 and their use in the diagnosis and treatment of rheumatoid arthritis and related diseases

In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to pad3 protein. ... The Johns Hopkins University

07/16/15 / #20150197502

Bis-acylated hydroxylamine derivatives

The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. ... The Johns Hopkins University

07/16/15 / #20150196584

Oxygen-controllable and hypoxia-inducible hydrogels

Novel hydrogels that can serve as 3d hypoxic microenvironments are disclosed. Oxygen controllable, hypoxia-inducible hydrogels (hi hydrogels) are composed of a phenolic agent and polymer backbone, which can form hydrogel networks via oxygen consumption in an enzyme-mediated crosslinking reaction. ... The Johns Hopkins University

07/16/15 / #20150195995

Small footprint green roof optimized for climbing plants

The present invention is directed to a system for a green roof that allows a green roof to be used more affordably and in a broader range of situations than currently available. The system includes a network of grow chambers suspended above the roof. ... The Johns Hopkins University

07/09/15 / #20150192581

Lateral flow device for diagnosing microbial infections

Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carriers with it a high mortality. ... The Johns Hopkins University

07/09/15 / #20150191761

Use of high flux scfa-derivatized monosaccharides in recombinant glycoprotein production

Methods of glycoprotein production employing monosaccharides capable of producing a global increase in flux through the sialic acid pathway are provided.. . ... The Johns Hopkins University

07/02/15 / #20150184150

Efficient, expansive, user-defined dna mutagenesis

The presently disclosed subject matter provides methods for the creation of one or more user-defined mutations that can be located anywhere in a target sequence, such as in a gene. These mutations can comprise single mutations, multiple mutations, or a comprehensive codon mutagenesis library, in which all possible single codon substitutions in a gene are created. ... The Johns Hopkins University

07/02/15 / #20150183881

Compositions and methods for targeted immunomodulatory antibodies and fusion proteins

The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. ... The Johns Hopkins University

07/02/15 / #20150183842

Cardiac arrhythmia treatment methods

Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical property of the heart. ... The Johns Hopkins University

07/02/15 / #20150183798

Monomeric trioxane amide sulfur compounds

Anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in plasmodium berghei-infected mice. Selected anilides derivatives administered orally as one single-digit dose combined with mefloquine hydrochloride were completely curative, i.e., all 5 of the mice in the particular treatment group had no detectable parasitemia on day 30 post infection, gained as much weight by day 30 post infection as the control mice (no infection), and behaved normally.. ... The Johns Hopkins University

07/02/15 / #20150182621

Compositions and methods for enhancing antigen-specific immune responses

Methods for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer and persistent viral infections, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a nucleic acid composition encoding an antigen or a biologically active homolog thereof and boosting the mammal by administering to the mammal an effective amount of an oncolytic virus comprising a nucleic acid encoding the antigen or the biologically active homolog thereof.. ... The Johns Hopkins University

06/25/15 / #20150177241

Biomarkers of immune response in mucosal lesions and their use with therapeutic vaccination

The present invention provides evidence of post-vaccination immunologic changes in target hpv induced cervical intraepithelial neoplasias that suggest the induction of clinically relevant tissue-localized immune responses, despite modest detectable responses in circulating t lymphocytes. The inventive methods allow for identification of immunological responses to hpv immunotherapies, and means for monitoring responses during clinical trials and treatment regimens.. ... The Johns Hopkins University

06/25/15 / #20150175963

Immortalization of cells including neuronal cells

The instant invention provides methods for immortalizing cells. The invention further provides immortalized cell lines, e.g., neuronal cell lines, and methods of using these cell lines in screening assays.. ... The Johns Hopkins University

06/25/15 / #20150174154

Skin and hair regeneration using polysaccharide-based hydrogels

Methods for promoting skin regeneration, promoting hair follicle regeneration, and reducing scarring by topically administering polysaccharide-based hydrogel compositions to injured skin are presented.. . ... The Johns Hopkins University

06/25/15 / #20150173703

Integration of quantitative calibration systems in computed tomography scanners

An embodiment in accordance with the present invention provides a device and method for a quantitatively calibrated computed tomography scanner. The device includes a gentry configured for receiving a patient or part of a patient. ... The Johns Hopkins University

06/18/15 / #20150168504

Chip-scale optomechanical magnetometer

An optomechanical oscillator for measuring a magnetic field may include a fixed substrate, a moveable mass separated from the fixed substrate by a slot, a photonic crystal comprising an optomechanical cavity formed at the slot, and a current source operably coupled to provide current to the photonic crystal. The moveable mass may be moveable responsive to placement of the optomechanical oscillator in a magnetic field based on interaction of the magnetic field and the current. ... The Johns Hopkins University

06/18/15 / #20150168398

Methods for identifying patterns of ifn induced expression and use in diagnosis, monitoring and therapy

The present inventors identified a subpopulation of genes induced by type i and type ii ifns in a human submandibular gland (hsg) epithelial cell line. Unexpectedly, it was found that the majority of genes that are highly up-regulated by ifn-α are also highly induced by ifn-γ. ... The Johns Hopkins University

06/18/15 / #20150167095

Consensus coding sequences of human breast and colorectal cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. ... The Johns Hopkins University

06/18/15 / #20150166962

Hydrogel-based vascular lineage cell growth media and uses thereof

A medium for growing vascular lineage cells is described. The vascular lineage cell growth medium includes an oligosaccharide-based hydrogel and a growth factor that promotes vascularization by vascular lineage cells.. ... The Johns Hopkins University

06/18/15 / #20150164906

Compounds and methods of use thereof for treating neurodegenerative disorders

Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.. . ... The Johns Hopkins University

06/18/15 / #20150164739

Cpr chest compression monitor and method of use

A chest compressions monitor for measuring the depth of chest compressions achieved during cpr. A displacement detector produces a displacement indicative signal indicative of the displacement of the cpr recipient's chest toward the recipient's spine. ... The Johns Hopkins University

06/18/15 / #20150164396

Non-invasive bio-fluid detector and portable sensor-transmitter-receiver system

The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic pdas such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as pdas including, but not limited to, cell phones.. ... The Johns Hopkins University

06/04/15 / #20150150643

Personalized computational modeling of atrial fibrosis to guide catheter ablation of atrial fibrillation

Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (af) patient with atrial fibrosis are disclosed. Three-dimensional imaging data representing the atria of the patient may be received. ... The Johns Hopkins University

06/04/15 / #20150150572

Dual balloon biliary stone extraction device

The present invention is directed to a method and apparatus for selective guide wire cannulation of a bile duct, removal of biliary calculi, and delivering hydrodynamic gene delivery are also provided. There is provided a method for straightening the terminal common bile duct to allow biliary calculi to be removed, assisting in creation of a gastoejunostomy, and selective guidewire cannulation. ... The Johns Hopkins University

05/28/15 / #20150148717

Automated chest compression apparatus

A system applies cardiopulmonary resuscitation (cpr) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. ... The Johns Hopkins University

05/28/15 / #20150148405

Expression construct for a lin28-resistant let-7 precursor microrna

Precursor microrna molecules that have been modified to prevent a protein involved in regulating developmental timing, oncogenesis, and/or neuronal growth from blocking processing of the precursor microrna sequence to the mature microrna are provided. Methods and kits for using the precursor microrna molecules also are provided.. ... The Johns Hopkins University

05/28/15 / #20150148389

Methods for treating or preventing brain infections

The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host cellular signaling molecules to prevent a pathogen from infecting the organ. For example, the administration of a compound to prevent a pathogen from crossing the blood-brain barrier to prevent a brain infection.. ... The Johns Hopkins University

05/28/15 / #20150148256

Bioluminescence imaging-based screening assay and inhibitors of abcg2

A bioluminescence imaging-based high-throughput assay for inhibitors of abcg2 is described. Compositions of inhibitors of abcg2 and methods of using abcg2 inhibitors are also described.. ... The Johns Hopkins University

05/21/15 / #20150142026

Therapeutic electrospun fiber compositions

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. ... The Johns Hopkins University

05/21/15 / #20150141900

Method and device for targeted delivery of fluid therapeutics

The present invention utilizes a catheter device for targeted delivery of therapeutic molecules in fluids to body cavities. The invention provides a device and method for targeted delivery of fluids to tissue cavities via deployment of a fluid soaked sponge from the catheter to contact surfaces within the body cavity.. ... The Johns Hopkins University

05/21/15 / #20150141861

Novel methodology for assessing the bounded-input bounded-output instability in qt interval dynamics: application to clinical ecg with ventricular tachycardia

The present invention is directed to a method for determining onset of ventricular arrhythmias using bounded-input bounded-output stability of qt interval (qti) dynamics. The method of the present invention includes two parts. ... The Johns Hopkins University

05/21/15 / #20150141359

Controlled release formulations for the delivery of hif-1 inhibitors

Controlled release dosage formulations for the delivery of one or more hif-1 inhibitors are provided. The controlled release formulations contain one or more hif-1 inhibitors conjugated to or dispersed in a polymeric vehicle. ... The Johns Hopkins University

05/21/15 / #20150139961

Reprogramming blood cells to pluripotent and multipotent stem cells

The present invention is based on the seminal discovery that cord blood (cb) and adult bone marrow (bm) cd34+ cells can be reprogrammed to early stem cells. The invention provides the reprogramming of cb and adult bone marrow (bm) cd34+ cells from subjects without any pre-treatment. ... The Johns Hopkins University

05/21/15 / #20150139909

Compositions and methods for treating or preventing osteoarthritis

The present invention relates to the field of osteoarthritis. More specifically, the present invention provides compositions and methods useful for treating or preventing osteoarthritis. ... The Johns Hopkins University

05/07/15 / #20150127698

Method and apparatus for remote application monitoring

A method executable via operation of configured processing circuitry to identify applications by remote monitoring may include initiating remote communication with a target device through an access point, the access point providing network access to the target device, providing a series of ping messages to the target device via the access point to determine a delay signature of an application running on the target device, and generating application identification information based on the delay signature.. . ... The Johns Hopkins University

05/07/15 / #20150126903

Integrated punch biopsy device

A punch biopsy tool includes a punch cutting element which includes an inner surface, an outer surface, and a cutting edge along a bottom edge, and which defines an aperture between the inner surface and the outer surface. The punch biopsy tool also includes a flexible cutting element which is disposed along the inner surface of the punch cutting element and is configured to be pulled through the aperture.. ... The Johns Hopkins University

05/07/15 / #20150126374

Hypermethylated gene markers for head and neck cancer

Methods and kits for diagnosing or predicting head and neck squamous cell carcinoma (hnscc) and for predicting responsivity to therapeutic regimens for treating hnscc are disclosed.. . ... The Johns Hopkins University

05/07/15 / #20150125033

Bone fragment tracking

A method of determining bone fragment navigation may include receiving pre-operative 2d image data of a reference bone structure and a bone fragment. The reference bone structure may include a first set of fiducial markers provided thereon, and the bone fragment may include a second set of fiducial markers provided thereon. ... The Johns Hopkins University

04/30/15 / #20150119948

Method for low voltage defibrillation with far-field stimuli of variable timings based on feedback from the heart

The present invention includes a method for cardiac defibrillation, especially low-voltage defibrillation, in a subject, including converting fibrillation into tachycardia and using feedback or an estimation thereof from the heart to time stimuli to occur when large amounts of tissue are excitable in the heart of the subject. The resultant tachycardia can then be terminated using a tachycardia termination protocol known to or conceivable by one of skill in the art. ... The Johns Hopkins University

04/30/15 / #20150119287

Single-molecule pcr on microparticles in water-in-oil emulsions

Modulation of the viscosity of the oil phase of a microemulsion used for amplification of dna on a bead increases the homogeneity of product beads and the amount of amplified dna per bead. Moreover the number of separate microemulsion populations that can be formed in parallel is increased using multi-well plates and mixer mill disrupter machines designed to lyse biological samples.. ... The Johns Hopkins University

04/30/15 / #20150118747

Electrostretched polymer microfibers for microvasculature development

An in vitro model system that guides the development of microvasculature, recapitulating the detailed organization of both its cellular and a-cellular components is established. Use of electrostretched fibrin microfibers enables both endothelial layer organization and co-culture of supporting perivascular (mural) cells such as vascular smooth muscle cells and pericytes. ... The Johns Hopkins University

04/30/15 / #20150118740

Self-contained cartridge and methods for integrated biochemical assay at the point-of-care

Provided is a sample processing cartridge. The sample processing cartridge can include a housing and a channel disposed in the housing. ... The Johns Hopkins University

04/30/15 / #20150118195

Electro-mechanically stretched micro fibers and methods of use thereof

The presently disclosed subject matter provides a scalable and electrostretching approach for generating microfibers exhibiting uniaxial alignment from polymer solutions. Such microfibers can be generated from a variety of natural polymers or synthetic polymers. ... The Johns Hopkins University

04/30/15 / #20150114007

Magnetocaloric materials for cryogenic liquification

System and methods for cryogenic magnetocaloric refrigeration are provided. The system may include a magnetocaloric material including a single ion anisotropy and primary magnetic interactions of at most two dimensions. ... The Johns Hopkins University

04/23/15 / #20150112301

Apparatus and method for endoluminal stent transit

An endoluminal stent transit device. The endoluminal stent transit device includes a wire having a distal end and a proximal end, and a guide element attached to the wire at the distal end, which is movable between a first position and a second position. ... The Johns Hopkins University

04/23/15 / #20150112044

Palladium catalyzed reactions executed on solid-phase peptide synthesis supports for the production of self-assembling peptides embedded with complex organic electronic subunits

Methods to synthesize self-assembling peptides embedded with complex organic electronic subunits are provided.. . ... The Johns Hopkins University

04/16/15 / #20150104819

Methods of using isoniazid for the diagnosis of lung infections

The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid.. . ... The Johns Hopkins University

04/16/15 / #20150104387

Psma-targeting compounds and uses thereof

Prostate-specific membrane antigen (psma) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.. ... The Johns Hopkins University

04/16/15 / #20150104188

Active beam shaping system and method using sequential deformable mirrors

An active optical beam shaping system includes a first deformable mirror arranged to at least partially intercept an entrance beam of light and to provide a first reflected beam of light, a second deformable mirror arranged to at least partially intercept the first reflected beam of light from the first deformable mirror and to provide a second reflected beam of light, and a signal processing and control system configured to communicate with the first and second deformable mirrors. The first deformable mirror, the second deformable mirror and the signal processing and control system together provide a large amplitude light modulation range to provide an actively shaped optical beam.. ... The Johns Hopkins University

04/09/15 / #20150099695

C1q/tnf-related protein-9 (ctrp9) and use in prevention and treatment of metabolic disorders

Compositions and methods for treatment of obesity and/or type ii diabetes and related metabolic disorders are provided wherein the methods and treatments comprise an effective amount of an isolated and/or purified c1q/tnf-related protein-9 (ctrp9) or a functional portion thereof, and a pharmaceutically acceptable carrier. Methods of screening for molecules which elevate levels of ctrp9 in vivo are also provided. ... The Johns Hopkins University

04/09/15 / #20150099669

Mass spectrometry imaging of glycans from tissue sections and improved analyte detection methods

The presently disclosed subject matter provides methods using mass spectrometry for direct profiling of n-linked glycans from a biological sample. In addition, the embodiments of the present invention also disclose novel methods, known as targeted analyte detection (tad), for improving the detection limit of maldi-ms. ... The Johns Hopkins University

04/09/15 / #20150099290

Insertion of charge in the hydrophobic interior of proteins as a strategy for engineering ph-sensitive switches

Methods are provided for engineering non-naturally occurring proteins comprising artificial ph-sensitive conformational switches that respond to a change in ph by causing a global unfolding of the proteins. Non-naturally occurring proteins comprising artificial ph-sensitive conformational switches that respond to a change in ph by causing a global unfolding of the proteins are also provided.. ... The Johns Hopkins University

04/09/15 / #20150096559

Manual ventilation feedback sensor for use in clinical and training settings

A manual ventilation feedback sensor for use in clinical and training settings is disclosed. Namely, a manual resuscitator device is disclosed that comprises a bag valve mask, a one-way valve, a manual ventilation bag, and a sensing module, wherein the sensing module can comprise a pressure sensor and/or flow transducer. ... The Johns Hopkins University

04/02/15 / #20150094669

Implantable three-way diaphragm valve

An embodiment in accordance with the present invention provides a valve including a housing having a top portion and a bottom portion. The top portion of the housing defines a first and second nozzle, and the bottom portion of the housing defines an opening. ... The Johns Hopkins University

04/02/15 / #20150094352

Methods and compositions for improving cognitive function

This invention relates to treating age-related cognitive impairment. This invention in particular relates to the use of inhibitors of synaptic vesicle protein 2a (sv2a), such as levetiracetam, seletracetam, and brivaracetam, in improving cognitive function in subjects that exhibit age-related cognitive impairment or are at risk thereof, including, without limitation, subjects having or at risk for mild cognitive impairment (mci), age-related cognitive decline (arcd) or age-associated memory impairment (aami).. ... The Johns Hopkins University

04/02/15 / #20150094222

Quantitative multiplex methylation specific pcr method- cmethdna, reagents, and its use

The cmethdna method of the present invention is a novel modification of the qm-msp method (u.s. Pat. ... The Johns Hopkins University

03/26/15 / #20150088098

Implanted tube and external interface for saline or drug delivery to the paranasal sinuses

An embodiment in accordance with the present invention provides an implanted catheter and an external device that the patient uses to inject a therapeutic into the implanted tube. The implanted catheter can be equipped with a fixation mechanism that secures the catheter in place and eases physician insertion and removal. ... The Johns Hopkins University

03/26/15 / #20150087956

X-ray diagnostic apparatus and medical image processing apparatus

An x-ray diagnostic apparatus according to the embodiment includes an x-ray tube, an x-ray detector, image generating unit generating time-series medical images of vasoganglion in a predetermined organ of a subject, region setting unit setting a first upstream and downstream region of a stenosis location in a first blood vessel in the vasoganglion on the medical images, curve generating unit generating a stenosis upstream and downstream curve indicating a change in pixel value in the time-series based on pixel values included in the first upstream and downstream region respectively, stenosis index generating unit generating a stenosis index indicating the degree of stenosis in the first blood vessel based on the stenosis upstream and downstream curve, and display unit displaying the stenosis index.. . ... The Johns Hopkins University

03/26/15 / #20150087702

Methods and compositions for reducing alcohol toxicity

The present invention comprises methods and compositions for reducing ethanol toxicity due to accumulation of acetaldehyde in a cell. A method comprises administering to a cell a composition comprising a compound that increases the expression, the amount of, and/or the activity of at least one member of the aldehyde dehydrogenase superfamily.. ... The Johns Hopkins University

03/26/15 / #20150087551

Methods and systems for sampling, screening, and diagnosis

Apparatus, systems, and methods for detecting, screening and sampling of cells are disclosed.. . ... The Johns Hopkins University

03/26/15 / #20150087053

Compositions and methods for increasing the expression and signalling of proteins on cell surfaces

The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. ... The Johns Hopkins University

03/26/15 / #20150086511

Survival, differentiation and structural integration of human neural stem cells grafted into the adult rat spinal cord

The present invention provides methods and compositions for treating spinal cord diseases and injuires. The methods involve transplanting neural stem cells which have been previously expanded in vitro into a patient such that the cells can ameliorate the disease or injury. ... The Johns Hopkins University

03/26/15 / #20150086484

Lipid-based drug carriers for rapid penetration through mucus linings

Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more peg-conjugated lipids, and optionally one or more additional materials that physically and/or chemically stabilize the particles. ... The Johns Hopkins University

03/19/15 / #20150080462

Compositions and methods for the treatment or prevention of disorders relating to oxidative stress

The present invention features methods for treating or preventing conditions, diseases, or disorders related to oxidative stress. In one embodiment, the method increases nrf2 biological activity or expression. ... The Johns Hopkins University

03/19/15 / #20150080451

Serine protease inhibitors

Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed.. . ... The Johns Hopkins University

03/19/15 / #20150079593

Mutations of the pik3ca gene in human cancers

Phosphatidylinositol 3-kinases (pi3ks) are known to be important regulators of signaling pathways. To determine whether pi3ks are genetically altered in cancers, we analyzed the sequences of the pi3k gene family and discovered that one family member, pik3ca, is frequently mutated in cancers of the colon and other organs. ... The Johns Hopkins University

03/19/15 / #20150079568

Medical sensors for clinical and training applications

The present invention is directed to systems for interfacing between sensors and sensor simulators and clinical monitors and devices. The present invention is used to incorporate sensors and sensor simulators into training and clinical demonstrations. ... The Johns Hopkins University

03/19/15 / #20150079115

Compositions and methods for preventing or relieving symptoms of infections

Food products and/or pharmaceutical preparations including (i) viral neutralizing antibodies or antibody fragments anchored to a probiotic microorganism and (ii) a carrier medium for delivering the viral neutralizing antibodies or antibody fragments anchored to probiotic microorganisms to the gut of a mammal. Also provided are methods of making food products and/or pharmaceutical preparations, which can be used to treat existing viral infections or prevent the spread or transmission of viral infection.. ... The Johns Hopkins University

03/19/15 / #20150079001

Imaging agents and methods of imaging naaladase or psma

The present invention relates to compounds particularly asymmetric urea compounds which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express naaladase and/or psma. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express naaladase and/or psma to which the compounds of the invention have an affinity.. ... The Johns Hopkins University

03/12/15 / #20150073597

Steady hand micromanipulation robot

A cooperative-control robot includes a base component, a mobile platform arranged proximate the base component, a translation assembly operatively connected to the base component and the mobile platform and configured to move the mobile platform with translational degrees of freedom substantially without rotation with respect to said the component, a tool assembly connected to the mobile platform, and a control system configured to communicate with the translation assembly to control motion of the mobile platform in response to forces by a user applied to at least a portion of the cooperative-control robot. The translation assembly includes at least three independently operable actuator arms, each connected to a separate position of the mobile platform. ... The Johns Hopkins University

03/12/15 / #20150073516

Evaporative therapeutic hypothermia device

The present invention provides a low-cost, low-power therapeutic hypothermia device for use in developing nations. The device includes a first and second receptacle separated by a space filled with a porous material such as sand. ... The Johns Hopkins University

03/12/15 / #20150072988

Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer

The present invention relates to methods of using amg 900, a small molecule pan aurora kinase inhibitor, in combination with histone deacetylase (hdac) inhibitor for the treatment of cancer, including solid tumors, hematologically derived tumors and the like. The invention further provides pharmaceutical compositions for administering the cancer therapeutic agents in combination.. ... The Johns Hopkins University

03/12/15 / #20150072360

Biomarkers of pulmonary hypertension

Methods are disclosed for predicting or diagnosing pulmonary artery hypertension (pah) and for determining the efficacy of pah therapy using biomarkers.. . ... The Johns Hopkins University

03/12/15 / #20150071946

Tumor-specific retrotransposon insertions

Described are biomarkers for neoplastic disease progression. Specifically, provided are methods of determining neoplastic disease progression by determining the presence of retrotransposon insertion.. ... The Johns Hopkins University

03/05/15 / #20150065886

Cohesive robot-ultrasound probe for prostate biopsy

An embodiment in accordance with the present invention provides a device and method for a transrectal ultrasound (trus) guided prostate biopsy. The device includes an ultrasound wand equipped with a lateral fire ultrasound sensor. ... The Johns Hopkins University

03/05/15 / #20150065849

Automated pneumothorax detection

A method of determining the presence of a pneumothorax includes obtaining a series of frames of image data relating to a region of interest including a pleural interface of a lung. The image data includes at least a first frame and a second frame. ... The Johns Hopkins University

03/05/15 / #20150065341

Methods of producing porous platinum-based catalysts for oxygen reduction

A porous metal that comprises platinum and has a specific surface area that is greater than 5 m2/g and less than 75 m2/g. A fuel cell includes a first electrode, a second electrode spaced apart from the first electrode, and an electrolyte arranged between the first and the second electrodes. ... The Johns Hopkins University

02/26/15 / #20150057188

Quantitative multiplex methylation-specific pcr

Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes. ... The Johns Hopkins University

02/26/15 / #20150057144

Nanostructured composite materials comprising refractory elements

A bicontinuous non-porous microstructure comprising a refractory phase and a non-refractory phase, wherein the refractory phase substantially comprises one or more refractory elements and the non-refractory phase comprises a void filled by one or more materials that are different than a material comprising the non-refractory phase in a bicontinuous network from which the nanocomposite refractory material is formed and methods of making the same are disclosed.. . ... The Johns Hopkins University

02/26/15 / #20150056267

Angiogenesis inhibitors

Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.. . ... The Johns Hopkins University

02/19/15 / #20150051288

Methods and compositions for treatment of autism

Disclosed herein are methods and compositions for treating autism. Disclosed herein are methods and compositions for treating an autism spectrum disorder.. ... The Johns Hopkins University

02/19/15 / #20150051161

Methods for the detection of advanced glycation endproducts and markers for disease

The present invention provides compositions and methods for detecting carboxymethyl-lysine (cml) and circulating receptor for advanced glycation end (rage) products, and methods for correlating cml and rage levels with age-related disease. In particular, serum cml and/or circulating receptor for advanced glycation end (rage) products can be used as a clinical biomarker in diagnostics to identify people who are at a higher risk of developing adverse ageing-related outcomes.. ... The Johns Hopkins University

02/19/15 / #20150051115

Biomarkers of brain injury

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injuries. ... The Johns Hopkins University

02/19/15 / #20150051100

Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease

The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter dna methylation in a cervical tissue sample from a subject, using a variety of methods which can detect dna methylation. ... The Johns Hopkins University

02/19/15 / #20150051085

Rapid aneuploidy detection

Massively parallel sequencing of cell-free, maternal plasma dna was recently demonstrated to be a safe and effective screening method for fetal chromosomal aneuploidies. Here, we report an improved sequencing method achieving significantly increased throughput and decreased cost by replacing laborious sequencing library preparation steps with pcr employing a single primer pair. ... The Johns Hopkins University

02/19/15 / #20150050288

Treatment of th17-mediated autoimmune disease via inhibition of stat3

Methods for treating autoimmune disease using one or more inhibitor of stat3 are provided herein. Also disclosed are methods for diagnosing and monitoring autoimmune disease or the propensity to develop autoimmune disease in a subject. ... The Johns Hopkins University

02/12/15 / #20150045799

Bone harvesting

Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula including a cutting surface positioned at or adjacent the distal end, the cutting surface being oriented at an angle, the angle being greater than 90 degrees relative to the longitudinal axis of the cannula, and the harvested bone is adapted to move from a position adjacent to the cutting surface through the cannula into the bone receptacle. ... The Johns Hopkins University

02/12/15 / #20150045241

Global dna hypomethylation and biomarkers for clinical indications in cancer

The present invention provides methods of determination of a global dna methylation index (gdmi) in a sample from a subject, using a variety of methods which can detect global, genome-wide, and gene-specific dna methylation to create methylation portraits that can be used for early detection, diagnosis, and clinical management in the personalized medicine space. Further, the invention provides methods of diagnosis of cancer, including gastric cancer and hepatocellular cancer in a subject, by comparing the gdmi in a sample obtained from a subject to the methylation index of standard controls. ... The Johns Hopkins University

02/12/15 / #20150044446

Cellulose hydrogel compositions and contact lenses for corneal applications

The present invention provides cellulose hydrogels having one or more of the following properties: high water content, high transparency, high oxygen permeability, high biocompatibility, high tensile strength and desirable thermal stability. The present invention further provides a process for preparing a cellulose hydrogel comprising (i) a step of activating cellulose, in which the activating step comprises contacting the cellulose with a solvent to activate the cellulose for a time duration from about 2 hours to about 30 hours; (ii) substantially dissolving the activated cellulose to form a solution; and (iii) gelling the solution to form a gel, in which the gelling step comprises allowing the solution to gel in an environment comprising a relative humidity from about 30% to about 80% at 35° c.. ... The Johns Hopkins University

02/12/15 / #20150044270

Sustained delivery of therapeutic agents to an eye compartment

Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or iop after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.. ... The Johns Hopkins University

02/12/15 / #20150044141

Synthesis and application of novel imaging agents conjugated to dpa 713 analogs for imaging inflammation

The present invention provides analog compounds of dpa-713 which specifically bind the translocator protein (tspo), which is upregulated in activated leukocytes, some malignant tumors and tissues involved in steroid biogenesis. These compounds are linked via a linking moiety to a variety of imaging agents, including, for example, near infra-red dyes. ... The Johns Hopkins University

02/05/15 / #20150039057

Implantable vestibular prosthesis

An implantable nerve stimulation device has a sensor system, a data processor in communication with the sensor system, and a nerve stimulation system in communication with the data processor and constructed to provide electrical stimulation to at least one branch of at least one vestibulocochlear nerve. The nerve stimulation system includes an electrode array that has a first plurality of electrodes structured to be surgically implanted in electrical communication with a superior branch of the vestibular nerve, a second plurality of electrodes structured to be surgically implanted in electrical communication with a horizontal branch of the vestibular nerve, a third plurality of electrodes structured to be surgically implanted in electrical communication with a posterior branch of the vestibular nerve, and a common crus reference electrode structured to be surgically implanted into a common crus of the vestibular labyrinth.. ... The Johns Hopkins University

02/05/15 / #20150038341

Digital amplification

The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential, analog nature of the polymerase chain reaction is transformed into a linear, digital signal suitable for this purpose. ... The Johns Hopkins University

02/05/15 / #20150037802

Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids

The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of nucleic acids. ... The Johns Hopkins University

02/05/15 / #20150037288

Methods for increasing the infectivity of viruses

Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. ... The Johns Hopkins University

02/05/15 / #20150036806

Method for real-time quality assurance assessment of gantry rotation and collimator rotation in radiation therapy

A method and device for real-time mechanical and dosimetric quality assurance measurements in radiation therapy provides a unified measurement of mechanical motion and radiation components of the machine. The device includes an imaging surface for receiving multiple energy sources. ... The Johns Hopkins University

02/05/15 / #20150034560

Method for selectively binding and separating phosphate anions

Disclosed is a method for selectively binding and separating phosphate anions from a liquid medium by providing a cross-linked molecularly imprinted polymer including cross-linked chitosan having selective binding affinity for phosphate ions, phosphate containing molecules, or a combination of both.. . ... The Johns Hopkins University

01/29/15 / #20150031990

Photoacoustic tracking and registration in interventional ultrasound

An intraoperative registration and tracking system includes an optical source configured to illuminate tissue intraoperatively with electromagnetic radiation at a substantially localized spot so as to provide a photoacoustic source at the substantially localize spot, an optical imaging system configured to form an optical image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the optical image, an ultrasound imaging system configured to form an ultrasound image of at least a portion of the tissue and to detect and determine a position of the substantially localized spot in the ultrasound image, and a registration system configured to determine a coordinate transformation that registers the optical image with the ultrasound image based at least partially on a correspondence of the spot in the optical image with the spot in the ultrasound image.. . ... The Johns Hopkins University

01/29/15 / #20150031976

Preterm labor monitor

A system, method and apparatus for monitoring uterine and/or cervical activity indicative of labor in a patient. The system includes a medical device and a data processor in communication with the medical device. ... The Johns Hopkins University

01/29/15 / #20150031677

Trioxane thioacetal monomers and dimers and methods of use thereof

Monomeric and dimeric trioxane thioacetals and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.. . ... The Johns Hopkins University

01/29/15 / #20150031573

Mirna analysis methods

The present invention provides a pcr-free, multiplexed ligation assay for mirna expression analysis that produces highly quantitative, 10-100 plex mirna profiling in a single reaction. The inventive methods use a 2-step ligation assay to generate an array of mirna specific ligation products that can be decoded and quantified by a size discrimination method such as gel electrophoresis or single molecule separation. ... The Johns Hopkins University

01/29/15 / #20150031048

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. ... The Johns Hopkins University

01/29/15 / #20150031022

Dna methylation markers and methods of use

The present invention provides methods for identifying metastases by detecting nucleic acid hypermethylation of one or more genes in one or more samples, and in particular in the lymph nodes. The invention further relates to dna methylation as a predictor of disease recurrence and patient prognosis, specifically in the field of cancer biology.. ... The Johns Hopkins University

01/29/15 / #20150030572

Identification of molecular pathways and methods of use thereof for treating retinal neurodegeneration and other neurodegenerative disorders

Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.. . ... The Johns Hopkins University

01/22/15 / #20150025861

Genetic screening computing systems and methods

Various techniques are disclosed that allow phenotype-related data to be aggregated from any number of online sources. A statistical model may be generated using the aggregated data that, based on (epi)genome, microbiome, or other omics information regarding a subject, predicts the probability of the subject having the phenotype.. ... The Johns Hopkins University

01/22/15 / #20150025546

Method and apparatus for cochlear implant surgery

A system for cochlear implant surgery includes a reference device having at least a portion adapted to be arranged at a fixed position relative to a cochlea of a patient to provide a reference position, an image acquisition and processing system adapted to acquire an image of at least a portion of the cochlea relative to the reference position and to provide an implant plan based at least partially on the acquired image, and an implant system adapted for implanting a cochlear lead array using the reference position and the implant plan.. . ... The Johns Hopkins University

01/22/15 / #20150025049

Compositions comprising exemestane and novel methods of use

In addition to its potent mechanism-dependent inhibition of estrogen biosynthesis, in accordance with the embodiments of the present invention, it has now been found that exemestane has novel chemoprotective properties which have hitherto not been explicitly recognized. The present invention provides methods for the use of compositions comprising exemestane for chemoprotection against a wide variety of non-mammary tumors (and possibly other chronic diseases) that are not estrogen-dependent, but have oxidative stress, inflammation and electrophile-damaging etiologies. ... The Johns Hopkins University

01/22/15 / #20150025044

Identification and use of compounds that affect the fidelity of eukaryotic translation initiation codon selection

A screening method for identifying compounds that alter the fidelity with which the initiation codon in mrnas is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. ... The Johns Hopkins University

01/22/15 / #20150024953

Methods for identifying eubacteria

This invention relates, e.g., to methods for detecting a eubacterium, determining if the eubacterium is gram-positive or gram-negative, and determining the species of the eubacterium in a sample.. . ... The Johns Hopkins University

01/22/15 / #20150024378

Analysis of dna-containing samples and resolution of mixed contributor dna samples

Methods for analyzing dna-containing samples are provided. The methods can comprise isolating a single genomic equivalent of dna from the dna-containing sample to provide a single isolated dna molecule. ... The Johns Hopkins University

01/15/15 / #20150018840

Mri-compatible, integrated force and torque sensors and systems that incorporate the sensors

A magnetic resonance imaging (mri) compatible sensor for measuring torque with respect to an axis of rotation in conjunction with an applied linear force includes a shaft arranged in a longitudinal direction substantially along the axis of rotation, a base component arranged along the axis of rotation and displaced with respect to the shaft, a torque detector assembly configured to be coupled to rotational motion of the shaft about the axis of rotation relative to the base component, and a linear-force detector assembly configured to be coupled to linear motion of the shaft from a force applied in a direction substantially coincident with the axis of rotation relative to the base component. The torque detector assembly and the linear-force detector assembly are substantially de-coupled from each other such that torque measurements are substantially independent of linear force measurements. ... The Johns Hopkins University

01/15/15 / #20150018302

Compositions comprising ndga derivatives and sorafenib and their use in treatment of cancer

The present invention provides pharmaceutical compositions comprising derivatives of ndga, including m4n (tetra-o-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition and treatment of neoplastic diseases, such as liver cancer, colon cancer, breast cancer, brain cancers and ovarian cancers, for example, in a subject. Compositions comprising derivatives of ndga, including m4n, sorafenib and additional therapeutic agents are also provided.. ... The Johns Hopkins University

01/15/15 / #20150018301

Lrrk-2-mediated neuronal toxicity

Leucine-rich repeat kinase-2 (lrrk2) mutations are a common cause of parkinson's disease. Inhibitors of lrrk2 kinase that are protective in in vitro and in vivo models of lrrk2-induced neurodegeneration were identified. ... The Johns Hopkins University

01/15/15 / #20150017724

Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation

This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (pscs) into endothelial cells (ecs) in vitro, by plating a single-cell suspension of pscs onto a suitable surface such as type iv collagen and culturing the cells with vegf after which ecs can be harvested. A preferred embodiment of the method first cultures the cells without vegf and then sequentially cultures the cells with vegf. ... The Johns Hopkins University

01/15/15 / #20150016701

Pulse sequence-based intensity normalization and contrast synthesis for magnetic resonance imaging

According to one or more of the embodiments herein, a subject image of biological tissue is acquired from a pulse sequence of a magnetic resonance imaging (mri) device, and one or more pulse sequence parameters used to acquire the subject image may be estimated based on a relationship between the subject image and the biological tissue. A new atlas image may then be synthesized using the pulse sequence and the estimated pulse sequence parameters of the subject image, and an intensity transformation between the new atlas image and a desired reference atlas image may be learned. ... The Johns Hopkins University

01/08/15 / #20150011929

Vibrating catheter luer accessory

A device and method of the present invention provides application of low-energy acoustic waves to indwelling surfaces of a catheter in order to remove and prevent microbial biofilm formation. The low-energy acoustic waves are generated by an electrically activated piezo element. ... The Johns Hopkins University

01/08/15 / #20150010925

Co-translational activation of a transcription factor by porteolytic cleavage and methods of use

A method for measuring expression of autoregulatory molecules within living cells is provided. An autoregulatory molecule and marker construct is expressed in vivo, where the marker is cleaved from the construct during translation. ... The Johns Hopkins University

01/01/15 / #20150004259

Nitroxyl progenitors in the treatment of heart failure

Administration of an hno/no+ donating compound, such as angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the hno/no− donating compound isopropylamine (ipa)/no (na(ch3)2chnhn(o)no) surprisingly exhibited positive inotropic effects in subjects experiencing heart failure that were superior to those caused by the hno/no− donating compound angeli's salt. ... The Johns Hopkins University

01/01/15 / #20150004172

Hypoxia-induced mitogenic factor

We found that fizz1/relmα is inducible by hypoxia in lung. The hypoxia-upregulated expression of fizz1/relmα was located in the pulmonary vasculature, bronchial epithelial cells, and type ii pneumocytes. ... The Johns Hopkins University








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