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The Johns Hopkins University patents (2016 archive)


Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Johns Hopkins University-related inventors


System and method for medical data analysis and sharing

A computer-implemented method may be provided for analyzing and disseminating medical information. The method may include steps performed by one or more processors including, receiving a plurality of patient medical data; aggregating the plurality of patient medical data, wherein access to patient private health information is restricted; receiving a query for medical information; analyzing the aggregated medical data based on the query; producing a result of the query based on the analyzing of the aggregated medical data; and transmitting the result of the query.. ... The Johns Hopkins University

Methods for beaming

Improvements on the basic method used for beaming increase sensitivity and increase the signal-to-noise ratio. The improvements have permitted the determination of intrinsic error rates of various dna polymerases and have permitted the detection of rare and subtle mutations in dna isolated from plasma of cancer patients.. ... The Johns Hopkins University

Methods for reducing anxiety and impulsivity in subjects initiating treatment with serotonin reuptake inhibitors

The present invention provides compositions and uses thereof for reducing anxiety and/or impulsivity, including, for example, suicidality, in a subject undergoing treatment with a serotonin reuptake inhibitor (sri) comprising administering to the subject an effective amount of a sri and an effective amount of a 5-ht1a receptor partial agonist/antagonist. In addition, the present invention provides dosing regimens for various ssris which can also reduce anxiety and/or impulsivity, including, for example, suicidality in a subject undergoing treatment with an ssri. ... The Johns Hopkins University

Non-linear associator and motion discriminator

An image analyzer includes processing circuitry that receives at least one image having a first set of bins and a second set of bins, shifts the first or second set of bins by a number of bins associated with a motion hypothesis to achieve sets of aligned bins, determines a product for each set of aligned bins, compares the products to a product threshold, and identifies an object based on the products that exceed the product threshold.. . ... The Johns Hopkins University

System for preventing instrument retention

A radio-frequency identification (rfid)-based system for automatically tracking objects used in surgical procedures, and methods of use thereof, are disclosed. More particularly, an objects monitoring system is provided that includes a set of rfid tagged-objects (e.g., rfid tagged-surgical instruments), an rfid reader, an rfid reader antenna installed in a disposable wearable article, a computing device, and optionally a centralized server. ... The Johns Hopkins University

System and method for structured low-rank matrix factorization: optimality, algorithm, and applications to image processing

The present invention provides a system and method for structured low-rank matrix factorization of data. The system and method involve solving an optimization problem that is not convex, but theoretical results should that a rank-deficient local minimum gives a global minimum. ... The Johns Hopkins University

Compositions and methods for diagnosing and treating inflammatory bowel disease and related disorders

The present invention features biomarkers capable of diagnosing inflammatory bowel disease and methods of using such biomarkers to diagnose and selecting treatments for inflammatory bowel diseases.. . ... The Johns Hopkins University

Hardware and system for single-camera stereo range determination

A range determiner assembly may include an image sensor, a detector board and processing circuitry. The image sensor may be configured to obtain image data for each of three views of a target at each of a plurality of different locations along the track of a craft moving at a determinable altitude above a surface of the earth. ... The Johns Hopkins University

Instrumented rail system

A deployable vehicle for an instrumented rail system includes a first locomotion module having a first mobility assembly configured to engage a first rail, a second locomotion module having a second mobility assembly configured to engage a second rail, an adjustable frame extendable between the first and second locomotion modules by a distance corresponding to the distance between the first and second rails, and a sensor module removably attachable to the frame. The sensor module includes a sensor suite having a plurality of sensors for gathering data while the vehicle is deployed. ... The Johns Hopkins University

Compositions and methods of treating cancer

The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using aqueous 32p. ... The Johns Hopkins University

Compositions and methods for treatment of neurodegenerative disease

Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.. . ... The Johns Hopkins University

Cooperatively-controlled surgical robotic system with redundant force sensing

A cooperatively controlled robotic system includes a main robot assembly, and an arm assembly comprising a proximal end and a distal end. The arm assembly is connected to the main robot assembly at the proximal end. ... The Johns Hopkins University

Fiber-optic methods and devices enabling multiphoton imaging with improved signal-to-noise ratio

The present invention is directed to a fiber optic device that enables multiphoton imaging with improved signal-to-noise ratio having a single piece of double-clad fiber (dcf). The device also includes all components for focusing, scanning and signal collection within an endomicroscope probe of 2.1 mm outer diameter (od). ... The Johns Hopkins University

Virion display array for profiling functions and interactions of human membrane proteins

Provided herein are recombinant virion arrays comprising human membrane bound proteins that retain their native conformations and/or interactions, recombinant hsv-1 virions, and methods of use including high-content, high-throughput assays for screening for ligands and/or drugs that bind human membrane bound proteins, diagnostic assays, proteomic assays, and bio-sensor assays. Also provided are recombinant hsv-1 virions comprising an envelope comprising a plurality of heterologous membrane bound proteins that retain their native conformations and/or interactions as well as recombinant hsv-1 bacterial artificial chromosome (bac) clones encoding heterologous membrane polypeptides.. ... The Johns Hopkins University

12/08/16 / #20160354509

Devices for and methods of treatment of metabolic syndromes

Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal endocrine system in key regions of the gut, thereby, producing therapeutic effects on obesity, diabetes and other metabolic syndromes. ... The Johns Hopkins University

12/08/16 / #20160354498

Imaging and therapy of virus-associated tumors

The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.. . ... The Johns Hopkins University

12/08/16 / #20160354464

Compositions and methods for modulating an immune response

The invention generally features compositions and methods for modulating an immune response. In particular embodiments, such compositions and methods modulate regulatory t cell suppressive activity.. ... The Johns Hopkins University

12/01/16 / #20160349270

Flip (fluorescence immunoprecipitation) for high-throughput immunoprecipitation

This application describes an assay for immunoprecipitation that is quick, reliable, easy to perform, and that can be used in a high throughput fashion because it does not rely on western blotting analysis even if it can be included in a standard ip/wb procedure without affecting the output of the analysis. Because of these features the flip assay is ideal for the high-throughput screening of ip-grade antibodies. ... The Johns Hopkins University

11/24/16 / #20160343946

Patterning devices using fluorinated compounds

A method for producing a spatially patterned structure includes forming a layer of a material on at least a portion of a substructure of the spatially patterned structure, forming a barrier layer of a fluorinated material on the layer of material to provide an intermediate structure and exposing the intermediate structure to at least one of a second material or radiation to cause at least one of a chemical change or a structural change to at least a portion of the intermediate structure. The barrier layer substantially protects the layer of the material from chemical and structural changes during the exposing. ... The Johns Hopkins University

11/24/16 / #20160343127

Automated anatomical labeling by multi-contrast diffeomorphic probability fusion

A computer-implemented method, system and non-transitory computer readable storage medium for classifying a region of interest of a subject, including receiving imaging data comprising at least one image element, the imaging data comprising the region of interest of the subject; providing a plurality of atlases, each of the plurality of atlases having a candidate region that corresponds to the region of interest of the imaging data, each of the plurality of atlases having at least one image element with associated location and property information; co-registering the plurality of atlases to the imaging data, using at least one processor; assigning a probability to generate a labeling parameter for the region of interest, the probability being associated with each atlas; and classifying the region of interest of the subject based on the assigning.. . ... The Johns Hopkins University

11/24/16 / #20160341808

System and method of obtaining spatially-encoded nmr parameters from arbitrarily-shaped compartments and linear algebraic modeling

An nmr method and system for acquiring and reconstructing a value of an nmr parameter spatially localized to a compartment of interest including performing a first mm of a portion of a sample with a first mri pulse sequence using the nmr system and using a set of k-space spatial encoding gradients or coil sensitivity encoding maps to obtain a first magnetic resonance image to identify a compartment of interest; generating a second mri pulse sequence that encodes the nmr parameter with a subset of the set of k-space spatial encoding gradients or the coil sensitivity encoding maps; applying the second mri pulse sequence using the nmr system to acquire spatial information relating to the nmr parameter from the compartment of interest; segmenting the first magnetic resonance image into a plurality of compartments that includes the compartment of interest; and reconstructing a value of the nmr parameter in the compartment.. . ... The Johns Hopkins University

11/24/16 / #20160341495

Combining complex flow manifold with three dimensional woven lattices as a thermal management unit

The present invention is directed to a manifold for directing cooling fluid and/or gas to a heat exchanger in a flow configuration designed to optimize heat transfer from the heat exchanger. The manifold can take many different forms such as a layered construction with distributed inlet paths, local outlet paths, a central collection changer and a path for fluid removal. ... The Johns Hopkins University

11/24/16 / #20160340430

Compositions and methods for targeted immunomodulatory antibodies and fusion proteins

The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. ... The Johns Hopkins University

11/24/16 / #20160339270

System and method for determining radiation dose to circulating blood

The present invention discloses systems and methods for calculating the radiation doses received by circulating blood cells. The present method may be applicable for calculating the radiation doses by circulating blood cells through any site in a patient. ... The Johns Hopkins University

11/24/16 / #20160339112

Antimicrobial compositions comprising single domain antibodies and pseudomonas exotoxin

The present invention provides heavy chain immunoglobulins of the vhh type or fragment thereof having affinity for a target antigen of interest, including glycoprotein d2 (gd2) of hsv-2 or antigen thereof, and for envelope proteins of hiv-1 or an antigen thereof linked to pseudomonas exotoxin a or functional fragments thereof. Also included are multimeric forms of the immunoglobulins and their use in the prevention and/or treatment of hsv2 and/or hiv-1.. ... The Johns Hopkins University

11/24/16 / #20160339091

Methods and compositions for enhanced cellular selectivity using nanocarrier-associated ligands

The presently disclosed subject matter provides methods and compositions for activation of clustered receptors on a target cell using nanocarrier-associated ligands, particularly methods and compositions for targeted activation of clustered receptors on antigen-experienced t cells using nanocarrier-associated antibodies.. . ... The Johns Hopkins University

11/24/16 / #20160339019

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.. ... The Johns Hopkins University

11/17/16 / #20160335768

Intelligent atlas for automatic image analysis of magnetic resonance imaging

A non-invasive imaging system, including an imaging scanner suitable to generate an imaging signal from a tissue region of a subject under observation, the tissue region having at least one substructure; a signal processing system in communication with the imaging scanner to receive the imaging signal from the imaging scanner; and a data storage unit in communication with the signal processing system, wherein the data storage unit stores an anatomical atlas comprising data encoding spatial information of the at least one substructure in the tissue region, and a pathological atlas corresponding to an abnormality of the tissue region, wherein the signal processing system is adapted to automatically identify, using the imaging signal, the anatomical atlas, and the pathological atlas, a presence of the abnormality or a pre-cursor abnormality in the subject under observation.. . ... The Johns Hopkins University

11/17/16 / #20160334413

Therapeutic and diagnostic methods for autism spectrum disorders and other conditions

The present invention relates to the field of autism. More specifically, the present invention provides methods for treating individuals with autism spectrum disorders. ... The Johns Hopkins University

11/17/16 / #20160333312

Methods for forming three-dimensional human retinal tissue in vitro

The present invention relates to the field of stem cells. More specifically, the invention provides methods and compositions useful for forming three-dimensional human retinal tissue in vitro. ... The Johns Hopkins University

11/17/16 / #20160332163

System and device for high throughput generation of combinatorial droplets and methods of use

The present invention is directed to a microfluidic system comprising a microfluidic chip and a method of performing a chemical assay wherein a sample is processed into multiple daughter droplets and said daughter droplets are incubated with varying reagents. The properties of these droplets can be detected to provide assay data.. ... The Johns Hopkins University

11/17/16 / #20160331845

Compositions of nucleic acid-containing nanoparticles for in vivo delivery

Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (peg) polymer having an average molecular weight less than 1 kda, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.. ... The Johns Hopkins University

11/17/16 / #20160331781

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

Various embodiments of the invention relate to compositions comprising marrow infiltrating lymphocytes (“mils”). The mils may be activated mils. ... The Johns Hopkins University

11/17/16 / #20160331447

Method and apparatus for selective treatment inside a body lumen

The present invention is directed to device and method for electrically modulating the function of nerves that control sympathetic activity of the renal arteries in the human body. The method includes modifying neural fibers that regulate sympathetic activity of renal tissue to accentuate or attenuate function. ... The Johns Hopkins University

11/17/16 / #20160331225

Automated methods to count corneal subbasal nerves

The present invention is directed to a software algorithm that measures the number of corneal nerve fibers in images captured by microscopy including images from patients obtained by in vivo corneal confocal microscopy, a noninvasive technique. The present invention solves a complicated segmentation problem, by exploiting the piece wise linear nature of the nerve fibers—i.e., the nerves are made up of a lot of straight line segments. ... The Johns Hopkins University

11/10/16 / #20160327560

Diagnostic biomarkers and therapeutic targets for pancreatic cancer

We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. ... The Johns Hopkins University

11/10/16 / #20160327506

Capacitive liquid crystal biosensors

A capacitive liquid crystal (lc) biosensor for sensing a target biological agent includes a support board; a flow channel on the support board, the flow channel having an inlet port at a first end and an exit port at a second end; at least two electrodes, the at least two electrodes including a first electrode on a flow channel first surface and a second electrode on a flow channel second surface opposite the flow channel first surface; an electricity source connected to the first electrode and the second electrode; and an lc sensor array positioned within the flow channel. An lc sensor array includes a sensor support surface; wells positioned on the sensor support surface; an organic lc phase within each of the plurality of wells; and an aqueous phase having an analyte positioned above the organic lc phase within the wells.. ... The Johns Hopkins University

11/10/16 / #20160326592

Alternative splice variant patterns of human telomerase reverse transcriptase (htert) in thyroid tumors to distinguish benign from malignant

This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of tert (telomerase reverse transcriptase) mrna which lacks the β sequence and the amount of tert mrna in the sample which comprises the β sequence, wherein a preponderance (e.g., at least about 55%) of tert mrna in the sample which comprises the β sequence indicates that the tumor is malignant, and wherein a preponderance of tert mrna which lacks the β sequence indicates that the tumor is not malignant.. . ... The Johns Hopkins University

11/10/16 / #20160324945

Immunogenic fusion proteins for the treatment of cancer

Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.. ... The Johns Hopkins University

11/03/16 / #20160319366

Ddx3 as a biomarker for cancer and methods related thereto

The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to a subject in need thereof a composition comprising a therapeutically or prophylactically effective amount of a compound that downregulates ddx3, for example a fused diimidazodiazepine ring compound or a pharmaceutically acceptable salt thereof. The invention also encompasses the use of ddx3 as a biomarker for diagnostic and treatment purposes, for example, to identify a hyperproliferative disorder susceptible to treatment by down regulation of ddx3.. ... The Johns Hopkins University

11/03/16 / #20160319341

Method and compositions for detection and enumeration of genetic variations

Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. ... The Johns Hopkins University

11/03/16 / #20160319324

Modulators of glycerophosphodiester phosphodiesterase proteins

The present invention relates to glycerophosphodiester phosphodiesterase (gde) proteins. More specifically, the present invention relates to targeting gde proteins to modulate its glycosylphosphatidylinositol (gpi)-cleaving activity. ... The Johns Hopkins University

11/03/16 / #20160317641

Methods of treatment of hpv related diseases

The present invention provides methods of mucosal tissue administration of therapeutic hpv vaccines, in a prime-boost regimen, which generated antigen-specific cd8+ t cell-mediated immune responses and the expression of tissue-resident memory t cell (trm) markers on the cd8+ t cells. In some embodiments, the inventive methods employed pngvl4a-sig/e7(detox)/hsp70 dna vaccine and ta-hpv in a prime-boost regimen which shows vaccination in the infected mucosal tissues, including those in the cervicovaginal tract, elicited potent antitumor effects and a more effective local immune response in the tissues and regional lymph node, when compared to intramuscular vaccination. ... The Johns Hopkins University

11/03/16 / #20160317459

Nanoparticle formulations with enhanced mucosal penetration

Hypotonic formulations were evaluated for delivering water-soluble drugs and for drug delivery with muco-inert (that is, non-adhesive) mucus-penetrating nanoparticles (mpp). Hypotonic formulations markedly increased the rate at which drugs and mpp reached the epithelial surface, including deep into the vaginal folds. ... The Johns Hopkins University

10/27/16 / #20160315950

Apparatus and method for enabling safe handling of malware

An apparatus for rendering malware files safe for handling may include processing circuitry configured to receive a executable object, divide the executable object into a plurality of segments, remove execution capability from each of the segments, encrypt each of the segments to generate an encrypted segment set, and reassemble the encrypted segment set as a dismembered executable object.. . ... The Johns Hopkins University

10/27/16 / #20160313346

Interferon-gamma release assays for diagnosis of invasive fungal infections

Methods, kits, and diagnostic devices are disclosed for diagnosing an invasive fungal infection in a subject by measuring a t-cell interferon gamma (ifn-γ) response after exposure to a fungal antigen.. . ... The Johns Hopkins University

10/27/16 / #20160311764

Activators of myosin ii for modulating cell mechanics

The present invention discloses small molecule compounds as activators of myosin ii by promoting its assembly and recruitment to contractile structures in the cell and methods of using such compounds. These compounds are useful to modulate cell and tissue mechanics. ... The Johns Hopkins University

10/27/16 / #20160311562

Release system for deploying satellites

A release system may include a space vehicle separation plate operably coupled to a space vehicle, a launch vehicle adaptor plate operably coupled to a launch vehicle capable of carrying the space vehicle into space or into a ballistic (non-orbital) trajectory for release of the space vehicle from the launch vehicle, an actuator release mechanism assembly and a biasing element assembly. The actuator release mechanism assembly may be configured to separably couple the space vehicle separation plate to the launch vehicle adaptor plate. ... The Johns Hopkins University

10/27/16 / #20160311108

Devices with low melting point alloy for control of device flexibility

A continuum device/manipulator includes a first flexible tube, a low melting point (lmp) alloy disposed within the first flexible tube, and a temperature adjustment element that applies heat or cooling to change a phase of the lmp alloy. Changing the phase of the lmp alloy controls a flexibility of the first flexible tube.. ... The Johns Hopkins University

10/27/16 / #20160310453

Combination of immunotherapy with local chemotherapy for the treatment of malignancies

The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.. ... The Johns Hopkins University

10/27/16 / #20160310223

Vehicle for navigating within an enclosed space

A vehicle includes a head section having a selectively actuated first plurality of claws, a tail section having a selectively actuated second plurality of claws, and a linear actuator operably coupling the head section to the tail section. The linear actuator is configured to be selectively extended and retracted. ... The Johns Hopkins University

10/20/16 / #20160307319

Gross feature recognition of anatomical images based on atlas grid

Computer systems, computer-implemented methods, and non-transitory computer readable storage media for gross feature recognition including receiving an image comprising a plurality of image elements representing the region of interest of the subject. Gross feature recognition can further include co-registering the image to an atlas to segment the plurality of image elements into a plurality of sub-regions corresponding to structures in the atlas, where the structures in the atlas are ordered in a first rank order according to a predetermined feature. ... The Johns Hopkins University

10/20/16 / #20160307316

Methods and systems for analyzing anatomy from multiple granularity levels

A method, computer system and computer readable storage medium for searching for one or more images having a region of interest similar to the region of a subject, including: receiving imaging data comprising a plurality of image elements of the region of interest of the subject; segmenting the imaging data of the region of interest of the subject into a plurality of sub-regions corresponding to various structures at a plurality of levels of granularity, the plurality of levels of granularity having a relationship such that a level of granularity has fewer structures at a lower level of granularity; and calculating at each of the plurality of levels of granularity an abnormality factor or risk factor for the segmented various structures of said region of interest, to provide a segmented said region of interest of said subject with at least one of said abnormality factor or risk factor associated therewith.. . ... The Johns Hopkins University

10/20/16 / #20160305956

Elevated ccl19 after completion of therapy for acute lyme disease identifies patients at risk for development of post-treatment lyme disease syndrome who will benefit from further antibiotic therapy

The present invention relates to the field of lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of lyme disease. ... The Johns Hopkins University

10/20/16 / #20160305941

Compositions and methods for characterizing a myopathy

The invention provides compositions, methods, and kits for diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample.. . ... The Johns Hopkins University

10/20/16 / #20160303209

Autoimmune antigens and cancer

Autoimmune diseases are thought to be initiated by exposures to foreign antigens that cross-react with endogenous molecules. Analyses of peripheral blood lymphocytes and serum suggested that mutations in autoimmune antigen targets sparked cellular immunity and cross-reactive humoral immune responses. ... The Johns Hopkins University

10/13/16 / #20160300382

Dynamical display based on chemical release from printed porous voxels

An embodiment in accordance with the present invention is directed to a device, system, and method for utilizing precisely patterned and chemically loaded three-dimensional porous containers akin to “chemical voxels” to enable dynamic visual patterns via spatial and temporal control of both local and global chemical release. Variations in porosity, volume, shape and relative positioning of the chemical voxels can be used to control the types of images that are formed with control in both space and time. ... The Johns Hopkins University

10/06/16 / #20160287903

System and method for determining amount of radioactive material to administer to a patient

A computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: assuming an activity retention limit; utilizing the activity retention limit to determine a dose rate for a phantom category; utilizing the dose rate for the phantom category to determine the dose rate for a second phantom category; and utilizing the dose rate for a second phantom category to find information regarding the second phantom category. In other embodiments, a computerized system and method are provided for determining an optimum amount of radioactivity to administer to a patient, comprising: obtaining at least one image relating to anatomy of a particular patient; obtaining multiple images regarding radioactivity distribution over time in the particular patient; combining the radioactivity images with the anatomy images; running a monte carlo simulation to obtain dose image information; and using the dose image information to obtain bed and/or eud information.. ... The Johns Hopkins University

09/29/16 / #20160281081

Programmed droplet rupture for directed evolution

A method of directed evolution screening includes selecting a protein expression platform for an evolution target, expressing a key rupture gene configured to trigger droplet rupture, developing gene regulatory circuits to control expression of the key rupture gene as a function of performance of the evolution target, encapsulating expression components in droplets, and triggering droplet rupture by expressing a rupture agent from the key rupture gene.. . ... The Johns Hopkins University

09/29/16 / #20160279882

Systems and methods for conformal additive manufacturing

Systems and methods for conformal additive manufacturing are disclosed. In particular, systems and methods are disclosed utilizing variable offset curves and/or a manipulated solution to laplace's equation to generate layers between an initial boundary and a desired boundary.. ... The Johns Hopkins University

09/29/16 / #20160279182

Cvs transplantation for treatment of bacterial vaginosis

Methods and materials for treating bacterial vaginosis (“bv”) are provided. Cervicovaginal secretions (“cvs”) from a woman with vaginal microbiota dominated (>50%) by one of the species of lactobacillus typically found in the human vagina, e.g. ... The Johns Hopkins University

09/22/16 / #20160273051

Urothelial cancer and methods of detection and targeted therapy

The invention provides methods for detecting a cellular proliferative disorder (e.g., urothelial cancer) in a subject by assessing the methylation status of the gulp1 promoter in a nucleic acid sample. The methods of the invention are useful for diagnostic, prognostic as well as therapeutic regimen predictions.. ... The Johns Hopkins University

09/22/16 / #20160273050

Use of the zmiz1 marker in directing treatment and predicting survival in cancer

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions for treating cancer and predicting patient survival. ... The Johns Hopkins University

09/22/16 / #20160271274

Synthesis and use of targeted radiation enhancing iron oxide-silica-gold nanoshells for imaging and treatment of cancer

Magnetic iron oxide nanoparticles (mions) having silica (simion) and gold-silica (ausimion) nanoshells, methods of their preparation, and their use in cancer imaging and therapy applications are disclosed.. . ... The Johns Hopkins University

09/22/16 / #20160270837

Atrial septal aneurysm transseptal access system

A transseptal access stability system (tass) and method of use thereof is disclosed. The tass includes a venous sheath for reducing the likelihood of complications that may arise when performing transseptal punctures. ... The Johns Hopkins University

09/22/16 / #20160270775

Minimally invasive laparoscopic retractor

An inflatable retractor for use in laparoscopic surgery of a patient's body includes an inflatable element disposed at a distal end of a retractor shaft. The retractor shaft includes a port for receiving insufflating fluid. ... The Johns Hopkins University

09/15/16 / #20160264556

Itraconazole analogs and use thereof

Provided herein are itraconazole analogs. Also provided herein are methods of inhibition of hedgehog pathway, vascular endothelial growth factor receptor 2 (vegfr2) glycosylation, angiogenesis and treatment of disease with itraconazole analogs.. ... The Johns Hopkins University

09/15/16 / #20160262605

Programmable multispectral illumination system for surgery and visualization of light-sensitive tissues

An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a portion of the light-sensitive tissue upon being illuminated by the illumination system, and an image display system in communication with the imaging system to display an image of the portion of the light-sensitive tissue. The illumination system is configured to illuminate the light-sensitive tissue with a reduced amount of light within a preselected wavelength range compared to multispectral illumination light, and the image of the portion of the light-sensitive tissue is compensated for the reduced amount of light within the preselected frequency range to approximate an image of the light-sensitive tissue under the multispectral illumination. ... The Johns Hopkins University

09/08/16 / #20160257000

Robot control, training and collaboration in an immersive virtual reality environment

System and methods to create an immersive virtual environment using a virtual reality system that receives parameters corresponding to a real-world robot. The real-world robot may be simulated to create a virtual robot based on the received parameters. ... The Johns Hopkins University

09/08/16 / #20160256515

Compositions and methods for prediction and treatment of human cytomegalovirus infections

The present invention relates to the field of virology. More specifically, the present invention provides compositions and methods useful for diagnosing and treating human cytomegalovirus. ... The Johns Hopkins University

09/08/16 / #20160256404

Drugs and gene carrier particles that rapidly move through mucous barriers

The invention generally relates to polymeric particles suitable for transporting bioactive agents across mucosal barriers. The invention also relates to methods of making and using those polymeric particles.. ... The Johns Hopkins University

09/01/16 / #20160251726

Hypermethylation biomarkers associated with poor survival outcomes for head and neck squamous cell cancer

In accordance with one or more embodiments, the inventors have conducted the first comprehensive integrated genomic and epigenomic analysis in hnscc, focusing on identifying genes that have concurrent promoter methylation, mutation and expression downregulation. The intersection of unbiased genome-wide methylation sequencing and methylation array screens uncovered 316 genes, which undergo promoter methylation in hnscc. ... The Johns Hopkins University

09/01/16 / #20160250310

Galectin-3 as immunological target

Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. ... The Johns Hopkins University

09/01/16 / #20160250194

Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors

The present invention provides methods of making and using 5-(2-(indol-3-yl)-2-oxoethylidene)-3-phenyl-2-thioxothiazolidin-4-one derivatives having hiv-1 or jsp-1 inhibitory activity.. . ... The Johns Hopkins University

08/25/16 / #20160243383

Unpowered respiratory protective headset and body suit and additional improvements to personal protective equipment

The invention relates to unpowered respiratory protective headsets for personal protective equipment and personal protective bodysuits with an unpowered respiratory protective headset.. . ... The Johns Hopkins University

08/25/16 / #20160243257

Mucus penetrating gene carriers

Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (cf) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. ... The Johns Hopkins University

08/25/16 / #20160242642

Systems and methods for diagnosis and therapy of vision stability dysfunction

Described herein are improved systems and methods for diagnosis and therapy of vision stability dysfunctions in a patient. One embodiment provides a device (1) for obtaining data from a patient (3). ... The Johns Hopkins University

08/18/16 / #20160238615

Solid phase extraction of global peptides, glycopeptides, and glycans using chemical immobilization in a pipette tip

Pipette tips comprising aldehyde-reactive or amino-reactive chemical moieties or other chemical moieties capable of conjugating to one or more reactive groups of amino acid side chains or protein modifications and methods for preparing the tips are provided. In addition, a high throughput method for identifying proteins, glycoproteins, and glycans in a plurality of samples using the pipette tips is also provided.. ... The Johns Hopkins University

08/18/16 / #20160237390

Tissue extracellular matrix particles and applications

An apparatus in the form of a chip is provided wherein the apparatus is prepared with decellularized extracellular matrix from various tissues and can be used to investigate the cellular interactions between the ecm and the various cell types. Three dimensional culture methods for investigating decellularized extracellular matrix from various tissues and interactions with various mammalian cell types are also provided. ... The Johns Hopkins University

08/18/16 / #20160235869

Derivatives of dibenzothiophene imaging of alpha-7 nicotinic acetylcholine receptors

The presently disclosed subject matter provides non-invasive methods for imaging, quantifying α7 nicotinic cholinergic receptors, and diagnosing a disease or condition associated with α7-nachrs. Methods for preparing radiolabeled derivatives of dibenzothiophene and compounds provided thereof also are provided.. ... The Johns Hopkins University

08/18/16 / #20160235865

Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy

Urea-based photosensitizers, which target prostate-specific membrane antigen (psma) for imaging and targeted therapy of psma-expressing tumors and cancers are disclosed.. . ... The Johns Hopkins University

08/18/16 / #20160235674

Sustained delivery of therapeutic agents to an eye compartment

Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing a core; a coating associated with the particle, wherein the coating is covalently or non-covalently associated with the particle and presents a hydrophilic region to the environment around the particle; and a therapeutic agent are disclosed. The eye compartment can exhibit reduced inflammation or iop after administration of the drug delivery systems to a patient than if a drug delivery system including an uncoated particle were administered to the patient.. ... The Johns Hopkins University

08/18/16 / #20160235046

Active echo fishing lure

An underwater imaging system is disclosed. A boat sonar transducer is configured to transmit and receive sonar signals and generate an image of water and surfaces using received sonar signals. ... The Johns Hopkins University

08/11/16 / #20160231549

Compressive imaging systems and methods

A compressive imaging system includes an illumination system arranged to illuminate an object of interest with illumination light, and a detection system configured to detect at least a portion of the illumination light after being at least one of reflected from, scattered from, or transmitted through the object of interest or to detect fluorescent light from the object of interest and to provide an imaging signal. The compressive imaging system further includes an image processing system configured to communicate with the detection system to receive the imaging signal. ... The Johns Hopkins University

08/11/16 / #20160228460

Nitroxyl progenitors in the treatment of heart failure

Administration of an hno/no− donating compound, such as angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the hno/no− donating compound isopropylamine (ipa)/no (na(ch3)2chnhn(o)no) surprisingly exhibited positive inotropic effects in subjects experiencing heart failure that were superior to those caused by the hno/no− donating compound angeli's salt. ... The Johns Hopkins University

08/11/16 / #20160228090

Photoacoustic tracking and registration in interventional ultrasound

According to some embodiments of the invention, an ultrasound imaging system having real-time tracking and image registration includes a fiducial-marker system comprising an ultrasound transmitter structured to provide a localized ultrasound pulse at an optically observable localized spot on a body of interest. The system further includes an optical imaging system, a two-dimensional ultrasound imaging system, an optical image processing system, and an ultrasound image processing system the ultrasound imaging system further includes a registration system configured to communicate with the optical image processing system and the ultrasound image processing system to receive information, the registration system being further configured to determine a coordinate transformation that registers the optical image with the two-dimensional ultrasound image based at least partially on information concerning the spatial locations determined for the combined ultrasound and optical fiducial marker observed in the optical image and in the two-dimensional ultrasound image.. ... The Johns Hopkins University

08/11/16 / #20160227990

Device and methods for color corrected oct imaging endoscope/catheter to achieve high-resolution

The present invention is directed to an achromatic endoscope which employs a diffractive microlens. Along with a broadband rotary joint and a custom 800 nm sd-oct system, ultrahigh-resolution 3d volumetric imaging over a large area becomes possible. ... The Johns Hopkins University

08/04/16 / #20160223565

Bk virus serology assessment of progressive multifocal leukoencephalopathy (pml) risk

The present invention provides methods, compositions, kits, etc. Related to the assessment of progressive multifocal leukoencephalopathy (pml) risk, based upon detecting the presence, absence and/or relative levels of serum antibody to bk virus and/or other indication of bk virus infection of a subject, in a subject and/or a sample of a subject. ... The Johns Hopkins University

08/04/16 / #20160223553

Biofilm formation to define risk for colon cancer

Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and/or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and/or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and/or biofilm-associated microbes are disclosed. ... The Johns Hopkins University

08/04/16 / #20160222466

Activities of multiple cancer-related pathways are associated with braf mutation and predict the resistance to braf/mek inhibitors in melanoma cells

The present inventors have identified specific oncogenic pathways preferentially activated in braf-mutated-melanoma cells and a pathway pattern that predicts resistance of braf-mutated melanoma to braf/mek inhibitors, providing novel clinical implications for melanoma therapy. In one embodiment, a method comprises (a) testing a sample oibraf-mutated melanoma cells isolated from a patient and measuring the expression levels of genes expressed in the following oncogenic pathways: tnfa, egfr, ifna, hypoxia, ifny, stat3 and myc; (b) calculating a 7-pathway activation pattern based on the measured expression levels of step (a); and (c) identifying the patient's resistance level to braf/mek inhibitor treatment based on comparison of the calculated 7-pathway activation pattern to a reference.. ... The Johns Hopkins University

08/04/16 / #20160222122

Integrin-modulating therapies for treating fibrotic disease

A method of treating scleroderma and other fibrotic conditions is disclosed. The method includes the step of administering to a subject having a fibrotic condition an effective amount of an agent capable of modulating the activity of one or more integrins. ... The Johns Hopkins University

08/04/16 / #20160220737

Oxygen-charged implantable medical devices for and methods of local delivery of oxygen via outgassing

Oxygen-charged (or oxygen-rich) implantable medical devices for and methods of local delivery of oxygen via outgassing is disclosed. The presently disclosed oxygen-charged implantable medical devices are, for example, polymeric implants that are functionalized to locally deliver oxygen from the implant surface for prolonged periods of time, thus increasing rates of healing and reducing rates of infection as compared with conventional medical implant devices.. ... The Johns Hopkins University

08/04/16 / #20160220692

Targeting the m2-tumor associated macrophage for cancer therapy

The present invention features methods of directly targeting specific cell surface receptors on the m2 macrophage for antibody or nanoparticle directed therapy.. . ... The Johns Hopkins University

08/04/16 / #20160220691

Novel self-assembling drug amphiphiles and methods for synthesis and use

The present invention provides herein the design of monodisperse, amphiphilic anticancer drugs—which are now termed “drug amphiphiles” (das)—that can spontaneously associate into discrete, stable supramolecular nanostructures with the potential for self-delivery (no additional carriers are needed). The quantitative drug loading in the resulting nanostructures is ensured by the very nature of the molecular design. ... The Johns Hopkins University

08/04/16 / #20160220578

Combination therapy for tuberculosis

The present invention relates to methods of treating tuberculosis, including multi-drug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (i), (s)—n-[[3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. ... The Johns Hopkins University

07/28/16 / #20160216356

Non-contact fiber optic localization and tracking system

A system for detecting and tracking one or more of direction, orientation and position of one or more light sources includes one or more optical fiber sensors configured to receive light from the one or more light sources and to generate a plurality of cones of light according to relative positions of the one or more optical fiber sensors relative to the one or more light sources. The system includes light data processing circuitry configured to detect characteristics of the plurality of cones of light and to determine one or more of direction, orientation, or position of the one or more light sources relative to the one or more optical fibers.. ... The Johns Hopkins University

07/28/16 / #20160215333

Safe sequencing system

The identification of mutations that are present in a small fraction of dna templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. ... The Johns Hopkins University

07/28/16 / #20160215282

Synthetic antiserum for rapid-turnaround therapies

A method for synthesizing an antiserum for rapid-turnaround therapies includes collecting antibody-secreting cells from a test subject, wherein the test subject has been exposed to a target biological agent and has produced an antibody response; selecting a subset of the antibody-secreting cells, the subset of the antibody-secreting cells producing antibodies that neutralize the target biological agent; generating variable-region-coding dna sequences from the antibodies that neutralize the target biological agent; tagging amplicons of the variable-region-coding dna sequences with unique nucleic acid identifiers to associate the variable-region-coding dna sequences derived from individual ones of the subset of the antibody-secreting cells; analyzing antibody-type distribution in a natural immune response; synthesizing antibodies from the variable-region-coding dna sequences to form synthetic antibodies; and mixing the synthetic antibodies in a proportion equal to the antibody-type distribution in the natural immune response to form the antiserum.. . ... The Johns Hopkins University

07/28/16 / #20160213669

Use of n-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine in combination with histone deacetylase inhibitors for treatment of cancer

The present invention relates to methods of using amg 900, a small molecule pan aurora kinase inhibitor, in combination with histone deacetylase (hdac) inhibitor for the treatment of cancer, including solid tumors, hematologically derived tumors and the like. The invention further provides pharmaceutical compositions for administering the cancer therapeutic agents in combination.. ... The Johns Hopkins University

07/21/16 / #20160208340

Tert promoter mutations in urothelial neoplasia

Tert promoter mutations occur in both papillary and flat lesion bladder cancers, are the most frequent genetic alterations identified to date in noninvasive precursor lesions of the bladder, are detectable in urine, and appear to be strongly associated with bladder cancer recurrence. The tert promoter mutations are useful urinary biomarker for both the early detection and monitoring of bladder neoplasia.. ... The Johns Hopkins University

07/21/16 / #20160208227

Compositions and methods for controlling microbial growth

Provided are modified microorganisms which are modified such that their growth can be controlled using exogenously provided compounds. The microorganisms can be modified by genetic alterations that include a promoter inducible by a first exogenously supplied compound. ... The Johns Hopkins University

07/21/16 / #20160206760

Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof

Surface conjugated diamagnetic chemical exchange saturation transfer (diacest) agent carriers and methods of making and using are described herein. The particles are safe alternatives to conventional paramagnetic or superparamagnetic metal-based mri contrast agents that are often toxic and therefore not biocompatible. ... The Johns Hopkins University

07/21/16 / #20160206583

Amino acid treatment of seizures

Methods for treating or preventing a seizure in a subject by administering to the subject a therapeutically effective amount of at least one d-amino acid or d-amino acid oxidase inhibitor are provided. In certain aspects, the method reduces the frequency, severity, and/or duration of one or more seizures in the subject. ... The Johns Hopkins University

07/14/16 / #20160201140

Ovarian cancer methylome

The present invention provides methods and kits for identifying a cell that exhibits or is predisposed to exhibiting unregulated growth by detecting hypennethylation of a gene or a regulatory region in at least one gene in the cell. Also provided are methods for diagnosis or prognosis of ovarian cancer in a subject. ... The Johns Hopkins University

07/14/16 / #20160200774

Papillomavirus-like particles (vlp) as broad spectrum human papillomavirus (hpv) vaccines

This invention relates, e.g., to a virus-like particle (vlp) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or hpv) l1 major capsid protein, into which is inserted a surface-displayed peptide comprising a neutralizing epitope of a papillomavirus l2 protein. Vaccine compositions comprising the vlp are described, as well as methods for inducing an immune response (e.g., vaccinating) a subject against papilloma virus, using the vlp, and kits comprising the vlp, for carrying out a method of the invention.. ... The Johns Hopkins University

07/14/16 / #20160199473

Mesothelin vaccines and model systems

Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic t cell response. ... The Johns Hopkins University

07/14/16 / #20160199464

Alginate and alginate lyase compositions and methods of use

The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.. ... The Johns Hopkins University

07/14/16 / #20160199463

Hdac2 defends vascular endothelium from injury

The invention features compositions comprising hdac2 and methods for protecting the vascular endothelium from injury.. . ... The Johns Hopkins University

07/07/16 / #20160193372

Methods of identifying surrogate imaging agents for alpha emitter radiopharmaceuticals and their use in treatment of disease

In accordance with one or more embodiments, the present invention provides a series of identified radiopharmaceuticals herein termed “imaging surrogates” whose pharmacokinetic behavior matches that of the alpharpt for several alpharpts currently under investigation as cancer therapeutics. Methods for identifying imaging surrogates are also provided. ... The Johns Hopkins University

07/07/16 / #20160193313

Immunogenic compositions and methods for treating neoplasia

The invention provides immunogenic compositions comprising neoplastic cells expressing a cytokine (gm-csf) formulated with at least one tlr agonist and methods of using the composition to induce or enhance an immune response.. . ... The Johns Hopkins University

07/07/16 / #20160193239

Cancer therapy via a combination of epigenetic modulation and immune modulation

Cancer therapies that combine epigenetic modulating agent(s) with immune modulating agent(s), which were remarkably identified to provide an improved treatment regimen over single agent therapy, are disclosed. In particular embodiments, the invention provides for improved treatment of nsclc in patients via administration of exemplary immune modulating agents anti-pd-1 antibody or anti-pd-l1 antibody, which were observed to show enhanced activity in combination with the exemplary epigenetic modulating agent 5-deoxyazacytidine. ... The Johns Hopkins University

07/07/16 / #20160192900

Device for utilizing transmission ultrasonography to enable ultrasound-guided placement of central venous catheters

Ultrasound is typically performed with the use of an external transcutaneous probe that emits ultrasonic energy and measures the timing of reflected waves, thus allowing measurement of fluid flow or formation of a two-dimensional image. Clinically, the modality is limited by attenuation of the signal with increasing depth of penetration of the ultrasound into tissues, as well as by similarities in echo-genicity between different tissues. ... The Johns Hopkins University

06/16/16 / #20160171695

Advanced treatment response prediction using clinical parameters and advanced unsupervised machine learning: the contribution scattergram

The present invention provides a method for detection of different ontologies using advanced unsupervised machine learning which will be used to visualize factors not visible to the human observer, such as unknown characteristics between imaging datasets and other factors to provide insights into the structure of the data. This methodology is referred to herein as contribution scattergram. ... The Johns Hopkins University

06/16/16 / #20160166643

Use of nrf2 inducers to treat epidermolysis bullosa simplex and related diseases

The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase ii enzyme inducers.. ... The Johns Hopkins University

06/16/16 / #20160166341

Shape tracking of a dexterous continuum manipulator

A shape sensor system includes a deflection sensor comprising an optical fiber having at least one fiber bragg grating (fbg) written therein and a substrate, the fiber being attached to the substrate with a selected bias distance from a neutral plane of the deflection sensor. The system further includes an optical source coupled to the fiber to provide input light to be at least partially reflected by the fbg, and an optical detection and processing system arranged to receive at least a portion of the output light and to determine a wavelength shift resulting from a change of an amount of deflection of the deflection sensor. ... The Johns Hopkins University

06/16/16 / #20160165973

Suit designs and doffing methodologies for personal protective equipment to prevent the spread of infectious agents to healthcare workers

The present invention relates to bodysuits for use as personal protective equipment comprising a torso portion comprising a front side; a back side including a sealable port through which a wearer can enter and exit the bodysuit when donning or doffing the bodysuit, respectively; a waist region; a neck opening; a pair of upper limb openings; and a pair of lower limb openings; two arm portions each extending from one of the upper limb opening; and two leg portions each extending from one of the lower limb opening and methods for the removal of such body suits.. . ... The Johns Hopkins University

06/09/16 / #20160160292

Tyrosine kinome

Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in ˜20% of colorectal cancers, with the majority of mutations occurring in ntrk3, fes, gucy2f and a previously uncharacterized tyrosine kinase gene called mcck/mlk4. ... The Johns Hopkins University

06/09/16 / #20160158270

Biomaterials comprising hyaluronic acid binding peptides and extracellular matrix binding peptides for hyaluronic acid retention and tissue engineering applications

The present invention provides novel biomaterial compositions and methods having a technology to improve retention of hyaluronic acid (ha). The biomaterial compositions utilize small ha binding peptides and extracellular matrix binding (ecm) peptides that are tethered to synthetic biocompatible polymers. ... The Johns Hopkins University

06/09/16 / #20160157753

Neural block determination

An apparatus for neural block determination is provided including processing circuitry configured to receive muscle movement measurements, analyze the muscle movement measurements in a frequency domain, and determine an effectiveness of an anesthetic based on the analysis of the muscle movement measurements in the frequency domain.. . ... The Johns Hopkins University

06/02/16 / #20160153044

A dna methylation and genotype specific biomarker of suicide attempt and/or suicide ideation

The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict suicide ideation and/or suicide attempt. ... The Johns Hopkins University

06/02/16 / #20160152526

Reactive composite foil

A reactive composite foil, including metallic fuel particles, oxidizer particles, and a diluent, which, when ignited, produces a self-propagating thermite reaction to produce a molten metal.. . ... The Johns Hopkins University

06/02/16 / #20160151519

Selectin ligands useful in the diagnosis and treatment of cancer

The present invention provides methods and compositions useful in the diagnosis and treatment of cancer. More specifically, the present invention provides compositions and methods of use comprising a targeting composition comprising a solid substrate, an antibody composition, and optionally a chemotherapeutic agent.. ... The Johns Hopkins University

06/02/16 / #20160151400

Hybrid scfa-hydroxyl-derivatized monosaccharides, methods of synthesis, and methods of treating disorders

Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.. . ... The Johns Hopkins University

05/26/16 / #20160146813

Multifunctional nanoprobe-enabled capture and early detection of microbial pathogens

The presently disclosed fluidic sensor system and method comprise multifunctional nanoprobe-enabled capture for early detection of chemical and/or biological pathogens in a liquid sample. This sensor system and method can be used for food and environmental monitoring.. ... The Johns Hopkins University

05/26/16 / #20160145305

Energy transfer within pi-conjugated peptide heterostructures in aqueous environments

Nanostructures comprising Π-conjugated peptides for energy migration in aqueous environments are disclosed. Conductive material comprising these nanostructures, and supramolecular assemblies comprising covalently-bound electron donor-acceptor chromophores for photoinduced electron transfer also are disclosed.. ... The Johns Hopkins University

05/26/16 / #20160143994

Myonectin (ctrp15), compositions comprising same, and methods of use

Disclosed is the novel myokine known as myonectin (ctrp15) an isolated nucleic acid encoding the myonectin (ctrp15) gene, and the amino acid sequence encoding the myonectin (ctrp15) protein. Methods of isolation of the nucleic acid, protein, polypeptides and methods of making anybodies to myonectin (ctrp15) protein are provided. ... The Johns Hopkins University

05/26/16 / #20160143934

Cardiac glycoside analogs and their use in methods for inhibition of viral infection

The present invention provides methods for inhibition of human herpes virus replication in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutically acceptable composition comprising a cardiac glycoside analog, including for example, a digitoxin analog and pharmaceutically acceptable carrier. Other methods of the present invention include administering a digitoxin analog along with at least one other biologically active compound and pharmaceutically acceptable carrier. ... The Johns Hopkins University

05/26/16 / #20160143509

System for stereo reconstruction from monoscopic endoscope images

According to some embodiments of the present invention, a system for stereo reconstruction from a monoscopic endoscope is provided. The monoscopic endoscope comprising an image pick-up element at a distal end thereof and a working channel defined by a body of the monoscopic endoscope. ... The Johns Hopkins University

05/19/16 / #20160139228

A multi-echo length and offset varied saturation (me-lovars) method for chemical exchange saturation transfer (cest) mr imaging

The present invention provides a novel approach for cest mr imaging, called multi-echo length and offset varied saturation (me-lovars) cest. This method allows efficient collection of additional cest data without penalty in scan time, which could be useful for enhancing the contrast, increasing the specificity or improving quantification of exchange. ... The Johns Hopkins University

05/19/16 / #20160136255

Vaccination with recombinant mycobacterium tuberculosis pknd attenuates bacterial dissemination to the brain

Vaccines comprising mycobacterium tuberculosis (m. Tuberculosis) pknd sensor polypeptides, compositions, kits, and methods of use for treating central nervous system tuberculosis are disclosed. ... The Johns Hopkins University

05/19/16 / #20160135901

Treatment simulator for brain diseases and method of use thereof

A treatment simulator for providing information on physiological states and effects of treatment of neurological disease, comprising a computer, and an application configured to operate with the computer. The application is capable of: obtaining radiological imaging from the brain; obtaining anatomical information from the radiological imaging within a region of interest within the brain; constructing a physiological states model which assesses physiological states of the region of interest; locating sources of interstitial flow of particulate matter and obtaining fluid conductivities of paths of the interstitial flow utilizing the anatomical information and the physiological states model; and creating a flow model of the particulate matter which assesses velocities of flow and interstitial pressure variations utilizing the sources of interstitial flow and the fluid conductivities.. ... The Johns Hopkins University

05/12/16 / #20160132754

Integrated real-time tracking system for normal and anomaly tracking and the methods therefor

The ability to identify anomalous behavior in video recordings is important for security and public safety. Current identification techniques, however, suffer from a number of limitations. ... The Johns Hopkins University

05/12/16 / #20160130662

Novel genomic marker of metastatic prostate cancer

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer in a patient. ... The Johns Hopkins University

05/12/16 / #20160130585

Aptamers for the treatment of sickle cell disease

The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (hbs), pharmaceutical compositions comprising the same, methods of use for diagnostics and treatment of sickle cell disease, methods of use as capture reagents, and methods of rational drug design.. . ... The Johns Hopkins University

05/12/16 / #20160130341

Antibodies to human resistin

The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and compositions for treating disorders associated with resistin. ... The Johns Hopkins University

05/12/16 / #20160129590

System and method for flexible human-machine collaboration

Methods and systems for enabling human-machine collaborations include a generalizable framework that supports dynamic adaptation and reuse of robotic capability representations and human-machine collaborative behaviors. Specifically, a method of enabling user-robot collaboration includes providing a composition of a robot capability that models a robot's functionality for performing a type of task action and user interaction capabilities; specializing the robot capability with an information kernel to provide a specialized robot capability, the information kernel encapsulating a set of task-related parameters associated with the type of task action; providing an instance of the specialized robot capability as a robot capability element that controls the robot's functionality based on the set of task-related parameters; providing instances of the user interaction capabilities as interaction capability elements; executing the robot capability element to receive user input via the user interaction capability elements; and controlling, based on the user input and the set of task-related parameters, the robot's functionality to perform a task action of the type of task action in collaboration with the user input.. ... The Johns Hopkins University

05/12/16 / #20160129149

Imidated biopolymer adhesive and hydrogel

Biologically compatible polymers carry an imide and can be used as an adhesive, a hydrogel or both. A second biologically compatible polymer reactive with the imidated polymer can be used therewith to seal openings.. ... The Johns Hopkins University

05/05/16 / #20160127398

Apparatus and method for efficient identification of code similarity

A method for identifying similarity between query samples and stored samples in an efficiently maintained reference library may include receiving a first threshold and a second threshold, receiving a plurality of binary reference samples, and processing each reference sample of the plurality of reference samples. The processing may include operations of assigning each reference sample a respective unique identifier, producing a reference sample fingerprint for each reference sample, and registering each respective unique identifier to reference sample fingerprint pair in a reference library. ... The Johns Hopkins University

05/05/16 / #20160126891

Ka band multi-chip modulator

A multi-chip module is provided including a multiplier configured to multiply a frequency of an input signal into a predetermined ka-band frequency center channel, a modulator configured to modulate the center channel, and an amplifier configured to amplify a modulated signal for output.. . ... The Johns Hopkins University

05/05/16 / #20160125586

Ice analysis based on active and passive radar images

An ice analyzer includes processing circuitry configured to receive a radiometer image including a geographic area including ice, receive a radar image including at least a portion of the geographic area, perform ice/water discrimination of the radiometer image and the radar image, generate a passive ice/water mask and an active ice/water mask based on the ice/water discrimination, merge the passive ice/water mask and the active ice/water mask into a typing mask, and type the ice based on the typing mask.. . ... The Johns Hopkins University

05/05/16 / #20160125005

Apparatus and method for profiling activities and transitions

A method and apparatus for generating a structured profile of activities and transitions is provided. The method includes receiving data related to a plurality of activities and a plurality of transitions, wherein each of the plurality of transitions is a path between a pair of activities among the plurality of activities, storing the data related to the plurality of activities and the plurality of transitions into the storage device, reducing a dimension of the data by indexing the data using state variables, generating a plurality of nodes, wherein each of the plurality of nodes corresponds to each of the plurality of activities, generating a plurality of links, wherein each of the plurality of links corresponds to each of the plurality of transitions, and storing the plurality of nodes and the plurality of links as the structured profile at the storage device.. ... The Johns Hopkins University

05/05/16 / #20160124966

Apparatus and method for efficient identification of code similarity

A method for identifying similarity between query samples and stored samples in an efficiently maintained reference library may include receiving a binary query sample and processing the binary query sample via operations including producing a query sample fingerprint from the binary query sample, scoring the query sample fingerprint with each previously stored fingerprint in the reference library to produce a matching score, and for each previously stored fingerprint for which the matching score meets or exceeds a predetermined threshold, reporting a corresponding reference sample unique identifier associated with the previously stored fingerprint and the matching score. Each previously stored fingerprint in the reference library has been determined, prior to storage, as not being duplicative of another fingerprint in the reference library.. ... The Johns Hopkins University

05/05/16 / #20160122390

A biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence lrrfstapfafidindvinf, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. ... The Johns Hopkins University

05/05/16 / #20160120523

Encapsulated cryoprobe for flexible bronchoscope

An embodiment in accordance with the present invention provides a device and method for capturing a tissue sample during biopsy. The device includes a sheath configured to be disposed about an outer surface of a cryoprobe. ... The Johns Hopkins University

05/05/16 / #20160120158

Compositions and methods for the study and treatment of acute kidney injury

The present invention relates to the field of nephrology. More specifically, the present invention provides compositions and methods useful for the study and treatment of acute kidney injury. ... The Johns Hopkins University

04/28/16 / #20160118715

Monopulse autotracking system for high gain antenna pointing

A method including receiving a monopulse transmission by a monopulse antenna determining an angle of arrival of the monopulse transmission, using processing circuitry operably coupled to the monopulse antenna, determining, using the processing circuitry, an angle error for a high gain antenna based on the angle of arrival of the monopulse transmission, and causing the positioning of the high gain antenna based on the angle error.. . ... The Johns Hopkins University

04/28/16 / #20160115203

Hybrid cyclic libraries and screens thereof

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. ... The Johns Hopkins University

04/28/16 / #20160115148

N-substituted hydroxylamine derivatives with carbon-based leaving groups

The disclosed subject matter provides certain n-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. ... The Johns Hopkins University

04/28/16 / #20160114145

Controlled outgassing of hyberbarically loaded materials for the delivery of oxygen and other therapeutic gases in biomedical applications

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.. . ... The Johns Hopkins University

04/28/16 / #20160114060

Psma-binding agents and uses thereof

Prostate-specific membrane antigen (psma) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. ... The Johns Hopkins University

04/28/16 / #20160113725

Method for computationally predicting optimal placement sites for internal defibrillators in pediatric and congenital heart defect patients

The present invention includes a method for determining optimal placement sites for internal defibrillators in pediatric and congenital heart defect patients. The method is executed by creating a personalized active heart-torso model. ... The Johns Hopkins University

04/28/16 / #20160113504

Multimodal laser speckle imaging

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the target as illuminated by the laser, receive from the at least one camera at least one image of the target as illuminated by the second light source, divide the laser speckle contrast image into subparts, and divide the at least one image of the target as illuminated by the second light source into identical subparts, determine whether each subpart includes a feature of a certain type by combining each subpart of the laser speckle contrast image with the at least one image of the target as illuminated by the second light source and comparing the combination with one or more criteria, and out-putting the location and type of features detected in a subpart of the images.. ... The Johns Hopkins University

04/07/16 / #20160098935

Clinical monitor emulator for cpr feedback

An embodiment in accordance with the present invention is directed to an electronic training tool having one or more sensor components. The sensor components include a single depth camera and accelerometer or force sensor. ... The Johns Hopkins University

04/07/16 / #20160098933

Method and system for quantifying technical skill

A system and method for quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user.. . ... The Johns Hopkins University

04/07/16 / #20160096891

Anti-b7-h5 antibodies and their uses

The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the b7-h5 ligand of the b7-h5:cd28h pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.. . ... The Johns Hopkins University

04/07/16 / #20160096271

Active vibration damping device

According to some embodiments of the present invention, a cooperatively-controlled robot includes a robotic actuator assembly comprising a tool holder and a force sensor. The cooperatively-controlled robot further includes a control system adapted to communicate with the robotic actuator assembly and the force sensor, and an actuator in communication with the control system and mechanically coupled to a tool. ... The Johns Hopkins University

04/07/16 / #20160095958

Bone regeneration using stromal vascular fraction, platelet-derived growth factor-rich hydrogel, three-dimensional printed poly-epsilon-caprolactone scaffolds

The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ascs to self-organize into vascularized bone. ... The Johns Hopkins University

04/07/16 / #20160095945

Use of non-labeled sugars and detection by mri for assessing tissue perfusion and metabolism

A method for magnetic resonance (mr) imaging or spectroscopy on a mr scanner to detect tissue physiological parameters in one or more tissue areas in a human or non-human subject includes administering to the subject a contrast enhancing physiologically tolerable amount of a sugar that is non-labeled, subjecting the subject to an mr procedure capable of generating mr signals encoding at least one tissue area in the subject in which the sugar either passes or is taken up, detecting a temporal variation in the mr signals in the at least one tissue area after the administering the sugar, determining at least one tissue-related parameter from the temporal variation, and ascertaining whether the at least one tissue-related parameter is abnormal.. . ... The Johns Hopkins University

03/31/16 / #20160091581

Device for cancellation of large magnetic susceptibility artifacts in magnetic resonance imaging of patients with pacemakers and implantable cardiac defibrillators

The present invention is directed to a system and method for reducing large magnetic artifact susceptibility in magnetic resonance imaging. The present invention is used to maximize cancellation of the magnetic field distortion cremated when objects with high variations in magnetic susceptibility are placed in a uniform magnetic field. ... The Johns Hopkins University

03/31/16 / #20160091443

Non-invasive sensing of free metal ions using ion chemical exchange saturation transfer

The invention features a novel non-invasive approach for imaging, detecting and/or sensing metal ions with improved sensitivity and specificity in a biological sample or tissue. In certain embodiments, the invention provides a mr contrast-based approach for imaging, detecting and/or sensing metal ions in the biological sample/tissue containing various background ions by using 19f-based chemical exchange saturation transfer (cest) technique.. ... The Johns Hopkins University

03/31/16 / #20160089212

Surgical system user interface using cooperatively-controlled robot

According to some embodiments of the present invention, a cooperatively controlled robot includes a robotic actuator assembly comprising a tool holder and a force sensor, a control system adapted to communicate with the robotic actuator assembly and the force sensor, and an output system in communication with the control system. The tool holder is configured to receive a tool to be manipulated by a user. ... The Johns Hopkins University

03/31/16 / #20160089046

Automatable method for directing catheter movement to target arrhythmia ablation using the cardiac activation sequence

The present invention is directed to an automatable method for directing electrophysiology catheter movement toward the site of arrhythmia origin using the cardiac activation sequence measured during arrhythmia and during pacing. The purpose of this method is to improve the speed and accuracy of localizing the site of arrhythmia origin for the purpose of targeting therapeutic ablation of the arrhythmia.. ... The Johns Hopkins University

03/24/16 / #20160083760

Method for late introduction of the (8r) hydroxyl group carbapenem beta-lactam antibiotic synthesis

The presently disclosed subject matter demonstrates that thng and thnq enzymes encoded by the thienamycin gene cluster in streptomyces cattleya oxidize the c-2 and c-6 moieties of carbapenems, respectively. Thnq stereospecifically hydroxylates ps-5 giving n-acetyl thienamycin. ... The Johns Hopkins University

03/24/16 / #20160082133

Chemical exchange saturation transfer (cest) based mri using reporter genes and substrates and methods thereof

The present invention features polypeptide or protein based reporters, wherein the mri contrast is generated by the protein itself, and methods, mri systems and mri imaging kits related thereto. The present invention also features enzyme based reporters, wherein the contrast is generated by the substrate/product of an enzyme, and methods, mri systems and mri imaging kits related thereto.. ... The Johns Hopkins University

03/24/16 / #20160082132

Compositions and methods for chemical exchange saturation transfer (cest) based magnetic resonance imaging (mri)

Compositions and methods for chemical exchange saturation transfer (cest) based magnetic resonance imaging (mri) or frequency labeled exchange (flex) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, n-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with oh/nh group ortho to the carboxylic acid group are disclosed. ... The Johns Hopkins University

03/24/16 / #20160081796

Removable middle ear implant sensor

A middle ear implant includes a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft that connects the first and second interface portions, a carrier plate removably mounted in one of the first or second interface portions, and a removable sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The removable sensor is configured to provide a dc signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures, and provide an ac signal output indicative of a frequency response of the implant. ... The Johns Hopkins University

03/24/16 / #20160081692

Inferior vena cava (ivc) shunt, double-balloon catheter for occlusion as a surgical tool

A double-balloon inferior vena cava (nc) shunt for use in controlling blood loss and simultaneously maintaining venous return is disclosed. The nc shunt comprises a first balloon-catheter unit and second balloon-catheter unit that are slidably coupled to one another to form an adjustable shunt. ... The Johns Hopkins University

03/24/16 / #20160081668

System and method for medical imaging calibration and operation

A system and method is provided for solving the ax=xb calibration problem. A calibration method is presented to determine the unknown x in the ax=xb calibration problem. ... The Johns Hopkins University

03/24/16 / #20160081618

Systems and methods for ultra-wideband (uwb) radar detection and tracking of tumors in real-time

An ultra-wideband (uwb) radar system for non-invasive, real-time tumor tracking includes an uwb transmitter arranged to transmit radar pulses to penetrate a region of interest of a patient; an uwb receiver arranged to receive radar return pulses after being reflected by tumor tissue in the region of interest of the patient; and an uwb signal processor constructed to communicate with the uwb receiver, wherein the uwb transmitter and the uwb receiver are constructed to be arranged sufficiently far away from the patient so as to avoid interfering with radiation treatment of the tumor.. . ... The Johns Hopkins University

03/24/16 / #20160081547

Eye tracking and gaze fixation detection systems, components and methods using polarized light

An eye tracking and gaze fixation detection system, includes an electronically scannable optical illumination system emits polarized near-infrared (nir) light to a retina in an eye of a subject; an optical detection system arranged in an optical path of the nir light after being reflected from the retina of the eye of the subject, the optical detection system providing a detection signal; and a signal processing system communicates with the optical detection system to receive the detection signal, wherein the optical illumination system emits the polarized nir light to illuminate at least a portion of a scanning path, wherein the scanning path is a spatially closed loop across a portion of the retina in the eye of the subject that repeats periodically over time, and wherein the signal processing system is configured to determine at least one of a gaze direction and a gaze fixation based on the detection signal.. . ... The Johns Hopkins University

03/17/16 / #20160078604

Integration of t2-preparation and motion tracking in magnetic resonance imaging

An embodiment in accordance with the present invention provides concurrent measurement of motion during t2-weighted magnetic resonance imaging. The present invention combines t2 preparation, a module used to impart t2 contrast, and motion measurement, tracking, and/or correction. ... The Johns Hopkins University

03/17/16 / #20160076094

Efficient deep sequencing and rapid genomic speciation of rna viruses (vrnaseq)

A method for limited input whole genome sequencing of rna viruses includes isolating a viral rna sample, converting the viral rna sample to a double-stranded viral cdna sample, constructing a double-stranded viral cdna amplicon library from the double-stranded viral cdna sample, and sequencing the double-stranded viral cdna amplicon library to obtain a double-stranded viral cdna sample sequencing read.. . ... The Johns Hopkins University

03/17/16 / #20160075667

Compositions and methods for chemical exchange saturation transfer (cest) magnetic resonance imaging (mri)

The invention features novel heterocyclic compounds that are useful as mri contrast agents. Specifically, the invention relates to a novel class of mri contrast agents that produce significantly improved contrast in mr images that is detectable through chemical exchange saturation transfer (cest) or frequency labeled exchange (flex) imaging. ... The Johns Hopkins University

03/17/16 / #20160074638

Ventriculoperitoneal shunt with pressure responsive element

A ventriculoperitoneal shunt includes a proximal catheter, a distal catheter, a shunt valve operably coupling the proximal catheter to the distal catheter, and a contrast container containing contrast material configured to change acoustic impedance proportionally to a change in pressure applied to the contrast container.. . ... The Johns Hopkins University

03/17/16 / #20160074535

Compositions and methods for the expression of crispr guide rnas using the h1 promoter

The presently disclosed subject matter provides compositions and methods for the expression of crispr guide rnas using the h1 promoter. In particular, compositions and methods are provided for the use of the h1 promoter to express crispr guide rna (grna) with altered specificity of the 5′ nucleotide, as well as use of the h1 promoter sequence as a bidirectional promoter to express cas9 nuclease and the grna simultaneously. ... The Johns Hopkins University

03/17/16 / #20160074520

Wound healing compositions comprising biocompatible cellulose hydrogel membranes and methods of use thereof

The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.. ... The Johns Hopkins University

03/17/16 / #20160074417

Sr-bi as a predictor of human female infertility and responsiveness to treatment

Methods of diagnosis and treatment of diseases and disorders related to de novo synthesis of cholesterol, based on allelic variants of the scavenger receptor class b type i receptor, and kits for use therein.. . ... The Johns Hopkins University

03/10/16 / #20160069884

Biomarkers for distinguishing between aggressive prostate cancer and non-aggressive prostate cancer

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing aggressive prostate cancer. ... The Johns Hopkins University

03/10/16 / #20160068817

In vitro model of metastatic cancer

The present invention relates to drug discovery and development. More specifically, the present invention provides methods and composition useful for screening anti-cancer agents. ... The Johns Hopkins University

03/03/16 / #20160063870

System for testing of autonomy in complex environments

A monitoring apparatus for deployment on an auv may include navigation equipment operable independent of guidance and control equipment of the auv and usable for determining auv navigation information during deployment of the auv, radio equipment operable independent of a radio module of the auv and for providing a communication link to a ground station for communication with testing staff, and a watchdog module comprising processing circuitry configured to monitor at least the auv navigation information relative to operational guidance to determine whether a constraint defined in the operational guidance is violated.. . ... The Johns Hopkins University

03/03/16 / #20160063037

Apparatus and method for distributed graph processing

A method for distributed graph processing is provided including receiving ingest data from at least one data source, generating, using processing circuitry, a data map comprising a graph of edges between a plurality of data vertices of the ingest data, determining at least two nodes of a cluster, and storing a portion of the ingest data and a portion of the data map at the at least two nodes.. . ... The Johns Hopkins University

03/03/16 / #20160062107

Active beam shaping system and method using sequential deformable mirrors

An active optical beam shaping system includes a first deformable mirror arranged to at least partially intercept an entrance beam of light and to provide a first reflected beam of light, a second deformable mirror arranged to at least partially intercept the first reflected beam of light from the first deformable mirror and to provide a second reflected beam of light, and a signal processing and control system configured to communicate with the first and second deformable mirrors. The first deformable mirror, the second deformable mirror and the signal processing and control system together provide a large amplitude light modulation range to provide an actively shaped optical beam.. ... The Johns Hopkins University

03/03/16 / #20160061385

Passive diode-like device for fluids

The present invention is directed to an improved fluid diode using topology optimization with finite element method (fem). Topology optimization as a flexible optimization method has been extended to the fluid field. ... The Johns Hopkins University

03/03/16 / #20160060229

N-hydroxylamino-barbituric acid derivatives

The present disclosure provides n-hydroxylamino-barbituric acid compounds of formulae (1)-(4), pharmaceutical compositions and kits comprising them, and methods of using such compounds or pharmaceutical compositions. The present disclosure provides methods of using such compounds or pharmaceutical compositions for treating heart failure.. ... The Johns Hopkins University

03/03/16 / #20160059415

System and method for flexible human-machine collaboration

Methods and systems for enabling human-machine collaborations includes a generalizable framework that supports dynamic adaptation and reuse of robotic capability representations and human-machine collaborative behaviors. Specifically, a computer-implemented method of enabling user-robot collaboration includes providing a composition of user interaction capabilities and a robot capability that models a functionality of a robot for performing a type of task action based on a set of parameters; specializing the robot capability with an information kernel that encapsulates the set of parameters; providing a robot capability element based on the robot capability and the information kernel and interaction capability elements based on the user interaction capabilities; connecting the robot capability element to the interaction capability elements; providing, based on the interaction capability elements, user interfaces to acquire user input associated with the set of parameters; and controlling, based on the user input and the information kernel, the functionality of the robot via the robot capability element to perform a task action of the type of task action.. ... The Johns Hopkins University

02/25/16 / #20160053370

Scalable processing of nanocomposites using photon-based methods

Using a modified cvd infusion process and femtosecond laser irradiation, the methods of the present invention demonstrate the ability to create core-shell nanoparticles of metal and metal oxide nanoparticles embedded within the bulk of an optically transparent substrate. With the use of optical masks and multiple precursor chemicals, the inventive methods make it possible to create nanoparticles or core-shell nanoparticles with drastically different compositions in close proximity to each other. ... The Johns Hopkins University

02/25/16 / #20160053331

Genetic amplification of iqgap1 in cancer

We examined iqgap1 copy gain and its relationship with clinicopathologic outcomes of thyroid cancer and investigated its role in cell invasion and molecules involved in the process. We found iqgap1 copy number (cn) gain≧3 in 1 of 30 (3%) of benign thyroid tumor, 24 of 74 (32%) follicular variant papillary thyroid cancer (fvptc), 44 of 107 (41%) follicular thyroid cancer (ftc), 8 of 16 (50%) tall cell papillary thyroid cancer (ptc), and 27 of 41 (66%) anaplastic thyroid cancer, in increasing order of invasiveness of these tumors. ... The Johns Hopkins University

02/25/16 / #20160053298

Methods for identifying proteins and compounds that modulate the activity of otub1

The present invention describes that otub1 cleavage of k48 poly-ubiquitin is stimulated by a select subset of e2 enzymes, and that this stimulation is regulated by the ubiquitin-charged state of the e2 and free ubiquitin. Structural and biochemical studies of otub1 and ubch5b show that the e2 stimulates binding of the polyubiquitin substrate by contacting the otub1 n-terminal ubiquitin-binding helix. ... The Johns Hopkins University

02/25/16 / #20160051698

Nanoscale artificial antigen presenting cells

This disclosure provides nano-scale artificial antigen presenting cells (aapc), which deliver stimulatory signals to lymphocytes, including cytotoxic lymphocytes, for use as a powerful tool for immunotherapy.. . ... The Johns Hopkins University

02/25/16 / #20160051597

C. novyi for the treatment of solid tumors in humans

The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a human. These methods include administering intratumorally to the human a unit dose of c. ... The Johns Hopkins University

02/18/16 / #20160050382

Flexible readout and signal processing in a computational sensor array

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. ... The Johns Hopkins University

02/11/16 / #20160040250

Tert promoter mutations in cancer

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain promoter mutations in cancer. ... The Johns Hopkins University

02/11/16 / #20160039003

Mechanical processing of reactive laminates

A method of producing a reactive powder includes providing a bulk structure of reactive material comprising a first reactant and a second reactant, the bulk structure having a preselected average spacing between the first and the second reactants; and mechanically processing the bulk structure of reactive material to produce a plurality of particles from the bulk structure such that each of the plurality of particles comprises the first and second reactants having an average spacing that is substantially equal to the preselected average spacing of the bulk structure of reactive material. The first and second materials of the plurality of particles react with each other in an exothermic reaction upon being exposed to a threshold energy to initiate the exothermic reaction and remain substantially stable without reacting with each other prior to being exposed to the threshold energy.. ... The Johns Hopkins University

02/11/16 / #20160038485

Phase 2 inducers and related signaling pathways protect cartilage against inflammation, apoptosis and stress

Disclosed herein are novel compounds, their use in the treatment and prevention of joint and/or cartilage inflammation that provide an alternative to the nsaids and selective cox-2 inhibitors by activating endogenous detoxifying cellular defense mechanisms that act to neutralize toxic cellular intermediate. These compounds are ppar-alpha agonists and/or phase 2 gene activators.. ... The Johns Hopkins University

02/11/16 / #20160038463

Methods and compositions for improving cognitive function

This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (cns) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2a (sv2a), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (cns) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment.. ... The Johns Hopkins University

02/11/16 / #20160038025

Apparatus and method for minimizing the influence of corneal birefringence on the analysis of eye fixation and focus using retinal birefringence scanning

The present invention provides apparatus and methods for detecting fixation of an eye of a subject on a target. The methods provide for optimization of parameters of the spinning half wave plate and the fixed wave plate in the retinal birefringence scanning (rbs) design to enable uses of the “spinning artifact” frequency component. ... The Johns Hopkins University

02/04/16 / #20160032406

Diagnostic method using palb2/us

The present invention provides a method for detecting mutations in the palb2 gene in pancreatic cancer patients and in individuals having a family history of pancreatic cancer. Methods are also provided for diagnosing a predisposition to pancreatic cancer, for predicting a patient's response to pancreatic cancer therapies, and for treating pancreatic cancer, based on presence of a palb2 mutation or abberant palb2 gene expression in a patient.. ... The Johns Hopkins University

02/04/16 / #20160030391

Methods and compositions for improving cognitive function

This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (cns) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2a (sv2a) in combination with memantine or a derivative or an analog thereof, in treating cognitive impairment associated with central nervous system (cns) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (mci), amnestic mci (amci), age-associated memory impairment (aami), age related cognitive decline (arcd), dementia, alzheimer's disease (ad), prodromal ad, post traumatic stress disorder (ptsd), schizophrenia or bipolar disorder, amyotrophic lateral sclerosis, cancer-therapy-related cognitive impairment, mental retardation, parkinson's disease (pd), autism, compulsive behavior, and substance addiction.. ... The Johns Hopkins University

02/04/16 / #20160029978

Task-based source-detector trajectories for tomographic imaging

An embodiment in accordance with the present invention provides a method for applying task-based performance predictors (measures of noise, spatial resolution, and detectability index) based on numerical observer models and approximations to the local noise and spatial resolution properties of the cbct reconstruction process (e.g., penalized-likelihood iterative reconstruction). These predictions are then used to identify projections views (i.e., points that will constitute the scan trajectory) that maximize task performance, beginning with the projection view that maximizes detectability, proceeding to the next-best view, and continuing in an (arbitrarily constrained) orbit that can be physically realized on advanced robotic c-arm platforms. ... The Johns Hopkins University

01/28/16 / #20160024591

Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer

The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various genetic markers associated with an increased risk of having or developing aggressive prostate cancer.. . ... The Johns Hopkins University

01/28/16 / #20160024211

Methods of modulating immune function

Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of b7-h7 to b7-hrcr, or the binding of b7-h2 to either icos, cd28, or ctla-4. ... The Johns Hopkins University

01/28/16 / #20160024210

Anti-h7cr antibodies

Antibodies and humanized variants thereof and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the b7-h7 counter-receptor, h7cr, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.. . ... The Johns Hopkins University

01/21/16 / #20160017344

The telomerator-a tool for chromosome engineering

The present invention relates to the field of chromosome engineering. More specifically, the present invention provides methods and compositions useful for inducibly linearizing circular dna molecules in vivo in yeast. ... The Johns Hopkins University

01/21/16 / #20160017327

Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity

The present invention provides antisense phosphorodiamidate morpholino oligomers which are useful for the suppression or inhibition of the htt gene involved in huntington's disease. The oligomers can selectively suppress mutant forms of the htt protein while allowing the normal protein to be expressed in sufficient quantity to retain its function in the cell. ... The Johns Hopkins University

01/21/16 / #20160016985

Short-chain fatty acid hexosamine analogs and their use in tissue engineering applications

A new class of molecules, c1—oh tributanoylated hexosamines, including, for example, galnac, glcnac and mannac, are demonstrated to increase cartilage-like tissue accumulation by il-1β-stimulated chondrocytes. Furthermore, all three molecules reduced nfkb1 and iκbα driven gene expression, consistent with nfκb inhibitory properties of these analogs. ... The Johns Hopkins University

01/21/16 / #20160015639

Cyclodextrin compositions encapsulating a selective atp inhibitor and uses thereof

The invention provides compositions comprising cyclodextrins encapsulating a selective atp inhibitor, as well as uses thereof.. . ... The Johns Hopkins University

01/21/16 / #20160015359

Lung sound denoising stethoscope, algorithm, and related methods

An electronic stethoscope includes an acoustic sensor assembly having a first microphone to detect biological sounds within a body, a detection system in communication with the first microphone to receive an auscultation signal from the first microphone, the auscultation signal including information of the biological sounds detected by the first microphone. The stethoscope also includes a second microphone in communication with the detection system to detect noise from an environment of the body. ... The Johns Hopkins University

01/14/16 / #20160013402

Magneto-electronic devices and methods of production

A magneto-electronic device includes a first electrode, a second electrode spaced apart from the first electrode, and an electric-field-controllable magnetic tunnel junction arranged between the first electrode and the second electrode. The electric-field-controllable magnetic tunnel junction includes a first ferromagnetic layer, an insulating layer formed on the first ferromagnetic layer, and a second ferromagnetic layer formed on the insulating layer. ... The Johns Hopkins University

01/14/16 / #20160010163

Dual sequence-capture method for quantifying trans renal hpv dna in urine

Methods for the quantifying hpv trans renal dna (trdna) from a urine sample from a subject using a dual sequence-capture approach are disclosed. The presently disclosed methods can be used to predict cancers including, but not limited to, cervical, anal, penile, and oropharyngeal cancers.. ... The Johns Hopkins University

01/14/16 / #20160008493

Radioactive substrates for aldehyde dehydrogenase

A detectable substrate for aldehyde dehydrogenase (aldh) can include a radiolabel. When acted upon by aldh in an aldh-expressing cell, e.g., cancer cells, the radiolabeled substrate accumulates in the aldh-expressing cell. ... The Johns Hopkins University

01/14/16 / #20160008380

Targeting glutamine metabolism in brain tumors

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for diagnosing and treating myc-driven tumors. ... The Johns Hopkins University

01/14/16 / #20160008331

Compositions and methods for treating inflammatory bowel disease

The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising administering to the patient a therapeutically effective amount of a stem cell mobilizer and an immunosuppressive agent. ... The Johns Hopkins University

01/14/16 / #20160007946

Method and device for generating a low-dose x-ray image preview, imaging system and computer program product

A method of generating a preview of at least one low-dose x-ray image includes the followings steps: obtaining an initial volumetric representation of a patient from an x-ray device; creating at least one x-ray image projection from the initial volumetric representation; injecting correlated noise into at least one of the x-ray image projections; and processing the noise-injected x-ray image projections to create at least one preview of a patient-specific low-dose x-ray for showing to a user. There are also described a device for generating at least one preview of a low-dose x-ray image, a corresponding imaging system, and a non-transitory computer readable medium.. ... The Johns Hopkins University

01/07/16 / #20160004837

Computational flow dynamics based method for stimating thromboembolic risk in patients with myocardial infarction

The present invention provides a method for determining thromboembolic risk in a patient. The method includes processing functional images of a patient's heart in order to create a computational fluid dynamic (cfd) modeling of the patient's heart. ... The Johns Hopkins University

01/07/16 / #20160002336

Methods of modulating immune function

Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of b7-h7 to b7-hrcr, or the binding of b7-h2 to either icos, cd28, or ctla-4. ... The Johns Hopkins University

01/07/16 / #20160002156

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

The invention relates to n-hydroxysulfonamide derivatives that donate nitroxyl (hno) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel n-hydroxysulfonamide derivatives release nho at a controlled rate under physiological conditions, and the rate of hno release is modulated by varying the nature and location of functional groups on the n-hydroxysulfonamide derivatives.. ... The Johns Hopkins University

01/07/16 / #20160000516

Virtual rigid body optical tracking system and method

A virtual rigid body optical tracking system includes a virtual rigid body generator for projecting a virtual rigid body, wherein the virtual rigid body forms a pattern of light on a surface. The virtual rigid body optical tracking system includes an optical detection system for detecting the pattern of light, and a data processing system in communication with the optical detection system. ... The Johns Hopkins University








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