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The Johns Hopkins University patents (2017 archive)


Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Johns Hopkins University-related inventors


Battery internal temperature sensing battery management system

A method is provided. The method is executable by a processor of a battery management system. ... The Johns Hopkins University

Biomarkers useful in the treatment of subjects having disease of the eye

The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, fuchs' dystrophy, diabetic macular edema (dme), geographic atrophy, stargardt's disease, or retinal vein occlusion (rvo), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.. . ... The Johns Hopkins University

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. ... The Johns Hopkins University

Systems and methods for genome modification and regulation

The present invention provides methods of systems and methods of site specific methylation.. . ... The Johns Hopkins University

Systems and methods for separating metallic and nonmetallic particles in a mixed-particle suspension

A continuous flow particle separation system for separating metallic and nonmetallic particles from a mixed-particle suspension includes a fluid channeling component defining an input channel and first and second output channels fluidly connected to the input channel at a bifurcated junction, a first electrode and a second electrode arranged proximate the input channel at least partially prior to the bifurcated junction, and an alternating current (ac) electric power source electrically connected to the first and second electrodes. The first and second electrodes have shapes configured to provide a spatially-gradient electric field across the input channel, and the ac electric power source is configured to provide an ac electric potential to the first and second electrodes to cause a separation of the metallic and nonmetallic particles by dielectrophoresis due to a difference in dielectrophoretic forces imposed on the metallic particles relative to those of the nanometallic particles such that first output fluid flow in the first output channel has an enriched concentration of metallic particles and second output fluid flow in the second output channel has an enriched concentration of nonmetallic particles relative to the mixed-particle suspension in said input channel.. ... The Johns Hopkins University

Pre-curved steerable catheter with pull-wires for dexterous deflection control

A pre-curved steerable catheter includes a catheter body (102) having a distal end portion. The distal end portion includes a permanently curved flexible end portion (110). ... The Johns Hopkins University

Combination therapy for tuberculosis

The present invention relates to methods of treating tuberculosis, including multidrug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (t), (s)—n-[[3-[3-fluoro-4-(4-thiomor-pholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. ... The Johns Hopkins University

Endoscopic gastric mucosal ablation/resection/exclusion (a/r/e) as a minimally invasive weight loss approach

The present invention is directed to a method of endoscopically ablating/resecting/excluding (a/r/e) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the x/a-like, ghrelin producing and other hormone cells. ... The Johns Hopkins University

Consensus coding sequences of human breast and colorectal cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. ... The Johns Hopkins University

System and method for conditioning of engineered tissues

A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. ... The Johns Hopkins University

Implantable body-driven shunt pump

An implantable, body-driven shunt pump includes a pump body defining a fluid inlet, a fluid outlet and a fluid chamber therebetween; an inlet valve arranged in the fluid inlet, the inlet valve being a one-way valve arranged such that it is operable to allow fluid flow into the fluid chamber and to prevent fluid flow out of the fluid chamber; and an outlet valve arranged in the fluid outlet, the outlet valve being a one-way valve arranged such that it is operable to allow fluid flow out of the fluid chamber and to prevent fluid flow into the fluid chamber. The pump body includes an expandable and contractible component in a portion of the pump body that defines the fluid chamber such that the fluid chamber changes volume in response to a change in pressure of fluid in the fluid chamber.. ... The Johns Hopkins University

Method and compositions for the prevention and treatment of a hiv infection

Described herein are methods of preventing or treating a hiv infection comprising administering to a mammal in need thereof, a pharmaceutically effective amount of a cd8+ t cell vaccine composition. Such methods comprising using cd8+ t cells which have been pre-stimulated with at least one hiv epitope, to thereby enhance a cd8+ t cell immune response against hiv in said mammal.. ... The Johns Hopkins University

Sunitinib formulations and methods for use thereof in treatment of glaucoma

Methods for increasing the encapsulation or incorporation of sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or other inhibitors of jnk signaling, which bind to dlk. ... The Johns Hopkins University

Direct estimation of patient attributes based on mri brain atlases

The present invention is directed to a context-based image retrieval (cbir) system for disease estimation based on the multi-atlas framework, in which the demographic and diagnostic information of multiple atlases are weighted and fused to generate an estimated diagnosis, on a structure-by-structure basis. The present invention demonstrates high accuracy in age estimation, as well as diagnostic estimation in alzheimer's disease. ... The Johns Hopkins University

12/14/17 / #20170356478

Three dimensional woven lattices for drag reduction and turbulence reduction

The present invention is directed to three dimensional (3d) woven lattices for drag and turbulence reduction. 3d woven lattice material can serve as a surface layer that regularizes the flow around a bluff body with beneficial effects on: 1) drag reduction, 2) decrease in turbulence intensity, 3) attenuation of flow-induced vibrations, and 4) aerodynamic noise cancellation. ... The Johns Hopkins University

12/14/17 / #20170355997

Methods and compositions for treating or preventing pruritis

The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.. . ... The Johns Hopkins University

12/14/17 / #20170355951

Mosquito salivary gland extraction device and methods of use

A device and method of use for augmenting the extraction of salivary glands from plasmodium-infected mosquitoes, where the sporozoite stage of plasmodium primarily resides. Sporozoites are useful for research as well as for the immunogen in whole parasite vaccines for the prevention of malaria. ... The Johns Hopkins University

12/07/17 / #20170348307

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.. ... The Johns Hopkins University

11/30/17 / #20170342599

Electrospinning aramid nanofibers

Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids dissolved in a solvent with an electrophile. ... The Johns Hopkins University

11/30/17 / #20170342399

Chaotrope- and volatile-free method for purifying nucleic acids from plasma

The presently disclosed subject matter provides methods and kits for purifying nucleic acids from blood plasma using a functionalized solid phase comprising a silica or polymer backbone and non-chaotropic and ethanol-free buffers.. . ... The Johns Hopkins University

11/30/17 / #20170340709

Methods of treatment using stem cell mobilizers

The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of at least one stem cell mobilizer. ... The Johns Hopkins University

11/30/17 / #20170340595

Compositions and methods for treating autism spectrum disorders

The instant disclosure features, among other things, compositions and methods for treating an autism spectrum disorder in a human. The compositions comprise an effective amount of: (1) an isothiocyanate (e.g., sulforaphane or a derivative thereof) or (2) a glucosinolate, and optionally, an enzyme, to thereby treat an autism spectrum disorder and/or reduce the severity of at least one symptom of the disorder. ... The Johns Hopkins University

11/30/17 / #20170340354

Image-guided embryo transfer for in vitro fertilization

A method for performing image-guided embryo transfer for in vitro fertilization includes performing a pre-operative magnetic resonance imaging (mri) scan of a subjects pelvic region to yield a first mri image dataset. A computer applies a segmentation routine to the first mri image dataset to yield segment data which is then used by the computer to create an anatomical model of the subjects pelvic region. ... The Johns Hopkins University

11/23/17 / #20170336387

Aggregation-assisted separation of plasma from whole blood

Methods for separating blood plasma from whole blood in the absence of performing centrifugation are provided. The method combines mechanical filtration and blood cell aggregation and is adapted for use in poc clinical testing.. ... The Johns Hopkins University

11/23/17 / #20170335442

Method for forming binder-free refractory carbide, nitride and boride coatings with a controlled porosity

The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. ... The Johns Hopkins University

11/23/17 / #20170333576

New scaffolds and multifunctional intermediates for imaging psma and cancer therapy

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to psma are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express psma or for cancer radiotherapy. ... The Johns Hopkins University

11/23/17 / #20170333375

Treatment of retinitis pigmentosa with n-acetylcysteine amide

The present invention includes a method for the treatment of retinitis pigmentosa in a human that comprises adminisering to the human a therapeutically effective amount of n-acetylcysteine amide (naca). In accordance with an embodiment, the present invention provides a method for the treatment of retinitis pigmentosa in an animal that comprises administering to the animal a therapeutically effective amount of n-acetylcystein amide (naca).. ... The Johns Hopkins University

11/16/17 / #20170327898

Ovarian carcinoma detection and prophylaxis

The evolutionary origin of high-grade serous ovarian carcinoma remains largely unknown. The vast majority of tumor-specific genomic alterations from ovarian cancers are present in fallopian tube stic lesions (average of 55 sequence alterations per tumor), including those affecting tp53, brca1, brca2 or pten genes. ... The Johns Hopkins University

11/16/17 / #20170327543

Polyionic papilloma virus-like particle (vlp) vaccines

The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (vlp) vaccines. ... The Johns Hopkins University

11/16/17 / #20170326136

Treatment of pain

This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4s,5r)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1h-imidazol-1-yl]carbonyl]-2-piperazinone).. ... The Johns Hopkins University

11/09/17 / #20170323118

Apparatus and method for private information retrieval

Apparatuses and methods for private information retrieval are provided. One example method may include receiving a query state machine that is an encoding of a search pattern. ... The Johns Hopkins University

11/09/17 / #20170321278

Detection and treatment of polycystic kidney disease

Compositions useful for examining the pkd1 gene are provided. In addition, methods for detecting mutations of the pkd1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. ... The Johns Hopkins University

11/09/17 / #20170319278

Systems and methods for atrial fibrillation treatment and risk assessment

According to some embodiments of the invention, a method for providing an atrial fibrillation (af) ablation treatment plan includes receiving imaging data for at least a portion of an atrial region of a subject's heart, and processing the imaging data to characterize tissue as one of fibrotic tissue or non-fibrotic tissue. The method further includes calculating a metric of spatial distribution of at least a portion of the tissue characterized as fibrotic tissue from the processing the imaging data, identifying a cardiac tissue ablation target based on the metric, and providing an af treatment plan that includes the cardiac tissue ablation target as at least a portion of the af treatment plan.. ... The Johns Hopkins University

10/26/17 / #20170311101

Middle ear implant sensor

A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft configured to connect the first interface portion and the second interface portion, and a sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The sensor may be configured to provide a dc signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures. ... The Johns Hopkins University

10/26/17 / #20170305990

Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions

The present invention features compositions of tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.. . ... The Johns Hopkins University

10/26/17 / #20170305847

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

The invention relates to n-hydroxysulfonamide derivatives that donate nitroxyl (hno) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel n-hydroxysulfonamide derivatives release nho at a controlled rate under physiological conditions, and the rate of hno release is modulated by varying the nature and location of functional groups on the n-hydroxysulfonamide derivatives.. ... The Johns Hopkins University

10/26/17 / #20170304214

Therapeutic electrospun fiber compositions

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. ... The Johns Hopkins University

10/12/17 / #20170295337

Flexible readout and signal processing in a computational sensor array

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. ... The Johns Hopkins University

10/12/17 / #20170293008

Measurement of blood volume using velocity-selective pulse trains on mri

The present invention is directed to a system and method for measuring blood volume using non-contrast-enhanced magnetic resonance imaging. The method of the present invention includes a subtraction-based method using a pair of acquisitions immediately following velocity-sensitized pulse trains for the label module and its corresponding control module, respectively. ... The Johns Hopkins University

10/12/17 / #20170292963

Biomarkers of cognitive dysfunction

The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in alzheimer's disease and other diseases of cognition. ... The Johns Hopkins University

10/12/17 / #20170291030

System and method for brain stimulation for improvement of motor symptoms in parkinson's disease and other movement disorders

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in parkinson's disease (pd) and other movement disorders. ... The Johns Hopkins University

10/05/17 / #20170288114

Thermoelectric polymer composites

An embodiment of the present disclosure is directed to a thermoelectric polymer composite. The composite comprises: at least one polymer selected from semiconducting polymers and conducting polymers; and at least one particle inclusion having one or more dimensions of 1 millimeter or less and at least one dimension of 10 nanometer or more. ... The Johns Hopkins University

10/05/17 / #20170281463

Ecg artifact reduction system

An ecg signal processing system which removes the cpr-induced artifact from measured ecg signals obtained during the administration of cpr.. . ... The Johns Hopkins University

10/05/17 / #20170280730

Compositions and methods useful for the prevention of malaria and dengue virus transmission

The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. ... The Johns Hopkins University

09/28/17 / #20170276742

Sterile rf coils for mr imaging systems

Sterile rf coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an rf coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. ... The Johns Hopkins University

09/28/17 / #20170276688

Anti-himf antibodies to treat lung diseases

Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. ... The Johns Hopkins University

09/28/17 / #20170276687

Compositions and methods for detecting anti-endothelial cell antibodies in allograft rejection

Provided herein are methods, compositions, and kits for diagnosing allograft rejection of organ transplants by identifying the presence of anti-endothelial cell antibodies. Such methods and compositions are independent of external confounders such as recipient age, transplant center, assay, cause of end-stage disease, co-morbidities, immunosuppression usage, and the like.. ... The Johns Hopkins University

09/28/17 / #20170275705

Biomarkers useful for determining response to pd-1 blockade therapy

Pd-l1 expression by tumor cells prior to treatment correlates highly with response to anti-pd-1 and anti-pd-l1 therapy (e.g., nivolumab (bristol-myers squibb), pembrolizumab (merck)) and anti-pd-l1 monotherapy (mpdl3280a (genentech/roche)). Nonetheless, the majority of patients with pd-li(+) tumors do not respond to pd-1 pathway blockade. ... The Johns Hopkins University

09/28/17 / #20170275673

Methods and compositions related to prostate cancer therapeutics

Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective therapeutic regimens for prostate cancer patients. ... The Johns Hopkins University

09/28/17 / #20170274102

Post-surgical imaging marker

A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. ... The Johns Hopkins University

09/28/17 / #20170273901

Sunitinib formulations and methods for use thereof in treatment of ocular disorders

Methods for increasing the encapsulation or incorporation of sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or its analog or a pharmaceutically acceptable salt thereof. ... The Johns Hopkins University

09/28/17 / #20170273797

Computer-assisted cranioplasty

Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element, wherein the reference unit is associated with a location of an anatomical feature of a being's anatomy; accessing a computer-readable reconstruction of the being's anatomy, the computer-readable reconstruction of the being's anatomy having a first updatable orientation, wherein the first updatable orientation is updated in response to the at least one signal; accessing a computer-readable reconstruction of an implant having a second updatable orientation; detecting a location of a pointer tool comprising a trackable element with the detector, the detector further configured to provide at least one other signal corresponding to a detected location of at least the pointer tool, wherein the pointer tool is associated with a location of an anatomical feature of interest; accessing at least one computer-readable reconstruction of a trace, the trace corresponding to a geometry of the anatomical feature of interest based on updated detected locations of the pointer tool; superimposing the at least one updatable, computer-readable trace on the second computer-readable reconstruction of the implant.. ... The Johns Hopkins University

09/21/17 / #20170271647

High energy density li-ion battery electrode materials and cells

A method of preparing a high capacity nanocomposite cathode of fef3 in carbon pores may include preparing a nanoporous carbon precursor, employing electrochemistry or solution chemistry deposition to deposit fe particles in the carbon pores, reacting nano fe with liquid hydrofluoric acid to form nano fef3 in carbon, and milling to achieve a desired particle size.. . ... The Johns Hopkins University

09/21/17 / #20170269174

System and method for real-time mri-guided object navigation

A magnetic resonance method and system are provided for magnetic resonance (mr) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory provides a path between a starting point and a target site within the tissue. ... The Johns Hopkins University

09/21/17 / #20170269106

Circulating pulmonary hypertension biomarker

Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (pah) and for determining the efficacy of pah therapy using biomarkers are provided.. . ... The Johns Hopkins University

09/21/17 / #20170269075

Biomarkers predictive of lupus progression and uses thereof

Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.. . ... The Johns Hopkins University

09/21/17 / #20170268063

Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer

Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, rnaseq, for examining circulating tumor cells.. . ... The Johns Hopkins University

09/21/17 / #20170268059

Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease

The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter dna methylation in a cervical tissue sample from a subject, using a variety of methods which can detect dna methylation. ... The Johns Hopkins University

09/21/17 / #20170267760

Checkpoint blockade and microsatellite instability

Blockade of immune checkpoints such as cytotoxic t-lymphocyte antigen-4 (ctla-4) and programmed death-1 (pd-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. ... The Johns Hopkins University

09/21/17 / #20170266232

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“mils”). The mils may be activated mils. ... The Johns Hopkins University

09/21/17 / #20170266120

Nanocrystals, compositions, and methods that aid particle transport in mucus

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (mpp) without any polymeric carriers, or with minimal use of polymeric carriers. ... The Johns Hopkins University

09/14/17 / #20170261497

Reagents and methods for engaging unique clonotypic lymphocyte receptors

Platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor can be used to induce and expand therapeutically useful numbers of specific lymphocyte populations. Antigen presenting platforms comprising a t cell affecting molecule and an antigen presenting complex can induce and expand antigen-specific t cells in the presence of relevant peptides, providing reproducible and economical methods for generating therapeutic numbers of such cells. ... The Johns Hopkins University

09/14/17 / #20170259083

Method and apparatus for determining treatment region and mitigating radiation toxicity

An apparatus for determining a contour of a treatment region in a patient includes a computer processor to receive input regarding a contour of at least one organ-at-risk (oar) adjacent to the treatment region; receive input regarding an initial contour of the treatment region; predict a radiation toxicity to the at least one oar based on the contour of the at least one oar, the initial contour of the treatment region, and a radiation treatment regimen; determine whether the predicted radiation toxicity exceeds a threshold; and determine a contour of the treatment region by iteratively modifying the initial contour of the treatment region, and any subsequent modified contours of the treatment region, until a stopping condition is satisfied. The stopping condition can be a preselected number of iterations or that the predicted radiation toxicity using the contour in place of the initial contour is first calculated is below said threshold.. ... The Johns Hopkins University

09/14/17 / #20170259082

Shape based initialization and qa of progressive auto-planning

A system and method for automatically generating radiation therapy treatment plans including one or more processors configured to capture geometries of organs at risk and a target volume specific to a subject, and use a shape-based algorithm to mine (152) a knowledgebase (38) of previously constructed treatment plans for similar geometries to the subject. The system and method interfaces (154) dosimetric information from a plan with a similar geometry as a patient specific starting point for a progressive tuning optimization algorithm resulting in fewer iterations. ... The Johns Hopkins University

09/14/17 / #20170258881

Annexin a2 as immunological target

Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. ... The Johns Hopkins University

09/14/17 / #20170258838

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“mils”). The mils may be activated mils. ... The Johns Hopkins University

09/07/17 / #20170252169

A cutting machine for resizing raw implants during surgery

Provided is a method for forming an implant with an autonomous manufacturing device. The method includes accessing a first computer-readable reconstruction of a being's anatomy; accessing a second computer-readable reconstruction of an implant; accessing a third computer-readable reconstruction comprising the first computer-readable reconstruction superimposed with the second computer readable reconstruction; generating at least one computer-readable trace from a point cloud; and forming an implant with an autonomous manufacturing device, wherein the autonomous manufacturing device forms the implant into a shape defined by at least one dimension of the computer-readable trace.. ... The Johns Hopkins University

09/07/17 / #20170252115

Rotating needle driver and apparatuses and methods related thereto

Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g., human). Such medical instruments include medical needles, biopsy needles, trocars, cutters and introducers. ... The Johns Hopkins University

09/07/17 / #20170251929

Novel device and method to measure ventricular arterial coupling and vascular performance

A device and method for analyzing of a disturbed pattern of pulse wave front results in a non-invasive, real-time diagnostic tool of arterial vascular performance on both a global and regional scale. The device provides a single number quantifying how well the arterial tree as a whole is coupled to receive and distribute a stroke volume of a single heartbeat. ... The Johns Hopkins University

08/31/17 / #20170248666

Magnetic resonance imaging coil with adjustable opening

A configurable coil arrangement for use with mri-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. ... The Johns Hopkins University

08/31/17 / #20170246320

Mucus penetrating gene carriers

Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (cf) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. ... The Johns Hopkins University

08/31/17 / #20170246277

Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

Antigen-specific t cells, including nave t cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining t cell reactivity with a library of candidate peptide antigens.. ... The Johns Hopkins University

08/31/17 / #20170246079

Automated chest compression apparatus

A system applies cardiopulmonary resuscitation (cpr) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. ... The Johns Hopkins University

08/31/17 / #20170245976

Implantable bioreactor for delivery of paracrine factors

An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. ... The Johns Hopkins University

08/24/17 / #20170242973

E-triage: an electronic emergency triage system

An embodiment in accordance with the present invention provides a system that uses simple standardized patient information routinely collected at triage to distribute patients amongst triage levels based on critical and time-sensitive outcomes. The present invention estimates the probability of electronic medical record (emr) recorded events for patients at triage. ... The Johns Hopkins University

08/24/17 / #20170240421

Method of carbon dioxide-free hydrogen production from hydrocarbon decomposition over metal salts

A process to decompose methane into carbon (graphitic powder) and hydrogen (h2 gas) without secondary production of carbon dioxide, employing a cycle in which a secondary chemical is recycled and reused, is disclosed.. . ... The Johns Hopkins University

08/24/17 / #20170238897

Self-calibrating projection geometry for volumetric image reconstruction

The present invention is directed to a method for enabling volumetric image reconstruction from unknown projection geometry of tomographic imaging systems, including ct, cone-beam ct (cbct), and tomosynthesis systems. The invention enables image reconstruction in cases where it was not previously possible (e.g., custom-designed trajectories on robotic c-arms, or systems using uncalibrated geometries), and more broadly offers improved image quality (e.g., improved spatial resolution and reduced streak artifact) and robustness to patient motion (e.g., inherent compensation for rigid motion) in a manner that does not alter the patient setup or imaging workflow. ... The Johns Hopkins University

08/17/17 / #20170233817

16s rrna saliva analysis unveils microbiome biomonitors linked to human papilloma virus and oropharyngeal squamous cell carcinoma

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful in the diagnosis and treatment of head and neck squamous cell carcinoma. ... The Johns Hopkins University

08/17/17 / #20170231713

Mr-levelcheck-2: method for localization of structures in projection images

An embodiment in accordance with the present invention provides a technique for localizing structures of interest in projection images (e.g., x-ray projection radiographs or fluoroscopy) based on structures defined in a preoperative 3d image (e.g., mr or ct). Applications include, but are not limited to, spinal interventions. ... The Johns Hopkins University

08/10/17 / #20170229160

Heavy metal multilayers for switching of magnetic unit via electrical current without magnetic field, method and applications

Provided is an electric-current-controllable magnetic unit, including: a substrate, an electric-current channel disposed on the substrate, the electric-current channel including a composite heavy-metal multilayer comprising at least one heavy-metal; a capping layer disposed over the electric-current channel; and at least one ferromagnetic layer disposed between the electric-current channel and the capping layer.. . ... The Johns Hopkins University

08/10/17 / #20170226593

Handheld nucleic acid-based assay for rapid identification

A method for identifying a target organism includes extracting a nucleic acid from a sample to form an extracted nucleic acid, amplifying the extracted nucleic acid to form a nucleic acid amplicon, tagging the nucleic acid amplicon with a capture probe and a detector probe to form a detector probe-nucleic acid amplicon-capture probe complex, and performing a detection assay on the detector probe-nucleic acid amplicon-capture probe complex to identify whether the target organism is present in the sample.. . ... The Johns Hopkins University

08/10/17 / #20170226532

Versatile genetic assembly system (vegas) to assemble pathways for expression

Provided are compositions and methods for use in assembling and expressing a plurality of transcription units using, in one aspect, homologous recombination in yeast. Yeast containing the plurality of transcription units, and isolated transcription units, are also provided. ... The Johns Hopkins University

08/10/17 / #20170226531

Piggybac transposon variants and methods of use

The present invention provides hyperactive piggybac transposons, in particular hyperactive piggybac transposons from trichoplusia ni (cabbage looper moth) that transpose at a higher frequency than wildtype. The invention also features integration defective piggybac transposons. ... The Johns Hopkins University

08/10/17 / #20170224709

Methods for treating inflammatory bowel disease using prostate specific membrane antigen (psma) inhibitors

Methods and compounds are disclosed for treating inflammatory bowel disease (ibd) by using prostate specific membrane antigen (psma) inhibitors.. . ... The Johns Hopkins University

08/10/17 / #20170224691

Pde inhibitors in immunotherapy

The invention features methods and compositions featuring a pde5 inhibitor for treating or preventing immunological-mediated disease in a subject.. . ... The Johns Hopkins University

08/10/17 / #20170224641

Methods and compositions for administration of 3-halopyruvate and related compounds for the treatment of cancer

The present disclosure relates to the discovery that compounds of the invention, particularly 3-bromopyruvate and related compounds, can be safely administered at concentrations effective for the treatment of cancer when formulated with an acidity of greater than or equal to ph of 2 and less than or equal to a ph of 6. Disclosed herein are novel and improved methods and compositions for the treatment of cancer using 3-halopyruvate and related compounds.. ... The Johns Hopkins University

08/03/17 / #20170223749

Apparatus and method for establishing and maintaining a communications link

An example apparatus for establishing a communications link is provided. The example apparatus may include a phased array antenna, a radio frequency beamformer, and a processor. ... The Johns Hopkins University

08/03/17 / #20170221385

Method and system for quantifying technical skill

A system and method for quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other data for another similar surgical task; quantifying the clinical skill of the user based on the comparing of the data for the surgical task to the other data for the other similar surgical task; outputting the clinical skill of the user.. . ... The Johns Hopkins University

08/03/17 / #20170218464

Psma-based molecular-genetic reporter system

The presently disclosed subject matter provides methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (psma) as an imaging reporter to image a variety of cells and tissues.. . ... The Johns Hopkins University

08/03/17 / #20170216363

Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases

The presently disclosed subject matter provides compositions, methods, and kits for transfecting adipose-derived mesenchymal stem cells (amscs) in freshly extracted adipose tissue using nanoparticles comprising biodegradable polymers self-assembled with nucleic acid molecules. The presently disclosed subject matter also provides methods for treating a neurological disease in a patient in need thereof, the method comprising administering the amscs transfected with the nucleic acid molecules to the patient, wherein the nucleic acid molecules encode one or more bioactive molecules functional in the treatment of a neurological disease, particularly wherein the neurological disease is a brain tumor.. ... The Johns Hopkins University

07/27/17 / #20170215009

Removable middle ear implant sensor

A middle ear implant includes a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft that connects the first and second interface portions, a carrier plate removably mounted in one of the first or second interface portions, and a removable sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The removable sensor is configured to provide a dc signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures, and provide an ac signal output indicative of a frequency response of the implant. ... The Johns Hopkins University

07/27/17 / #20170209387

Glutaminase inhibitor discovery and nanoparticle-enhanced delivery for cancer therapy

Currently available glutaminase inhibitors are generally poorly soluble, metabolically unstable, and/or require high doses, which together reduce their efficacy and therapeutic index. These can be formulated into nanoparticles and delivered safely and effectively for treatment of pancreatic cancer and other glutamine addicted cancers. ... The Johns Hopkins University

07/20/17 / #20170207855

Apparatus and method for implementing a photonic radio front end

Apparatuses and methods for implementing a photonic radio front end are provided. An example apparatus may include a photonic comb filter configured to generate a photonic pulse train at a plurality of carrier frequencies, and a photonic upconverter. ... The Johns Hopkins University

07/20/17 / #20170207540

Helical antenna apparatus and methods

Example apparatuses and methods relating to antennas are provided. An example apparatus in the form of an antenna assembly includes a first conductor structurally formed into a plurality of first conductor structural waves and a second conductor structurally formed into a plurality of second conductor structural waves. ... The Johns Hopkins University

07/20/17 / #20170207521

Contrawound helical antenna apparatus and method

Example apparatuses and methods relating to antennas are provided. An example apparatus in the form of an antenna assembly includes a first conductor formed into a first helical structure wound around a central axis and a second conductor formed into a second helical structure wound around the central axis. ... The Johns Hopkins University

07/20/17 / #20170204419

Mrgprx2/mrgprb2 expressing cell based assay to detect pseudo-allergic drug reactions and to identify blockers to prevent the adverse reactions

The present invention relates to cells and methods for detecting compounds that induce a pseudo-allergic-type reaction and methods for reducing the severity of a pseudo-allergic-type reaction.. . ... The Johns Hopkins University

07/20/17 / #20170203438

Robot control, training and collaboration in an immersive virtual reality environment

System and methods to create an immersive virtual environment using a virtual reality system that receives parameters corresponding to a real-world robot. The real-world robot may be simulated to create a virtual robot based on the received parameters. ... The Johns Hopkins University

07/20/17 / #20170203244

Water purification device

A water purification device includes a heavy metal removal layer configured to remove heavy metal ions and perfluorinated compounds from contaminated water. The water purification device may further include a biological species removal layer configured to remove biological species from the contaminated water and a support layer configured to provide support for the water purification device.. ... The Johns Hopkins University

07/20/17 / #20170203099

Artifact control and miniaturization of the safe direct current stimulator for neural prostheses

An embodiment in accordance with the present invention provides a device and method to deliver direct ionic current safely to target neural tissue, while also eliminating interruptions in the output of the device that can result from the non-ideal operation of the valves used to control the current flow in the device. The device includes two valve-operated systems that work in tandem. ... The Johns Hopkins University

07/20/17 / #20170202985

Imaging and therapy of virus-associated tumors

The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.. . ... The Johns Hopkins University

07/20/17 / #20170202867

Methods of inhibiting cancer stem cells with hmga1 inhibitors

The presently disclosed subject matter relates to methods of inhibiting cancer stem cells and growth of aggressive and/or poorly differentiated metastatic tumors comprising the cancer stem cells with hmga1 inhibitors. The presently disclosed subject matter also provides methods of selecting and treating a subject with aggressive and/or poorly differentiated metastatic cancer using hmga1 inhibitors.. ... The Johns Hopkins University

07/13/17 / #20170201097

Adaptive power system

An adaptive power system includes an energy source, a bidirectional current source electrically connected between the energy source, and a power distribution bus of a power distribution system. The bidirectional current source delivers and absorbs power from the power distribution system to buffer a dynamic load profile of a dynamic load. ... The Johns Hopkins University

07/13/17 / #20170196887

Compositions comprising exemestane and novel methods of use

In addition to its potent mechanism-dependent inhibition of estrogen biosynthesis, in accordance with the embodiments of the present invention, it has now been found that exemestane has novel chemoprotective properties which have hitherto not been explicitly recognized. The present invention provides methods for the use of compositions comprising exemestane for chemoprotection against a wide variety of non-mammary tumors (and possibly other chronic diseases) that are not estrogen-dependent, but have oxidative stress, inflammation and electrophile-damaging etiologies. ... The Johns Hopkins University

07/06/17 / #20170195904

Aggregate radio interference modeling and simulation platform

An apparatus comprising processing circuitry may be configured to execute an interference simulation using a plurality of processing functions on interference data defined for each of a plurality of geographically diverse emitters interfering with one or more victim receivers via a data processing platform. The data processing platform may be defined via an interpretive language that does not use compiling. ... The Johns Hopkins University

07/06/17 / #20170189526

Suppression of myeloid derived suppressor cells and immune checkpoint blockade

Impressive responses have been observed in patients treated with checkpoint inhibitory anti-pd-1 or anti-ctla-4 antibodies. However, immunotherapy against poorly immunogenic cancers remains a challenge. ... The Johns Hopkins University

07/06/17 / #20170189359

Graphene nanostructure-based pharmaceutical composition for preventing or treating neurodegenerative diseases

The present disclosure relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases, the pharmaceutical composition including a graphene nanostructure as an active ingredient.. . ... The Johns Hopkins University

07/06/17 / #20170188991

High quality closed-loop ultrasound imaging system

A closed-loop ultrasound system includes an ultrasound receiver, an ultrasound transmitter at least one of integral with or at a predetermined position relative to the ultrasound receiver, and a trigger circuit configured to receive detection signals from the ultrasound receiver and to provide trigger signals to the ultrasound transmitter in response to received detection signals. The ultrasound transmitter is configured to transmit ultrasound energy in response to the trigger signals.. ... The Johns Hopkins University

06/29/17 / #20170183392

Compositions and methods for increasing the expression and signalling of proteins on cell surfaces

The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. ... The Johns Hopkins University

06/29/17 / #20170182321

Methods for improving heart function

The invention provides methods related to improving heart function.. . ... The Johns Hopkins University

06/29/17 / #20170182213

Cornea mimetic biomaterials: vitrified collagen-cyclodextrin implants

The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen-based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. ... The Johns Hopkins University

06/22/17 / #20170178349

Method for deformable 3d-2d registration using multiple locally rigid registrations

An embodiment in accordance with the present invention provides a method for 3d-2d registration (for example, registration of a 3d ct image to a 2d radiograph) that permits deformable motion between structures defined in the 3d image based on a series of locally rigid transformations. This invention utilizes predefined annotations in 3d images (e.g., the location of anatomical features of interest) to perform multiple locally rigid registrations that yield improved accuracy in aligning structures that have undergone deformation between the acquisition of the 3d and 2d images (e.g., a preoperative ct compared to an intraoperative radiograph). ... The Johns Hopkins University

06/22/17 / #20170176408

Detection of hiv-1-associated neurocognitive disorders

Provided is a method of detecting mild neurocognitive disturbance (mncd) or hiv associated dementia (had) in a patient comprising detecting the level of acetyl spermine and/or acetyl spermidine from a cerebrospinal fluid test sample of the patient; and comparing the level of acetyl spermine and/or acetyl spermidine in the test sample to the level of the acetyl spermine and/or acetyl spermidine in a cerebrospinal fluid control sample or to a control value for lack of neurocognitive impairment, mncd or had; wherein an elevated level of acetyl spermine and/or acetyl spermidine in the test sample as compared to the level in the control sample or a control value for lack of neurocognitive impairment, or a level of acetyl spermine and/or acetyl spermidine that is similar to that of a control value for mncd or had, indicates that the patient suffers from mncd or had. Also provided are methods for measuring the progression of an hiv-1-associated neurocognitive disorder, as well as methods for staging such a disorder.. ... The Johns Hopkins University

06/22/17 / #20170175206

Methods and compositions for correlating genetic markers with risk of aggressive prostate cancer

The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.. . ... The Johns Hopkins University

06/22/17 / #20170175201

The tgf(beta)-mir200-mig6 pathway and its use in the treatment of cancer as an indicator of resistance to egfr inhibitors

The present invention provides methods for identifying the susceptibility of a cancer cell or population of cells to treatment with epidermal growth factor (egf) tyrosine kinase inhibitors (tkis), such as erlotinib. Methods for the in vitro diagnosis of the susceptibility of a tumor in a subject to treatment with tkis and monitoring tumor susceptibility during treatment are also provided.. ... The Johns Hopkins University

06/22/17 / #20170174749

Mimetic peptides derived from collagen type iv and their use for treating angiogenesis- and lymphangiogenesis- dependent diseases

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, active non-cysteine analogs (mimetics), which exhibit anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models are disclosed. ... The Johns Hopkins University

06/22/17 / #20170173215

Engineered cardiac derived compositions and methods of use

The present invention establishes a new standard for investigative studies of patient-specific, genetic cardiac diseases at a functional, tissue level by creating a novel platform for the study of cardiac related diseases, including cardiac conduction dysfunction, arrhythmias and depressed contractility for example. Provided herein are novel compositions of human engineered heart slices (ehs) formed from thin slices of decellularized cardiac tissue. ... The Johns Hopkins University

06/22/17 / #20170173172

Selective dendrimer delivery to brain tumors

A composition comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for the treatment or alleviation of one or more symptoms of a brain tumor have been developed. The dendrimers comprise one or more ethylene diamine-core poly(amidoamine) (pamam) hydroxyl-terminated generation-4, 5, 6, 7, 8, 9, or 10, most preferably generation 6 (g4-10-oh) dendrimers. ... The Johns Hopkins University

06/22/17 / #20170172794

Reservoir device for intraocular drug delivery

A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. ... The Johns Hopkins University

06/15/17 / #20170171226

Method and apparatus for remote malware monitoring

A method executable via operation of configured processing circuitry to identify applications by remote monitoring may include initiating remote communication with a target device through an access point, the access point providing network access to the target device, providing a series of ping messages to the target device via the access point to determine a delay signature of an application running on the target device, comparing the delay signature of the application to a plurality of malware traffic signatures stored in a malware traffic signature library, and determining a matching score between the delay signature of the application and at least some of the malware traffic signatures.. . ... The Johns Hopkins University

06/15/17 / #20170168059

Biomarkers for assessing cancer patients for treatment

A method for selecting treatment options for patients is provided. The method comprises a procedure for selecting patients that should not be placed on active surveillance (as) but receive active treatment even though the morphologic analysis of the patient's biopsy may show a gleason score that would traditionally have placed the patient in as without any further treatment. ... The Johns Hopkins University

06/15/17 / #20170165363

Cancer cell migration inhibitors and their use in therapeutic treatments

Described are methods of treating or preventing cancer in patients by administering interleukin 6 (il-6) inhibitor and interleukin 8 (il-8) inhibitor, in a concentration ratio range to inhibit the migration of cancer cells.. . ... The Johns Hopkins University

06/08/17 / #20170159095

Method of production of recombinant glycoproteins with increased circulatory half-life in mammalian cells

Provided herein are methods and recombinant expression systems for the production of recombinant glycoproteins that have increased sialic acid content and contain predominantly alpha2-6 sialic acid linkages. Also provided herein are recombinant glycoproteins that have an increased in vivo circulatory half-life. ... The Johns Hopkins University

06/08/17 / #20170158770

Compositions and methods for targeted immunomodulatory antibodies and fusion proteins

The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. ... The Johns Hopkins University

06/08/17 / #20170157147

Glucocorticoid-loaded nanoparticles for prevention of corneal allograft rejection and neovascularization

Particles encapsulating a glucocorticoid such as dexamethasone sodium phosphate (dsp) into a matrix such as biodegradable poly(lactic-coglycolic acid) (plga) which is densely coated with hydrophilic polymer such as peg or pluronic® f127, exhibit sustained release of dsp for up to 7 days in vitro. These nanoparticles can be used to prevent corneal graft rejection or corneal neovascularization.. ... The Johns Hopkins University

06/08/17 / #20170156928

Tool and tool system having independent axial and transverse force sensing

A force-sensing tool includes a tool shaft that has a proximal end and a distal end, a flexure section attached at a first end to the distal end of the tool shaft, a tool tip operatively connected to the flexure section such that axial forces applied to the tool tip are coupled primarily to a first portion of the flexure section and transverse forces applied to the tool tip are coupled primarily to a second portion of the flexure section, an axial force sensor coupled to the first portion of the flexure section, and a transverse force sensor coupled to the second portion of the flexure section. The axial force sensor responds to axial forces applied to the tool tip substantially independently of the transverse forces applied to the tool tip under a designed operating range of forces, and the transverse force sensor responds to transverse forces applied to the tool tip substantially independently of the axial forces applied to the tool tip under the designed operating range of forces.. ... The Johns Hopkins University

06/08/17 / #20170156805

Tool exchange interface and control algorithm for cooperative surgical robots

A system and method for tool exchange during surgery for cooperatively controlled robots comprises a tool holder for receiving a surgical tool adapted to be held by a robot and a surgeon, a tool holding element for constraining downward motion of the tool while allowing low force removal of the surgical tool from the holder, a first sensor for detecting if the surgical tool is docked within the tool holder, and a selector for automatically selecting different movements or actions of the tool holder to be performed based upon information detected by the first sensor. The system and method of the present invention provides an advantage to an often slow moving cooperative robot, by increasing the speed by which the tool holder may move in the direction away from the patient.. ... The Johns Hopkins University

05/18/17 / #20170135961

Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer

. . The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (psma), which is expressed by almost all solid tumors. This strategy takes advantage of both the avidity of the functionalized nanoparticle for binding to psma and the ability of the nanoparticle to be retained for longer periods of time in the tumor due to enhanced leakage via epr into the tumor interstitium and poor clearance due to underdeveloped or non-existent lymphatics within the tumor.. ... The Johns Hopkins University

05/18/17 / #20170135659

System, method and computer readable medium for preview of low-dose x-ray projection and tomographic images

A novel method for simulating radiation dose reduction that enables previews of low-dose x-ray projection images, low-dose computed tomography images and/or cone-beam ct images. Given an existing projection or set of projections of the patient acquired at a nominal dose, the method provides a means to produce highly accurate preview images that accurately reflect the image quality associated with reduced radiation dose. ... The Johns Hopkins University

05/18/17 / #20170135583

Coherent optical imaging for detecting neural signatures and medical imaging applications using holographic imaging techniques

A neural imaging system may include an imaging array, an image data processor operably coupled to the imaging array to process image data received from the imaging array, and a beam angle separator disposed between the imaging array and an object being imaged. The beam angle separator may be configured to separate an object beam reflected from the object being imaged into a plurality of reference beams each having different angular separation with respect to the object beam. ... The Johns Hopkins University

05/18/17 / #20170135581

Coherent optical imaging for detecting neural signatures and medical imaging applications using common-path coherent optical techniques

Example apparatuses and methods relating to imaging systems are provided. An example imaging system may include an optical source configured to generate an optical beam, a beam splitter configured to split the optical beam into a reference beam and an object beam, and a beam combiner configured to route a combined beam with reference beam and object beam components along a common path into a target medium. ... The Johns Hopkins University

05/11/17 / #20170131768

Systems and methods for human-machine subconscious data exploration

Systems, computer readable media, and method concern includes generating data renderings for a data set. The data renderings for the data set include one or more of visual renderings of portions of the data set and one or more sonic renderings of portions of the data set. ... The Johns Hopkins University

05/11/17 / #20170131320

Robust particle velocity measurement

A method for particle velocity measurement may include transmitting an optical beam from an optical source, splitting the optical beam into a first beam and a second beam where the first beam and the second beam each have different polarizations, directing the first beam and the second beam toward an object, and determining a velocity of the object based on receiving the first and second beams reflected from the object.. . ... The Johns Hopkins University

05/11/17 / #20170131143

Photodetection circuit and operating method thereof

A photodetection circuit includes an avalanche photodiode and a mode switching circuit that may be configured to selectively switch an operating mode of the photodetection circuit between linear mode and geiger mode. The photodetection circuit may further include a quenching circuit configured to quench and reset the avalanche photodiode in response to an avalanche event when the photodetection circuit is operated in geiger mode. ... The Johns Hopkins University

05/11/17 / #20170128378

Nanocrystals, compositions, and methods that aid particle transport in mucus

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (mpp) without any polymeric carriers, or with minimal use of polymeric carriers. ... The Johns Hopkins University

05/11/17 / #20170128145

Laparoscopic ultrasound robotic surgical system

A lus robotic surgical system is trainable by a surgeon to automatically move a lus probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2d ultrasound image slices captured by the lus probe according to stored instructions are processable into a 3d ultrasound computer model of an anatomic structure, which may be displayed as a 3d or 2d overlay to a camera view or in a pip as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. ... The Johns Hopkins University

05/11/17 / #20170128144

Laparoscopic ultrasound robotic surgical system

A lus robotic surgical system is trainable by a surgeon to automatically move a lus probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2d ultrasound image slices captured by the lus probe according to stored instructions are processable into a 3d ultrasound computer model of an anatomic structure, which may be displayed as a 3d or 2d overlay to a camera view or in a pip as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. ... The Johns Hopkins University

05/11/17 / #20170128041

Laparoscopic ultrasound robotic surgical system

A lus robotic surgical system is trainable by a surgeon to automatically move a lus probe in a desired fashion upon command so that the surgeon does not have to do so manually during a minimally invasive surgical procedure. A sequence of 2d ultrasound image slices captured by the lus probe according to stored instructions are processable into a 3d ultrasound computer model of an anatomic structure, which may be displayed as a 3d or 2d overlay to a camera view or in a pip as selected by the surgeon or programmed to assist the surgeon in inspecting an anatomic structure for abnormalities. ... The Johns Hopkins University

05/11/17 / #20170127983

Systems and methods for sampling calibration of non-invasive analyte measurements

Systems and methods of the present invention provide a calibration model that requires minimal information compared with prior techniques. These systems and methods represent the first generalized approach for combined treatment of spectroscopic measurements of a dynamic, mass-transfer system with the underlying kinetic model of said system. ... The Johns Hopkins University

05/04/17 / #20170123030

Gesture-controlled mr imaging system and method

A magnetic resonance imaging system and method are provided that include user control of certain functions using physical gestures, such as hand motions or the like. The gesture control aspects can include one or more cameras, and a processor configured to detect and recognize gestures corresponding to predetermined commands and to provide signals to execute the commands. ... The Johns Hopkins University

05/04/17 / #20170122933

Method for rapidly designing pharmaceutical preparations for preventing viral infection

Certain embodiments of the present invention include a method for rapidly designing pharmaceutical preparations for preventing viral infection that have adapted to growth in various culturing systems but maintain antigenic similarity to the original virus. The method may include serial passaging a plurality of instances of a targeted virus strain from an infected first animal in respective droplets in second animal cells, in parallel synthesizing antibodies that neutralize the targeted virus strain in a third animal, and selecting the second animal cell-adapted viral lineages that are neutralized by the antibodies to identify second animal cell-adapted viral lineages having antigenic similarity to the targeted virus strain.. ... The Johns Hopkins University

05/04/17 / #20170122870

Detector and method for detecting an agent in an aerosol

A detector for detecting an agent within an aerosol is provided. The detector may include a liquid feeder configured to generate a droplet comprised of an assay reagent. ... The Johns Hopkins University

05/04/17 / #20170121775

Detection and prognosis of lung cancer

Methods and tools are provided for detecting and predicting lung cancer. The methods and tools are based on epigenetic modification due to methylation of genes in lung cancer or pre-lung cancer. ... The Johns Hopkins University

05/04/17 / #20170120441

Generation of robotic user interface responsive to connection of peripherals to robot

Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining a peripheral property set corresponding to the robotic peripheral, wherein the peripheral property set includes one or more properties of the robotic peripheral; modifying, based on the peripheral property set, a robotic property set that includes one or more properties of the robot to provide a modified robotic property set; generating, during runtime, a robotic graphical user interface (“rgui”) dynamically based on the peripheral property set, wherein the rgui provides at least one user-accessible interface to control the robot and the robotic peripheral; and controlling, based on the modified robotic property set, the robot and the robotic peripheral in response to user input received via the rgui.. . ... The Johns Hopkins University

05/04/17 / #20170120440

Method, device, and computer-readable medium for mobile device management of collaborative industrial robot

Provided is a method, device, and computer-readable medium for controlling a robot graphic user interface (“rgui”) on a mobile device. The method can include determining a distance, a position, or both of the mobile device with respect to a first robot; and causing, by a processor, a first rgui to be displayed on a display of the mobile device based on the determining.. ... The Johns Hopkins University

05/04/17 / #20170119897

Dendrimer compositions and use in treatment of necrotizing enterocolitis and other gastrointestinal disorders

A dendrimer formulation, such as a pamam dendrimer or a multiarm peg polymeric formulation has been developed for oral administration to the gastrointestinal tract for treatment of inflammatory diseases associated with infection or cancer. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of necrotizing enterocolitis.. ... The Johns Hopkins University

05/04/17 / #20170119683

Biopolymer-encapsulated glycosyl transferase inhibitor compositions and methods for treating diabetes and cardiac indications

The present invention relates to compositions comprising a biopolymer-encapsulated glycosyltransferase inhibitor and methods for treating and reducing a symptom of atherosclerosis or cardiac hypertrophy and/or diabetes using said compositions.. . ... The Johns Hopkins University

05/04/17 / #20170119662

Hypotonic microbicidal formulations and methods of use

Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing hiv infection, the microbiocidal is tenofovir, or a prodrug or derivative thereof. ... The Johns Hopkins University

04/27/17 / #20170114333

Improvements to eukaryotic transposase mutants and transposon end compositions for modifying nucleic acids and methods for production and use in the generation of sequencing libraries

Hyperactive hermes transposase mutants and genes encoding them are disclosed. These transposases are easily purified in large quantity after expression in bacteria. ... The Johns Hopkins University

04/27/17 / #20170114108

Genetically encoded histone reporter allele constructs

Non-fret-based fusion protein reporter molecules are provided that can be used to monitor histone modifications in living cells. Transgenic animals, particularly non-human mammals, whose genomes comprise an expression cassette encoding a non-fret-based fusion protein reporter, are also provided. ... The Johns Hopkins University

04/27/17 / #20170114013

Low calcemic, highly antiproliferative, analogs of calcitriol

The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.. . ... The Johns Hopkins University

04/27/17 / #20170112459

Informatics radiomics integration system (iris): a novel combined informatics and radiomics method for integration of many types of data for classification into different groups for improved visualization

An embodiment in accordance with the present invention includes a novel informatics method for the integration of different variables or ontologies using an advanced unsupervised machine learning method which will be used to visualize factors not visible to the human observer. These factors can be unknown characteristics between imaging datasets and other factors which will provide insights into the structure of the data. ... The Johns Hopkins University

04/20/17 / #20170106067

Combinatorial immunotherapy for pancreatic cancer treatment

The invention features compositions and methods for treating and preventing pancreatic cancer.. . ... The Johns Hopkins University

04/13/17 / #20170100354

Compositions and methods for treating kabuki syndrome and related disorders

A method is provided for treating a mendelian disorder of the epigenetic machinery (e.g., kabuki syndrome) in a subject in need thereof. In particular, the method comprises administering to the subject a ketogenic composition in an amount sufficient to produce a physiologically acceptable ketosis in the subject. ... The Johns Hopkins University

04/06/17 / #20170096660

Fabrication of hierarchical silica nanomembranes and uses thereof for solid phase extraction of nucleic acids

The present invention provides a novel method to fabricate silica nanostructures on thin polymer films based on silica deposition and self-wrinkling induced by thermal shrinkage. These micro- and nano-scale structures have vastly enlarged the specific area of silica, thus the silica nanomembranes can be used for solid phase extraction of nucleic acids. ... The Johns Hopkins University

04/06/17 / #20170095653

Universal microport

The present invention is directed to a device that provides an implantable port, particularly for use with animal models, such as small animal models like mouse models. A microport device according to an embodiment of the present invention includes a reservoir and a catheter for delivery of substances held within the reservoir. ... The Johns Hopkins University

04/06/17 / #20170095591

Device and method for a nanofiber wrap to minimize inflamation and scarring

The present invention is directed to a device and method for a nanofiber wrap to minimize inflation and scarring of nerve tissue and maximize the nutrient transport. More particularly, the present invention is directed to a novel semi-permeable nanofiber construct prepared from biocompatible materials. ... The Johns Hopkins University

04/06/17 / #20170095566

Compositions and methods for enhancing transport through mucus

The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.. ... The Johns Hopkins University

04/06/17 / #20170095547

Malarial antigens derived from subtilisin-like protease 2 and vaccines and methods of use

The present invention provides immunogenic compositions comprising one or more subtilisin-like protease 2 antigens, functional fragments or homologs thereof, from various plasmodium species, methods, vectors comprising the antigens, and methods of use for the treatment of malaria and related disease.. . ... The Johns Hopkins University

04/06/17 / #20170095511

In vitro pre-conditioned bone marrow-derived mesenchymal stem cells and uses thereof

Disclosed is a composition including: an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (bmscs), wherein the bmscs express neuronal markers, and wherein the neuronal markers are pgp9.5, nse, tuj1, huc/d and neuronal nitric oxide synthase (nnos). Methods of preparing the bmscs are also provided. ... The Johns Hopkins University

04/06/17 / #20170095436

Methods for treating mendelian disorders of the epigenetic machinery

A method is provided for treating a mendelian disorder of the epigenetic machinery in a subject in need thereof. In particular, the method comprises administering a therapeutically effective amount of an agent that restores balance between open and closed chromatin states at one or more target genes, wherein the agent that restores balance between open and closed chromatin states at one or more target genes is an agent that ameliorates the effect of a defective gene encoding a component of the epigenetic machinery.. ... The Johns Hopkins University

04/06/17 / #20170095194

System and method for seizure detection and responsivity testing

The present invention is directed to a computer application for seizure detection using biometric data and responsivity testing. The computer application collects biometric data and responsiveness test results from biometric sensors and an interactive user interface in order to identify and confirm seizures and monitor for severity, duration, and permit logging and notification. ... The Johns Hopkins University

03/30/17 / #20170092093

Bluetooth beacon system for industrial machine safety

The present invention provides a system and method for increasing construction site safety. The present invention reduces the risk of a construction or similar large vehicle or piece of mobile machinery hitting a construction worker. ... The Johns Hopkins University

03/30/17 / #20170087271

Drug loaded microfiber sutures for ophthalmic application

Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular surgery and repair have been developed. The suture materials are made from a combination of a biodegradable, biocompatible polymer and a hydrophilic biocompatible polymer. ... The Johns Hopkins University

03/30/17 / #20170087253

Engineering synthethic brain penetrating gene vectors

A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged peg, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. ... The Johns Hopkins University

03/30/17 / #20170086736

Methods and systems using non-labeled antimetabolites and analogs thereof as theranostic agents

A method, computer-readable medium and system of planning, guiding and/or monitoring a therapeutic procedure, can include: receiving a non-labeled therapeutic agent by a subject, said non-labeled therapeutic agent comprises at least one type of water-exchangeable proton that is exchangeable with protons in surrounding water molecules so as to enhance detection by a chemical exchange saturation transfer (cest) process; acquiring a plurality of cest magnetic resonance images of said non-labeled therapeutic agent within a region of interest of said subject for a corresponding plurality of times; and assessing at least one of a therapeutic plan or therapeutic effect of said non-labeled therapeutic agent in tissue of said subject based on said plurality of magnetic resonance images. . ... The Johns Hopkins University

03/30/17 / #20170086675

Quantitative tissue property mapping for real time tumor detection and interventional guidance

The present invention is directed to a method for real-time characterization of spatially-resolved tissue optical properties using oct/lci. Imaging data are acquired, processed, displayed and stored in real-time. ... The Johns Hopkins University

03/23/17 / #20170083682

Method, system and computer-readable media for treatment plan risk analysis

A method, system and computer readable medium of: providing feature data of at least one organ at risk or target volume of said patient from a database of non-transitory data stored on a data storage device of prior patients data; generating, using a data processor, a distribution of dose points of the at least one organ at risk or target volume of said patient based on said feature data; calculating, using the data processor, at least one of (i) a probability of toxicity for the at least one organ at risk or (ii) a probability of treatment failure for the at least one target volume, based on said distribution of dose points; assessing, using the data processor, a dosimetric-outcome relationship based on the calculated probability; and automatically formulating, using the data processor, a treatment plan using the dosimetric-outcome relationship to minimize the at least one treatment-related risk.. . ... The Johns Hopkins University

03/23/17 / #20170080063

Highly soluble aquaporin-4 extracellular loop c peptide immunization for treatment of neuromyelitis optica

The present invention provides pharmaceutical compositions for treating neuromyelitis optica (nmo) comprising a therapeutically effective amount of loop c sequence-containing peptide of aquaporin-4 (aqp4) water channel, or a therapeutically effective fragment or variant thereof. The invention also provides methods for treating nmo by administering therapeutically effective amounts of loop c sequence-containing peptide(s) of aqp4, optionally in an immunosuppressive setting, and also provides diagnostics for detection of nmo in a subject, screening methods for identification of nmo-treating therapeutics and nmo model systems.. ... The Johns Hopkins University

03/23/17 / #20170079666

Vetebral osteotomy saw guide

The vertebral osteotomy saw guide allows precise osteotomies to be performed through the vertebral column in conjunction with a thread-wire saw. The guide is designed so that it can mount to rods commonly used during spinal surgery for spinal stabilization. ... The Johns Hopkins University

03/23/17 / #20170079581

Mri-guided intraarterial catheter-based method for predicting territory of local blood brain barrier opening

The present invention provides a method of administering a therapeutic agent directly to the brain parenchym through a compromised region of the blood-brain barrier in a subject having a brain disorder, that involves first disrupting the blood-brain barrier (bbb) at an isolated region by locally administering an effective amount of a hyperosmolar agent at said region using a catheter, followed by administering a therapeutically effective amount of a therapeutic agent. The step of disrupting the bbb is carried out with non-invasive mr (magnetic resonance) imaging with a contrast agent to visualize local parenchymal transcatheter perfusion at said isolated bbb region thereby indicating that the bbb region is compromised. ... The Johns Hopkins University

03/16/17 / #20170076096

Apparatus and method for preventing access by malware to locally backed up data

A method for providing malware protection in connection with processing circuitry including hardware resources and software resources managed by a primary operating system may include providing a trusted operating system to control access to a portion of a local storage area of the hardware resources. In this context, only the trusted operating system is configured to enable writing to the portion of the local storage area. ... The Johns Hopkins University

03/16/17 / #20170074958

Methods and systems of assessing tissue vascular permeability using non-labeled dextran

A method of assessing tissue vascular permeability for nanotherapeutics using non-labeled dextran can include: receiving a non-labeled, physiologically-tolerable dextran solution by a subject; acquiring a plurality of magnetic resonance images of a distribution of the dextran solution within at least one region of interest of the subject for a corresponding plurality of times; and assessing a tissue vascular permeability of the at least one region of interest to dextran particles in the dextran solution based on differences between the plurality of magnetic resonance images, wherein the dextran solution is a substantially mono-disperse solution of dextran particles of one size.. . ... The Johns Hopkins University

03/16/17 / #20170073776

Pca3, pca3 genes, and methods of use

The present invention relates, in general, to a prostate-specific antigen, pca3. In particular, the present invention relates to nucleic acid molecules coding for the pca3 protein; purified pca3 proteins and polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to pca3 proteins and polypeptides; hybridomas containing the antibodies; nucleic acid probes for the detection of nucleic acids encoding pca3 proteins; a method of detecting nucleic acids encoding pca3 proteins or polypeptides in a sample; kits containing nucleic acid probes or antibodies; bioassays using the nucleic acid sequence, protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with prostate cancer; therapeutic uses; and methods of preventing prostate cancer in an animal.. ... The Johns Hopkins University

03/16/17 / #20170073390

Method for identifying and validating dominant t helper cell epitopes using an hla-dm-assisted class ii binding assay

Rational design of immunotherapeutics relies on clear knowledge of the immunodominant epitopes of antigens. Current methods for identifying kinetically stable peptide-mhc complexes are in many cases inadequate for a number of reasons. ... The Johns Hopkins University

03/16/17 / #20170072064

Highly stable biodegradable gene vector platforms for overcoming biological barriers

A major challenge in non-viral gene delivery remains finding a safe and effective delivery system. Colloidally stable non-viral gene vector delivery systems capable of overcoming various biological barriers, are disclosed. ... The Johns Hopkins University

03/16/17 / #20170072040

Mesothelin vaccines and model systems

Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic t cell response. ... The Johns Hopkins University

03/16/17 / #20170071675

An imaging toolbox for guiding cardiac resynchronization therapy implantation from patient-specific imaging and body surface potential mapping data

The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a crt therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for crt therapy. ... The Johns Hopkins University

03/09/17 / #20170069967

Metasurface antenna

An antenna is provided including an electromagnetic metasurface. The electromagnetic characteristics of the antenna are dynamically tunable.. ... The Johns Hopkins University

03/09/17 / #20170069062

Small maritime target detector

A detection system may include processing circuitry configured to receive synthetic aperture radar image data that has been or will be divided into a plurality of image tiles and perform initial screening to reject image tiles not having a threshold level of energy. The processing circuitry may be further configured to perform advanced screening to eliminate image tiles based on background noise to generate screened image tiles and generate a feature vector for an energy return of the screened image tiles. ... The Johns Hopkins University

03/09/17 / #20170067088

Cationic polymer systems for selective bacterial capture

A device and methods of use thereof for isolating one or more microorganisms from a biological sample, the device comprising a polymeric surface having one or more cationic polymers covalently grafted thereto, wherein the one or more cationic polymers have a selective affinity for the one or more microorganisms.. . ... The Johns Hopkins University

03/09/17 / #20170066140

Rigid temporary attachment device for a robotic gripper

An attachment device includes a robot-engaging portion having a recess formed in an outer surface thereof for receiving a finger of a robot. The attachment device also includes a tool-engaging portion coupled to the robot-engaging portion. ... The Johns Hopkins University

03/09/17 / #20170065712

Chimeric vaccines

The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen sequence and a domain for trafficking the protein to an endosomal compartment, irrespective of whether the antigen is derived from a membrane or non-membrane protein. ... The Johns Hopkins University

03/09/17 / #20170065674

Hypoxia-induced mitogenic factor

We found that fizz1/relmα is inducible by hypoxia in lung. The hypoxia-upregulated expression of fizz1/relmα was located in the pulmonary vasculature, bronchial epithelial cells, and type ii pneumocytes. ... The Johns Hopkins University

03/02/17 / #20170058275

Platform and method for identifying past exposure to chemical agents or heavy metals

A method for determining past exposure to chemical agents or heavy metals may include coating a capture material with a capture reagent. The capture reagent may be selected based on an ability of the capture reagent to bind with a target antibody, and the target antibody may be an indicator associated with a particular chemical agent or heavy metal. ... The Johns Hopkins University

03/02/17 / #20170058268

Compositions for targeted dna methylation and their use

The present invention provides an in vitro directed evolution selection system to create modified methyltransferases which improve methyltransferase specificity and use it to optimize and provide fusion proteins comprising a zinc finger methyltransferase derived from m.sssi. The resulting fusion proteins show increased target methylation specificity and greatly decreased non-target methylation compared to wild-type enzyme activity. ... The Johns Hopkins University

03/02/17 / #20170056310

Compositions and methods for promoting skin regeneration and hair growth

The present invention relates to the field of wound healing. Specifically, the present invention provides compositions and methods for promoting skin regeneration, more specifically, the generation of de novo hair follicles. ... The Johns Hopkins University

03/02/17 / #20170056075

A spinal probe incorporating an electromechanical system for detection and prevention of breaches during surgery

The present invention is directed to an innovative pedicle probe that uses a force-sensing electromechanical system coupled with haptic and visual feedback. The probe of the present invention reduces the rate of pedicle screw breaches during spinal fusion surgery. ... The Johns Hopkins University

02/23/17 / #20170051347

Safe sequencing system

The identification of mutations that are present in a small fraction of dna templates is essential for progress in several areas of biomedical research. Though massively parallel sequencing instruments are in principle well-suited to this task, the error rates in such instruments are generally too high to allow confident identification of rare variants. ... The Johns Hopkins University

02/23/17 / #20170051294

Regulated switch for gene expression

A system for controlling gene expression in yeast comprises a repressible gene expression plasmid that has a regulator binding sequence for camr and a target gene sequence. The system also includes a transcription enhancer expression plasmid; wherein said transcriptional activator protein binds to the regulator binding sequence in the absence of a transcriptional inhibitor. ... The Johns Hopkins University

02/23/17 / #20170050947

Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors

The disclosed subject matter provides certain n-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition. ... The Johns Hopkins University

02/23/17 / #20170049912

Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (psma) and uses thereof

The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. ... The Johns Hopkins University

02/23/17 / #20170049598

Gastric device and method of use thereof

The present invention provides a low-risk, unobtrusive and noninvasive method and device for treatment of obesity and eating disorders. In embodiments, the device is a gastric device suitable for placement in a stomach of a subject. ... The Johns Hopkins University

02/23/17 / #20170049396

Device and method for detection of periodic leg movements

The present invention is directed to a computer application for monitoring and tracking leg and foot movements and positions and a device for facilitating the computer tracking of the leg and foot movements. The application uses an accelerometer, gyroscope or other movement detectors in available devices such as a phone, movement tracker, personal music device, tablet computing device, other similar device or a device specifically designed to detect movements and positions and to track the movement and changes in position of the patient's leg and foot. ... The Johns Hopkins University

02/16/17 / #20170044150

Identification of compounds which inhibit atg8-atg3 protein-protein interaction and their use as antiparasitical agents

The present invention provides compounds or a pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs thereof which can block the atg8-atg3 protein-protein interaction, which is associated with autophagy in apicomplexan organisms. Pharmaceutical compositions comprising these compounds and their use for the suppression and treatment of various parasitical diseases are also provided.. ... The Johns Hopkins University

02/16/17 / #20170043130

Securement device with attachable members for use with a catheter

The present invention describes a securement device that maintains proper placement of a percutaneous catheter and incorporates a universal fitting for the attachment of various, interchangeable, active and passive technologies. The securement device includes a unique catheter hub that enables attachment of active technology to provide diagnostic, therapeutic, and monitoring applications of physiologic, anatomic, and other clinically relevant properties or conditions. ... The Johns Hopkins University

02/16/17 / #20170043126

Catheter hub with removable extensions

In one aspect, the present invention is directed to a multi-lumen catheter with self-sealing hub and an attachable extension assembly. In a preferred aspect, the present invention can allows removal of the external fluid connections of an elongated percutaneous medical article, such as a catheter or cannula. ... The Johns Hopkins University

02/16/17 / #20170043027

Dendrimer compositions and their use in treatment of diseases of the eye

The present invention provides compositions comprising pamam dendrimers conjugated with one or more biologically active agents, and their use systemically to target activated microglia/macrophages in retina/choroid and generally, inflammatory and/or angiogenic diseases of the eye.. . ... The Johns Hopkins University

02/16/17 / #20170043021

Compositions comprising cyclodextrin incorporated collagen matrices for use in biomedical applications

The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen-based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. ... The Johns Hopkins University

02/16/17 / #20170043011

Synthetic hepatitis c genome and methods of making and use

Synthetic representative hcv subtypes, including a 1a and 1b genome, dubbed bole1a and bole1b, are provided using an inventive method of bayesian phylogenetic tree analysis, ancestral sequence reconstruction and covariance analysis. Bole1a branches centrally among 390 full-genome sequences used in its design, a carefully curated 143 sequence full-genome dataset, and separate genomic regions including an independent set of 214 e1e2 sequences from a baltimore cohort. ... The Johns Hopkins University

02/16/17 / #20170042886

Procaspase combination therapy for glioblastoma

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. ... The Johns Hopkins University

02/16/17 / #20170042829

Methods of preparing polyelectrolyte complex nanoparticles

The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (pec) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates pec nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.. ... The Johns Hopkins University

02/16/17 / #20170042730

Surgical system providing hands-free control of a surgical tool

A surgical system provides hands-free control of at least one surgical tool includes a robot having a tool connector, a smart tool attached to the tool connector of the robot, and a feedback control system configured to communicate with the smart tool to provide feedback control of the robot. The smart tool includes a tool that has a tool shaft having a distal end and a proximal end, a strain sensor arranged at a first position along the tool shaft, at least one of a second strain sensor or a torque-force sensor arranged at a second position along the tool shaft, the second position being more towards the proximal end of the tool shaft than the first position, and a signal processor configured to communicate with the strain sensor and the at least one of the second strain sensor or the torque-force sensor to receive detection signals therefrom. ... The Johns Hopkins University

02/09/17 / #20170039161

Dual autonomous telemetry data acquisition system and real time opto-isolated receivers for use therewith

A serial digital data acquisition receiver (sddar) or system of receivers may include an opto-isolator assembly, sampling logic and a usb interface. Both a clk signal and a data signal may each pass through the opto-isolator assembly upon receipt of the clk and data signals at the sddar or system. ... The Johns Hopkins University

02/09/17 / #20170038397

Assay reagents for a neurogranin diagnostic kit

The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. ... The Johns Hopkins University

02/02/17 / #20170032208

System and method for detecting and tracking a curvilinear object in a three-dimentional space

A system for detecting and tracking a curvilinear object in a three-dimensional space includes an image acquisition system including a video camera arranged to acquire a video image of the curvilinear object and output a corresponding video signal, the video image comprising a plurality n of image frames each at a respective time ti, where i=1, 2, . . ... The Johns Hopkins University

02/02/17 / #20170031048

Method for estimating permeability of fractured rock formations from induced slow fluid pressure waves

An embodiment in accordance with the present invention includes a method for estimating the permeability of fractured rock formations from the analysis of a slow fluid pressure wave, which is generated by pressurization of a borehole. Wave propagation in the rock is recorded with tfi™. ... The Johns Hopkins University

02/02/17 / #20170029772

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix

The present invention is in the area of pluripotent stem cells and more particularly deals with a method to differentiate a vascular network from stem cells.. . ... The Johns Hopkins University

02/02/17 / #20170029382

Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels

The present invention provides compounds of formula i which are capable of inhibition of the activation of hnav1.1 or hnav1.6 sodium channels in neurons. Pharmaceutical compositions comprising these compounds are also provided. ... The Johns Hopkins University

02/02/17 / #20170028181

Method of manufacturing an implantable pressure-actuated drug delivery system

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. ... The Johns Hopkins University

02/02/17 / #20170027915

Treatment of autoimmune disorders and infections using antagonists of sgk1 activity

The present invention provides novel methods for treating th2-mediated immune disorders and enhancing th1-mediated immune responses in a subject comprising administering to the subject, a pharmaceutical composition comprising a serum-glucocorticoid regulated kinase 1 (sgk1) inhibitor and a pharmaceutically acceptable carrier. Methods for treating a wide range of autoimmune diseases are also taught. ... The Johns Hopkins University

01/26/17 / #20170023341

Structural component that will fragment into particles of selected geometry and reactivity

An embodiment in accordance with the present invention provides a method for creating and consolidating fragments and a useable structure formed from said consolidated fragments. The method includes swaging a metal powder into a first consolidated structure. ... The Johns Hopkins University

01/26/17 / #20170023310

Three dimensional woven lattices as novel multi-functional architectures

The present invention is directed to devices formed from three-dimensional (3d) structures composed of metallic, ceramic or polymeric wires or bundles and yarns of wires that are either solid or hollow like a tube. The devices of the present invention offer the potential for 3d structures with multiple properties optimized concurrently, in some cases using a topology optimization routine that includes the 3d manufacturing constraints. ... The Johns Hopkins University

01/26/17 / #20170023084

Three dimensional lattice weaves with tailored damping properties

The present invention is directed to three dimensional weaves composed of wires or yarns that offer the potential for damping not achievable with solid materials, including high temperature damping. Three damping mechanisms have been identified: (1) internal material damping, (2) frictional energy dissipation (coulomb damping), and (3) inertial damping (tuned mass damping). ... The Johns Hopkins University

01/26/17 / #20170022572

Tert and braf mutations in human cancer

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions related to certain mutations in cancer. ... The Johns Hopkins University

01/26/17 / #20170022494

Two-hybrid based screen to identify disruptive residues at multiple protein interfaces

The present invention is based, at least in part, on the development of a mating-based yeast two-hybrid screen that allows simultaneous screening for mutations that disrupt yeast two-hybrid interactions between a protein and multiple interacting partners. By coupling pcr mutagenesis and homologous recombination/gapped plasmid repair with a mating-based assay, the present invention allows screening for unique mutations that disrupt interaction with one partner, but not others. ... The Johns Hopkins University

01/26/17 / #20170022154

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

The invention relates to n-hydroxysulfonamide derivatives that donate nitroxyl (hno) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel n-hydroxysulfonamide derivatives release nho at a controlled rate under physiological conditions, and the rate of hno release is modulated by varying the nature and location of functional groups on the n-hydroxysulfonamide derivatives.. ... The Johns Hopkins University

01/26/17 / #20170021014

Vaccine adjuvants for cytomegalovirus prevention and treatment

The present invention relates to the field of virology. More specifically, the present invention provides methods and compositions useful for treating human cytomegalovirus using bacterial cell wall components mdp and tri-dap as vaccine adjuvants. ... The Johns Hopkins University

01/26/17 / #20170020931

Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-ctla-4 and/or anti-pd-1 antibodies to treat solid tumor malignancies

The presently disclosed subject matter provides methods and kits for treating solid tumors in a subject by using a combination of anti-ctla-4 and/or anti-pd-1 antibodies with at least one member of the group consisting of a bacterium, bacterial product, and an immunoregulatory entity. In particular embodiments, the bacteria are toxin-depleted, anaerobic bacteria, such as clostridium novyi-nt.. ... The Johns Hopkins University

01/26/17 / #20170020693

Multi-modal neural interfacing for prosthetic devices

Methods and systems to interface between physiological devices and a prosthetic device, including to receive a plurality of types of physiological activity signals from a user, decode a user movement intent from each of the plurality of signals types, and fuse the movement intents into a joint decision to control moveable elements of the prosthetic device.. . ... The Johns Hopkins University

01/19/17 / #20170018297

Skyrmion based universal memory operated by electric current

A method for generating a skyrmion, comprising: depositing a vertical metallic nanopillar electrode on a first side of a helimagnetic thin film, the helimagnetic thin film having a contact on a second side to provide a current drain; injecting a current through the vertical metallic nanopillar electrode to generate a rotating field; and applying a static upward magnetic field perpendicular to the helimagnetic thin film to maintain an fm phase background.. . ... The Johns Hopkins University

01/19/17 / #20170017831

Face detection, augmentation, spatial cueing and clutter reduction for the visually impaired

An apparatus for improving performance of a retinal implant may include processing circuitry. The processing circuitry may be configured to receive image data corresponding to a camera field of view, determine whether a particular object is detected within the camera field of view, perform image data processing to enable a representation of a portion of the image data corresponding to an implant field of view to be provided on a retinal implant where the implant field of view is smaller than the camera field of view, and, responsive to the particular object being located outside the implant field of view, provide a directional indicator in the implant field of view to indicate a location of the particular object relative to the implant field of view.. ... The Johns Hopkins University

01/19/17 / #20170016903

Genes encoding secreted proteins which identify clinically significant prostate cancer

The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for identification of individuals having clinically significant cancer. ... The Johns Hopkins University

01/19/17 / #20170016884

A novel, high-throughput, nanotopographic platform for screening cell migratory behavior

The present invention is directed to creating a highly versatile, high throughput, and convenient platform for interrogating migration phenotypes of gb cells in the context of diverse environmental parameters. Specifically, engineered substrates are employed to mimic the mechanical signals of natural ecm topography, and combine these tools with chemical cues presented in soluble and immobilized forms (pdgf and laminin, respectively). ... The Johns Hopkins University

01/19/17 / #20170014441

Induction of thyroid iodide-handling gene expression in human cancers

Dual suppression of the map kinase and pi3k/akt pathways showed synergistic or greatly enhanced anti-melanoma cell effects, compared to suppression of a single pathway, including the inhibition of cell proliferation, transformation and invasion, induction of g0/g1 cell cycle arrest and, importantly, cell apoptosis. Remarkably, suppression of either pathway induces the expression of thyroid iodide-handling genes and dual suppression of the two pathways synergistically and robustly induces expression of these genes, accompanied by uptake of radioiodine in the cells. ... The Johns Hopkins University

01/19/17 / #20170014026

Eye alignment monitor and method

An eye alignment monitor and method are described for the detection of variability of the relative alignment of the two eyes with each other, thereby detecting deficits of binocular function, for use as a screening device for these abnormalities especially in infants and young children. Each embodiment includes means for tracking of the positions of a subject's two eyes simultaneously, and furthermore includes repetitive calculation of the relative positions of the two eyes with respect to each other. ... The Johns Hopkins University

01/12/17 / #20170009303

Predicting response to epigenetic drug therapy

The present invention relates to the field of epigenetics. More specifically, the present invention provides methods and compositions useful for predicting response to epigenetic drug therapy. ... The Johns Hopkins University

01/12/17 / #20170009242

Crispr-mediated genome engineering for protein depletion

The present invention provides compositions and methods for tagging a target gene with a degron (e.g., auxin-inducible degron) in a variety of eukaryotic cells using the crispr genome-editing technology. Also provided are cells that have been genetically modified using such compositions and methods.. ... The Johns Hopkins University

01/12/17 / #20170009204

Low oxygen tension enhances endothelial fate of human pluripotent stem cells

Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (evc) derivation induces endothelial commitment and maturation of pluripotent stem cells. ... The Johns Hopkins University

01/12/17 / #20170007666

Compositions and methods for treating diabetes

The present invention relates to the field of diabetes mellitus. More specifically, the present invention provides compositions and methods useful for treating diabetes. ... The Johns Hopkins University

01/12/17 / #20170007542

Compositions and methods relating to reduced mucoadhesion

The present invention generally relates to reducing the mucoadhesive properties of a particle. In some embodiments, the particle is coated with and/or associated with a (poly(ethylene glycol))-(poly(propylene oxide))-(poly(ethylene glycol)) triblock copolymer. ... The Johns Hopkins University

01/05/17 / #20170002345

Methods for efficient, expansive, user-defined dna mutagenesis

The presently disclosed subject matter provides methods for the creation of one or more user-defined mutations that can be located anywhere in a target sequence, such as in a gene. These mutations can comprise single mutations, multiple mutations, or a comprehensive codon mutagenesis library, in which all possible single codon substitutions in a gene are created. ... The Johns Hopkins University

01/05/17 / #20170000565

Orthognathic biomechanical simulation

Disclosed is a method of simulating mastication. The method includes obtaining computer-readable three-dimensional representations of a first skeletal fragment including a portion of at least one of a mandible and a maxilla and of a recipient skeletal fragment including a portion of at least one of a mandible and a maxilla. ... The Johns Hopkins University

01/05/17 / #20170000505

Computer-assisted craniomaxillofacial surgery

A surgical system is provided. The system includes a reference unit, an implant and a detector. ... The Johns Hopkins University

01/05/17 / #20170000498

Patient-specific trackable cutting guides

A surgical guide assembly having an attachment device configured to be coupled to a bone. A cut location indicator is coupled to the attachment device. ... The Johns Hopkins University

01/05/17 / #20170000497

Cranial reference mount

A surgical guide assembly includes a body having an opening formed at least partially therethrough. An arm extends from the body. ... The Johns Hopkins University








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