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The Penn State Research Foundation patents


Recent patent applications related to The Penn State Research Foundation. The Penn State Research Foundation is listed as an Agent/Assignee. Note: The Penn State Research Foundation may have other listings under different names/spellings. We're not affiliated with The Penn State Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Penn State Research Foundation-related inventors


Image-based global registration system and method applicable to bronchoscopy guidance

A global registration system and method identifies bronchoscope position without the need for significant bronchoscope maneuvers, technician intervention, or electromagnetic sensors. Virtual bronchoscopy (vb) renderings of a 3d airway tree are obtained including vb views of branch positions within the airway tree. ... The Penn State Research Foundation

Mobile monitoring of fracture healing in external fixators

A device for and a method of monitoring the healing status of a fractured bone in a person's limb is disclosed. The external fixation device may include one or more rods or struts that incorporate strain gauges designed to measure the mechanical forces on the strut when force is applied to the fractured bone. ... The Penn State Research Foundation

Guitar support

A guitar support for supporting a guitar during a performance includes a base, a stand having an upper portion, a lower portion, and a curved middle portion. A lower end of the lower portion is connected to the base. ... The Penn State Research Foundation

Nanostructure surface coated medical implants and methods of using the same

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed. The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.. ... The Penn State Research Foundation

Glucose oxidase compositions as a neonate anticonvulsant

Neonatal seizure is different from adult seizure, and many antiepileptic drugs that are effective in adults often fail to treat neonatal seizure. Gluconic acid, a natural organic acid enriched in fruits and honey, and the glucose oxidase enzyme, is shown herein to potently inhibit neonatal epilepsy both in vitro and in vivo. ... The Penn State Research Foundation

Biochemical sensing using microbubbles on a chip using whispering gallery mode resonance

A sensing and analysis system on a chip for sensing and analyzing chemical or biological analytes includes a chromatography column having an inlet and an outlet formed on the chip for temporal separation of components of analytes and at least one whispering gallery mode (wgm) optical resonator for sensing of the components. The chromatography column is formed on a first wafer layer. ... The Penn State Research Foundation

Radio frequency treatment to phytosanitize wood packaging materials used in international shipping

A method for treating wood packaging materials using radio frequency heating includes the steps of heating wood packaging materials using rf heating and applying a pressure before the heating or incrementally applying a pressure during the heating until a temperature of the wood packaging materials reaches at least 60° c. And that temperature is maintained for at least 1 minute.. ... The Penn State Research Foundation

High definition optical coherence tomography imaging for non-invasive examination of heritage works

A high-speed, high-definition optical coherence tomography (oct) imaging system for non-invasive examination of an artwork in a macroscopic scale includes a high-speed, large field-of-view oct imaging platform which includes a spectral domain oct imaging system and a pair of linear motors configured to translate the artwork in two orthogonal directions creating a 2d stage system for scanning the artwork and acquiring volumetric oct data from adjacent, non-overlapping regions of interests on the artwork. The linear motors each have an accuracy compatible with the lateral resolution of the oct system. ... The Penn State Research Foundation

Individualized preoperative planning system and method

An individualized preoperative planning system for fracture fixation constructs provides fracture assessment before automatically performing finite element simulations to generate biomechanics associated with a large number of fracture fixation construct design alternatives. Data visualization utilizing multivariate plots or surrogate modeling based on the simulation results are then provided to surgeons enabling surgeons to view, adjust and optimize their fracture fixation construct designs.. ... The Penn State Research Foundation

Bedside stereotactic ultrasound guidance device, system and method

The present invention provides fixation devices, locking assemblies, and methods for using the same. The fixation devices of the invention are capable of accurate insertion of medical devices by providing detection means of a patient's internal anatomy and localizing a desired target. ... The Penn State Research Foundation

De novo structural protein design for manufacturing high strength materials

Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming subsequences form crystallites comprising stacks of one or more β-sheets and the amorphous subsequences form a network of hydrogen bonds. ... The Penn State Research Foundation

Switchable liquid repellent and active water harvesting surface

A substrate with a switchable surface has been developed that can rapidly switch its surface character such as between two distinct liquid-repellent modes: (1) a superhydrophobic mode and (2) a slippery mode. Such surfaces have demonstrated adaptive liquid repellency and water harvesting capabilities.. ... The Penn State Research Foundation

Automatically computing emotions aroused from images through shape modeling

Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. ... The Penn State Research Foundation

Chemical reprogramming of human glial cells into neurons with small molecule cocktail

Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain crizotinib (cri), flurbiprofen, lithium chloride (li), vitamin c (vc), ceritinib (cer) or pirfenidone (pfd). ... The Penn State Research Foundation

05/31/18 / #20180147604

Slippery rough surfaces

Substrates having a textured surface that can maintain or improve droplet mobility in both the cassie and wenzel states include a textured surface and a conformal lubricant layer thereover. The textured surface can include a plurality of raised first elements and a plurality of second elements thereon and the conformal lubricant layer over the plurality of raised first elements and covering the plurality of second elements. ... The Penn State Research Foundation

05/24/18 / #20180142184

Multi-surfactant systems

Multi-surfactant systems where two or more surfactant molecules are coupled to control the spatial distribution of polar groups of the combined surfactant molecules are disclosed. The system can be implemented by an aqueous medium including an associate charge constant surfactant and charge variable surfactant. ... The Penn State Research Foundation

05/03/18 / #20180117083

Compositions and methods for combating bacterial infections by killing persister cells with mitomycin c and/or cisplatin

The present disclosure provides a method for killing persister cells with mitomycin c and/or cisplatin, or derivatives thereof. Recalcitrant infections are difficult to treat due to persister cells, a subpopulation of all bacterial populations that is highly tolerant against all traditional antibiotics since the cells are dormant and antibiotics are designed to kill growing cells. ... The Penn State Research Foundation

04/12/18 / #20180100788

3d laser ablation tomography and spectrographic analysis

A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. ... The Penn State Research Foundation

04/05/18 / #20180095220

Transition metal doped zinc selenide optical fibers and methods for making the same

The invention relates to cr2+:znse core optical fibers and methods of fabricating thereof, including a hybrid physical-chemical vapor deposition reaction. The invention relates also to cr2+:znse optical fiber lasers, in particular to a crystalline semiconductor optical fiber laser.. ... The Penn State Research Foundation

03/29/18 / #20180090309

Vertical 2d structures for advanced electronic and optoelectronic systems

The present invention relates to methods for fabricating vertical homogenous and heterogeneous two-dimensional structures, the fabricated vertical two-dimensional structures, and methods of using the same. The methods demonstrated herein produce structures that are free standing and electrically isolated.. ... The Penn State Research Foundation

03/22/18 / #20180079869

Vesicles formed from block copolymers, and novel block copolymers

Vesicles formed from a block copolymer comprising at least one (poly)2-c1-3alkyl-2-oxazoline block and at least one polybutadiene block; and membranes comprising such vesicles. Block copolymers comprising at least one (poly)2-c1-3alkyl-2-oxazoline block and at least one polybutadiene block, provided that the copolymer is not the diblock copolymer consisting of 40 butadiene units and 190 2-methyl-2-oxazoline units terminated by a hydroxy group, are novel, and also form part of the invention.. ... The Penn State Research Foundation

03/08/18 / #20180064347

Handheld device and multimodal contrast agent for early detection of human disease

Systems comprising a combination of the handheld imaging system with a nanoparticle multimodal contrast agent are disclosed. The imaging system exploits the advantages of both near-infrared emission and the photoacoustic effect by employing calcium phosphosilicate nanocolloid that encapsulates nir and ct/mri contrast agents for enhanced deep tissue imaging as well as a portable nir/pa system using a tunable pulsed laser, ccd imaging technology and acoustic transducer arrays. ... The Penn State Research Foundation

03/01/18 / #20180062447

Self-regulated reconfigurable resonant voltage/current-mode method and device for extended-range inductive power transmission

A current-based resonant power delivery (crpd) device and method with multi-cycle switching that enables efficient inductive power transmission at large distances. The proposed crpd switches the rx lc-tank for several cycles to utilize it as a current source. ... The Penn State Research Foundation

03/01/18 / #20180056248

Membrane surface activation to eliminate fouling and concentration polarization in water purification systems

Disclosed herein is a membrane comprising a bonding layer; and an activation layer disposed on the bonding layer and in contact with it; where the activation layer comprises catalyst nanoparticles that are operative to decompose impurities contained in an aqueous solution to generate gas bubbles that remove a sludge disposed on the membrane. Disclosed herein too is a method of purifying an aqueous solution comprising disposing in the aqueous solution, a membrane that comprises a bonding layer and an activation layer; where the activation layer comprises catalyst nanoparticles; partitioning the aqueous solution into a concentrate portion and a filtrate portion; where the activation layer contacts the concentrate portion; and decomposing impurities contained in the aqueous solution to generate gas bubbles that remove a sludge disposed on the membrane.. ... The Penn State Research Foundation

03/01/18 / #20180055838

Methods and compositions for treatment of dermal and epidermal wounds

This disclosure relates to compositions and methods for the treatment of dermal and epidermal wounds. In particular, the disclosure relates to treating dermal and epidermal wounds based on application of a composition comprising an opioid receptor antagonist, a pharmaceutically acceptable carrier, and an enkephalinase. ... The Penn State Research Foundation

02/08/18 / #20180040704

Controlled synthesis and transfer of large area heterostructures made of bilayer and multilayer transition metal dichalocogenides

Embodiments are presented herein that provide a tmd system wherein the first layered material is made of heterobilayers or multilayers with semiconducting direct band gaps. The first layered material may be made of multiple layers of different tmd with different stackings, exhibiting smaller direct and indirect band gaps smaller than monolayer systems of tmd.. ... The Penn State Research Foundation

02/01/18 / #20180030494

Low sequence bias single-stranded dna ligation

The invention provides compositions and methods for ligating single stranded nucleic acids wherein the ligation is based on fast, efficient, and low-sequence bias hybridization of an acceptor molecule with a donor molecule. In one embodiment, the structure of the donor molecule comprises a stem-loop intramolecular nucleotide base pairing (i.e., hairpin) and a 3′-overhang region such that the overhang is able to hybridize to nucleotides present in the 3′ end of the acceptor molecule.. ... The Penn State Research Foundation

01/25/18 / #20180021736

Nano-pore arrays for bio-medical, environmental, and industrial sorting, filtering, monitoring, or dispensing

Micro- or nano-pores are produced in a membrane for various applications including filtration and sorting functions. Pores with at least one cross-sectional dimension in or near the nano-scale are provided. ... The Penn State Research Foundation

01/18/18 / #20180018543

Identifying visual storm signatures from satellite images

Satellite images from vast historical archives are analyzed to predict severe storms. We extract and summarize important visual storm evidence from satellite image sequences in a way similar to how meteorologists interpret these images. ... The Penn State Research Foundation

01/04/18 / #20180001043

Tracheal protective neonatal ventilation device

The present invention relates to a tracheal protective ventilation device specially adapted for use with neonates, a stylet that aids in insertion and spatial verification of the tracheal protective ventilation device, and methods for using the same. The ventilation provided by the devices of the present invention is atraumatic to the trachea and the glottis compared to ventilation devices currently available in the art, and has the additional feature of allowing the administration of nutritional matter to the gut without interrupting airflow.. ... The Penn State Research Foundation

12/28/17 / #20170369858

Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and method of using them to produce medium-chain fatty acids

Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to seq. Id. ... The Penn State Research Foundation

12/28/17 / #20170369344

Processes and treatment systems for treating high phosphorous containing fluids

Disclosed herein are processes for treating high-p fluid involving (1) providing a high-p containing stream; (2) chemically treating the high-p stream such that a majority of dissolved p in the stream is transformed into a solid form via sorption of p onto particles placed or precipitated within the stream; and (3) removing the solid form containing p from the chemically treated fine solids stream, such that > about 90% of the total p is removed from the high-p fluid. Also disclosed are systems for treating a high-p stream, the systems involving (1) a chemical treatment station operable to chemically treat and transform equal to or greater than about 90% of dissolved p in a high-p stream into a solid form; and (2) a liquid-solid separator station operable to remove the solid form containing p from the chemically treated high-p stream.. ... The Penn State Research Foundation

12/21/17 / #20170362692

Thermal barrier coatings

High temperature stable thermal barrier coatings useful for substrates that form component parts of engines such as a component from a gas turbine engine exposed to high temperatures are provided. The thermal barrier coatings include a multiphase composite and/or a multilayer coating comprised of two or more phases with at least one phase providing a low thermal conductivity and at least one phase providing mechanical and erosion durability. ... The Penn State Research Foundation

12/21/17 / #20170360075

Medical food for the treatment of malaria and/or iron deficiency

The present invention encompasses compositions and methods for treating or preventing malaria, compositions and methods for treating or preventing iron deficiency, and compositions and methods for simultaneously treating or preventing malaria and iron deficiency.. . ... The Penn State Research Foundation

12/14/17 / #20170358090

Systems and methods for detection of significant and attractive components in digital images

Systems, methods, and computer-readable media for electronically assessing a visual significance of pixels or regions in an electronic image are disclosed. A method includes receiving the electronic image, performing a composition analysis on the electronic image, the composition analysis includes partitioning the electronic image into a plurality of segments or a plurality of parts, constructing an attributed composition graph having a plurality of nodes, where each node corresponds to a segment or a part and where each node includes one or more attributes, modeling the visual significance of the electronic image based on the attributed composition graph using a statistical modeling process or a computational modeling process to obtain a plurality of values, and constructing a composition significance map having a significance score for each segment or each part according to the values obtained from the statistical modeling process or the computational modeling process.. ... The Penn State Research Foundation

12/14/17 / #20170354707

Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair

Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via transforming growth factor beta (tgf-β), bone morphogenetic protein (bmp), glycogen synthase kinase 3 (gsk-3), and γ-secretase/notch pathways. ... The Penn State Research Foundation

12/07/17 / #20170352394

Low power sense amplifier based on phase transition material

A sense amplifier utilizes a phase transition material (ptm) in conjunction with cmos circuits to provide a precise sensing threshold. The sense amplifier can be used in memory applications to sense states of stored bits with high accuracy and robustness. ... The Penn State Research Foundation

11/30/17 / #20170345155

Medical image reporting system and method

This invention relates generally to medical imaging and, in particular, to a method and system for automatic lymph node station mapping, automatic path or route report generation. A computer-based system for automatically locating the central chest lymph-node stations in a 3d mdct image is described. ... The Penn State Research Foundation

11/09/17 / #20170320964

Modulators of acyl-coa lysocardiolipin acyltransferase 1 (alcat1) and uses thereof

Compositions of modulators of acyl-coa lysocardiolipin acyltransferase 1 (alcat1) expression, function or activity are provided. In particular, inhibitors of alcat1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. ... The Penn State Research Foundation

10/26/17 / #20170304463

Regenerating functional neurons for treatment of disease and injury in the nervous system

Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing neurod1 into a glial cell, particularly into a reactive astrocyte or ng2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous neurod1 in the glial cell, wherein expressing exogenous neurod1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous neurod1 to the glial cell.. ... The Penn State Research Foundation

10/26/17 / #20170303542

Synergistic benzoxaborole-containing anti-fungicidal composition

An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are(is) separately controllable by a benzoxaborole and an anti-fungal compound of a preselected frac target site code is disclosed, as is a method of its use. A composition contains a diluent medium having dissolved or dispersed therein a synergistic effective amount of each of a first and a second anti-fungal compound. ... The Penn State Research Foundation

09/28/17 / #20170274100

Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo

Non-aggregating resorbable calcium phosphosilicate nanoparticles (cpnps) are bioconjugated to targeting molecules that are specific for particular cells. The cpnps are stable particles at normal physiological ph. ... The Penn State Research Foundation

09/14/17 / #20170263946

Carbon-based nanostructure membranes

The disclosure features methods for preparing a carbon nanostructure-based membranes, the methods including initiating self-assembly of a plurality of carbon nanostructures by suspending the nanostructures in a liquid where the liquid has a density that exceeds a density of the nanostructures, forming a membrane on a surface by removing the liquid, thereby depositing the nanostructures on the surface, and heating the membrane in a vessel that includes hydrogen gas.. . ... The Penn State Research Foundation

09/14/17 / #20170260151

Novel selenazolidine and thiazolidine compounds for treating cancer and other diseases

The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.. ... The Penn State Research Foundation

09/07/17 / #20170253648

Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2

Pharmaceutical compositions and methods for the treatment of dennd1a.v2 related disorders, such as pcos, are provided. In particular, humanized and mouse monoclonal antibodies specific for dennd1a.v2 and methods for using the same are provided.. ... The Penn State Research Foundation

09/07/17 / #20170253646

Functional peptide analogs of pedf

The invention provides compositions and methods relating to bioactive peptide analogs of pedf.. . ... The Penn State Research Foundation

09/07/17 / #20170252079

Bone repair system and method

A bone repair system and method for percutaneously fixing a first bone segment to a second bone segment, such as rib bone segments, in a body of a patient include drilling a first hole through the first bone segment and a second hole through the second bone segment, and feeding a first tether through the first hole and a second tether through the second hole, each tether having a proximal end and a distal end. The first and second tether distal ends are withdrawn from the body while the first and second tether proximal ends have not passed through the first and second bone segments, respectively. ... The Penn State Research Foundation

08/31/17 / #20170250442

Nanofilled solid polymer electrolytes

Embodiments of the disclosure relate to solid electrolytes comprising nanowhiskers. More particularly, embodiments of the disclosure relate to solid electrolytes comprising peo6lix crystalline complex and nanowhiskers to stabilize the peo6lix crystalline complex.. ... The Penn State Research Foundation

08/31/17 / #20170250433

Ammonia-based thermoelectrochemical systems and methods

Thermally regenerative ammonia-based battery systems and methods of their use to produce electricity are provided according to aspects described herein in which ammonia is added into an anolyte to charge the battery, producing potential between the electrodes. At the anode, metal corrosion occurs in the ammonia solution to form an ammine complex of the corresponding metal, while reduction of the same metal occurs at the cathode. ... The Penn State Research Foundation

08/24/17 / #20170239373

Generating gabaergic neurons in brains

This document provides methods and materials for generating gabaergic neurons in brains. For example, methods and materials for using nucleic acid encoding a neurod1 polypeptide and nucleic acid encoding a dlx2 polypeptide to trigger glial cells (e.g., ng2 glial cells or astrocytes) within the brain (e.g., striatum) into forming gabaergic neurons (e.g., neurons resembling medium spiny neurons such as darpp32-positive gabaergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided.. ... The Penn State Research Foundation

08/17/17 / #20170233819

Method and therapeutic use of pign and other genes or gene products that pign interacts with for prognosis and treatment of hematological neoplasias

The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan anchor biosynthesis protein, and providing an appropriate treatment or preventive measure, on the basis of this risk.. . ... The Penn State Research Foundation

08/17/17 / #20170232439

Separation of low-abundance cells from fluid using surface acoustic waves

An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided. ... The Penn State Research Foundation

08/10/17 / #20170226342

Compositions and methods related to proteins capable of reversible transition to a melt

Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (srt) protein and a plasticizer or a solvent to obtain a mixture of the srt protein and the plasticizer. ... The Penn State Research Foundation

08/10/17 / #20170224690

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy and tumor cells as an anticancer therapy

Methods and compositions relating to tic10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. ... The Penn State Research Foundation

08/03/17 / #20170216477

Composite materials

A composite material is formed by combining an expandable polymer having a charge with another polymer having an opposite charge to produce. In particular, the composite material can be prepared by combining the polymers with a medium such as and water, and expanding the mixture using a treatment that expands the mixture to produce, for example, insoluble porous foam-like composites.. ... The Penn State Research Foundation

07/27/17 / #20170209478

Encapsulation and high loading efficiency of phosphorylated drug and imaging agents in nanoparticles

Method of producing nanoparticle of drug and imaging agents are provided. The phosphorylated encapsulated drugs and imaging agents could be encapsulated at therapeutic levels, were encapsulated at higher amounts. ... The Penn State Research Foundation

07/27/17 / #20170209438

A compound for anti-cancer therapy that acts by targeting gof mutant p53 and stimulates p73 to restore the p53 pathway signaling

The invention includes compositions comprising nsc59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.. ... The Penn State Research Foundation

07/20/17 / #20170206988

Thermoacoustic enhancements for nuclear fuel rods and other high temperature applications

A nuclear thermoacoustic device includes a housing defining an interior chamber and a portion of nuclear fuel disposed in the interior chamber. A stack is disposed in the interior chamber and has a hot end and a cold end. ... The Penn State Research Foundation

07/20/17 / #20170202998

Antimicrobial polymers

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) an alkoxylated or alkenoxylated citric acid, citrate, or ester of citric acid, and optionally a non-alkoxylated and non-alkenoxylated citric acid, citrate, or ester of citric acid, with (ii) a polyol. ... The Penn State Research Foundation

07/13/17 / #20170201026

Antenna apparatus and communication system

An antenna includes a first body having a ring monopole and a second body positioned below the first body. The second body can have a plurality of notched ring resonators. ... The Penn State Research Foundation

06/22/17 / #20170179853

Energy harvesting device using electroactive polymer nanocomposites

An energy harvesting device includes: a first nanoporous electrode and a second nanoporous electrode, each of which is configured to which store electrical charge; a first current collector connected to the first nanoporous electrode and a second current collector connected to the second nanoporous electrode; and an enclosure that contains the first and second nanoporous electrodes and the first and second current collectors and transfers a force applied from the outside to the first nanoporous electrode and the second nanoporous electrode, wherein at least one of the first nanoporous electrode and the second nanoporous electrode comprises an ion conductive polymer.. . ... The Penn State Research Foundation

06/22/17 / #20170175258

Facile route to templated growth of two-dimensional layered materials

The present invention relates to methods for fabricating a laterally-limited two-dimensional structure through template synthesis. The methods of the invention are useful in forming homogenous and heterogeneous layered materials. ... The Penn State Research Foundation

06/22/17 / #20170175086

Paramyxovirus virus-like particles as protein delivery vehicles

Provided are modified virus-like particles (vlps) of paramyxoviruses, compositions containing them, methods of using the vlps for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting vlps, and methods for screening for anti-viral compounds using the vlps. The modified vlps contain a contiguous recombinant polypeptide that contains i) all or a segment of a c-terminal domain of a paramyxovirus nucleocapsid protein and ii) a polypeptide sequence of a distinct protein. ... The Penn State Research Foundation

06/15/17 / #20170166952

Polymer-based signal amplification for protein and cell detection

The present invention relates generally to compositions, methods and kits for detection of a molecule of interest. The present invention is based, at least in part, on the design of nucleic acid oligonucleotides such that they can be used as molecular building blocks which can be assembled (polymerized) to form a dsdna polymerization product which can be detected and further, can be disassembled (depolymerized) such that the polymerization product is no longer detectable. ... The Penn State Research Foundation

06/08/17 / #20170162325

High temperature dielectric materials, method of manufacture thereof and articles comprising the same

Disclosed herein is a dielectric composite comprising an organic polymer that has a glass transition temperature greater than or equal to about 250° c.; and a dielectric filler present in an amount effective to impart to the dielectric composite a dielectric constant that varies by less than 5% over a temperature range of 25° c. To 300° c., with an applied alternating electric field having a frequency of 104 hz and a maximum operating electric field strength of at least 250 megavolt per meter. ... The Penn State Research Foundation

06/08/17 / #20170159121

Genomic regions with epigenetic variation that contribute to phenotypic differences in livestock

The invention provides compositions and methods for selecting milk-producing livestock with a preferred phenotype. In one embodiment, the method includes detecting methylation status of one or more genes and gene regulatory regions in a sample to identify the preferred phenotype.. ... The Penn State Research Foundation

06/08/17 / #20170159013

Chemical reprogramming of human glial cells into neurons with small molecule cocktail

Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain crizotinib (cri), flurbiprofen, lithium chloride (li), vitamin c (vc), ceritinib (cer) or pirfenidone (pfd). ... The Penn State Research Foundation

06/08/17 / #20170158768

Compositions and methods for targeting of the surfactant protein a receptor

Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (spr) including the spr for surfactant proteins a (spa). Specific binding partners, including mono-clonal antibodies, for the sp-r210l and sp-r210s isoforms, and methods of using such binding partners are included. ... The Penn State Research Foundation

06/01/17 / #20170152283

Inhibitors of the farnesoid x receptor and uses in medicine

Disclosed are inhibitors of the farnesoid x receptor, for example of formula (i), wherein r1, r2, r4, x, y, z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a farnesoid x receptor in a mammal, and a method of treating or preventing obesity in a mammal.. ... The Penn State Research Foundation

05/11/17 / #20170131319

Automated sampling system

The automated sampling system has a water tight case that encloses a testing instrument. In the preferred embodiment, the testing instrument is a field-portable ion chromatography instrument designed to test water samples. ... The Penn State Research Foundation

05/04/17 / #20170121624

Self-healable coatings and methods of making the same

A robust and self-healing coating has been developed by incorporating a thermally self-healing chemical coating on smooth and/or roughened solid. When the chemically coated solid is combined with a lubricating fluid, the material system is capable to repel a broad range of liquids and solids. ... The Penn State Research Foundation

05/04/17 / #20170121363

Compounds, compositions and methods for coloring edible materials

The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. ... The Penn State Research Foundation

04/27/17 / #20170116369

Method for designing overall stoichiometric conversions and intervening metabolic reactions

The present invention describes a two-step computational procedure that both identifies the optimum overall stoichiometry of conversion, along with alternate co-reactant (or co-product) combinations, of a feedstock substrate to a biochemical product, and selects for (non-)native reactions accessed from a universal database to identify at least one stoichiometry-balanced minimal metabolic network, in terms of number of reactions or sum of the flux in the network, that maximize carbon or energy efficiency while satisfying thermodynamic feasibility requirements. A representation of the overall stoichiometry of conversion and the minimal metabolic network as designed can be stored.. ... The Penn State Research Foundation

04/27/17 / #20170112988

Smart tip lvad inlet cannula

Embodiments of the invention provide a left ventricular assist device (lvad) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide automatic speed control. A cannula may include two or more independent sensors. ... The Penn State Research Foundation

04/27/17 / #20170112136

Biofilms, components and methods of use to reduce biofouling and contamination

Biofilms are provided which are capable of regulating their own thickness, reducing contamination and preventing biofouling. Constructs are introduced into bacteria that comprise nucleic acid molecules encoding an autoinducer synthase polypeptide, a transcriptional regulator and a biofilm dispersal protein. ... The Penn State Research Foundation

04/20/17 / #20170109603

Automatically computing emotions aroused from images through shape modeling

Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. ... The Penn State Research Foundation

04/06/17 / #20170096717

Antibacterial and plasmid elimination agents

Inhibitors of the tmrna pathway have antibacterial activity with broad species specificity, including b. Anthracis and other pathogens of military and civilian interest. ... The Penn State Research Foundation

03/30/17 / #20170088471

Cold sintering ceramics and composites

Cold sintering of materials includes using a process of combining at least one inorganic compound, e.g., ceramic, in particle form with a solvent that can partially solubilize the inorganic compound to form a mixture; and applying pressure and a low temperature to the mixture to evaporate the solvent and densify the at least one inorganic compound to form sintered materials.. . ... The Penn State Research Foundation

03/23/17 / #20170083608

Accelerated discrete distribution clustering under wasserstein distance

Computationally efficient accelerated d2-clustering algorithms are disclosed for clustering discrete distributions under the wasserstein distance with improved scalability. Three first-order methods include subgradient descent method with re-parametrization, alternating direction method of multipliers (admm), and a modified version of bregman admm. ... The Penn State Research Foundation

03/23/17 / #20170080404

Polyolefin interpenetrated network material for hydrocarbon recovery

Interpenetrated polyolefin network for use in recovering or containing hydrocarbons such as hydrocarbons contained in oil, are disclosed. Advantageously, the interpenetrated polyolefin networks absorb the hydrocarbon, including viscous hydrocarbons and crude oils, to form a gel that can be collected and processed by heat to release the collected hydrocarbons.. ... The Penn State Research Foundation

03/23/17 / #20170080125

Methods of promoting bone growth and healing

In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method described herein comprises disposing a graft or scaffold in a bone growth site. ... The Penn State Research Foundation

03/23/17 / #20170079936

Compositions and methods relating to proliferative diseases

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. ... The Penn State Research Foundation

03/09/17 / #20170069970

Antenna apparatus and communication system

An antenna apparatus can include a transmission medium that is positioned within layers of an antenna apparatus that are positioned adjacent to a first upper layer that is configured to include a signal receiving and transmission element (e.g. An antenna, patch antenna, etc.). ... The Penn State Research Foundation

03/09/17 / #20170068795

Compositions and methods for assessing risk of autism spectrum disorder during early childhood

The invention includes an early detection system for asd that combines the assessment of various factors and comorbid conditions to accurately generate a prediction model for assessing the degree of asd.. . ... The Penn State Research Foundation

03/09/17 / #20170067912

Compositions and methods for diagnosing barrett's esophagus stages

Provided is an immunohistochemistry panel that facilitates the discrimination between the early and late stages of barret's esophagus in a method that involves testing a biological sample for expression of cdx2, p120ctn, c-myc and jagged1 proteins, comparing the amount of the cdx2, p120ctn, c-myc and jagged1 proteins to reference values, and providing a diagnosis of or aiding in a physician's diagnosis, of the individual as having high-grade dysplasia (hgd) or esophageal adenocarcinoma (eac) by determining less cdx2 protein relative to non-dysplastic barrett's esophagus (nd-be) and low-grade dysplasia (lgd) cdx2 protein values, but more cdx2 protein than a normal cdx2 protein reference value; and less p120ctn protein relative to nd-be, lgd and normal 120ctn protein reference values; and increased c-myc protein relative to nd-be and lgd protein reference values; and increased jagged1 protein relative to normal and nd-be jagged1 protein reference values. Kits for making the protein determinations are also provided.. ... The Penn State Research Foundation

03/09/17 / #20170065728

Self-powered enzyme micropumps

Drug delivery devices, sensors, and micropumps provided herein can utilize a reaction of an analyte triggered by an enzyme to drive fluid flow. In some cases, a drug delivery device can include a reservoir including a drug (e.g., insulin) and have an enzyme (e.g., glucose oxidase) positioned adjacent to said reservoir. ... The Penn State Research Foundation

03/02/17 / #20170059454

3d laser ablation tomography

A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. ... The Penn State Research Foundation

02/16/17 / #20170045690

Optical scramblers

The disclosure features optical scramblers that can be used with spectrographs and other optical measurement systems, including doppler-based radial velocity measurement systems and other precision spectroscopy. In one aspect, an optical scrambler includes a first fiber configured to receive measured light from an optical collection system, a second fiber configured to deliver the measured light to a detection system, and an optical coupling element positioned between a light output surface of the first fiber and a light input surface of the second fiber and configured to deliver the measured light from the first fiber to the second fiber. ... The Penn State Research Foundation

02/09/17 / #20170038285

Sizable tunable enrichment platform for capturing nano particles in a fluid

The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. ... The Penn State Research Foundation

01/26/17 / #20170023384

Intrusion detection system for an undersea environment

An intrusion detection system includes a suspended optical fiber having a neutral buoyancy and an optical time-domain reflectometer connected to the suspended optical fiber at an origin location. The suspended optical fiber is connected to a mooring at a first end of the suspended optical fiber and further includes at least one terminal end. ... The Penn State Research Foundation

01/26/17 / #20170022587

Carbon-based nanotube/metal composite and methods of making the same

A nanocomposite comprising metal and carbon-based nanotube (cnt), wherein the carbon-based nanotube comprises a doping element selected from the group consisting of boron (b), iron (fe), zinc (zn), nickel (ni), cadmium (cd), tin (sn), antimony (sb), nitrogen (n) and the combination thereof, and methods of making the nanocomposite.. . ... The Penn State Research Foundation

01/26/17 / #20170020768

Neonatal chest splint for applying negative distending pressure

The present invention relates to devices and methods for assisting breathing in a subject. In one embodiment, the device of the present invention is a splint that can be used to apply negative distending pressure, i.e., outward pull, to one or both of the chest walls and/or the abdomen of a subject. ... The Penn State Research Foundation

01/19/17 / #20170016008

Design of mrna sequences to control co-translational folding of proteins

This invention relates to optimized heterologous production of properly folded and functional proteins. The present invention provides systems and methods involving determination of the optimal mrna sequence, based on the underlying rates at which codons are translated and folding kinetic of nascent-protein, that maximizes co-translational protein folding of domains in order to maximize the proper folding and quality of the protein produced. ... The Penn State Research Foundation

01/12/17 / #20170012351

Antenna apparatus and communication system

An antenna includes a first body having an array of resonators; a spacer adjacent to the first body, and a second body adjacent to the spacer such that the spacer is between the first and second bodies. The first body can be configured as an artificial metasurface ground plane and the second body can be configured as a monopole.. ... The Penn State Research Foundation

01/05/17 / #20170003471

Composite cable assembly with neutral buoyancy

An above bottom fiber (abf) cable includes an elongated fiber cable having microspheres adhered to the abf by an adhesive lightly coated to the outer surface of the abf. The elongated fiber is negatively buoyant while the microspheres and adhesives are positively buoyant, resulting in the abf being controllably buoyant in a fluid environment. ... The Penn State Research Foundation

01/05/17 / #20170000790

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy

Methods and compositions relating to tic10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. ... The Penn State Research Foundation








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