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The Rockefeller University patents


Recent patent applications related to The Rockefeller University. The Rockefeller University is listed as an Agent/Assignee. Note: The Rockefeller University may have other listings under different names/spellings. We're not affiliated with The Rockefeller University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Rockefeller University-related inventors


Crispr-cas component systems, methods and compositions for sequence manipulation

. . The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... The Rockefeller University

Tri-specific antibodies for hiv therapy

Provided are tri-specific fusion antibodies created to target multiple epitopes of the human immunodeficiency virus (hiv). The fusion antibodies provide improved potency and breadth against hiv as compared to monospecific and bispecific antibodies, and additionally provide a high barrier against viral resistance. ... The Rockefeller University

Anti-inflammatory polypeptides

This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.. . ... The Rockefeller University

Anti-tumor agents and methods of use

The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.. ... The Rockefeller University

Methods and compositions for translational profiling and molecular phenotyping

Methods and compositions are provided for translational profiling and molecular phenotyping of specific tissues, cells and cell subtypes of interest. The methods provided herein facilitate the analysis of gene expression in the selected subset present within a heterogeneous sample.. ... The Rockefeller University

Treatment and diagnosis of melanoma

The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.. ... The Rockefeller University

Anti-inflammatory agents

This invention concerns anti-inflammatory agents and methods for treating inflammatory disorders. Also disclosed are methods for identifying or evaluating anti-inflammatory agents or compositions.. ... The Rockefeller University

Method of rna isolation from clinical samples

The disclosure provides methods for isolating nucleic acids from a biological fluid. In one aspect, the disclosure provides a method for isolating rna. ... The Rockefeller University

Immune complex

The present invention relates to immunogenic immune complexes, related compositions, and related methods. This invention addresses the above-described un-met need by providing an immune complex (ic) or immune complexes (ics), which take advantages of type ii fc receptor (fcr) interactions and signaling to elicit broader and more potent protective immune responses. ... The Rockefeller University

Anti-inflammatory polypeptides

This invention concerns anti-inflammatory agents, compositions, and methods for treating inflammatory disorders.. . ... The Rockefeller University

Anti-mertk agonistic antibodies and uses thereof

The present disclosure provides antibodies that specifically bind to mer tyrosine kinase (mertk) (e.g., human mertk, or both human and mouse mertk) and compositions comprising such antibodies, wherein said antibody agonizes mertk signaling on endothelial cells. The present disclosure also provides methods for treating cancer, by administering an antibody that specifically binds to mertk and agonizes mertk signaling on endothelial cells.. ... The Rockefeller University

Compositions and methods for use in diagnosis of alzheimer's disease

Provided are compositions and methods useful in the diagnosis of alzheimer's disease (ad). The methods involve immunologically testing a b biological samples for an amount of high molecular weight kininogen (hk) and cleaved high molecular weight kininogen (hkc), wherein determining less hk relative to a normal control, or determining more hkc relative to a normal control, or a combination thereof, aids in diagnosis of ad. ... The Rockefeller University

Treatment of angiogenesis disorders

This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.. ... The Rockefeller University

Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes

The present disclosure relates to adenovirus protein modifications to augment immune response to a transgene of a recombinant adenovirus and to circumvent pre-existing anti-adenovirus immunity. Some embodiments are directed to a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding a plasmodium circumsporozoite protein, or antigenic portion thereof, operably linked to a heterologous promoter and a modified capsid or core protein, wherein an immunogenic epitope of plasmodium circumsporozoite is inserted into or replaces at least part of a capsid or core protein. ... The Rockefeller University

11/09/17 / #20170320935

Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods

The invention provides a polypeptide containing at least one igg fc region, wherein said at least one igg fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.. . ... The Rockefeller University

11/09/17 / #20170319525

Treatment and diagnosis of melanoma

The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods.. ... The Rockefeller University

10/26/17 / #20170306346

Improved agronomic characteristics under water limiting conditions for plants expressing pub10 polypeptides

The present invention provides methods and compositions for modulating drought tolerance and/or other agronomic traits in plants. This invention relates to compositions and methods for down-regulating the level and/or activity of pub10 in plants for creation of plants with improved abiotic stress tolerance, preferably improved drought tolerance. ... The Rockefeller University

10/05/17 / #20170283492

Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods

The invention provides a polypeptide containing at least one igg fc region, wherein said at least one igg fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.. . ... The Rockefeller University

09/07/17 / #20170253659

Antibodies to cd40 with enhanced agonist activity

Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human cd40. Such antibodies optionally comprise fc regions with enhanced specificity for fcγriib. ... The Rockefeller University

09/07/17 / #20170252328

Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines

Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by sonic hedgehog are disclosed. The method involves exposing the cells to 5-acyl-6,7-dihydrothieno[3,2-c]pyridines of formula i. ... The Rockefeller University

08/31/17 / #20170247463

Modulating agonistic tnfr antibodies

The instant invention relates to agents (e.g., agonistic antibodies) able to stimulate the immune system of a mammalian animal and activate target-cell specific t lymphocyte responses. Such agents may be identified based on the ability to engage a receptor from the tnfr superfamily and thereby mimic the natural ligand for the receptor from the tnfr superfamily. ... The Rockefeller University

08/17/17 / #20170233729

Compositions and methods for transcription-based crispr-cas dna editing

Provided are compositions and methods for cleaving a dna sequence in a cell. The methods involve comprising introducing into a cell a recombinant vector containing a clustered regularly interspaced short palindromic repeats (crispr) system. ... The Rockefeller University

08/03/17 / #20170218050

Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods

The invention provides a polypeptide containing at least one igg fc region region, said polypeptide having a higher anti-inflammatory activity and a lower cytotoxic activity as compared to an unpurified antibody and methods of production of such polypeptide.. . ... The Rockefeller University

07/27/17 / #20170212130

Compositions and methods for rapid production of versatile nanobody repertoires

Provided are compositions and methods for producing large repertoires of recombinant nanobodies with high affinities and specificities against any antigen. Included are methods for making and identifying nanobodies produced by camelids, the nanobodies themselves, modifications of the nanobodies, expression vectors encoding the nanobodies, cdnas encoding the nanobodies, cells comprising the expression vectors and/or cdna, and methods of making the nanobodies recombinantly. ... The Rockefeller University

07/27/17 / #20170210786

Combination of broadly neutralizing hiv antibodies and viral inducers

The present invention relates to methods and agents for preventing the establishment of hiv-1 latent reservoirs or for reducing the size of the reservoirs. Specifically, the disclosure provides methods and agents for preventing the establishment of hiv-1 latent reservoirs or for reducing the size of the reservoirs, the methods comprising administering to the subject a therapeutically effective amount of an isolated anti-hiv antibody, and administering to the subject two or more viral transcription inducers in effective amounts to induce transcription of an hiv provirus in the cells. ... The Rockefeller University

06/22/17 / #20170175142

Crispr-cas systems and methods for altering expression of gene products

. . The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are vectors and vector systems, some of which encode one or more components of a crispr complex, as well as methods for the design and use of such vectors. ... The Rockefeller University

05/11/17 / #20170130214

Acinetobacter lysins

Acinetobacter lysin polypeptides and variants peptides with killing activity against gram negative bacteria. Methods for treating bacterial infections or bacterial colonization using acinetobacter lysin polypeptides.. ... The Rockefeller University

03/30/17 / #20170088608

Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods

The invention provides a polypeptide containing at least one igg fc region, wherein said at least one igg fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α 2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.. . ... The Rockefeller University








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