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The Scripps Research Institute patents


Recent patent applications related to The Scripps Research Institute. The Scripps Research Institute is listed as an Agent/Assignee. Note: The Scripps Research Institute may have other listings under different names/spellings. We're not affiliated with The Scripps Research Institute, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Scripps Research Institute-related inventors


 new patent  Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject

Methods are provided for detecting circulating tumor cells in a mammalian subject. Methods of diagnosing cancer in a mammalian subject are provided. ... The Scripps Research Institute

 new patent  Polymerization of silyl- and fluoro-containing monomers

Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a bifluoride or poly(hydrogen fluoride) fluoride salt. ... The Scripps Research Institute

 new patent  Engineered outer domain (eod) of hiv gp120, mutants and use thereof

The present invention relates to engineered outer domain (eod) immunogens of hiv gp120 and mutants thereof and methods of making and using the same. The present invention also includes fusions of eod to various protein multimers to enhance immunogenicity. ... The Scripps Research Institute

Long adapter single stranded oligonucleotide (lasso) probes to capture and clone complex libraries

Long adapter single strand oligonucleotide (lasso) probes that can be used to capture and clone thousands of kilobase-sized dna fragments in a single reaction, as well as methods of generating the same.. . ... The Scripps Research Institute

Combined chemical and genetic approaches for generation of induced pluripotent stem cells

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.. . ... The Scripps Research Institute

Small molecule analogs of the nemo binding peptide

The invention is directed to a method of inhibiting, within a living cell, the interaction between nf-κb essential modulator (“nemo”) with iκb kinase-β (ikk-β) at the nemo binding domain (nbd), comprising exposing the cell to an effective amount or concentration of a compound of the invention, a nemo-binding domain analog (nbda). The invention is further directed to a method of treating a condition in a patient, wherein inhibiting the interaction between nf-κb essential modulator (“nemo”) with iκb kinase-β (ikk-β) at the nemo binding domain (nbd) is medically indicated, comprising administering to the patient an effective dose of a compound of the invention. ... The Scripps Research Institute

Induction of pluripotent cells

The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (ipscs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of ipsc generation from human fibroblasts, within seven days of treatment. ... The Scripps Research Institute

Natural antisense and non-coding rna transcripts as drug targets

Small interfering rna (sirna) knock down antisense transcripts, and regulate the expression of their sense partners. This regulation can either be discordant (antisense knockdown results in sense transcript elevation) or concordant (antisense knockdown results in concomitant sense transcript reduction).. ... The Scripps Research Institute

Methods of enhancing cell survival of stem cells

The present invention relates compounds for stabilizing cells and methods of their use.. . ... The Scripps Research Institute

Proximity based methods for selection of binding partners

The invention provides methods for identifying binding partners (e.g., peptide ligands) that binds to a target protein (e.g., a cellular receptor). The methods entail co-localized expression of the target protein and candidate binding partners, and selection of binding partners based on their proximity in the plasma membrane.. ... The Scripps Research Institute

Systems and methods for genomic annotation and distributed variant interpretation

A computer-based genomic annotation system, including a database configured to store genomic data, non-transitory memory configured to store instructions, and at least one processor coupled with the memory, the processor configured to implement the instructions in order to implement an annotation pipeline and at least one module filtering or analysis of the genomic data.. . ... The Scripps Research Institute

Chimeric antigen receptor t cell switches and uses thereof

Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (car-ecs). The switches generally comprise a chimeric antigen receptor-interacting domain (car-id) and a target interacting domain (tid). ... The Scripps Research Institute

Method of using non-rare cells to detect rare cells

The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (ctcs). The invention is applicable at two distinct stages of ctc detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. ... The Scripps Research Institute

Novel kappa opioid ligands

The invention provides novel ligands of kappa (κ) opioid receptors, such as can be used to modulate a kappa opioid receptor. Methods of synthesis and methods of use are also provided. ... The Scripps Research Institute

03/29/18 / #20180089049

Modularly assembled small molecules for the treatment of myotonic dystrophy type 1

Transcriptomes provide a myriad of potential rnas that could be the targets of therapeutics or chemical genetic probes of function. Cell permeable small molecules, however, generally do not exploit these targets, owing to the difficulty in the design of high affinity, specific small molecules targeting rna. ... The Scripps Research Institute

03/29/18 / #20180086820

Enantiopure haptens for nicotine vaccine development

The invention provides chiral haptens (−)-3′-amnic and (−)-n4n for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation.. ... The Scripps Research Institute

03/22/18 / #20180080026

Cell-specific internalizing rna aptamers against human ccr5 and uses therefore

Provided herein are fluoropyrimidine-modified rna aptamers capable of binding ccr5. The compositions and methods provided herein are, inter alia, useful for the delivery of antiviral drugs (e.g., sirnas) and preventing hiv entry into a target cell.. ... The Scripps Research Institute

03/08/18 / #20180065976

Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. ... The Scripps Research Institute

02/08/18 / #20180037532

Recovery process for functionalized compound reaction product

. . Provided is a process for recovery of a functionalized compound reaction product comprising contacting (i) an oxidizing electrophile comprising a main group element, and (ii) a compound comprising at least one c—h bond, in an acidic medium to form a reaction milieu comprising a functionalized compound reaction product, contacting the reaction milieu with a water-immicible organic solvent, separating the water-immiscible organic solvent from the reaction milieu, wherein the functionalized compound reaction product is dissolved in the water-immiscible organic solvent, and separating the functionalized compound reaction product and the water-immiscible organic solvent. The water-immiscible extraction solvent can be the same compound as the compound comprising as least one c—h bond, for example, propane or n-butane.. ... The Scripps Research Institute

01/11/18 / #20180009823

Anticancer drug candidates

Enediyne compounds having a structure according to formula (i), where r1, r2, r3, r4, r5, r6, r7 and x are defined herein.. . ... The Scripps Research Institute

01/11/18 / #20180009792

Chromenone inhibitors of monocarboxylate transporters

The invention provides compounds effective as inhibitors of monocarboxylate transporters such as mct1 and mct4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on mct1, mct4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type ii diabetes.. ... The Scripps Research Institute

01/11/18 / #20180009770

Novel modulators of sphingosine phosphate receptors

Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphingosine-1-phosphate receptor subtype 3. ... The Scripps Research Institute

01/11/18 / #20180009739

Ligand-enabled meta-c-h activation using a transient mediator

An alternative approach to formation of a c-c bond at a meta-position of an aromatic compound is disclosed that employs an ethylenically unsaturated bicyclic compound as a transient mediator to achieve meta-selective c-h activation with a simple and common ortho-directing group. The use of a pyridine-based ligand assists in relaying the palladium catalyst to the meta-position by the unsaturated bicyclic compound following initial ortho-c-h activation.. ... The Scripps Research Institute

01/11/18 / #20180008605

Pteridine dione monocarboxylate transporter inhibitors

The invention provides compounds effective as inhibitors of monocarboxylate transporters such as mct1 and mct4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on mct1, mct4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type ii diabetes.. ... The Scripps Research Institute

01/04/18 / #20180002671

Chemical approaches for generation of induced pluripotent stem cells

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.. . ... The Scripps Research Institute

01/04/18 / #20180002425

Methods and compositions related to modulators of eukaryotic cells

The invention provides methods for identifying protein modulators (e.g., antibody agonists) of eukaryotic cells. The methods typically involve expressing a combinatorial agent library (e.g., via lentiviral vectors) inside a eukaryotic cell type (e.g., a mammalian cell) and then directly selecting for agents (e.g., antibodies) that are agonist of a target molecule (e.g., a signaling receptor) that modulates a phenotype of or elicits a cellular response in the cell. ... The Scripps Research Institute

01/04/18 / #20180002343

Heterocyclic inhibitors of monocarboxylate transporters

The invention provides compounds that inhibit monocarboxylate transporters, such as mct1 and mct4. Compounds of the invention can be used for treatment of a condition in a patient, wherein the condition is characterized by the heightened activity or by the high prevalence of mct1 and/or mct4, such as cancer or type ii diabetes.. ... The Scripps Research Institute

12/21/17 / #20170362211

Small molecule inhibitors of fibrosis

Described herein are compounds and compositions for the treatment of a fibrotic disease.. . ... The Scripps Research Institute

12/07/17 / #20170349595

Small molecule myristate inhibitors of bcr-abl and abl and methods of use

The present invention provides novel heteroaryl compounds of formula (i) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.. ... The Scripps Research Institute

11/16/17 / #20170327512

Modulators of vasopressin receptors with therapeutic potential

Compounds comprising piperazines, piperidines, spiro-furanopiperidines, and analogs thereof are provided that are modulators, such as positive allosteric modulators, of one or more subclasses of vasopressin receptors. The compounds can be selective modulators of one or more subclasses of vasopressin receptors. ... The Scripps Research Institute

11/09/17 / #20170320921

Protein m related immunoglobulin-binding polypeptides

The invention relates to a group of isolated polypeptides and derivatives that can bind genetically to immunoglobulins or antibodies. The invention also relates to industrial and other applications of these molecules, e.g., antibody purifications.. ... The Scripps Research Institute

10/26/17 / #20170305899

Antibiotic compounds and compositions, and methods for identification thereof

Disclosed herein are compounds and methods for inhibiting bacterial dna repair enzymes, including addab and recbcd helicase-nucleases. Pharmaceutical compositions and methods for treating a subject with an antibacterial agent are also disclosed herein.. ... The Scripps Research Institute

10/12/17 / #20170292129

Treatment of c9ftd/als by targeting rna expanded repeat sequences

A repeat expansion in c90rf72 causes frontotemporal dementia and amyotrophic lateral sclerosis (c9ftd/als). Rna of the expanded repeat (r(ggggcc)exp) forms nuclear foci or undergoes repeat-associated non-atg (ran) translation producing “c9ran proteins”. ... The Scripps Research Institute

10/05/17 / #20170283776

Reprogramming cells

The present invention provides for methods, compositions, and kits for producing an induced pluripotent stem cell from a non-pluripotent mammalian cell using a 3′-phosphoinositide-dependent kinase-1 (pdk1) activator or a compound that promotes glycolytic metabolism as well as other small molecules.. . ... The Scripps Research Institute

09/28/17 / #20170275222

Process for the functionalization of heteroalkanes and arenes

Provided are methods and materials for the functionalization of a heteroalkane or arene using an oxidizing electrophile as a stoichiometric agent or catalyst. The reaction involves the replacement of a hydrogen atom on an sp3-hybridized carbon atom of the heteroalkane or of a hydrogen atom on an sp2-hybridized carbon atom of the arene. ... The Scripps Research Institute

09/14/17 / #20170260502

Generation and maintenance of stem cells

The present invention provides for the generation and maintenance of pluripotent cells by culturing the cells in the presence of an alk5 inhibitor.. . ... The Scripps Research Institute

09/07/17 / #20170255743

Systems and methods for genomic annotation and distributed variant interpretation

A computer-based genomic annotation system, including a database configured to store genomic data, non-transitory memory configured to store instructions, and at least one processor coupled with the memory, the processor configured to implement the instructions in order to implement an annotation pipeline and at least one module filtering or analysis of the genomic data.. . ... The Scripps Research Institute

08/24/17 / #20170241984

High-throughput screening for compounds modulating expression of cellular macromolecules

A method of screening for compounds that module expression of specific macromolecules, the “target”. The method is particularly useful in that it does not require separation of target-bound and excess ligand and therefore enables, but is not limited to, high throughput screening for compounds that increase or decrease the levels or amounts of a target present in a biological sample. ... The Scripps Research Institute

08/17/17 / #20170234859

Specific targeting of rna expanded repeat sequences

The present invention provides small molecule compounds that can form covalent adducts with specific sequences of rna, such as the hairpin loop r(cug)exp sequence which is a cause of myotonic dystrophy type 1 (dm1), or the r(cgg)exp sequence which is a cause of fragile x-associated tremor/ataxia syndrome (fxtas); to methods of making the small molecule compounds; and to methods of using the small molecular compounds in the treatment of dm1 or of fxtas in patients afflicted therewith. The invention further provides a method for identifying an rna target of a small molecule drug in vivo, using a small molecule drug conjugated to an rna-reactive crosslinker group and a reporter group, contacting a cell or nucleic acid extract with the small molecule drug conjugate, then separating rna targets crosslinked to the small molecule drug conjugate by interaction of the affinity group with a complementary affinity group.. ... The Scripps Research Institute

08/10/17 / #20170226121

Modulators of virus assembly as antiviral agents

In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis b virus (hbv) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the hbv capsid structure and methods for their use are described.. ... The Scripps Research Institute

08/10/17 / #20170224838

Nanoparticle-based tumor-targeted drug delivery

An aqueous tumor-targeting liposome nanoparticle composition comprises an aqueous dispersion of liposome nanoparticles. The nanoparticles preferably encapsulate an anti-cancer chemotherapeutic agent, which can be added to a pre-formed liposome composition or can be incorporated in the liposomes during the formation of the liposomes. ... The Scripps Research Institute

08/03/17 / #20170218127

Polymerization method and polymers formed therewith

Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a basic catalyst. ... The Scripps Research Institute

08/03/17 / #20170217963

Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders

The invention provides compounds effective as sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.. . ... The Scripps Research Institute

08/03/17 / #20170217943

Small molecule inhibitors of fibrosis

Described herein are compounds and compositions for the treatment of a fibrotic disease.. . ... The Scripps Research Institute

07/27/17 / #20170210818

Constant region antibody fusion proteins and compositions thereof

Disclosed herein are antibody fusion constructs and uses thereof. The antibody fusion construct may comprise an antibody fusion protein. ... The Scripps Research Institute

07/20/17 / #20170202822

Methods and compositions for enhancing cancer therapy

The present invention provides methods and compositions for enhancing efficacy of anti-hormone treatment, or for preventing cancer relapse or progression following treatment. The invention also provides methods for re-sensitizing or sensitizing treatment resistant cancer cells or patients with treatment-refractory cancer cells to continuing or starting anti-hormone treatment. ... The Scripps Research Institute

07/13/17 / #20170196985

Sulfur(vi) fluoride compounds and methods for the preparation thereof

This application describes a compound represented by formula (i): (i) wherein: y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; z is o, nr, or n; x1 is a covalent bond or —ch2ch2—, x2 is o or nr; and r comprises h or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.. ... The Scripps Research Institute

07/13/17 / #20170196964

Novel arenavirus vaccine

The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated virus (lav), wherein the lav is a codon deoptimized (cd) arenavirus.. . ... The Scripps Research Institute

07/06/17 / #20170192003

Compositions and methods for fluid biopsy of melanoma

The present invention provides methods for identifying circulating melanoma cells (cmcs) in a biological sample and methods for diagnosing metastatic melanoma in a subject. The methods disclosed can be used on non-enriched blood samples to identify cmc using detectable agents that are specific for a biomarker of cmcs and assessing the morphology of the cells having the detectable agents. ... The Scripps Research Institute

07/06/17 / #20170190669

Pyrazole compounds and methods of making and using same

Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of one or more of magl, abhd6, and faah. ... The Scripps Research Institute

06/29/17 / #20170183353

N-hydroxy bicyclic hydantoin carbamates as tools for indetification of serine hydrolase targets

Provided herein are n-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. ... The Scripps Research Institute

06/15/17 / #20170165333

Compositions and methods for inducing immune tolerance

The present invention provides liposomal compositions for inducing immune tolerance. The compounds typically comprise a liposome displaying a specific antigen and also a binding moiety for a sialic acid binding ig-like lectin (siglec) expressed on b cells. ... The Scripps Research Institute

06/08/17 / #20170159019

Reprogramming of cells to a new fate

The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.. ... The Scripps Research Institute

06/01/17 / #20170152291

N- (hydrophobe-substituted) vancosaminyl [psi-[c(=nh) nh] tpg4] vancomycin and [psi-[ch2nh]tpg4] vancomycin

The total synthesis and evaluation of key analogs of vancomycin containing single atom changes in the binding pocket are disclosed as well as their peripherally modified, n-(hydrophobe-substituted) derivatives exemplified by a n-4-(4′-chlorob-phenyl)-methyl derivative and their pharmaceutically acceptable salts are disclosed. Their evaluation indicates the combined pocket and peripherally modified analogs exhibit a remarkable spectrum of antimicrobial activity and truly impressive potencies against both vancomycin-sensitive and -resistant bacteria, and likely benefit from two independent and synergistic mechanisms of action. ... The Scripps Research Institute

04/27/17 / #20170115303

Cysteine reactive probes and uses thereof

Disclosed herein are methods, compositions, probes, polypeptides, assays, and kits for identifying a cysteine containing protein as a binding target for a small molecule fragment. Also disclosed herein are methods, compositions, and probes for mapping a biologically active cysteine site on a protein and screening a small molecule fragment for interaction with a cysteine containing protein.. ... The Scripps Research Institute

04/27/17 / #20170112843

Compounds and methods for inducing chondrogenesis

The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.. . ... The Scripps Research Institute

04/20/17 / #20170107275

Enantiopure haptens for nicotine vaccine development

The invention provides chiral haptens (−)-3′-amnic and (−)-n4n for use in generating antibodies in a patient specific for (−)-nicotine. The haptens can be conjugated to suitable carrier proteins and administered as an antigenic mixture, optionally comprising adjuvant(s), to a patient suffering from nicotine or tobacco addiction or habituation.. ... The Scripps Research Institute

04/20/17 / #20170107221

Pharmacophore for trail induction

There are disclosed imidazolinopyrimidinone compounds that have activity to induce trail gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of formula i herein. ... The Scripps Research Institute

04/13/17 / #20170101400

Trail enhancers for the selective killing of cancer cells

The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor cell, by administration of an effective amount of an n-acyl homoserine lactone analog (ahl), optionally in conjunction with a tumor modulating agent such tumor necrosis factor (tnf) related apoptosis inducing ligand (trail) to the patient. Novel bioactive analogs of an n-acyl homoserine lactone are also provided.. ... The Scripps Research Institute

04/06/17 / #20170095524

Methods for modulating cancer cells and stem cells

The present invention provides methods for modulating pluripotency of stem cells and proliferation of cancer cells. The modulation is achieved by promoting dephosphorylation of mrna-binding protein 3 (rbm3) and down-regulating expression or cellular level of pluripotency factor lin28. ... The Scripps Research Institute

03/23/17 / #20170081640

Combined chemical and genetic approaches for generation of induced pluripotent stem cells

The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.. . ... The Scripps Research Institute

02/23/17 / #20170050941

Novel modulators of sphingosine phosphate receptors

Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. ... The Scripps Research Institute

02/09/17 / #20170035877

Soluble hiv-1 envelope glycoprotein trimers

The present application relates to novel hiv-1 envelope glycoproteins which may be utilized as an hiv-1 vaccine immunogens, antigens for crystallization and for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions which are formulated into the vaccines of the present invention.. ... The Scripps Research Institute

02/02/17 / #20170029829

Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters

A recombinantly expressed nucleotide triphosphate transporter efficiently imports the triphosphates of unnatural nucleotides into cells, and the endogenous cellular machinery incorporates those nucleotides into cellular nucleic acids. Ubps can therefore form within the cell's nucleic acids. ... The Scripps Research Institute

01/12/17 / #20170009250

Production of therapeutic proteins in photosynthetic organisms

The present disclosure relates to methods of expressing therapeutic proteins in photosynthetic organisms and the therapeutic proteins produced by the methods. The therapeutic proteins include high-mobility group box 1 (hmgb1) protein, fibronectin domain (10) (10fn3), fibronectin domain (14) (14fn3), interferon beta (ifnβ), proinsulin and vascular endothelial growth factor (vegf). ... The Scripps Research Institute

01/05/17 / #20170002148

Polymerization method and polymers formed therewith

Condensation of fluoro-substituted and silyl-substituted monomers provides polymers suitable for use, e.g., as engineering polymers. A monomer composition is condensed in the presence of a basic catalyst. ... The Scripps Research Institute

01/05/17 / #20170002076

Targeting agent antibody conjugates and uses thereof

Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two or more different receptors, co-receptors, antigens, or cell markers on one or more cells. ... The Scripps Research Institute








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