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The Translational Genomics Research Institute patents


Recent patent applications related to The Translational Genomics Research Institute. The Translational Genomics Research Institute is listed as an Agent/Assignee. Note: The Translational Genomics Research Institute may have other listings under different names/spellings. We're not affiliated with The Translational Genomics Research Institute, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Translational Genomics Research Institute-related inventors


Systems and methods for obtaining biological molecules from a sample

The present invention relates to a method of creating a biomarker profile, the method comprising the steps of: obtaining a sample of biofluid from a subject, wherein the sample is stored on a sample collection apparatus; removing the sample from the sample collection apparatus; extracting nucleic acids from the sample; sequencing the extracted nucleic acids to generate sequence data; and analyzing the sequence data using a two-step analytical methodology to create the biomarker profile. The present invention athletic performance in a subject.. ... The Translational Genomics Research Institute

Systems and methods for treating cancer

Embodiments of the invention provide a method of treating cancer, the method comprising providing a subject having cancer cells, and contacting the cancer cells with a therapeutically effective amount of a g2/m checkpoint inhibitor. Embodiments of the invention also provide a method of treating cancer in a subject, the method comprising the steps of: (a) receiving a sample of the cancer cells from the subject; (b) determining if at least a portion of the sample of the cancer cells is lkb 1 deficient; and (c) contacting the cancer cells with a therapeutically effective amount of a g2/m checkpoint inhibitor.. ... The Translational Genomics Research Institute

Methods for detecting and treating fungal infections

Methods are provided to detect and treat a fungal infection. The method may include the steps of obtaining a sample from a subject suspected of having a fungal infection, detecting an uncharacterized fungal protein (cimg_09001/cpsg_01366) in the sample, and determining the presence on the fungal infection if the uncharacterized fungal protein is detected.. ... The Translational Genomics Research Institute

Quality assessment of circulating cell-free dna using multiplexed droplet digital pcr

The present invention provides a method of determining integrity and/or quantity of cell free dna (cfdna) in a bio logical sample comprising amplifying target sequences with at least a first primer/probe set and at least a second primer probe/set, amplifying the target sequences of differing lengths, and monitoring for detection of the labels of the oligonucleotide probes, and determining the integrity and/or quantity of the cfdna based on the level of detection of the label of the oligonucleotide probe from the first primer/probe set compared to the level detection of the label of the oligonucleotide probe from the second primer/probe set. The present invention also provides methods for generating a library with the cfdna for sequencing and analysis.. ... The Translational Genomics Research Institute

Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers

The present invention provides a method of diagnosing a breast cancer central nervous system (cns) metastasis in a subject, comprising determining the expression level of at least one biomarker in a subject-derived brain or breast tissue comparing the subject-derived expression level with a normal control level obtained from normal brain or breast cells; and correlating an increase or decrease of the subject-derived expression level as compared to the normal control level to a diagnosis of a breast cancer cns metastasis. The present invention also provides a method for the treatment of a breast cancer cns metastasis in a subject comprising administering to the subject an inhibitor of an overexpressed gene associated with cns metastasis.. ... The Translational Genomics Research Institute

Methods and kits used in classifying adrenocortical carcinoma

The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients.. . ... The Translational Genomics Research Institute

Method of characterizing sequences from genetic material samples

Among other aspects provided herein is a method describing the use of single nucleotide polymorphism (snp) genotyping microarrays to resolve whether genetic material (such as genomic dna) derived from a particular individual is present in a genetic material mixture (such as a complex genomic dna mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic material (such as genomic dna) of specific individuals within a series of complex genomic mixtures is possible.. ... The Translational Genomics Research Institute

Genetic signature of vulnerability to inhibitors of base excision repair (ber) in cancer

The invention relates to the identification of genetic signatures and expression profiles that are a part of the base excision repair (ber) pathway, a major dna repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by ber inhibitors for malignant glioma by determining the presence of a low level of expression of apex 1, a low level of expression of apex 2, and a high level of expression of mpg.. ... The Translational Genomics Research Institute

Biomarkers and methods of use thereof

Methods useful in the prediction and detection of a triple negative cancer subtype using biomarkers are provided herein.. . ... The Translational Genomics Research Institute

Canine autoimmune conditions and diagnosis and treatment thereof

The disclosure includes methods of identifying a dog at risk of developing a an autoimmune disease or condition, for example a hypothyroid disease or condition, comprising testing whether the dog exhibits one or more selected single nucleotide polymorphisms (snps), together with diagnostic kits for carrying out such methods, methods of treatment or prophylaxis of such autoimmune disease or condition, e.g., comprising administering an effective amount of tea extract to a dog in need thereof, and a canine diet or supplement comprising tea extract, useful for treatment of prophylaxis of such autoimmune disease or condition, or for maintenance of thyroid health in a dog.. . ... The Translational Genomics Research Institute

Methods used to treat cancer

The invention encompasses methods used in the sensitization and treatment of cancer based upon the expression of sgef.. . ... The Translational Genomics Research Institute

Autophagy inhibitors

The present invention relates to compounds of formula iii, formula 111(a), formula v, formula v(a), formula a, formula a 1, formula a2, formula a 3, or a pharmaceutically acceptable salt thereof that are useful as pharmaceutical agents, individually and/or in a combination with a chemotherapeutic agent: plx-4032 (vemurafenib), or the catalytic mtor inhibitor azd8055, to treat a cancer and/or a cancer metastasis, for example a cancer harboring a braf protein kinase mutation and/or a hras protein mutation. Also, a method of treating and/or preventing malaria in a subject, the method comprising administering a therapeutically effective amount of a compound of formula a, formula a 1, formula a2, formula a 3, or a pharmaceutically acceptable salt thereof to the subject in need.. ... The Translational Genomics Research Institute








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