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The University Of Florida Research Foundation Incorporated patents


Recent patent applications related to The University Of Florida Research Foundation Incorporated. The University Of Florida Research Foundation Incorporated is listed as an Agent/Assignee. Note: The University Of Florida Research Foundation Incorporated may have other listings under different names/spellings. We're not affiliated with The University Of Florida Research Foundation Incorporated, we're just tracking patents.

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Current reference based selective harmonic current mitigation pulsed width modulation

Methods and apparatuses for selective harmonic current mitigation pulse width modulation (shcm-pwm) are provided. Low switching frequencies can be utilized for grid connected cascaded h-bridge multilevel rectifiers to meet harmonic requirements within an extended harmonic spectrum. ... The University Of Florida Research Foundation Incorporated

Patient in-the-loop participatory care and monitoring

Methods and systems for patient participatory care and monitoring are provided for applications including respiratory care, ecg monitoring, capnography, infusion pump alarm prevention/management, pressure sore prevention, incentive spirometry, consciousness monitoring during sedation, pain management and other care and monitoring modalities. A patient in-the-loop system includes an input interface for receiving data acquired from a monitoring, controlling or sensing device, a storage device for storing the data at a first location, and a processor for analyzing artifacts in the data and determining whether the patient provided a deliberate action with respect to the device as a response to a prompt or query. ... The University Of Florida Research Foundation Incorporated

Ultrasound-guided medical tool insertion simulators

A medical tool insertion simulation apparatus. The medical tool insertion simulation apparatus may comprise a syringe having an injection end, and an elongated member protruding from the injection end of the syringe. ... The University Of Florida Research Foundation Incorporated

Capsid-modified, raav3 vector compositions and uses in gene therapy of human liver cancer

Disclosed are next-generation multi-mutated capsid protein-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using these high transduction efficiency vector constructs in a variety of therapeutic applications including, inter alia, as delivery agents for the treatment or amelioration of one or more diseases or abnormal conditions in an affected mammal using in vivo and/or ex situ viral vector-based gene therapy protocols. ... The University Of Florida Research Foundation Incorporated

Hematopoietic stem cells in combinatorial therapy with immune checkpoint inhibitors against cancer

The novel synergistic combination of immune checkpoint blockade and hematopoietic stem cell transplantation and/or hematopoietic stem cell mobilization yield synergistic effects in disease therapy.. . ... The University Of Florida Research Foundation Incorporated

Joint fountain code and network coding for multiple-source-multiple-destination wireless communication

Network protocols and methods of transmitting data over wireless networks, including wireless mesh networks, are provided. A method of data transmission in wireless networks can include sending packets from one or more terminal nodes to one or more relay nodes, recoding the packets in the one or more relay nodes, and transmitting the recoded packets from the one or more relay nodes to the one or more terminal nodes. ... The University Of Florida Research Foundation Incorporated

Microfluidic trap

Provided herein are microfluidic devices that can be configured to generate an electrophoretic flow that is in opposition to a fluid flow through a microcapillary of a microfluidic device provided herein. Also provided herein are methods that include adding an amount of particle to the inlet area of a microfluidic device as provided herein, generating a first fluid flow through a microcapillary of a microfluidic device provided herein; and applying a uniform electric field to the microfluidic device, where the uniform electric field generates an electrophoretic flow that is in opposition to the fluid flow.. ... The University Of Florida Research Foundation Incorporated

Tissue decellularization methods

Provided herein are methods of producing an acellular tissue product wherein the method can include the step of inducing apoptosis and washing the tissue after induction of apoptosis with a tonic solution. Also provided herein are acellular tissue products produced by the methods provided herein and methods of administering the acellular tissue products to a subject in need thereof.. ... The University Of Florida Research Foundation Incorporated

Laparoscopic tissue removal system

Provided herein are laparoscopic tissue removal systems, components, and uses thereof.. . ... The University Of Florida Research Foundation Incorporated

Regret benefit ratio link scheduler for wireless backhaul with directional antennas

A wireless system can include a plurality of directional antennas and a scheduler scheduling multiple links between the plurality of directional antennas. The scheduler can schedule the multiple links concurrently in the same time slot based on regret benefit ratio (rbr). ... The University Of Florida Research Foundation Incorporated

Porous stabilized beds, methods of manufacture thereof and articles comprising the same

Disclosed herein is a method comprising disposing a first particle in a reactor; the first particle being a magnetic particle or a particle that can be influenced by a magnetic field, an electric field or a combination of an electrical field and a magnetic field; fluidizing the first particle in the reactor; applying a uniform magnetic field, a uniform electrical field or a combination of a uniform magnetic field and a uniform electrical field to the reactor; elevating the temperature of the reactor; and fusing the first particles to form a monolithic solid.. . ... The University Of Florida Research Foundation Incorporated

Propionibacterium fruedenreichii as a probiotic for infants

The invention pertains to the benefits of propionibacterium freudenreichii supplementation in infant foods, for example, preterm infant foods such as human donor milk or infant milk formula. Accordingly, the invention provides a method of administering an infant food comprising a pharmaceutically effective amount of p. ... The University Of Florida Research Foundation Incorporated

Vanishing via for hardware ip protection from reverse engineering

A semiconductor device can include a first metal trace, a first via disposed on the first metal trace, a second metal trace disposed on the first via, and an insulator interposed between the first metal trace and the first via. The insulator can be configured to lower an energy barrier or redistribute structure defects or charge carriers, such that the first metal trace and the first via are electrically connected to each other when power is applied. ... The University Of Florida Research Foundation Incorporated

System and method for automated model calibration, sensitivity analysis, and optimization

A computer-implemented interface apparatus for automated calibration can include an architecture for automatically managing interchangeable input parameters, interchangeable output objective functions, and interchangeable optimization methods. Prior to calibration, this architecture allows a user to quickly and easily eliminate the vast majority of input values and combinations, thus drastically simplifying the process of calibration (via simulation-based optimization). ... The University Of Florida Research Foundation Incorporated

07/12/18 / #20180194716

Therapeutic compounds and methods of use

The invention relates to protein biding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-ht2c disorders, including diseases and disorders mediated by gpcrs.. ... The University Of Florida Research Foundation Incorporated

07/12/18 / #20180193489

Recombinant adeno-associated virus vectors to target medullary thyroid carcinoma

Provided herein are nucleic acids, recombinant adeno-associated virus (raav) particles, and compositions, as well as methods of use thereof for transducing medullary thyroid carcinoma cells and in treatment of disease, such as medullary thyroid carcinoma. In some aspects, the nucleic acid comprises a truncated calcitonin promoter, which is optionally encapsidated within a raav particle. ... The University Of Florida Research Foundation Incorporated

07/12/18 / #20180193437

Compositions and methods for reducing organ rejection by reducing heparan sulfate in donor transplants

Disclosed here are polypeptides, derived from the myxomavirus-derived secreted glycoprotein, m-t7, comprising point mutations that interfere with chemokine-glycosaminoglycan binding. Compositions containing such m-t7 derived polypeptides with point mutations are therefore useful in preventing, blocking and/or reducing rejection of a transplant.. ... The University Of Florida Research Foundation Incorporated

06/28/18 / #20180182501

Nuclear reactor having efficient and highly stable carbon-based thermal transfer fluid

A pressurized water nuclear reactor (pwnr) includes a core having a containment shield surrounding a reactor vessel having fuel assemblies that contain fuel rods filled with fuel pellets, and control rods, and a steam generator thermally coupled to the reactor vessel. A flow loop includes the steam generator, a turbine, and a condenser, and a pump for circulating a water-based heat transfer fluid in the loop. ... The University Of Florida Research Foundation Incorporated

06/28/18 / #20180179620

Nickel titanium alloys, methods of manufacture thereof and article comprising the same

Disclosed herein is a shape memory alloy comprising 45 to 50 atomic percent nickel; and 1 to 30 atomic percent of at least one metalloid selected from the group consisting of germanium, antimony, zinc, gallium, tin, and a combination of one or more of the foregoing metalloids, with the remainder being titanium. The shape memory alloy may further contain aluminum. ... The University Of Florida Research Foundation Incorporated

06/28/18 / #20180177776

Compositions for the treatment of cancer and uses thereof

The invention pertains to compositions comprising inhibitors of pi3k, akt and/or mtor, one or more 4-quinolinemethanols and a pharmaceutically acceptable excipient. These compositions can contain subtherapeutic amounts of each active ingredient (pi3k, akt, mtor, one or more 4-quinolinemethanols and various combinations thereof). ... The University Of Florida Research Foundation Incorporated

06/21/18 / #20180171083

Fiber reinforced elastomeric sheets with tunable strain relationships

A soft structure fiber reinforcement technology is provided. In an example embodiment, the fiber reinforced elastomeric sheet comprises a sheet of elastomeric matrix; and a fiber array comprising a plurality of fibers embedded within the elastomeric matrix. ... The University Of Florida Research Foundation Incorporated

06/21/18 / #20180168139

Furniture protector against bed bugs and other crawling insects

Pitfall traps, coasters, devices, apparatus, systems and methods for capturing crawling insects, such as bed bugs, and/or for preventing the insects from climbing up furniture legs to furniture such as beds, cots, chairs and any type of furniture where a person would rest or sleep. Smooth slick surfaces and/or pesticide treated surfaces can be located on underside facing horizontal or angled surfaces used with or without sticky surfaces which all can be used to prevent insect and bed bug travel and assist in helping trap the insects and bed bugs.. ... The University Of Florida Research Foundation Incorporated

06/14/18 / #20180165526

Gatoreye system for smart transportation

Various examples are provided for smart transportation and sensing systems. In one example, an apparatus for smart transportation sensing includes a reflector integrated in a contoured roadway unit configured to protect the reflector from damage by vehicles traveling along a transportation surface; and a radio frequency identification (rfid) tag integrated in the contoured roadway unit. ... The University Of Florida Research Foundation Incorporated

06/14/18 / #20180165478

Uniquified fpga virtualization approach to hardware security

Novel methods of virtualization with unique virtual architectures on field-programmable gate arrays (fpgas) are provided. A hardware security method can include providing one or more field-programmable gate arrays (fpgas), and creating an application specialized virtual architecture (or overlay) over the one or more fpgas (for example, by providing an overlay generator). ... The University Of Florida Research Foundation Incorporated

06/14/18 / #20180161295

Treatment of closed head injury and hemorrhagic stroke with hbed

The present invention provides methods for treating closed head injuries or hemorrhagic strokes using a compound of formula (i), or a pharmaceutically acceptable salt thereof. Compounds of formula (i) may act as iron chelators to prevent formation of highly reactive radicals leading to additional damage in the closed head injuries or hemorrhagic strokes.. ... The University Of Florida Research Foundation Incorporated

06/07/18 / #20180159368

Wireless power transfer using one or more rotating magnets in a receiver

The present disclosure is directed towards wireless power transfer using one or more rotating magnets in a receiver. An exemplary embodiment provides for a system comprising a transmitter that generates a dynamic magnetic field and a receiver comprising a magnet and a coil. ... The University Of Florida Research Foundation Incorporated

06/07/18 / #20180154492

Hybrid tool with both fixed-abrasive and loose-abrasive phases

Various examples are provided for hybrid tools including fixed-abrasive and loose- abrasive phases. In one example, a hybrid tool for finishing an internal surface of a workpiece includes a metallic rod and magnetic abrasive bonded to one or more defined portions of the metallic rod by an adhesive that dissolves when n contact with a lubricant used to finish the internal surface of the workpiece. ... The University Of Florida Research Foundation Incorporated

06/07/18 / #20180153826

Materials and methods for the treatment of cystic fibrosis

In preferred embodiments, the invention pertains to the treatment of cystic fibrosis (cf) using an agonistic of casr. In a specific embodiment, the subject invention provides a method of treating cf in a subject by administering to the subject a composition comprising a calcimimetic. ... The University Of Florida Research Foundation Incorporated

06/07/18 / #20180153528

Coaxial biopsy needles

Various examples of methods, devices, apparatus and systems are provided for coaxial biopsy needles. In one example, a coaxial biopsy needle includes an external needle including cutting edges at a distal end, the external needle affixed to an outer casing of a syringe at a proximal end and an inner stylette coaxially located within the external needle, where the inner stylette is affixed to a plunger of the syringe at a proximal end. ... The University Of Florida Research Foundation Incorporated

06/07/18 / #20180153469

Wireless battery-free diagnostic mouth guard

Various examples of methods, systems, and apparatus are provided for monitoring using an improved mouth guard apparatus. In one example, a battery-free diagnostic mouth guard includes a biting force-voltage transducer comprising a piezoelectric film; a compact resonance tank comprising a wireless sensor; and a transmitting antenna for transmitting sensing data. ... The University Of Florida Research Foundation Incorporated

05/31/18 / #20180152824

Ad-hoc social network (ahsn) system, ahsn-enabled device, and methods of use

Embodiments include a system comprising: a publisher communication device configured to publish a social message for the publisher device for delivery using a short-range wireless communication protocol to followers within an area and a forwarding message from another device for a destination device using a delay tolerant network (dtn) communication protocol without the need of the internet, including public or private telecommunications network, or the radio access network (ran), including public or private cellular or wi-fi networks. The system comprises a destination device within the area of the publisher device to receive, via the short-range wireless communication protocol, the forwarding message using a dtn communication protocol from the publisher device. ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180143430

Pre-capture de-identification (pcdi) imaging system and pcdi optics assembly

A de-identification assembly comprising an object tracking sensor (435) to track features of an object; and a mask generator (432) to produce rays of light in response to the tracked features of the object, the rays of light representing a de-identification mask of the object. The assembly includes a beamsplitter (422) having a first side configured to receive rays of light representing the object and a second side configured to receive the rays of light of the mask from the mask generator (432). ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180142194

Growth media for three-dimensional cell culture

A three-dimensional cell growth medium is described. The cell growth medium may comprise hydrogel particles swollen with a liquid cell growth medium to form a granular gel yield stress material which undergoes a phase transformation from a solid phase to a liquid-like phase when an applied stress exceeds the yield stress. ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180142034

Chimeric antigen receptors and uses thereof

Provided herein are chimeric antigen receptors (cars) comprising an antigen binding domain (e.g., cd19, cd30, gd2, etc.), transmembrane domain (e.g., cd28), and a cytoplasmic domain (e.g., cd27, 4-1bb, etc.). In some aspects, the disclosure relates to use of the cars in t cells, compositions, kits and methods.. ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180140718

Electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, and methods of using electroactive supramolecular polymeric assemblies

Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.. . ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180140581

Metabolically programmed metal chelators and uses thereof

The present invention provides compounds of formula (i), which are “metabolically programmed” metal chelators, e.g., lipophilic, absorbable (e.g., orally absorbable), and effective metal chelators that are converted in vivo to their hydrophilic, nontoxic metabolites. The present invention also provides compounds of formula (ii), which are also “metabolically programmed” metal chelators. ... The University Of Florida Research Foundation Incorporated

05/24/18 / #20180140381

Guided orthodontic bracket application

A computer-implemented method and system for guiding the placement of orthodontic brackets are provided. The system can include an at least one indexing tool designed to conform to at least a portion of a patient's teeth or alveolar process. ... The University Of Florida Research Foundation Incorporated

05/17/18 / #20180136201

Characterizing liquids using magnetic discs

The present disclosure is directed towards characterizing liquids through the use of magnetic discs that rotate in response to dynamic magnetic fields. In some embodiments, a light beam is transmitted into the liquid while the magnetic discs rotate, and one or more parameters a light beam signal associated with the transmitted light beam are identified. ... The University Of Florida Research Foundation Incorporated

05/17/18 / #20180135074

Recombinant aav vectors for gene therapy of human hematopoietic disorders

Provided herein are recombinant aav (raav) particles comprising a nucleic acid vector comprising a parvovirus b 19p6 promoter operatively linked to a heterologous gene, such as a human globin gene, and raav capsid proteins comprising one or more amino acid substitutions in a surface exposed loop of the capsid protein that result, e.g., in increased p antigen binding compared to a corresponding un-mutated aav capsid protein. Also provided are methods and compositions related to such capsid proteins, methods of targeting gene expression to a cell of erythroid lineage, methods of treating a hemoglobinopathy using such raav particles, and methods for efficient transduction of a host cell suspension with a raav.. ... The University Of Florida Research Foundation Incorporated

05/17/18 / #20180133372

Magnetically templated tissue engineering scaffolds and methods of making and using the magnetically templated tissue engineering scaffolds

The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.. . ... The University Of Florida Research Foundation Incorporated

05/17/18 / #20180133194

Method of treating inflammation using natural compounds and/or diet

The current invention is directed to a treatment of an inflammatory disease comprising administering to a subject in need of such treatment a composition comprising epigallocatechin-3-gallate (egcg), curcumin, glucosinolates and/or derivatives thereof and medium chain triglycerides and, optionally, providing a ketogenic diet or a modified ketogenic diet to the subject. In an embodiment, the inflammatory disease is increased inflammation in the subject caused by the administration of a microtubule stabilizing drug such as paclitaxel.. ... The University Of Florida Research Foundation Incorporated

05/03/18 / #20180121689

Ucr: an unclonable environmentally-sensitive chipless rfid tag

Chipless rfid tags and methods of using the same are provided. Each rfid tag provided herein can generate a unique and unclonable (unclonable chipless rfid, or ucr) identifier from its intrinsically random manufacturing process. ... The University Of Florida Research Foundation Incorporated

05/03/18 / #20180119119

Directed differentiation of pluripotent stem cells by bacterial injection of talen proteins

In some aspects, the disclosure relates to methods and compositions for delivery of proteins into mammalian cells. In some embodiments, the disclosure provides a genetically engineered bacterium that may be useful for delivery of proteins into mammalian cells. ... The University Of Florida Research Foundation Incorporated

05/03/18 / #20180117178

Aav vector for treatment of friedreich's ataxia

Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve use of a fxn coding sequence, a truncated fxn 3′ utr, and a promoter.. ... The University Of Florida Research Foundation Incorporated

05/03/18 / #20180116988

Methods of preventing and treating autoimmunity

Methods of preventing, treating or ameliorating autoimmune diabetes by modulating the binding of mhc class ii molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of methyldopa. Pharmaceutical compositions containing therapeutically effective amounts of methyldopa in extended release formulations and methods of using the same are also provided.. ... The University Of Florida Research Foundation Incorporated

04/19/18 / #20180106677

Integrated miniature polarimeter and spectrograph using static optics

Embodiments provide an integrated miniature polarimeter and spectrograph (imps) and associated methods for using an imps to determine stokes parameters to describe a source beam. In one embodiment an imps is provided comprising a spectropolarimeter module. ... The University Of Florida Research Foundation Incorporated

04/19/18 / #20180105559

Aav vectors with high transduction efficiency and uses thereof for gene therapy

The present invention provides aav capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the vp3 region. Also provided are raav virions comprising the aav capsid proteins of the present invention, as well as nucleic acid molecules and raav vectors encoding the aav capsid proteins of the present invention. ... The University Of Florida Research Foundation Incorporated

04/12/18 / #20180100165

Raav-guanylate cyclase compositions and methods for treating leber's congenital amaurosis-1 (lca1)

Disclosed are viral vector compositions comprising polynucleotide sequences that express one or more biologically-active mammalian guanylate cyclase proteins. Also disclosed are methods for their use in preventing, treating, and/or ameliorating at least one or more symptoms of a disease, disorder, abnormal condition, or dysfunction resulting at least in part from a guanylate cyclase deficiency in vivo. ... The University Of Florida Research Foundation Incorporated

04/05/18 / #20180094344

Nickel titanium alloys, methods of manufacture thereof and article comprising the same

Disclosed herein is a shape memory alloy comprising 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium. Disclosed herein too is a method of manufacturing a shape memory alloy comprising mixing together to form an alloy nickel, hafnium, aluminum and titanium in amounts of 48 to 50 atomic percent nickel, 15 to 30 atomic percent hafnium, 1 to 5 atomic percent aluminum; with the remainder being titanium; solution treating the alloy at a temperature of 700 to 1300° c. ... The University Of Florida Research Foundation Incorporated

03/29/18 / #20180086999

Mixtures, articles having low coefficients of friction, methods of making these, and methods of using these

The present disclosure provides for mixtures, methods for making mixtures, articles, methods for making articles, and methods of using articles. In an aspect, the articles have superior tribological properties owing to combinations of polytetrafluoroethylene and an irradiated fluoropolymer described herein.. ... The University Of Florida Research Foundation Incorporated

03/15/18 / #20180074538

Common-mode (cm) electromagnetic interference (emi) reduction in resonant converters

An apparatus comprises: a first inductor coupled to a first node and a second node; a second inductor coupled to a third node and a fourth node; a third inductor coupled to the fourth node and a fifth node, wherein the first inductor, the second inductor, and the third inductor form a transformer; and a compensation capacitor coupled to the fourth node and one of the first node and the second node and comprising a compensation capacitance. A method of manufacturing a resonant converter, the method comprises: obtaining the resonant converter, wherein the resonant converter comprises a transformer; determining a parasitic capacitance of the transformer; calculating a compensation capacitance based on the parasitic capacitance; and adding a compensation capacitor across the transformer, wherein the compensation capacitor comprises the compensation capacitance.. ... The University Of Florida Research Foundation Incorporated

03/15/18 / #20180074048

Use of anoctamin as a biomarker for radiation biodosimetry

In one embodiment, the present invention pertains to the use of anoctamin as a biomarker for determining radiation dosimetery. In certain embodiments, the present invention relates to the use of anoctamin as a biomarker for diagnosing the presence of radiation toxicity in a subject who has been exposed to ionizing radiation, as well as for determining the absorbed radiation dose in a subject who has been exposed to a known or unknown dose of ionizing radiation. ... The University Of Florida Research Foundation Incorporated

03/08/18 / #20180067291

Telescope and telescope array for use in spacecraft

A catadioptric telescope is a modified version of a conventional maksutov-cassegrain optical telescope. In accordance with the invention, the reflecting surfaces of the primary mirror and the secondary spot mirror are on the second surfaces of the primary mirror and correcting lens, respectively. ... The University Of Florida Research Foundation Incorporated

03/08/18 / #20180064760

Methods for treating or preventing graft versus host disease

A method of treating or preventing graft versus host disease (gvhd) in a subject receiving a graft comprising hematopoietic cells is provided. The method comprises contacting the graft ex vivo with an amount of a myxoma virus effective to inhibit proliferation of t lymphocytes in the graft and to treat or prevent gvhd in the host subject following infusion of the graft into the subject. ... The University Of Florida Research Foundation Incorporated

03/01/18 / #20180063509

Optical privatizing device, system and method of use

Embodiments are directed to an optical privatizing device (100), system and methods of use. The device includes a removable frame (101) removably attachable to a sensor housing (1a). ... The University Of Florida Research Foundation Incorporated

03/01/18 / #20180057840

Raav vector compositions, methods for targeting vascular endothelial cells and use in treatment of type i diabetes

Disclosed are capsid-modified raav expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations that include them. Also disclosed are methods of preparing and using novel capsid-protein-mutated raav vector constructs in a variety of diagnostic and therapeutic applications including, inter alia, as delivery agents for diagnosis, treatment, or amelioration of one or more diseases, disorders, or dysfunctions of the mammalian vascular system, and complications from type i diabetes. ... The University Of Florida Research Foundation Incorporated

03/01/18 / #20180057682

Organic microgel system for 3d printing of silicone structures

An organic microgel system as support material for 3d printing of soft materials such as silicone and methods for manufacturing and using the organic microgel system are disclosed. In some embodiments, the organic microgel system comprises a plurality of microgel particles formed by blending a di-block copolymer and a tri-block copolymer in an organic solvent. ... The University Of Florida Research Foundation Incorporated

02/22/18 / #20180051279

Methods of identifying biologically active random peptides in plants and libraries of plants expressing candidate biologically active random peptides

The present disclosure provides methods and systems for identifying biologically active random peptides (barps) in plants. The present disclosure also provides libraries of transformed plants, where each plant expresses a different candidate barp. ... The University Of Florida Research Foundation Incorporated

02/22/18 / #20180049654

Devices, systems and methods for plethysmographic monitoring at the nose

The present invention relates to novel lip/cheek probes for detection of pulse-based differences in light absorbence across the vascularized tissue of a lip or cheek of a patient. These probes are fabricated to provide signals to estimate arterial oxygen saturation, and/or to obtain other photoplethysmographic data. ... The University Of Florida Research Foundation Incorporated

02/15/18 / #20180044698

Site-specific integrating recombinant aav vectors for gene therapy and improved production methods

Provided herein are methods of site-specific integration of a heterologous sequence into a host genome (e.g., by administering a recombinant adeno-associated virus (raav) to a host cell in the presence of a rep protein), and methods for treating diseases and disorders by delivering an raav that comprises a nucleic acid vector comprising a rep protein. Also provided herein are methods and compositions for producing raav particles with improved titer and transduction efficiencies.. ... The University Of Florida Research Foundation Incorporated

02/15/18 / #20180044379

Co-assembly peptides, nanostructures, and methods of making and using the same

Provided herein are charge complementary peptides that can be optionally coupled to a cargo polypeptide that are capable of self-assembling under stimulating conditions. The charge complementary peptides can be capable of forming supramolecular structures. ... The University Of Florida Research Foundation Incorporated

02/15/18 / #20180044291

Artificial self-sufficient cytochrome p450s

The disclosure relates to the field of fusion proteins. In some aspects, the invention relates to artificial fusion proteins comprising cytochrome p450 enzymes linked to reductase enzymes and uses thereof. ... The University Of Florida Research Foundation Incorporated

02/08/18 / #20180038873

Use of nhe3 as a biomarker for radiation biodosimetry

Embodiments of the present invention are directed to the use of nhe3 as an early biomarker for radiation biodosimetry. In other embodiments, the present invention relates to the use of nhe3 as a biomarker for determining the absorbed radiation dose in a subject who has been exposed to a known or unknown dose of ionizing radiation. ... The University Of Florida Research Foundation Incorporated

02/08/18 / #20180038746

Mems capacitive shear sensor system having an interface circuit

A sensor system comprising a micro-electro-mechanical systems (mems)-based capacitive floating element shear stress sensor, the associated packaging, and the interface circuitry required for operation as an instrumentation-grade sensing system is disclosed herein. One implementation of the interface circuitry is an analog synchronous modulation/demodulation scheme enabling time-resolved measurements of both mean and dynamic wall shear stress events, where a modulation section couples to the sensor for sensing wall shear stress at the surface of an object in a fluid and generates at least one bias signal from the sensor output signal. ... The University Of Florida Research Foundation Incorporated

02/08/18 / #20180037466

Method for the generation of power

Disclosed herein is a method comprising heating a strontium-containing compound using radiation in a first reactor; decomposing the strontium-containing compound into an oxide and carbon dioxide as a result of heat generated by the exposure to the radiation; reacting the oxide and the carbon dioxide in a second reactor; where the oxide and carbon dioxide react to produce heat; heating a working fluid using the heat produced in the second reactor; and driving a turbine with the heated working fluid to generate energy. Disclosed herein too is a composition comprising strontium carbonate; and strontium zirconate; where the mass ratio of strontium carbonate to strontium zirconate 2:8 to 8:2.. ... The University Of Florida Research Foundation Incorporated

02/08/18 / #20180036428

Capsid-modified raav vectors and methods of use

Disclosed are tyrosine-modified raav vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant raav vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of raav vectors.. ... The University Of Florida Research Foundation Incorporated

02/08/18 / #20180036385

Aav-mediated gene therapy for rpgr x-linked retinal degeneration

Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (aav) carrying a nucleic acid sequence encoding a normal retinitis pigmentosa gtpase regulator (rpgr gene), or fragment thereof, under the control of regulatory sequences which express the product of the gene in the photoreceptor cells of the subject, and a pharmaceutically acceptable carrier.. ... The University Of Florida Research Foundation Incorporated

02/01/18 / #20180033511

Optoelectronic nuclear batteries based on radionuclide nanoencapsulation and organic photodiodes

Embodiments of the present disclosure relate to compositions including a doped material, batteries including the composition, photovoltaic devices including the battery, and the like.. . ... The University Of Florida Research Foundation Incorporated

02/01/18 / #20180030209

Mesh size control of lubrication in gemini hydrogels

A device comprises a surface that is a hydrogel having a targeted mesh size that permits a low-speed friction coefficient near or lower that that typically reported for cartilage of 0.01 to 0.02, a transition. The device can be a contact lens to sit on the cornea where, during a blink, eyelid slides past the eye surface at about 100 mm s−1. ... The University Of Florida Research Foundation Incorporated

02/01/18 / #20180030096

Recombinant aav1, aav5, and aav6 capsid mutants and uses thereof

Provided herein are modified recombinant adeno-associated virus (raav) capsid proteins, such as modified raav1, raav5, and raav6 capsid proteins, raav particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof.. . ... The University Of Florida Research Foundation Incorporated

01/25/18 / #20180025510

Common-mask guided image reconstruction for enhanced four-dimensional cone-beam computed tomography

A system for constructing images representing a 4dct sequence of an object from a plurality of projections taken from a plurality of angles with respect to the object and at a plurality of times, first portions of the object being less static than second portions of the object. The system may comprise a processor configured to: iteratively process projections of the plurality of projections for a plurality of groups, each group comprising projections collected while the first portions of the object are in corresponding locations, with each iteration comprising: reconstructing first image portions representing the first portions of the object, the reconstructing of each first image portion of the first image portions being based on projections in a respective group of the plurality of groups; and reconstructing the second image portion, the second image portion representing the second portions of the object, based on projections in multiple groups of the plurality of groups and on the reconstructed first image portions.. ... The University Of Florida Research Foundation Incorporated

01/25/18 / #20180022815

Bi-specific chimeric antigen receptor and uses thereof

Provided herein are bi-specific chimeric antigen receptors (cars), such as those specific for cd138 and bcma. Use of the cars in immune cells (e.g., t cells), compositions, and methods are also contemplated.. ... The University Of Florida Research Foundation Incorporated

01/18/18 / #20180019491

Hydrogen oxidation and generation over carbon films

An electrode comprises an acid treated, cathodically cycled carbon-comprising film or body. The carbon consists of single walled nanotubes (swnts), pyrolytic graphite, microcrystalline graphitic, any carbon that consists of more than 99% sp2 hybridized carbons, or any combination thereof. ... The University Of Florida Research Foundation Incorporated

01/18/18 / #20180017569

Medication adherence monitoring system

The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. ... The University Of Florida Research Foundation Incorporated

01/18/18 / #20180015251

Context-sensitive flow interrupter and drainage outflow optimization system

Embodiments of the invention provide methods and devices for improved drainage systems and tubing. In one embodiment, a context-sensitive flow interrupter is provided that inhibits or facilitates flow of fluid when engaged with a mating holder. ... The University Of Florida Research Foundation Incorporated

01/18/18 / #20180015172

Engineered receptor/ligand system for delivery of therapeutic agents

Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date. ... The University Of Florida Research Foundation Incorporated

01/11/18 / #20180008737

Self-sterilizing device using plasma fields

Embodiments of the invention relate to a method and apparatus for self-sterilizing a surface or other portion of the apparatus and/or sterilizing other objects. Embodiments can utilize self-generated and/or remotely controlled plasma fields for the purpose of self-sterilization and/or sterilization of another object. ... The University Of Florida Research Foundation Incorporated

01/11/18 / #20180008328

Articles comprising reversibly attached screws comprising a biodegradable composition, methods of manufacture thereof and uses thereof

Disclosed herein is an article comprising a first screw and a second screw, the first screw being reversibly attached to the second screw such that a longitudinal axis of the first screw coincides with or is parallel to a longitudinal axis of the second screw; the first screw and the second screw each comprising a biodegradable composition, the biodegradable composition comprising a metal or metal alloy comprising magnesium, strontium, zinc, calcium or a combination comprising at least one of the foregoing. Methods of making and using the article are also disclosed herein.. ... The University Of Florida Research Foundation Incorporated

01/11/18 / #20180008155

Methods and devices for central photoplethysmographic monitoring

Provided according to embodiments of the present invention are methods of monitoring individuals that include securing a photoplethysmography probe to at least one of a pre-auricular region and a post-auricular region of the individual and obtaining photoplethysmography signals from the photoplethysmography probe. Photoplethysmography probes and helmets related to such methods are also described herein.. ... The University Of Florida Research Foundation Incorporated

01/04/18 / #20180007772

Devices employing one or more plasma actuators

Various embodiments relate to plasma actuators that generate fluidic flow. In one or more embodiments, a plasma actuator includes a first electrode and a second electrode. ... The University Of Florida Research Foundation Incorporated

12/28/17 / #20170372640

Simulation features combining mixed reality and modular tracking

Techniques and systems are described for providing modularity, tracking and simulation features of a mixed reality simulator. A modular approach to tracking systems, tracked instruments, and interchangeable modular physical models is described. ... The University Of Florida Research Foundation Incorporated

12/28/17 / #20170370050

Waste to energy ash and engineered aggregate in road construction

Described herein are compositions and methods for waste-to-energy ash in engineered aggregate in road construction.. . ... The University Of Florida Research Foundation Incorporated

12/28/17 / #20170367976

Pharmaceutical capsules for medication adherence monitoring and methods of forming the same

Provided according to embodiments of the invention pharmaceutical capsules that include a capsule body and a capsule cap, wherein the capsule cap envelops an open end of the capsule body to form a capsule core; and an adherence sheath that envelops a portion of the capsule core. Related capsules and methods of making such capsules are also provided herein.. ... The University Of Florida Research Foundation Incorporated

12/21/17 / #20170362577

Recombinant aav production in mammalian cells

The present invention includes methods and compositions for the production of high titer recombinant adeno-associated virus (raav) in a variety of mammalian cells. The disclosed raav are useful in gene therapy applications. ... The University Of Florida Research Foundation Incorporated

12/14/17 / #20170356009

Genome-modified recombinant adeno-associated virus vectors

Provided herein are recombinant adeno-associated virus (raav) nucleic acid vectors that comprise one or more modifications within at least one inverted terminal repeat (itr) region. Exemplary modifications include itr sequences comprising a glucocorticoid responsive element and/or a transcription factor binding site. ... The University Of Florida Research Foundation Incorporated

12/07/17 / #20170348387

Aav-mediated gene therapy for nphp5 lca-ciliopathy

Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with leber congenital amaurosis (lca) in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (aav) carrying a nucleic acid sequence encoding a normal nphp5 protein, or fragment thereof, under the control of regulatory sequences which express the nphp5 protein in the photoreceptor cells of the subject, and a pharmaceutically acceptable carrier.. ... The University Of Florida Research Foundation Incorporated

12/07/17 / #20170347602

Oat variety fl0720

The invention provides oat seed and plants of the oat variety fl0720 that have resistance to crown rust. The invention further provides seed and plants of the oat variety fl0720 and progeny produced with at least one of these plants as a parent. ... The University Of Florida Research Foundation Incorporated

11/30/17 / #20170343488

Three-dimensional image reconstruction using transmission and scatter radiography methods

A method for image reconstruction includes irradiating an object with a beam of radiation from a radiation source, measuring an attenuated portion of the beam, estimating a density of the object, determining a predicted attenuated portion of the beam using the density estimate, and iteratively adjusting the density estimate of the object. The predicted attenuated portion and the measured attenuated portion are compared to determine a signal difference. ... The University Of Florida Research Foundation Incorporated

11/23/17 / #20170333628

Devices and methods for minimizing infusion of air into an intravenous fluid line from an intravenous fluid bag by a pressure infusion cuff

The problem of infusing air into iv tubing and into a patient from a iv fluid bag inside a pressure infusion cuff is solved by collar embodiments that inhibit the air from being forced into the iv tubing. A collar can include one or more curved arms that create a channel in which that part of the fluid bag is protected against being squeezed by a pressure infusion cuff. ... The University Of Florida Research Foundation Incorporated

11/16/17 / #20170330657

Nanocomposite magnetic materials for magnetic devices and systems

Nanocomposite magnetic materials, methods of manufacturing nanocomposite magnetic materials, and magnetic devices and systems using these nanocomposite magnetic materials are described. A nanocomposite magnetic material can be formed using an electro-infiltration process where nanomaterials (synthesized with tailored size, shape, magnetic properties, and surface chemistries) are infiltrated by electroplated magnetic metals after consolidating the nanomaterials into porous microstructures on planar substrates. ... The University Of Florida Research Foundation Incorporated

11/16/17 / #20170327875

Sensitive and rapid method for candidatus liberibacter species detection

Dna amplification methods using novel primers obtained from the novel genes hyvi and hyvii from the candidatus liberibacter asiaticus genome are useful for detecting ca. L. ... The University Of Florida Research Foundation Incorporated

11/16/17 / #20170326257

Satiation peptides for weight loss and altered taste sensitivity

The present application provides methods and compositions for aav-mediated delivery of pyy and glucagon-like peptide 1 or an analog thereof (e.g., exendin-4) to a subject (e.g., the saliva of a subject). In some embodiments, compositions and methods for topical delivery of ex-4 and pyy peptides also are provided. ... The University Of Florida Research Foundation Incorporated

11/09/17 / #20170321306

Radiation shielding and mitigating alloys, methods of manufacture thereof and articles comprising the same

Embodiments of the present disclosure include compositions that include magnesium and gadolinium or magnesium and one or more metals.. . ... The University Of Florida Research Foundation Incorporated

11/09/17 / #20170320018

Continuous electrokinetic dewatering of phosphatic clay suspensions

Various methods and systems are provided for electrokinetic dewatering of suspensions such as, e.g., phosphatic clay. In one example, among others, a system for continuous dewatering includes a cake formation zone including a first anode and a first cathode each extending across a first portion of a separation chamber; a cake dewatering zone including a second anode and a second cathode; an inlet configured to supply a dilute feed suspension comprising solids suspended in water to the cake formation zone; and a conveying belt extending between the first anode and the first cathode and between the second anode and the second cathode. ... The University Of Florida Research Foundation Incorporated

10/26/17 / #20170304797

Solar thermochemical reactor, methods of manufacture and use thereof and thermogravimeter

Disclosed herein is a solar thermochemical reactor comprising an outer member, an inner member disposed within an outer member, wherein the outer member surrounds the inner member and wherein the outer member has an aperture for receiving solar radiation and wherein an inner cavity and an outer cavity are formed by the inner member and outer member and a reactive material capable of being magnetically stabilized wherein the reactive material is disposed in the outer cavity between the inner member and the outer member.. . ... The University Of Florida Research Foundation Incorporated

10/26/17 / #20170304794

Solar thermochemical reactor and methods of manufacture and use thereof

Disclosed herein is a solar reactor comprising a reactor member; an aperture for receiving solar radiation, the aperture being disposed in a plane on a wall of the reactor member, where the plane is oriented at any angle other than parallel relative to the centerline of the reactor member; a plurality of absorber tubes, wherein the absorber tubes are oriented such that their respective centerlines are at an angle other than 90° relative to the centerline of the reactor member; and wherein the aperture has a hydraulic diameter that is from 0.2 to 4 times a hydraulic diameter of at least one absorber tube in the plurality of absorber tubes; and a reactive material, the reactive material being disposed in the plurality of absorber tubes.. . ... The University Of Florida Research Foundation Incorporated

10/12/17 / #20170294528

High electron mobility transistors with improved heat dissipation

Iii-nitride based high electron mobility transistors (hemts), such as algan/gan hemts on silicon substrates, with improved heat dissipation are described herein. A semiconductor device having improved heat dissipation may include a substrate having a top surface and a bottom surface, a nucleation layer on the top surface of the substrate, a transition layer on the nucleation layer, a buffer layer on the transition layer, a barrier layer on the buffer layer, and a metal layer filling a via hole that extends from the bottom surface of the substrate to a bottom surface of the transition layer.. ... The University Of Florida Research Foundation Incorporated

10/05/17 / #20170284429

Electro-fluid transducers

The present disclosure is directed towards electro-fluid transducers that may influence the flow of a fluid in and around a channel. In one such embodiment, a system comprises a first electrode at least partially encapsulated by a first dielectric; a second electrode at least partially encapsulated by a second dielectric, wherein a portion of a channel exists between the first dielectric and the second dielectric; a third electrode positioned in the channel; and a fourth electrode positioned in the channel, wherein the electrodes influence a flow of a fluid in the channel upon the electrodes being energized.. ... The University Of Florida Research Foundation Incorporated

09/28/17 / #20170275337

High-transduction-efficiency raav vectors, compositions, and methods of use

The present invention provides aav capsid proteins comprising modification of one or a combination of the surface-exposed lysine, serine, threonine and/or tyrosine residues in the vp3 region. Also provided are raav virions comprising the aav capsid proteins of the present invention, as well as nucleic acid molecules and raav vectors encoding the aav capsid proteins of the present invention. ... The University Of Florida Research Foundation Incorporated

09/28/17 / #20170275178

Room temperature multiferroic thin films

Various examples are provided for multiferroic thin films. In one example, a multiferroic thin film device includes a thin film of multiferroic material and an electrode disposed on a side of the thin film of multiferroic material. ... The University Of Florida Research Foundation Incorporated

09/21/17 / #20170268019

Methods and compositions for preventing or reducing infections of crop plants by bacterial and fungal pathogens

The present invention teaches methods and compositions useful for treating, preventing, or curing pathogen infections of living plants. In particular, the present invention teaches methods of enhancing plant response to pathogen-associated molecular patterns. ... The University Of Florida Research Foundation Incorporated

09/21/17 / #20170267811

Broadly absorbing electrochromic polymers

Copolymers including dioxythiophene repeating units and no acceptor units allow the formation of electrochromic polymers (ecps) with vivid neutral state colors and very colorless oxidized states that can be switched rapidly. The dioxythiophene repeating units can included in sequences where all of one type of dioxythiophene is included exclusively as isolated dyads or triads within the copolymer, or the copolymer can be an alternating copolymer with propylenedioxythiophene units. ... The University Of Florida Research Foundation Incorporated

09/21/17 / #20170267700

Precursors for electron beam-induced deposition of gold and silver

Precursors are prepared and employed in electron beam induced decomposition (ebid). The ebid precursors are complexes of the formula: x-m-y, where m is au or ag; x is f, cl, br, i, cn, or1, o2cr2, or r3; y is p(or)3, nr3, unsubstituted or substituted pyrrole, unsubstituted or substituted pyridine, unsubstituted or substituted pyrrolidine, or unsubstituted or substituted piperidine; and where r, r1, r2, r3, and substituents of the substituted pyrrole, pyridine, pyrrolidine, or piperidine are independently h, c1-c8 alkyl, c6-c10 aryl, c1-c8 perfluoroalkyl, c1-c8 partially fluorinated alkyl, and sir5r6r7 where r5, r6, and r7 are independently h, c1-c8 alkyl, or c1-c8 fluorinated alkyl. ... The University Of Florida Research Foundation Incorporated

09/21/17 / #20170267576

Durable and optically transparent superhydrophobic surfaces

Durable and optically transparent superhydrophobic surfaces have a coating of ceramic nanoparticles attached to a transparent substrate that are bound to the substrate through a flexible linker and a fluorocarbon moiety is bound to the surface of the ceramic nanoparticles. The nanoparticles provide the topography required for superhydrophobic surfaces and the fluorocarbon attached to the surface renders the particles hydrophobic. ... The University Of Florida Research Foundation Incorporated

09/14/17 / #20170260403

Durable and superhydrophobic over coating

An overcoat that imparts a superhydrophobic surface to a painted surface of an object is a suspension of hydrophobic particles in a polymeric binder and a plasticizer in a solvent or mixed solvent. The particles are a metal oxide that is surface functionalized with a fluorinated alkyl silane or an alkyl silane. ... The University Of Florida Research Foundation Incorporated

08/31/17 / #20170245495

Chemical lure for asian citrus psyllid

The present disclosure relates to compositions containing a mixture of e.g. One or more or two or more compounds released by a citrus plant in quantities that are altered during infection with huanglongbing disease, where the composition is an attractant for psyllids. ... The University Of Florida Research Foundation Incorporated

08/24/17 / #20170240570

Novel small molecule anticancer agents

The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.. ... The University Of Florida Research Foundation Incorporated

08/24/17 / #20170239393

Magnetic nanoparticle embedded nanofibrous membrane

Various examples are provided for magnetic particle imbedded nanofibrous membranes. In one example, among others, a nanofibrous membrane includes one or more electrospun nanofibers forming form a layer of nanofibers, and a plurality of magnetic nanoparticles embedded in the one or more electrospun nanofibers. ... The University Of Florida Research Foundation Incorporated

08/24/17 / #20170238871

Novel pulse oximeter probes and methods for using the same

Provided according to embodiments of the invention are photoplethysmography probes designed for use on a user's nasal alar. Methods of using such photoplethysmography probes are also provided herein.. ... The University Of Florida Research Foundation Incorporated

08/17/17 / #20170233754

Materials and methods to increase plant growth and yield

The present invention relates to materials and methods for modulating growth rates, yield, and/or resistance to drought conditions in plants. In one embodiment, a method of the invention comprises increasing expression of an hc1 gene (or a homolog thereof that provides for substantially the same activity), or increasing expression or activity of the protein encoded by an hc1 gene thereof, in a plant, wherein expression of the hc1 gene or expression or activity of the protein encoded by an hc1 gene results in increased growth rate, yield, and/or drought resistance in the plant.. ... The University Of Florida Research Foundation Incorporated

08/10/17 / #20170230144

Joint fountain coding and network coding for loss-tolerant information spreading

A network system for increasing data throughput and decreasing transmission delay from a source node to a sink node via a relay node. The network system may comprise a source node configured to encode a plurality of data packets using rateless coding and transmit the plurality of data packets; at least one relay node configured to receive at least one of the plurality of data packets from the source node, and if the at least one relay node has received a sufficient quantity of the plurality of data packets, regenerate, re-encode, and relay the plurality of data packets; and a sink node configured to receive one or more of the plurality of data packets from the at least one relay node, and if the sink node has received the sufficient quantity of the plurality of data packets, regenerate and decode the plurality of data packets.. ... The University Of Florida Research Foundation Incorporated

08/10/17 / #20170224531

Preservative removal from eye drops

A bak removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (phema). ... The University Of Florida Research Foundation Incorporated

08/03/17 / #20170221387

Interactive mixed reality system and uses thereof

. . An interactive mixed reality simulator is provided that includes a virtual 3d model of internal or hidden features of an object; a physical model or object being interacted with; and a tracked instrument used to interact with the physical object. The tracked instrument can be used to simulate or visualize interactions with internal features of the physical object represented by the physical model. ... The University Of Florida Research Foundation Incorporated

08/03/17 / #20170218395

Methods of packaging multiple adeno-associated virus vectors

Provided herein are methods related to co-packaging of multiple raav particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or rnas of interest into a single cell preparation.. . ... The University Of Florida Research Foundation Incorporated

08/03/17 / #20170217984

Ligands for alpha-7 nicotinic acetylcholine receptors and methods of treating neurological and inflammatory conditions

Compounds are provided which bind to an allosteric site on the mammalian alpha-7 nicotinic acetylcholine receptor (alpha-7 nachr) and act as positive allosteric modulators with or without allosteric agonist activity. The compounds are useful in diagnosing, preventing, or treating a variety of disorders involving cognition, learning, memory, neurodegeneration, drug addiction, inflammation, chronic pain, and neuropathic pain. ... The University Of Florida Research Foundation Incorporated

08/03/17 / #20170217771

Solar thermochemical reactor, methods of manufacture and use thereof and thermogravimeter

Disclosed herein is a solar thermochemical reactor comprising an outer member, an inner member disposed within an outer member, wherein the outer member surrounds the inner member and wherein the outer member has an aperture for receiving solar radiation and wherein an inner cavity and an outer cavity are formed by the inner member and outer member and a reactive material capable of being magnetically stabilized wherein the reactive material is disposed in the outer cavity between the inner member and the outer member.. . ... The University Of Florida Research Foundation Incorporated

08/03/17 / #20170216543

Patterns for flow control and bioadhesion control

Disclosed herein is an article including a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface; the spaced features arranged in a plurality of groupings; the groupings of features comprising repeat units; the spaced features within a grouping being spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway.. . ... The University Of Florida Research Foundation Incorporated

07/27/17 / #20170212365

Uv blocker loaded contact lenses

Uv absorbing appliances, such as contact lenses, are prepared by including at least one uv absorbing compound in the appliances. Uv absorbing compounds can be water insoluble and/or reside in uv absorbing nanoparticles having a mean diameter less than 10 nm. ... The University Of Florida Research Foundation Incorporated

07/27/17 / #20170209497

Sustained release angiogenesis modulating compositions and methods for induction and modulation of angiogenesis

The present disclosure provides compositions including a human placental extract and biodegradable microparticles, sustained release angiogenesis-modulating compositions, compositions and methods for releasing a placental extract to a target over a period of time, and methods for inducing and/or modulating angiogenesis and identifying modulators of angiogenesis. The present disclosure also provides methods of making a composition, including a placental extract that can induce and/or modulate angiogenesis.. ... The University Of Florida Research Foundation Incorporated

07/27/17 / #20170209420

Uses of 4'-desferrithiocin analogs

Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of formula (i). ... The University Of Florida Research Foundation Incorporated

07/20/17 / #20170203126

System for delivering conformal radiation therapy while simultaneously imaging soft tissue

A device and a process for performing high temporal- and spatial-resolution mr imaging of the anatomy of a patient during intensity modulated radiation therapy (imrt) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open mri, multileaf-collimator or compensating filter-based imrt delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.. ... The University Of Florida Research Foundation Incorporated

07/13/17 / #20170201858

Dynamic user-defined check-in points

Techniques and systems are disclosed for enhancing the flexibility and resiliency of mobile social networking platforms. Techniques enable dynamic, user-defined check-in points with mobile devices so that users may define ad hoc, location-based communities. ... The University Of Florida Research Foundation Incorporated

07/13/17 / #20170200546

Mitigation of contamination of electroplated cobalt-platinum films on substrates

Various embodiments to mitigate the contamination of electroplated cobalt-platinum films on substrates are described. In one embodiment, a device includes a substrate, a titanium nitride diffusion barrier layer formed upon the substrate, a titanium layer formed upon the titanium nitride diffusion barrier layer, a platinum seed layer, and a cobalt-platinum magnetic layer formed upon the platinum seed layer. ... The University Of Florida Research Foundation Incorporated

07/13/17 / #20170197988

Macrocyclic compounds and methods of treatment

The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.. . ... The University Of Florida Research Foundation Incorporated

07/06/17 / #20170194553

Laterally curved actuators of shape memory materials

A unimorph composite actuator (uca) has a deformable substrate that has a lateral curvature relative to an axis or curve of the substrate and at least one shape memory material (smm) attached to at least a portion of a face of the substrate. The curvature of the substrate assists the restoration of the original structure after being fixed in a deformed conformation. ... The University Of Florida Research Foundation Incorporated

07/06/17 / #20170191708

Architecture for absorption based heaters

An absorption based heater is constructed on a fluid barrier heat exchanging plate such that it requires little space in a structure. The absorption based heater has a desorber, heat exchanger, and absorber sequentially placed on the fluid barrier heat exchanging plate. ... The University Of Florida Research Foundation Incorporated

07/06/17 / #20170191117

Rapid detection of infectious agents

The invention generally relates to a method for detecting a target nucleic acid in a sample. This invention is useful for detecting bacterial or viral agents in a sample, and is able to detect nucleic acids from a broad variety of, e.g., bacteria, rather than only one or a few different bacteria at a time.. ... The University Of Florida Research Foundation Incorporated

06/29/17 / #20170186710

Glass interposer integrated high quality electronic components and systems

Various integrated high quality electronic components and systems, and methods of their manufacture, are presented. In one example, a device includes a glass substrate or interposer including one or more metalized through-glass vias (tgvs). ... The University Of Florida Research Foundation Incorporated

06/29/17 / #20170184354

Cryogenic heat transfer by a nanoporous surface

Various methods and systems are provided for cryogenic heat transfer by nanoporous surfaces. In one embodiment, among others, a system includes a cryogenic fluid in a flow path of the system; and a system component in the flow path that includes a nanoporous surface layer in contact with the cryogenic fluid. ... The University Of Florida Research Foundation Incorporated

06/29/17 / #20170183798

Nanofibrous carbon microstructures

Various examples of methods and systems related to nanofibrous microstructures including carbon nanofibrous microelectrode arrays are provided. In one example, a method includes electrospinning photosensitive nanofibers on a patterned substrate; immersing the photosensitive nanofibers in a refractive index matching medium; and exposing the immersed photosensitive nanofibers to ultraviolet (uv) light through the patterned substrate or through a front side photomask. ... The University Of Florida Research Foundation Incorporated

06/29/17 / #20170183349

Biisoquinoline compounds and methods of treatment

The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating dis-orders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.. . ... The University Of Florida Research Foundation Incorporated

06/22/17 / #20170174928

Superhydrophobic and oleophobic ceramic polymer composite coating

An article having a superhydrophobic or oleophobic ceramic polymer composite surface is formed by the coating of the surface with a fluid comprising a polymer, copolymer, or polymer precursor and a plurality of glass, ceramic, or ceramic-polymer particles. The particles have fluorinated surfaces and at least a portion of the polymer's repeating units that are fluorinated or perfluorinated. ... The University Of Florida Research Foundation Incorporated

06/22/17 / #20170174619

Hdac inhibitor compounds and methods of treatment

The instant invention describes hydrazide-containing compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.. . ... The University Of Florida Research Foundation Incorporated

06/15/17 / #20170166757

Superoleophobic alumina coatings

A superhydrophobic surface can be formed by contacting an article with a suspension of fluorinated boehmite particles to leave a film of the fluorinated boehmite particles after removal of the suspending fluid. The film can be transparent or the film can be translucent or opaque. ... The University Of Florida Research Foundation Incorporated

06/08/17 / #20170159297

Retrofit/repair technique for asphalt shingle roofs that exhibit premature adhesive tab seal failures

Devices, systems and methods for providing a retrofit and repair technique and device for asphalt shingle roof coverings or roofing systems that exhibit premature adhesive tab seal failures. A device can have a handle at one end and a blade tip end at the other end has the blade tip inserted under a shingle to be repaired. ... The University Of Florida Research Foundation Incorporated

06/08/17 / #20170158831

Durable superhydrophobic surfaces

A superhydrophobic appliance is an elastomeric material with a surface having a multiplicity of re-entrant features. The elastomeric material can be a polydimethylsiloxane network. ... The University Of Florida Research Foundation Incorporated

06/08/17 / #20170157396

Functional electrical stimulation cycling device for people with impaired mobility

Functional electrical stimulation (fes) cycling devices and associated methods are generally described. An fes cycling device may comprise a crank, two or more pedals connected to the crank, one or more sensors adapted to measure position and/or velocity of the crank, and one or more electrodes configured to deliver electrical stimulation to a person associated with the cycling device. ... The University Of Florida Research Foundation Incorporated

06/08/17 / #20170157388

Apparatuses and methods for securing deep brain stimulation leads

Various examples are provided for securing deep brain stimulation (dbs) leads. In one example, among others, a dbs cap for securing a dbs lead includes a base ring adapted to be mounted within a counterbore opening formed in the skull, a lead securing element that mounts to the base ring, and. ... The University Of Florida Research Foundation Incorporated

06/01/17 / #20170155287

Wireless power transfer via electrodynamic coupling

Wireless power transmission (wpt) systems are provided. According to an embodiment, the wpt system uses one or more power transmitting coils and a receiver for electromagnetically coupled wireless power transfer. ... The University Of Florida Research Foundation Incorporated

06/01/17 / #20170152338

Polyurethanes, articles comprising the same and methods of manufacture thereof

Disclosed herein a composition comprising a urethane of the fig. 3; where hydroxyl or amine linkages on the urethane of the fig. ... The University Of Florida Research Foundation Incorporated

05/18/17 / #20170138941

Devices for detecting target biological molecules from cells and viruses

Described herein are fluid-manipulation-based devices. Fluid manipulations as described herein can be configured to perform assays on biological samples. ... The University Of Florida Research Foundation Incorporated

05/18/17 / #20170137515

Car based immunotherapy

The disclosure provides chimeric antigen receptors (cars), t cells comprising such cars, nucleic acids that encode such cars, and methods of use thereof, e.g., to treat cancer such as b cell malignancies.. . ... The University Of Florida Research Foundation Incorporated

05/18/17 / #20170136074

Probiotic arginolytic oral compositions and methods of making and using probiotic arginolytic oral compositions

The present disclosure provides methods of using probiotic arginolytic oral compositions including isolated arginolytic bacterial strains to increase arginolytic activity in the oral cavity, increase ammonia-producing bacteria in the oral cavity, and/or to treat and/or prevent oral disorders, such as caries.. . ... The University Of Florida Research Foundation Incorporated

05/18/17 / #20170135297

Hybrid tomatoes and methods of making hybrid tomatoes

The present disclosure provides hybrid tomatoes that produce better-tasting fruit, methods of producing and identifying the hybrid tomatoes and methods of identifying the chemical composition of a tomato that leads to a better-tasting fruit.. . ... The University Of Florida Research Foundation Incorporated

05/11/17 / #20170130208

Compositions and methods for purifying recombinant adeno-associated virus

Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (raav) particles.. . ... The University Of Florida Research Foundation Incorporated

05/11/17 / #20170128624

Method for decellularization of tissue grafts

The subject invention pertains to materials and methods for processing tissue to produce a natural, acellular replacement tissue that is immunocompatible with a recipient. According to the subject invention, harvested tissue is subjected to wash solutions wherein only amphoteric detergent(s) are used (e.g., anionic detergents are excluded). ... The University Of Florida Research Foundation Incorporated

05/04/17 / #20170121631

Articles having low coefficients of friction, methods of making the same, and methods of use

Briefly described, embodiments of this disclosure include articles and methods of making articles.. . ... The University Of Florida Research Foundation Incorporated

05/04/17 / #20170121530

Durable and scalable superhydrophobic paint

A paint that imparts a superhydrophobic surface on an object is a suspension of hydrophobic particles in a polymeric binder and a plasticizer in a solvent or mixed solvent. The particles are a metal oxide that is surface functionalized with a fluorinated alkyl silane or an alkyl silane. ... The University Of Florida Research Foundation Incorporated

05/04/17 / #20170119916

Clo2 on-demand disinfectant sponge or wipe and method of making

A disinfectant appliance has a plurality of chlorite absorbent particles, a plurality of redox resin particles, and at least one absorbent material combined such that the absorbent material allows and can promote: infusion of water into the disinfectant appliance; release of the chlorite from the chlorite absorbent particles into the water to form a chlorite comprising solution; contacting of the chlorite comprising solution with the redox resin particles; and the expulsion of clo2 comprising solution from the disinfectant appliance onto a surface to be disinfected. The disinfectant appliance can include a storage section and can include a handle. ... The University Of Florida Research Foundation Incorporated

05/04/17 / #20170119668

Polymeric particles, method for cytosolic delivery of cargo, methods of making the particles

Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.. . ... The University Of Florida Research Foundation Incorporated








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