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The University Of Kansas patents


Recent patent applications related to The University Of Kansas. The University Of Kansas is listed as an Agent/Assignee. Note: The University Of Kansas may have other listings under different names/spellings. We're not affiliated with The University Of Kansas, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The University Of Kansas-related inventors


Sheathless interface for capillary electrophoresis/electrospray ionization-mass spectrometry

Provided herein are capillaries for use in an electrophoretic separations. The capillaries can comprise an elongated tubular wall defining a path for fluid flow from an inlet to a tapered outlet; and a decoupler junction positioned within the elongated tubular wall upstream of the tapered outlet. ... The University Of Kansas

Aerial vehicles and methods of use

An aerial vehicle capable of convertible flight from hover to linear flight includes a body having a longitudinal body axis, a plurality of forward wings, a plurality of aft wings, at least one motor, and at least three aerodynamic propulsors driven by the at least one motor. Each forward wing extends a forward wing plane. ... The University Of Kansas

Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds

The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. ... The University Of Kansas

Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same

Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.. ... The University Of Kansas

Enalapril compositions

Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.. ... The University Of Kansas

Scanning resonator microscopy

A method of imaging a sample via scanning resonator microscopy is provided comprising positioning a whispering gallery mode (wgm) optical resonator at a first location over the surface of the sample, the wgm optical resonator characterized by at least one resonance frequency, wherein the wgm optical resonator is mounted to the free end of an atomic force microscopy (afm) cantilever such that the wgm optical resonator moves with the afm cantilever, and wherein the afm cantilever is operably coupled to an afm system configured to provide a topographical image of the sample; evanescently coupling excitation light into the wgm optical resonator; detecting light derived from the excitation light to monitor for a shift in the at least one resonance frequency induced by the surface of the sample; and repeating steps (a)-(c) at least at a second location over the surface of the sample.. . ... The University Of Kansas

Heated lens lighting arrangement

According to aspects of the embodiments, a lighting fixture is designed to help prevent the accumulation of snow or ice on the light emitting face (e.g., lens) of the lighting fixture. The lighting fixture harvests both the light and heat generated by at least one light source, such as but not limited to at least one led light source. ... The University Of Kansas

Compact orthopedic anti-rotation device

Embodiments of the present invention relate to systems, methods, and apparatus for immobilizing and/or securing bone portions. Particularly, at least one embodiment involves a compact anti-rotation device that can secure adjacent bones and/or bone portions in a manner that prevents or limits relative rotational movement thereof.. ... The University Of Kansas

Delayed gelling agents

The invention is directed to delayed gelation agents comprising a degradable polymeric cage containing therein one or more gelation agents. The cage degrades in situ, e.g., in an oil reservoir, thus releasing the gelation agent(s), which can then crosslink second polymers in situ to form a gel.. ... The University Of Kansas

Biphenyl amides with modified ether groups as hsp90 inhibitors and hsp70 inducers

Provided herein are compounds of the formulas: (i) wherein: n, x2, r3, r3′, r4, r4′, r5, r5′, r6, and r6′ are as defined herein. Pharmaceutical compositions of the compounds are also provided. ... The University Of Kansas

Compounds and methods for increasing hair growth

A method of promoting hair growth can include: a polypeptide having a sequence that has at least 75% complementarity to or at least 75% identical to spr4; and topically administering the polypeptide to a subject. This can include putting or causing the polypeptide to be in the skin, such as in any dermal layer. ... The University Of Kansas

Biomolecule-carbon nanostructure nanocomposites for optoelectronic devices

An optoelectronic device comprises a nanocomposite comprising a carbon nanostructure having a surface and a bio molecule adsorbed on the surface and forming a heterojunction at the interface of the carbon nanostructure and the biomolecule, the carbon nanostructure and the biomolecule each characterized by respective conduction band edges and valence band edges. The device further comprises first and second electrodes in electrical communication with the nanocomposite. ... The University Of Kansas

Co-initiator and co-monomer for use in preparing polymer related compositions, methods of manufacture, and methods of use

The present disclosure relates to tertiary amine co-initiators that demonstrate reduced leaching and which may be utilized in dental restoration and other biomedical applications. Embodiments of the present disclosure provide compounds and compositions for use in preparing polymers and light curable dental resin composites, as well as methods for preparing photocurable polymer-based dental restorative materials. ... The University Of Kansas

Nanogels for delayed gelation

The instant application relates to nanogels or compositions that hold multivalent metal ions until some level of nanogel degradation has occurred, then slowly release the multivalent metal ions for gelation with carboxylate containing polymers. Compositions comprising such nanogels, together with polymers that can be crosslinked with multivalent metal ions, allow the deployment of such mixtures in various applications, and greatly increased gelation times.. ... The University Of Kansas

11/23/17 / #20170334892

Lkb1-ampk activators for therapeutic use in polycystic kidney disease

. . Compounds are provided for use in treating polycystic kidney disease (pkd) and in associated methods that include a method of modulating (e.g., activating) liver kinase b1 (lkbi); and a method of modulating (e.g., decreasing activity) mammalian target of rapamycin (mtor). The methods may include introducing the compound in a therapeutically effective amount to a subject having pkd. ... The University Of Kansas

11/16/17 / #20170327313

System and methods for archiving and retrieving specimens

Embodiments of the present invention include a system and methods for archiving and/or retrieving specimens. Embodiments of the system of the present invention include a movement mechanism, an archival structure, and a software program. ... The University Of Kansas

10/26/17 / #20170304329

Methods of bladder cancer treatment with ciclopirox, ciclopirox olamine, or a ciclopirox prodrug

A method of treating bladder cancer is provided. The method of treating bladder cancer can include: providing a pharmaceutical composition having ciclopirox or ciclopirox olamine or a ciclopirox-pom prodrug having a structure of one of the formulae provided herein or derivative thereof or stereoisomer thereof or pharmaceutically acceptable salt thereof; and administering the pharmaceutical composition to a subject having the bladder cancer. ... The University Of Kansas

09/14/17 / #20170260184

Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds

The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. ... The University Of Kansas

09/14/17 / #20170260141

Antagonists of the kappa opioid receptor

The present technology is directed to compounds, compositions, and methods related to non-morphinan-like kappa opioid receptor (kor) antagonists. The technology is suited to treat addiction, diuresis, depression, post traumatic stress disorder, an eating disorder, panic disorder, social anxiety disorder, general anxiety disorder, obsessive compulsive disorders, excessive or unreasonable specific phobias, and/or other conditions related to anxiety or aversion-reward responses.. ... The University Of Kansas

09/07/17 / #20170253582

Triazole modified coumarin and biphenyl amide-based hsp90 inhibitors

Provided herein are compounds of the formulas: which are 90-kda heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided. ... The University Of Kansas

08/03/17 / #20170218022

Targeted conformationally-constrained kinked endosomal disrupting peptides

A peptide can have a sequence of one of seq id nos: 78-91. A conformationally-constrained kinked peptide includes: a conformationally-constraining portion and a kinked portion linked to the conformationally-constraining portion that conformationally constrains the kinked portion having a peptide sequence of one of seq nos: 78-97. ... The University Of Kansas

08/03/17 / #20170216092

Cannula for external drainage of subretinal fluid

A cannula device for draining sub-retinal fluid externally to the eye includes a shaft, an outer sleeve, and an inner sleeve. The outer sleeve and the inner sleeve have a curve therein to access the back of the eye externally. ... The University Of Kansas

07/27/17 / #20170210971

Low ph crosslinking of polymers

The invention is directed to polymers that self-crosslink at acidic ph or can be crosslinked by phenolic agents in brine. Such polymers have lower viscosity and can be pumped deep into reservoirs, where they will cross link in situ, thus increasing their viscosity and/or form a gel and blocking thief zones. ... The University Of Kansas

07/27/17 / #20170209483

Antibiotic activity of iron sequestering polymers

A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a benzene ring with more than one hydroxyl group at any position that is free. ... The University Of Kansas

07/13/17 / #20170199269

Techniques for navigating uavs using ground-based transmitters

Systems, methods, apparatuses and computer-readable storage media for navigating an unmanned aerial vehicle (uav) using signals of opportunity are disclosed. The uav may include a receiver for detecting a plurality of signals at two or more receiver elements. ... The University Of Kansas

07/06/17 / #20170190738

Cyclic tetrapeptide stereoisomers

Cyclic tetrapeptide stereochemical isomers of cj-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.. ... The University Of Kansas

06/29/17 / #20170181968

Enalapril compositions

Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.. ... The University Of Kansas

06/22/17 / #20170176450

Systems and methods for identifying protein stabilizers

A device for studying protein conformation transformation can include a macroscopic substrate, and chaperonin proteins bound to the substrate, each chaperonin protein being capable of binding to a protein of interest during or after undergoing protein conformation transformation. The device may also include the proteins of interest bound to the substrate, where the substrate is included in a label-free assay system. ... The University Of Kansas

05/18/17 / #20170137115

Radar energy absorbing deformable low drag vortex generator

A family of radar energy absorbing deformable low drag vortex generators (rad-ldvg) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface features while reducing radar returns from structural details. ... The University Of Kansas

05/18/17 / #20170135683

Solenoid occlusion device

The present disclosure relates to devices and methods for delivery of a ferrofluid to a targeted treatment site, such as delivery of a ferroadhesive to a pathological fistula to occlude the fistula. A device includes a catheter having a lumen and a distal opening. ... The University Of Kansas

05/04/17 / #20170122973

Systems, methods, and devices for fluid data sensing

A fluid sensing device includes an outer body, an inner body coupled to the outer body by one or more inner body support struts and extending at least partially out from the outer body, and an aft body disposed at least partially within the outer body at a location aft of the inner body, the aft body being coupled to the outer body by one or more aft body support struts. The inner body includes a hollow interior for housing one or more inner body sensors, and the aft body houses one or more aft body sensors. ... The University Of Kansas

04/27/17 / #20170114053

Heterocyclic compounds and methods of use thereof

Disclosed are compounds of formula (i), formula (ii), and formula (iii): wherein ar, r1, a, and x are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis c. ... The University Of Kansas

04/20/17 / #20170107497

Improved reliability of assays using a multi-divot platform and multi-source, multi-cell type clusters

Described herein are 3-dimensional clusters of reaggregated cells comprising cells reaggregated from at least two different cell sources, such as different cell types, different donors, and combinations thereof. Methods of making, using, and cryopreserving these 3-dimensional clusters of reaggregated cells are also described herein.. ... The University Of Kansas

03/09/17 / #20170067018

Reprogramming of human wharton's jelly cells to produce hair cells

A method of transforming human cells into mechanosensory hair cells (mhcs), such as inner hear hair cells in the cochlea and vestibular organs, can include: causing human wharton's jelly cells (hwjcs) to increase expression of or biological function of hath1 so as to transform the hwjcs into mhcs. The method can include; administering a nucleic acid that encodes hath1 to the hwjcs; causing inhibited expression of or biological function of hes1 and/or hes5 in the hwjcs; administering a nucleic acid that inhibits hes1 and/or a nucleic acid that inhibits hes5 to the hwjcs; causing inhibited expression of or biological function of hes1 and/or hes5 in the wjcs by administering a nucleic acid that inhibits hes1 and/or a nucleic acid that inhibits hes5; nucleic acids are administered includes a sequence of seq id no: 2, seq id no: 3, and/or seq id no: 4.. ... The University Of Kansas

03/09/17 / #20170065742

Methacrylated devitalized cartilage and devitalized cartilage particles

An implantable composition can include methacrylated solubilized devitalized cartilage (mesdvc) with or without devitalized cartilage (dvc) particles. These compositions can be hydrogel precursors. ... The University Of Kansas

03/09/17 / #20170065540

Methods and compositions for treating infection

Provided herein are compositions and methods for treating or preventing infection.. . ... The University Of Kansas

02/23/17 / #20170051000

C-terminal hsp90 inhibitors

Hsp90 c-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.. ... The University Of Kansas

02/23/17 / #20170049079

Modular force sensor system, device, and method for behavioral measurement

Implementations of the present invention relate to for analyzing behavior of small live test subjects. More specifically, methods and devices of the present invention can allow a researcher to use a single device for analyzing effects of genetic modifications made to the test subjects on the test subject's behavior and movements. ... The University Of Kansas

02/16/17 / #20170044425

Stability improvement of co2 foam for enhanced oil recovery applications using polyelectrolytes and polyelectrolyte complex nanoparticles

Polyelectrolyte nanoparticles are generated to stabilize foam for use in enhanced oil recovery. Stability is further enhanced by optimizing ph and a ratio of polycationic and polyanioinic materials, resulting in stronger and longer lasting foams in the presence of crude oil. ... The University Of Kansas

02/02/17 / #20170029421

Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds

The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof. ... The University Of Kansas

02/02/17 / #20170028073

Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators

Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.. . ... The University Of Kansas

02/02/17 / #20170028072

Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators

Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use.. . ... The University Of Kansas

01/26/17 / #20170021399

Laboratory fume hood system having recessed heat exchanger system

A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a primary fluid loop containing chilled fluid and a secondary fluid loop containing a cooling fluid which is in thermal communication the laboratory device. The primary fluid loop is located behind the fume hood wall and not in the interior work area.. ... The University Of Kansas

01/12/17 / #20170007684

Bifunctional conjugate compositions and associated methods

Bifunctional conjugate compositions are provided comprising a signal-1 moiety bound to a first polymer carrier, wherein the combined size of the signal-1 moiety and the first polymer carrier is about 1 nanometer to about 500 nanometers; and a signal-2 moiety bound to a second polymer carrier, wherein the combined size of the signal-2 moiety and the second polymer carrier is about 1 nanometer to about 500 nanometers. In some embodiments, the signal-1 moiety and the signal-2 moiety are bound to the same polymer carrier. ... The University Of Kansas








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