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The University Of Notre Dame Du Lac patents


Recent patent applications related to The University Of Notre Dame Du Lac. The University Of Notre Dame Du Lac is listed as an Agent/Assignee. Note: The University Of Notre Dame Du Lac may have other listings under different names/spellings. We're not affiliated with The University Of Notre Dame Du Lac, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The University Of Notre Dame Du Lac-related inventors


Copolymer nanofilters with charge-patterned domains

The further advancement of membrane separation processes requires the development of more selective membranes. In this study, membranes that take inspiration from biological systems and use multiple functionalities of unique chemical design to control solute transport through chemical factors in addition to steric factors are detailed. ... The University Of Notre Dame Du Lac

Ionic liquids comprising heteraromatic anions

Some embodiments described herein relate to ionic liquids comprising an anion of a heteraromatic compound such as optionally substituted pyrrolide, optionally substituted pyrazolide, optionally substituted indolide, optionally substituted phospholide, or optionally substituted imidazolide. Methods and devices for gas separation or gas absorption related to these ionic liquids are also described herein.. ... The University Of Notre Dame Du Lac

Multifunctional micellar nanoparticle-based drug and targeting agent system

Embodiments provide systems, methods, and compositions for nanoparticle-based drug delivery to target cells or tissues. A drug delivery system may include a nanoparticle with a targeting component and a therapeutic component. ... The University Of Notre Dame Du Lac

Methods and apparatus for a shear-enhanced cnt-assembly nanosensor platform for ultra-sensitive and selective protein detection

A nanoscale protein-sensing platform with a non-equilibrium on-off switch that employs dielectrophoretic and hydrodynamic shear forces to overcome these thermodynamic limitations with irreversible kinetics. The detection sensitivity is achieved with complete association of the antibody-antigen-antibody (ab-ag-ab) complex by precisely and rapidly assembling carbon nanotubes (cnt) across two parallel electrodes via sequential dc electrophoresis and dielectrophoresis (dep), and with single-cnt electron tunneling conductance. ... The University Of Notre Dame Du Lac

Methods and apparatus for mitigation of current reversal in capillary zone electrophoresis-electrospray device

The combined capillary electrophoresis electrospray mass spectrometry apparatus has a circuit to handle excess current allows separations under a wide range of electrophoretic conditions. The apparatus includes an electrospray with an emitter and an electrospray interface connected with a separation capillary configured to transport a sample with an injection end and a distal end. ... The University Of Notre Dame Du Lac

Synthesis and utility of new capgroup largazole analogs

Analogs of largazole are described herein. Methods of treating cancer, blood disorders, autoimmune disease, and alzheimer's disease using largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. ... The University Of Notre Dame Du Lac

Method for preparing largazole analogs and uses thereof

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. ... The University Of Notre Dame Du Lac

Potentiators of beta-lactam antibiotics

We disclose herein that the blar1 protein of methicillin-resistant staphylococcus aureus (mrsa), an antibiotic sensor/signal transducer, is phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochemical events that unleash induction of antibiotic resistance. ... The University Of Notre Dame Du Lac

Method and apparatus of plasma flow control for drag reduction

A plasma plate is used to minimize drag of a fluid flow over an exposed surface. The plasma plate includes a series of plasma actuators positioned on the surface. ... The University Of Notre Dame Du Lac

Quinazolinone antibiotics

A new class of antibiotics effective against methicillin-resistant staphylococcus aureus (mrsa) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (pbp) 2a. ... The University Of Notre Dame Du Lac

System for capillary electrophoresis for peptide and protein analysis

The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary and thermally initiating polymerization of the monomer thereby providing a capillary comprising an internal polymeric coating for separating, identifying, and quantifying components of an analyte.. ... The University Of Notre Dame Du Lac

Peripherally substituted monocyclic beta-lactams

The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.. . ... The University Of Notre Dame Du Lac

Enhanced cosite transmitter-receiver isolation

Systems and methods for improving isolation between a cosite transmitter-receiver system. The transmitter may send a first plurality of transmit signals from multiple transmit ports. ... The University Of Notre Dame Du Lac

Linear combinations of transmit signals by a receiver

A multi-port transmitter can synthesize and send a first plurality of transmit signals having a separability characteristic which permits them to be differentiated from one another. A receiver can then detect one or more receiver signals which include one or more combinations of received versions of the first plurality of transmit signals. ... The University Of Notre Dame Du Lac

11/23/17 / #20170333524

Molecular constructs and uses thereof

Molecular constructs and dual recognition constructs having a sequence encoding a tcr affinity weakening motif, and dna and rna sequences corresponding thereto, are presented. Modified t-cells and other cells transformed with the molecular contracts express a modified tcr that imparts a reduction, in non-specific binding, an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) t-cells, are described. ... The University Of Notre Dame Du Lac

11/16/17 / #20170325932

Additive manufacturing device for biomaterials

An additive manufacturing (am) device for biomaterials comprises a reservoir, a shaft, and a material delivery head. The device can be used for intracorporeal additive manufacturing. ... The University Of Notre Dame Du Lac

09/28/17 / #20170274053

Acceleration of diabetic wound healing

The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme mmp-8, or the topical treatment of the wound with mmp-8 in combination with administration of an mmp-9 inhibitor, to accelerate the healing of the wound.. ... The University Of Notre Dame Du Lac

09/21/17 / #20170269035

Voltammetry in high-voltage fields

Herein are described an instrument and a method for using the same. The instrument comprises a fluid channel fluidly connected to at least a first fluid reservoir and a second fluid reservoir; a counter electrode (ce), a reference electrode (re), and a working electrode (we); and a potentiostat. ... The University Of Notre Dame Du Lac

09/07/17 / #20170253916

Exosomal biomarkers diagnostic of tuberculosis

The disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain rna biomarkers present in secreted extracellular vesicles isolated from a bodily fluid. The rna biomarkers in the secreted extracellular vesicles may include a certain mycobacterium rnas as well as certain host cell rnas. ... The University Of Notre Dame Du Lac

08/31/17 / #20170248640

Methods and apparatus for spin wave-based spectrum analyzers

An example device includes a magnetic film, two or more spin wave generators, and one or more detectors. The magnetic film is capable of supporting spin waves. ... The University Of Notre Dame Du Lac

08/31/17 / #20170247766

Late er+ breast cancer onset assessment and treatment selection

A method for determining the likelihood of late er− breast cancer disease relapse/recurrence is disclosed. Late er+ breast cancer disease onset and/or recurrence is determined for a period of 5 to 20 years after an initial er+ breast cancer disease onset in a patient. ... The University Of Notre Dame Du Lac

08/10/17 / #20170229737

Ion transport in binary-salt ionic liquids

The viscosity of various ionic liquids (il), the solvent tetraethylene glycol dimethyl ether (g4), and their mixtures, with or without lithium salts, were measured experimentally. Various compositions were studied spectroscopically. ... The University Of Notre Dame Du Lac

07/06/17 / #20170190685

Selective matrix metalloproteinase inhibitors

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (mmps). The compounds can be selective mmp inhibitors, for example, selective inhibitors of mmp-2, mmp-9, and/or mmp-14. ... The University Of Notre Dame Du Lac

06/22/17 / #20170179093

Inter-chip alignment

First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is positioned contiguous to the first edge surface of the first integrated device. ... The University Of Notre Dame Du Lac

06/15/17 / #20170166607

Antibody purification via affinity chromatography

Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography. ... The University Of Notre Dame Du Lac

05/04/17 / #20170125555

Group iii-nitride compound heterojunction tunnel field-effect transistors and methods for making the same

A tunnel field-effect transistor device includes a p-type gan source layer, an ntype gan drain layer, and an interlayer interfaced between the source-layer and the drain layer. These devices employ polarization engineering in gan/inn heterojunctions to achieve appreciable interband tunneling current densities. ... The University Of Notre Dame Du Lac

05/04/17 / #20170125521

Group iii-nitride compound heterojunction tunnel field-effect transistors and methods for making the same

A tunnel field-effect transistor device includes a p-type gan source layer, an n-type gan drain layer, and an interlayer interfaced between the source-layer and the drain layer. In one example, the interlayer includes an indium nitride (inn) layer. ... The University Of Notre Dame Du Lac

04/20/17 / #20170108485

Integrated membrane sensor for rapid molecular detection

Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic markers present in real samples. Its various components can be easily integrated in a modular fashion for different applications. ... The University Of Notre Dame Du Lac

04/13/17 / #20170103979

Systems and methods for filtering and computation using tunnelling transistors

An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (tfets) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of the tfets that is not on an end of the matrix, a drain of the tfet is electrically coupled with the source of at least one of the other tfets at a node of the matrix and a source of the tfet is electrically coupled with the drain of at least one of the other tfets at another node of the matrix. The electrical circuit further comprises a plurality of capacitors, wherein a respective one of the plurality of capacitors is electrically coupled with each node that includes the source of at least one tfet and the drain of at least one tfet. ... The University Of Notre Dame Du Lac

04/06/17 / #20170098716

Two-dimensional heterojunction interlayer tunneling field effect transistors

A two-dimensional (2d) heterojunction interlayer tunneling field effect transistor (thin-tfet) allows for particle tunneling in a vertical stack comprising monolayers of two-dimensional semiconductors separated by an interlayer. In some examples, the two 2d materials may be misaligned so as to influence the magnitude of the tunneling current, but have a modest impact on gate voltage dependence. ... The University Of Notre Dame Du Lac

03/23/17 / #20170085255

Mixed signal processors

Various processor architectures for mixed signal computation exploit the unique characteristics of advanced cmos technologies, such as fin-based, multi-gate field effect transistors, and/or emerging technologies such as tunnel field effect transistors (tfets). The example processors disclosed herein are cellular neural network (cnn)-inspired and eliminate the need for voltage controlled current sources (vccss), which have previously been utilized to realize feedback and feed-forward templates in cnns and are the dominant source of power consumption in a cnn array. ... The University Of Notre Dame Du Lac

03/09/17 / #20170069860

Cell-based electromechanical biocomputing

A diode and logic gate comprising cells is disclosed. A method of making the diode and logic gate comprising cells is disclosed.. ... The University Of Notre Dame Du Lac

02/23/17 / #20170054583

Space-polarization modulated communications

Methods and systems relating to topics in space-polarization modulated communications. The topics include: adaptive space-polarization modulated communications using channel state information at the transmitter; adaptive decision boundaries at the receiver; carrier frequency offset estimation for multi-carrier modulation schemes; transmission of analog images using polarization and coherence dispersion information; and reduction of peak-to-average power ratio in multi-carrier modulation schemes.. ... The University Of Notre Dame Du Lac

01/26/17 / #20170021339

Methods of making and using layered cobalt nano-catalysts

A method of making ldo-co nanoparticles is described herein. A method of using ldo-co nanoparticles, particularly in the treatment of wastewater, is described herein.. ... The University Of Notre Dame Du Lac

01/19/17 / #20170019193

Use of coherent signal dispersion for signal source association

A signal source association method and receiver. A receiver can be used to detect a plurality of signals transmitted from a plurality of transmission sources. ... The University Of Notre Dame Du Lac

01/19/17 / #20170016367

Glass catalyst compositions for improved hydrothermal durability

A diesel soot filter includes a substrate having a surface disposed at least partially within a fluid path of the diesel soot filter. A glass catalyst is disposed on the surface of the substrate such that an exhaust gas contacts at least a portion of a surface of the glass catalyst as the exhaust gas moves within the diesel soot filter. ... The University Of Notre Dame Du Lac

01/19/17 / #20170015647

Selective matrix metalloproteinase inhibitors

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (mmps). The compounds can be selective mmp inhibitors, for example, selective inhibitors of mmp-2, mmp-9, and/or mmp-14. ... The University Of Notre Dame Du Lac








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