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Ucl Business Plc patents


Recent patent applications related to Ucl Business Plc. Ucl Business Plc is listed as an Agent/Assignee. Note: Ucl Business Plc may have other listings under different names/spellings. We're not affiliated with Ucl Business Plc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | Ucl Business Plc-related inventors


Chimeric protein

The present invention provides a chimeric protein which comprises a multi-spanning transmembrane protein fused to a fas endodomain, wherein the multi-spanning transmembrane protein binds an extracellular ligand, leading to activation of the fas endodomain. The chimeric protein is useful as a suicide gene. ... Ucl Business Plc

Adeno-associated virus factor viii vectors

The invention provides improved adeno-associated virus (aav) factor viii (fviii) vectors, including aav fviii vectors that produce a functional factor viii polypeptide and aav fviii vectors with high expression activity.. . ... Ucl Business Plc

Prosthetic heart valve

A prosthetic heart valve (1) for implantation at the mitral annulus of a heart, the prosthetic heart valve comprising: a support framework (10) reversibly transformable between a collapsed configuration and an expanded configuration; and one or more leaflets connected to the framework; wherein, in the expanded configuration: the support framework defines a fluid pathway through the prosthetic heart valve, the fluid pathway having a portion with a d-shaped cross section for engaging the mitral annulus; and the one or more leaflets allow fluid to pass through the fluid pathway in a first direction but prevent fluid from flowing in the opposite direction.. . ... Ucl Business Plc

Apparatus and method for registering pre-operative image data with intra-operative laparoscopic ultrasound images

A method and apparatus are provided for registering pre-operative three dimensional (3-d) image data of a deformable organ comprising vessels with multiple intra-operative two-dimensional (2-d) ultrasound images of the deformable organ acquired by a laparoscopic ultrasound probe during a laparoscopic procedure. The apparatus is configured to: generate a 3-d vessel graph from the 3-d pre-operative image data; use the multiple 2-d ultrasound images to identify 3-d vessel locations in the deformable organ; determine a rigid registration between the 3-d vessel graph from the 3-d pre-operative image data and the identified 3-d vessel locations in the deformable organ; and apply said rigid registration to align the pre-operative three dimensional (3-d) image data with the two-dimensional (2-d) ultrasound images, wherein the rigid registration is locally valid in the region of the deformable organ of interest for the laparoscopic procedure.. ... Ucl Business Plc

Natural killer cell priming composition

The present invention relates to a composition for priming a human natural killer (nk) cell. The present invention provides a natural killer (nk) cell priming composition which comprises (i) a cd2 ligation agent; (ii) an nkp46 ligation agent; and (iii) an lfa-1 ligation agent. ... Ucl Business Plc

T cell which expresses a gamma-delta t cell receptor (tcr) and a chimeric antigen receptor (car)

The present invention provides a t cell which expresses a gamma-delta t cell receptor (tcr) and a chimeric antigen receptor (car), wherein the car comprises: an antigen binding domain; a transmembrane domain; and a co-stimulatory intracellular signalling domain; wherein the intracellular signalling domain provides a co-stimulatory signal to the t cell following binding of antigen to the antigen binding domain.. . ... Ucl Business Plc

Nucleic acid construct for expressing more than one chimeric antigen receptor

The present invention provides a nucleic acid construct comprising the following structure: a-x—b in which a and b are nucleic acid sequences encoding a first and a second chimeric antigen receptor (car); and x is a nucleic acid sequence which encodes a cleavage site, wherein the first and second car recognise different antigens; the first and second car comprise or associate with activating endodomains; and (a) the first and/or second car comprises an intracellular retention signal; and/or (b) the signal peptide of the first or second car comprises one or more mutation(s) such that it has fewer hydrophobic amino acids.. . ... Ucl Business Plc

Nucleic acid construct for expressing more than one chimeric antigen receptor

The present invention provides a nucleic acid construct comprising the following structure: a-x-b in which x is a nucleic acid sequence which encodes a cleavage site; and a and b are nucleic acid sequences encoding a first and a second chimeric antigen receptor (car), each car comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second cars bind to different antigens, wherein the spacer of the first car is different to the spacer of the second car and wherein one of the first or second cars is an activating car comprising an activating endodomain and the other car is an inhibitory car comprising a ligation-off inhibitory endodomain; and wherein: (a) the first and/or second car comprises an intracellular retention signal; and/or (b) the signal peptide of the first or second car comprises one or more mutation(s) such that it has fewer hydrophobic amino acids.. . ... Ucl Business Plc

Layered bodies, compositions containing them and process for producing them

A layered body comprising: a core region; at least one intermediate layer disposed around the core region; and an outer layer disposed around the at least one intermediate layer, wherein at least one of the at least one intermediate layers comprises a gas, the layered body having at least one dimension, measured across the body and through the core region, of 100 μm or less.. . ... Ucl Business Plc

Nucleic acid construct

The present invention provides a nucleic acid construct comprising the following structure: a-x-b in which a and b are nucleic acid sequences encoding a first and a second polypeptide of interest (poi); and x is a nucleic acid sequence which encodes a cleavage site, wherein either the first or second poi is a transmembrane protein which comprises an intracellular retention signal.. . ... Ucl Business Plc

Nucleic acid construct

The present invention provides a nucleic acid construct comprising the following structure: a-x—b in which a is nucleic acid sequence encoding a first polypeptide which comprises a first signal peptide; b is nucleic acid sequence encoding a second polypeptide which comprises a second signal peptide and x is a nucleic acid sequence which encodes a cleavage site, wherein the first signal peptide or the second signal peptide comprises one or more mutation(s) such that it has fewer hydrophobic amino acids.. . ... Ucl Business Plc

Layered bodies, compositions containing them and process for producing them

A layered body comprising: a core region; at least one intermediate layer disposed around the core region; and an outer layer disposed around the at least one intermediate layer, wherein at least one of the at least one intermediate layers comprises a gas, the layered body having at least one dimension, measured across the body and through the core region, of 100 μm or less.. . ... Ucl Business Plc

Detecting activity in peripheral nerves

There is disclosed a method of determining electrical properties in a peripheral nerve of a human or animal subject using a plurality of electrodes spaced around a perimeter of the nerve, by applying a probe electrical signal to each of a plurality of combinations of the electrodes, and using the resulting electrical responses to determine the electrical properties, for example by carrying out an electrical impedance tomography image reconstruction.. . ... Ucl Business Plc

Protein-based t-cell receptor knockdown

The invention relates to protein-based t-cell receptor knockdown, and its use in t-cell therapies.. . ... Ucl Business Plc

03/08/18 / #20180066280

Retroviral and lentiviral vectors

The present invention provides a retroviral or lentiviral vector having a viral envelope which comprises: (i) a mitogenic t-cell activating transmembrane protein which comprises a mitogenic domain and a transmembrane domain; and/or (ii) a cytokine-based t-cell activating transmembrane protein which comprises a cytokine domain and a transmembrane domain, wherein the mitogenic or cytokine-based t-cell activating transmembrane protein is not part of a viral envelope glycoprotein. When cells such as t-cells of natural killer cells are transduced by such a viral vector, they are simultaneously activated by the mitogenic t-cell activating transmembrane protein and/or the cytokine-based t-cell activating transmembrane protein.. ... Ucl Business Plc

03/08/18 / #20180064758

Chimeric antigen receptor

The present invention provides a chimeric antigen receptor (car) comprising an antigen-binding domain with an affinity in the range of 50 nm to 500 nm, wherein said affinity comprises component kinetics such that the association rate constant (kon) is greater than or equal to 1×105 m−1 s−1, and/or the dissociation rate constant (koff) is greater than or equal to 0.01 s−1.. . ... Ucl Business Plc

02/22/18 / #20180050065

Chimeric antigen receptor

The present invention provides a chimeric antigen-receptor (car)-forming polypeptide comprising: (i) an antigen-binding domain; (ii) a coiled-coil spacer domain; (iii) a transmembrane domain; and (iv) an endodomain. The invention also provides a multimeric car formed by association of a plurality of car-forming polypeptides by virtue of association of their coiled-coil spacer domains.. ... Ucl Business Plc

02/15/18 / #20180044417

Chimeric antigen receptor (car) comprising a cd19-binding domain

There is provided a chimeric antigen receptor (car) comprising a cd19-binding domain which comprises a) a heavy chain variable region (vh) having complementarity determining regions (cdrs) with the following sequences: cdr1-gy-afsss (seq id no. 1); cdr2-ypgded (seq id no. ... Ucl Business Plc

02/01/18 / #20180030477

Gene therapy to improve vision

The invention relates to the use of gene therapy vectors to improve vision by introducing into healthy rod photoreceptor cells of a patient suffering from cone photoreceptor dysfunction and/or degeneration a nucleic acid encoding a gene product that is light-sensitive and/or that modulates endogenous light-sensitive signaling in a photoreceptor cell, such that the range of light intensities to which the rod photoreceptor responds is extended and/or the speed at which the rod photoreceptor responds to light is increased.. . ... Ucl Business Plc

02/01/18 / #20180028609

Treatment

The invention provides an antibody or fragment thereof that specifically binds to human lrg1.. . ... Ucl Business Plc

02/01/18 / #20180028570

Angiogenic factors

The disclosure relates to methods for obtaining angiogenic factors, as well as to methods of treating cardiovascular disease and methods for stimulating angiogenesis.. . ... Ucl Business Plc

02/01/18 / #20180028117

Ultrasound probe

Provided herein is a probe for ultrasound imaging of tissue. The probe comprises an optical relay having an optically absorbing coating at the distal end of the probe for generating ultrasound from excitation light via the photoacoustic effect, wherein the generated ultrasound propagates as an ultrasound beam into the tissue; and an ultrasound receiver separate from the optical relay. ... Ucl Business Plc

01/25/18 / #20180021458

Optimized rpe65 promoter and coding sequences

The present invention relates to the prevention and/or treatment of retinal dystrophyin a patient, including leber congenital amaurosis (lca).. . ... Ucl Business Plc

01/18/18 / #20180016335

Signalling system

The present invention relates to a chimeric antigen-receptor (car) signalling system comprising; (i) a targeting component comprising an antigen-binding domain, a transmembrane domain and a first heterodimerization domain; and (ii) an intracellular signalling component comprising a signalling domain and a second heterodimerization domain; wherein spontaneous heterodimerization between the first and second heterodimerization domains causes the targeting component and signalling component to form a functional car complex.. . ... Ucl Business Plc

01/18/18 / #20180015211

Blood filter

A blood filter device having an iron-chelating molecule, a haem-binding molecule and a haemoglobin-binding molecule bound to a support. Use of the device in a vessel containing blood, for example a blood bag or a flow line, removes haemolysis-derived components from the blood.. ... Ucl Business Plc

12/14/17 / #20170354627

Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies

Disclosed herein are methods of preventing, treating, and delaying the onset or progression of diseases associated with hepatic stellate cells (hscs), such as non-alcoholic fatty liver disease (nafld), fibrosis, and liver cancer, using ammonia-lowering therapies.. . ... Ucl Business Plc

12/07/17 / #20170349632

Quinolium conjugates of cyclosporin

The present invention relates to conjugates of cyclosporin with quinolium mitochondrial targeting groups, and their therapeutic uses.. . ... Ucl Business Plc

11/23/17 / #20170334998

Chimeric antigen receptor (car) with antigen binding domains to the t cell receptor beta constant region

The present disclosure relates to a chimeric antigen receptor (car) which comprises an antigen-binding domain which selectively binds tcr beta constant region 1 (trbc1) or trbc2; cells; such a t cells comprising such a car; and the use of such cells for the treatment of a t-cell lymphoma or leukaemia in a subject.. . ... Ucl Business Plc

11/23/17 / #20170334964

Ligand

The present invention provides a variant proliferation-inducing ligand (april), which has a higher binding affinity to bcma than wild-type april; and/or altered binding kinetics compared with wild-type april, and/or a higher bcma:taci (transmembrane activator and calcium modulator and cyclophilin ligand interactor) binding ratio than wild-type april and which comprises mutations at one or more of the following positions: a125, v174, t175, m200, p201, s202, h203, d205 and r206.. . ... Ucl Business Plc

11/16/17 / #20170327596

Method

The present invention provides a method for increasing the sensitivity of a t cell expressing a cell-surface antibody to a target antigen, which comprises the step of lowering the affinity of the antibody to the target antigen by at least 100-fold. The invention also provides chimeric antigen receptor comprising an antibody domain having an affinity for antigen in the range 100-1 μm, its encoding nucleic acid sequence and uses thereof.. ... Ucl Business Plc

10/12/17 / #20170291875

Quinolones as inhibitors of class iv bromodomain proteins

The present invention provides compounds of formula (i) as described herein and pharmaceutically acceptable salts, hydrates and solvates thereof for use in medicine, for example in the treatment of acute myeloid leukaemia:. . ... Ucl Business Plc

09/14/17 / #20170260269

Signalling system

. . The present invention provides a chimeric antigen receptor (car) signalling system comprising; (i) a receptor component comprising an antigen binding domain, a transmembrane domain and a first binding domain; and (ii) an intracellular signalling component comprising a signalling domain and a second binding domain which specifically binds the first binding domain of the receptor component; wherein, binding of the first and second binding domains is disrupted by the presence of an agent, such that in the absence of the agent the receptor component and the signalling component heterodimerize and binding of the antigen binding domain to antigen results in signalling through the signalling domain, whereas in the presence of the agent the receptor component and the signalling component do not heterodimerize and binding of the antigen binding domain to antigen does not result in signalling through the signalling domain.. . ... Ucl Business Plc

08/31/17 / #20170246004

Subtalar joint implant

A subtalar joint implant (20) is disclosed for replacing a natural subtalar joint existing between the talus (102) and calcaneum (104) bones of a patient. In an embodiment the implant comprises talar (22) and calcaneal (24) portions that are configured to slide over each other in the implanted state. ... Ucl Business Plc

08/24/17 / #20170240920

Method and means for purifying retroviral vectors

The present invention relates to a producer cell which expresses a tagging protein at the cell surface, such that retroviral vectors produced by the cell are tagged with the tagging protein, wherein the tagging protein comprises: i) a binding domain which binds to a capture moiety ii) a spacer; and iii) a membrane targeting domain such that, when incorporated a retroviral vector, the tagging protein facilitates purification of the retroviral vector from cellular supernatant via binding of the tagging protein to the capture moiety. The present invention also relates to a retroviral vector comprising such a producer cell-derived tagging protein.. ... Ucl Business Plc

08/03/17 / #20170216454

Rpgr gene therapy for retinitis pigmentosa

Methods for treating a human subject who has x-linked retinitis pigmentosa (xlrp) or another clinically-defined ophthalmological condition due to a loss-of-function mutation in the gene encoding the retinitis pigmentosa gtpase regulator (rpgr) protein, the method comprising administering to the subject a nucleic acid comprising an adeno-associated viral vector comprising an abbreviated human rpgr cdna.. . ... Ucl Business Plc

07/06/17 / #20170189364

Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy

The present invention relates to use of ornithine in the manufacture of a medicament for use in combination with at least one of phenylacetate and phenylbutyrate for preventing or treating liver decompensation or hepatic encephalopathy. The invention also relates to use of at least one of phenylacetate and phenylbutyrate in the manufacture of a medicament for use in combination with ornithine for preventing or treating liver decompensation or hepatic encephalopathy.. ... Ucl Business Plc

06/29/17 / #20170184570

Diagnostics

The present invention relates to the detection or diagnosis of infection or inflammation in a patient. In particular, the invention provides methods that allow the detection of markers in a sample from a patient or subject, such as a blood sample, which will indicate whether the patient or subject has an infection or has an inflammatory response.. ... Ucl Business Plc

06/29/17 / #20170182212

Collagen biomaterials

This invention relates to methods of producing collagen biomaterials by admixing (i) a solution of monomeric collagen, (ii) a solution of polymeric collagen, (ii) cargo particles, and (iv) a non-collagen blocking polymer, to produce a collagen solution. The collagen solution is then allowed to solidify to produce a collagen hydrogel. ... Ucl Business Plc

06/22/17 / #20170173184

Treatment

The present invention relates to the prevention and/or treatment of lysosomal storage diseases in a patient.. . ... Ucl Business Plc

06/08/17 / #20170157112

Hif inhibitors

The invention provides inhibitors of hypoxia-inducible factors (hif), and their use in the prevention or inhibition of diseases characterised by abnormal hif activity or levels, such as tumour progression, and the treatment of cancer. The invention encompasses pharmaceutical compositions with a mechanism of action for blocking elevated hif activity in diseases, such as cancer.. ... Ucl Business Plc

05/18/17 / #20170137480

Rpgr-ofr15 variant gene in the treatment of retinitis pigmentosa

The present invention relates to the treatment of ocular disease, specifically retinitis pigmentosa, by gene therapy using a modified version of the rpgr-orf15 gene.. . ... Ucl Business Plc

04/27/17 / #20170112967

Human liver scaffolds

This invention relates to methods for decellularising human liver tissue to produce human hepatic extracellular matrix (ecm) scaffolds, for example for use in therapy or disease modelling. The methods involve mechanically damaging cells in the tissue, for example by freeze thaw, and then subjecting the liver tissue to multiple cycles of osmotic stress, detergent treatment and protease and/or dnaase treatment to produce a decellularised human ecm scaffold.. ... Ucl Business Plc

04/20/17 / #20170108519

Apparatus and method for testing medicaments

Apparatus for testing the solubility of a medical dosage form includes a chamber (12) for holding a solvent medium (18), in the preferred embodiment a bicarbonate based buffer system. The apparatus also includes a ph probe (66) which is connectable to a supply of carbon dioxide (32, 34), as well as to a supply of helium (40), the supplies being controlled by a control unit (50). ... Ucl Business Plc

03/09/17 / #20170066838

Chimeric antigen receptor

. . Provision of a chimeric antigen receptor (car) comprising a disialoganglioside (gd2)-binding domain which comprises a) a heavy chain variable region (vh) having complementarity determining regions (cdrs) with the following sequences: b) a light chain variable region (vl) having cdrs with the following sequences: t cells expressing such a car are useful in the treatment of some cancers.. . ... Ucl Business Plc

03/09/17 / #20170066827

Chimeric antigen receptor

The present disclosure relates to a chimeric antigen receptor (car) which comprises an antigen-binding domain which selectively binds tcr beta constant region 1 (trbc1) or trbc2; cells; such a t cells comprising such a car; and the use of such cells for the treatment of a t-cell lymphoma or leukaemia in a subject.. . ... Ucl Business Plc

03/09/17 / #20170065349

System and method for computer-assisted planning of a trajectory for a surgical insertion into a skull

A system and method are provided for using a computer system to assist in planning a trajectory (960a, 960b) for a surgical insertion into a skull. The method comprises providing the computer system with a three-dimensional representation of the skull and of critical objects located within the skull, wherein the critical objects comprise anatomical features to be avoided during the surgical insertion. ... Ucl Business Plc

03/02/17 / #20170056534

Detecting a therapeutic cell

The present invention relates to a method of detecting a therapeutic cell expressing a dopamine transporter (dat) at a central nervous system (cns) site in a subject, which comprises the administration of a dat tracer to the subject, wherein the presence of a therapeutic cell which expresses the dat is determined.. . ... Ucl Business Plc

02/16/17 / #20170042838

Treatment of fibrosis

The present invention relates an aldehyde dehydrogenase inhibitor for use in the treatment or prevention of fibrosis.. . ... Ucl Business Plc

02/02/17 / #20170027936

Abl1 inhibitor for treating and preventing ocular neovascularisation

The present invention relates to an abelson murine leukaemia viral oncogene homolog 1 (abl1) inhibitor for use in the treatment of ocular neovascularisation associated with a non-cancerous condition. The invention also relates to the use of an abl1 inhibitor as a complementary therapy with vegf or vegf receptor inhibitor treatment and provides pharmaceutical compos itions and kits comprising one or both inhibitors.. ... Ucl Business Plc

01/19/17 / #20170016054

Detecting increase or decrease in the amount of a nucleic acid having a sequence of interest

A method of detecting copy number variations in foetal or tumour dna within a sample of circulating cell-free dna includes carrying out amplification of dna such that amplification of longer dna molecules is discriminated against. This results in preferential amplification of foetal or tumour dna, which can then be analysed using, for example,array comparative genome hybridisation.. ... Ucl Business Plc

01/19/17 / #20170016047

Enriching a sample of circulating cell-free nucleic acids

A method of enriching a sample of circulating cell-free dna for dna derived from a foetus or from a tumour includes carrying out amplification of dna such that amplification of longer dna molecules is discriminated against. This results in preferential amplification of foetal or tumour dna, which can then be analysed using, for example, array comparative genome hybridisation.. ... Ucl Business Plc

01/19/17 / #20170014508

Chimeric antigen receptor (car) signalling system

The present invention relates to a chimeric antigen receptor (car) signalling system comprising; (i) a receptor component comprising an extracellular antigen-binding domain, a transmembrane domain and a intracellular first chemical inducer of dimerization binding domain 1 (cbd1); and (ii) an intracellular signalling component comprising a signalling domain and a second chemical inducer of dimerization binding domain 2 (cbd2); wherein cbd1 and cbd2 are capable of simultaneously binding to a chemical inducer of dimerization (cid); wherein, in the absence of the cid, binding of the antigen-binding component to antigen does not result in signalling through the signalling component; whilst, in the presence of the cid, the receptor component and the signalling component heterodimerize and binding of the antigen-binding domain to antigen results in signalling through the signalling domain.. . ... Ucl Business Plc








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