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University Of Cincinnati patents

Recent patent applications related to University Of Cincinnati. University Of Cincinnati is listed as an Agent/Assignee. Note: University Of Cincinnati may have other listings under different names/spellings. We're not affiliated with University Of Cincinnati, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Cincinnati-related inventors

Combination therapy including sapc-dops for the treatment of pancreatic cancer

Disclosed herein, according to the present invention, are methods of treating pancreatic cancer comprising administering a first pharmaceutical composition comprising saposin c and dioleoylphosphatidylserine (sapc-dops) and administering a second pharmaceutical composition comprising an anti-neoplastic agent. Optionally, additional pharmaceutical compositions may be administered. ... University Of Cincinnati

Methods of diagnosing clostridium difficile infection or recurrence in a subject

Methods are described for identifying cdi patients as well as cdi patients at risk for recurrence. Embodiments include: (1) flow cytometry of circulating peripheral blood mononuclear cells (pbmc) to phenotype for the less efficient immunoglobulin response to bacterial toxins and surface antigens that characterizes patients who will become recurrent; (2) stratification by means of complete blood count (cbc) using a coulter counter to detect the differences in lower angle light scatter (lal), which has a larger range in the recurrent population; and (3) stratification by means of complete blood count (cbc) using a coulter counter to detect the lower axial light loss (al2) exhibited in recurrent patients.. ... University Of Cincinnati

Methods for accelerated and enhanced cardiac differentiation of ips cells by electrical stimulation

Methods of generating cardiomyocytes from induced pluripotent stem cells (ipscs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from ipscs using electrical stimulation. ... University Of Cincinnati

Augmented neuromuscular training system and method

An augmented neuromuscular training system and method for providing feedback to a user in order to reduce movement deficits associated with injury risk, prior injury or disease pathology.. . ... University Of Cincinnati

Grading, staging, and prognosing cancer using osteopontin-c

The present disclosure provides methods and kits that can be used to determine the grade or stage of a breast or other cancer, such as a ductal carcinoma in situ (dcis). By determining the grade, stage, or aggressiveness of a cancer, appropriate therapeutic regiments can be selected and administered to the patient with the cancer. ... University Of Cincinnati

Methods for treating acute myeloid leukemia and nanoparticle complexes of mir-22 utilized therein

Compositions and methods for treating acute myeloid leukemia (aml) based on upregulating expression of microrna-22 (mir-22), and a nanoparticle delivery system that utilizes flt3-functionalized polyamidoamine (pamam) dendromirs for targeted delivery of mir-22 and/or agents that upregulate expression of mir-22 to aml cells.. . ... University Of Cincinnati

Targeting metabolic adaptive responses to chemotherapy

Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits s6k1, mtorc1 or upstream or downstream pathway components of s6k1 or mtorc1, in association with administration of at least one inhibitor of pparα, pparδ, or pgc1α. ... University Of Cincinnati

Smart oxygenation system employing automatic control using spo2-to-fio2 ratio

A system for assessing lung function in a patient is enclosed. The oxygen delivery system in the system (e.g., a ventilator or portable standalone system) preferably includes an oximeter sensor for receiving spo2 from a patient. ... University Of Cincinnati

Automated detection of spreading depolarizations

Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from eeg recordings of confirmed spreading depolarizations (sd) in a reference brain-injured patient cohort; (b) recording an eeg of the brain injured patient to generate recorded eeg waveforms; (c) detecting a slow potential change present in a recorded eeg waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected spc to a reference database of sd waveform template to identify a candidate sd; and (e) rejecting a candidate sd as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate sd as a detected sd.. . ... University Of Cincinnati

Pharmaceutical compositions and therapeutic methods of use comprising selective agonists of melanocortin 1 receptor

Short tri- and tetrapeptides according to the following formula i ar(ch2)mx1—x2—co—x3—x4—x5-(trp)n-nx6r are potent, selective agonists of melanocortin 1 receptor (mc1r). Provided herein are pharmaceutical compositions including formula i peptide agonists of mc1r and methods of treating skin diseases and disorders that include administering to an individual in need thereof a therapeutic amount of a formula i peptide. ... University Of Cincinnati

Methods and materials for prolonged sweat stimulation

A method for stimulating and sensing sweat includes dosing a sweat stimulant to skin effective to generate sweat at a generation rate of at least 0.1 nl/min/gland for a duration of six hours or more per dose of the sweat stimulant, and sensing generated sweat using a device placed on the skin comprising at least one sensor specific to an analyte in sweat. The dosing comprises at least one of: applying a charge density of less than 320 mc/cm2/day or applying a one-time dose of the sweat stimulant.. ... University Of Cincinnati

Method of diagnosing breast cancer, monitoring treatment of breast cancer, and treating breast cancer

Described are methods of detecting circulating hotair in breast cancer patients. The detection of circulating hotair may aid in the treatment of triple-negative breast cancer (“tnbc”) or anti-estrogen resistant breast cancer. ... University Of Cincinnati

Sweat sensing devices with prioritized sweat data from a subset of sensors

A sweat sensor device for sensing at least one analyte includes a plurality of sensors for sensing said at least one analyte and for producing data. Data from a subset of said plurality of sensors is prioritized over data from sensors of said plurality of sensors which are outside said subset. ... University Of Cincinnati

Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease

Acoustically responsive stabilized microbubbles formulated with a phospholipid monolayer shell, an encapsulated bioactive gas, and an encapsulated perfluorocarbon gas of the formula cxfy in a volume ratio of from about 10:1 to about 1:10, wherein x is greater than or equal to 3, are disclosed. Also provided are methods for promoting localized vasodilation in a patient in need thereof by delivering a microbubble comprising a phospholipid monolayer shell and an encapsulated bioactive gas locally to a target diseased section of the patient's vasculature; and releasing the bioactive gas at the target diseased section, wherein the microbubble comprises the bioactive gas in a ratio of from about 10:1 to about 1:10 by volume with a perfluorocarbon gas.. ... University Of Cincinnati

02/08/18 / #20180036410

Antimicrobial compositions of aminoglycosidic antibiotics and zinc ion chelators specifically formulated for enhanced inhibition of bacterial colonization and antibacterial efficacy

Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described.. ... University Of Cincinnati

02/08/18 / #20180035928

Devices for integrated indirect sweat stimulation and sensing

A sweat sensing device includes at least one sweat generation unit capable of initiating sudomotor axon reflex (sar) sweating in an indirect stimulation region and at least one analysis unit capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit is located above the indirect stimulation region when the sweat sensing device is placed on skin.. ... University Of Cincinnati

01/04/18 / #20180000837

Methods and compositions for suppressing ige-mediated anaphylaxis

Methods for suppressing ige-mediated anaphylaxis are provided herein, which include administering to a person in need thereof a combination of at least two therapeutic agents selected from the group consisting of an antihistamine, one or more beta-adrenergic agonists, and one or more tyrosine kinase antagonists. Also provided herein are methods of suppressing ige-mediated anaphylaxis associated with immunotherapeutic desensitization of a subject, and pharmaceutical compositions for suppressing ige-mediated anaphylaxis.. ... University Of Cincinnati

12/28/17 / #20170372480

Systems, media, and methods for pre-processing and post-processing in additive manufacturing

Systems, methods, and media for pre-processing and post-processing in additive manufacturing are provided. A method includes receiving object geometry data. ... University Of Cincinnati

12/21/17 / #20170365094

Localized contour tree method for deriving geometric and topological properties of complex surface depressions based on high resolution topographical data

Computer-implemented methods for detecting and characterizing surface depressions in a topographical landscape based on processing of high resolution digital elevation model data according to a local tree contour algorithm applied to an elevation contour representation of the landscape, and characterizing the detected surface depressions according to morphometric threshold values derived from data relevant to surface depressions of the topographical area. Non-transitory computer readable media comprising computer-executable instructions for carrying out the methods are also provided.. ... University Of Cincinnati

12/21/17 / #20170363563

Carbon nanotube based reference electrodes and all-carbon electrode assemblies for sensing and electrochemical characterization

A carbon nanotube-based reference electrode and an all-carbon nanotube microelectrode assembly for electrochemical sensing and specialized analytics are disclosed, along with methods of manufacture, and applications including detection of ionic species including heavy metals in municipal and environmental water, monitoring of steel corrosion in steel-reinforced concrete, and analysis of biological fluids.. . ... University Of Cincinnati

12/14/17 / #20170358400

Graphene paper and a process for making graphene paper and a graphene electrode

Described are processes for making graphene pellet (gp) with a three-dimensional structure. The process includes forming a nickel pellet from nickel powder to function as a catalyst for graphene growth, exposing the nickel pellet to a hydrocarbon under conditions sufficient to grow graphene, and etching nickel from graphene with an acid resulting in a graphene pellet. ... University Of Cincinnati

12/14/17 / #20170357086

Electrofluidic display and methods for making

A method for manufacturing a freestanding film having at least one population of through holes cumulatively totaling at least 1% of the film area, wherein the standard deviation of hole diameters is less than 25% and a thickness less than 25 micrometers, the film provides a carrier substrate, a photo-curable material, a release agent and deposits a photo-curable material on the substrate, selectively curing the material and leaving uncured material in the pattern of holes, dissolving away the uncured material and removing the cured material from the carrier substrate. Methods and apparatus are described.. ... University Of Cincinnati

12/07/17 / #20170349553

Small- molecule inhibitors targeting g-protein-coupled rho guanine nucleotide exchange factors

Provided are inhibitors of rho gtpase activation, and, in particular, compounds that inhibit rhoa activation by an rhogef. Also provided are related pharmaceutical compositions and methods. ... University Of Cincinnati

11/30/17 / #20170340715

Materials and methods useful for treating glioblastoma

The present invention provides compositions and methods useful for treating cancers such as glioblastoma. Sapc-dops was found to be synergistically effective at inducing cell death when administered in conjunction with rampamycin. ... University Of Cincinnati

10/26/17 / #20170308672

Methods for determining risk and treating diseases and conditions that correlate to weather data

Methods and model equations are provided for predicting a risk of a subject who experiences adverse medical events associated with the weather, of experiencing a new-onset event. Methods include a) identifying a climate region of interest; b) collecting daily mean barometric pressure (bp) data for a time frame and dividing the days of the time frame into at least upper, middle and lower quantile bp days to identify the upper quantile bp days.. ... University Of Cincinnati

10/05/17 / #20170281377

Methods for making magnesium biodegradable stents for medical implant applications

Methods for making a magnesium biodegradable stent for medical implant applications, using magnesium foil or pure magnesium or magnesium alloys that are biodegradable and performing a lithographic technique to configure the features and dimensions of the magnesium foil, and rolling the magnesium foil to form a cylinder.. . ... University Of Cincinnati

09/28/17 / #20170274043

Therapeutic uses of cd137pos regulatory t cells in treating autoimmune diseases

A method for treating or preventing a t-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble cd137 or cd137pos regulatory t cells. Also provided are pharmaceutical compositions for treating or preventing t-cell-mediated autoimmune diseases, the pharmaceutical compositions including a therapeutically effective amount of soluble cd137 or cd137pos regulatory t cells and a pharmaceutically-acceptable carrier.. ... University Of Cincinnati

09/28/17 / #20170274042

Pharmaceutical compositions comprising soluble cd137

A method for treating or preventing a t-cell-mediated autoimmune disease is provided herein, the method including administering to a mammal in need thereof a therapeutically effective amount of soluble cd137 or cd137pos regulatory t cells. Also provided are pharmaceutical compositions for treating or preventing t-cell-mediated autoimmune diseases, the pharmaceutical compositions including a therapeutically effective amount of soluble cd137 or cd137pos regulatory t cells and a pharmaceutically-acceptable carrier.. ... University Of Cincinnati

08/31/17 / #20170248035

Enhanced dry-cooling system and method for increasing power plant efficiency and output

The presently disclosed subject matter relates to enhanced dry-cooling systems and methods. More specifically, the presently disclosed subject matter relates to enhanced dry-cooling systems for increasing power plant efficiency and output. ... University Of Cincinnati

08/31/17 / #20170245788

Sweat sensing with analytical assurance

A sweat sensor device (200) with analytical assurance includes at least one sensor (220) for detecting a first analyte, and at least one calibration medium (270) containing at least the first analyte. When the first analyte in the at least one calibration medium (270) comes into contact with the at least one sensor (220), the calibration medium (270) provides a calibration of the at least one sensor (220). ... University Of Cincinnati

08/24/17 / #20170239386

Magnesium single crystal for biomedical applications and methods of making same

A biomedical implant (16, 18) is formed from magnesium (mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. ... University Of Cincinnati

07/13/17 / #20170199373

Dosing and sealing of fluid-based electro-optical devices and displays

A method for manufacturing an electrofluidic device comprising the steps of providing a first plate with features for holding a first fluid, filling a first fluid into features on a first plate; providing a second plate and sealing a second plate onto the first plate forming stacked plates with at least one cavity between the plates, and leaving at least one fill port for a second fluid. Thereafter, the stacked plates are cooled to increase the viscosity of the first fluid so that the first fluid maintains a fixed position as a second fluid is filled into the cavity. ... University Of Cincinnati

06/08/17 / #20170162881

Multi-functional porous carbon-supported microporous inorganic membranes for redox flow batteries

A separator for a redox flow battery includes a support layer having a first side, and a zeolite layer formed on the first side of the support layer. The support layer includes a porous substrate that is a carbon substrate or a carbon coated substrate. ... University Of Cincinnati

05/18/17 / #20170135594

Non-invasive detection of spreading depolarization using scalp electroencephalography

Non-invasive electroencephalogram (eeg)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one channel of a scalp eeg of an injured brain hemisphere of the patient include (a) recording a baseline scalp eeg pattern in the patient at a channel exhibiting high amplitude delta activity; (b) recording a continuous scalp eeg pattern in the patient across a time frame at the at least one channel; and (c) detecting a spreading depolarization during the time frame by observing at least one feature indicative of a spreading depolarization in the continuous scalp eeg recording pattern relative to the baseline scalp eeg pattern at the at least one channel. Scalp eeg recordings are time-compressed prior to analysis. ... University Of Cincinnati

05/11/17 / #20170128418

Compositions and methods for improving lactation

The present disclosure relates to the use of pharmaceutical agents to manipulate serotonin in animal mammary glands. Use of the serotonin agents results in increased pthrp levels, resulting in the release of calcium from the bone, which improves lactation.. ... University Of Cincinnati

04/13/17 / #20170100102

Advanced sweat sensor adhesion, sealing, and fluidic strategies

A sweat sensor device (200) includes one or more sweat sensors (220) and a seal (280) covering the one or more sweat sensors (220). The seal (280) is adapted to protect the sweat sensors (220) from outside contaminants when the device (200) is placed on the skin (12). ... University Of Cincinnati

04/06/17 / #20170095233

Devices with reduced sweat volumes between sensors and sweat glands

A sweat sensor device (400c) for sensing sweat on the skin (12) includes one or more sweat sensors (420) and a volume-reducing component that provides a volume-reduced pathway (480) for sweat between the one or more sweat sensors (420) and sweat glands in said skin (12) when the device (400c) is positioned on said skin (12). The volume-reducing component may include a volume-reducing material (470) and a pressure-permeated component (460), a sweat dissolvable material (490), a mechanically compliant material (570) for conforming to the skin (12), an adhesive with a vertically anisotropic sweat pathway, and microcap sules (1385) including a barrier material. ... University Of Cincinnati

04/06/17 / #20170095184

Sweat monitoring and control of drug delivery

The concentration of an administered compound, such as a drug (d), in an organ or a bodily fluid, such as blood, is determined directly through detecting the drug (d) or its metabolites (dm) in sweat. The concentration may be determined indirectly by administering the drug (d) together with one or more tracer compounds (t, t2) or metabolites thereof (tm, t2m) or by detecting concentrations and trends of other analytes present in the body that react to the presence of the drug (d). ... University Of Cincinnati

04/06/17 / #20170095183

Vertical-flow electronic bio-chemical sensing devices

An electronic sweat sensor (300) includes a plurality of porous substrates (310, 312), each porous substrate (310, 312) having an electrically conductive surface (320, 322). The porous substrates (310, 312) have a generally planar surface. ... University Of Cincinnati

03/16/17 / #20170074893

Devices and methods for analyzing a blood coagulation property

A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. ... University Of Cincinnati

03/16/17 / #20170071210

Silver nanoparticle-enhanced photosensitizers

The present invention relates generally to compositions and methods of killing bacteria using a surface plasmon coupled to a photosensitizer. A nanostructure (10) may include a silver nanoparticle core (12), a mesoporous silica shell (14), and a photosensitizer (16). ... University Of Cincinnati

02/16/17 / #20170044680

Additive manufacturing by localized electrochemical deposition

A method of electrolytic additive manufacturing provides 3-d parts. The method can be used to form parts from particulate material in an electrolytic bath. ... University Of Cincinnati

02/09/17 / #20170035425

Methods for partial diversion of the intestinal tract

Devices and methods are used to modify a metabolic pathway of a digestive system by creating a pathway within the intestinal tract through an anastomosis between a proximal location within the intestinal tract and a distal location within the intestinal tract. In some examples, the small intestine has a first initial length and the created pathway defines a second length of the intestinal tract that is approximately ten to seventy percent of the first initial length of the small intestine.. ... University Of Cincinnati

02/02/17 / #20170029523

Stimulation via tlr4/md-2 to reverse type 1 diabetes

Disclosed are methods and compositions for treating type i diabetes in a subject. Agents selected from a tlr4 agonist, a tlr4/md-2 agonist, or a combination thereof may be used in the disclosed methods and compositions. ... University Of Cincinnati

01/19/17 / #20170016899

Methods of detecting influenza virus

Provided herein is a method of detecting the presence of influenza virus in a sample while minimizing false positives due to presence of one or more other pathogens in the sample, the method including measuring the enzymatic activity of neuraminidase (na) in the sample under one or more differentiating conditions selected from the group consisting of ph, binding to anti-nana antibody, size exclusion, hemagglutinin (ha) binding, chemical inhibition, and combinations thereof.. . ... University Of Cincinnati

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009


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