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University Of Kentucky Research Foundation patents


Recent patent applications related to University Of Kentucky Research Foundation. University Of Kentucky Research Foundation is listed as an Agent/Assignee. Note: University Of Kentucky Research Foundation may have other listings under different names/spellings. We're not affiliated with University Of Kentucky Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Kentucky Research Foundation-related inventors


Electrical double layer in nanopores for detection and identification of molecules and submolecular units

Systems for detecting analytes in electrical double layer nanopore devices and methods of use are provided.. . ... University Of Kentucky Research Foundation

Antifungal compounds

Compounds and compositions having antifungal activity, and methods of using the antifungal compounds and compositions, are described for use in treating fungal infections.. . ... University Of Kentucky Research Foundation

Eis inhibitors

Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase eis, a mediator of kanamycin resistance in mycobacterium tuberculosis.. . ... University Of Kentucky Research Foundation

Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes

Compositions and methods for reducing the level of nornicotine and n′-nitrosonornicotine (nnn) in nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome p450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. ... University Of Kentucky Research Foundation

Chloroquine induction of par-4 and treatment of cancer

Described herein are methods for treating cancer in a subject in need thereof by administering chloroquine, or a salt or prodrug thereof, optionally with another agent that promotes par-4 production to induce prostate apoptosis response-4 (par-4) production by host cells, particularly non-cancerous host cells, to promote apoptosis in cancer cells, including androgen insensitive prostate cancer cells.. . ... University Of Kentucky Research Foundation

Amidated dopamine neuron stimulating peptide restoration of mitochondrial activity

The present invention relates to the use of novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (gdnf) peptides (or “amidated dopamine neuron stimulating peptides (adns peptides)”), for treating brain diseases and injuries that result in dopaminergic deficiencies and mitochodrial dysfunction, e.g., reduced complex i enzyme activity.. . ... University Of Kentucky Research Foundation

Rna nanoparticles and method of use thereof

. . The presently-disclosed subject matter relates to an artificial rna nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to rna nanoparticles and rna dendrimers, and methods of disease diagnosis and treatments using the rna nanostructure and rna dendrimers.. ... University Of Kentucky Research Foundation

Process and material for removal of nitrosamines from aqueous systems

The present invention relates to a method and system for removing nitrosamines from amine-based carbon capture systems by circulating waterwash through a filter of activated carbon. Nitrosamine emission control strategies are critical for the success of amine-based carbon capture as the technology approaches industrial-scale deployment. ... University Of Kentucky Research Foundation

Pyranonaphthoquinone compounds and methods of use thereof

. . Provided herein are pyranonaphthoquinone compounds and methods of using pyranonaphthoquinone compounds. The method of using the pyranonaphthoquinone compounds includes selectively inhibiting 4e-bp1 phosphorylation by administering at least one pyranonaphthoquinone or pyranonaphthoquinone analog to a subject in need thereof. ... University Of Kentucky Research Foundation

Compositions and methods for treating retinal degradation

The present disclosure relates to compounds, compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by alu rna associated with a cell, for reducing atp-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species in a cell. The present disclosure further relates to compounds, compositions, and methods for use in protecting an rpe cell and/or for treating, including prophylactic and therapeutic treatment, of conditions associated with retinal damage and/or degradation including, but not limited to, dry age related macular degeneration (amd) and wet amd, alzheimer disease, various forms of arthritis, atherosclerosis, diabetes mellitus, chronic obstructive pulmonary disease, inflammatory bowel disease, and duchenne muscular dystrophy.. ... University Of Kentucky Research Foundation

Compact low-cost fiberless diffuse speckle contrast flow-oximeter

. . A low-cost compact fiberless diffuse speckle contrast flowmeter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (ccd) or complementary metal oxide semiconductor (cmos) for directly contacting the tissue and measuring a parameter such as blood flow in a deep/thick volume of tissue (up to 10 mm depth). The small laser diode is fixed at a certain distance (0 to 20 mm) from the imaging device and directly contacts the tissue. ... University Of Kentucky Research Foundation

Polyborosiloxane binders

Electrodes for rechargeable batteries that include silicon and a binder are provided. Binders for use with silicon electrodes are provided, including polysiloxane binders that can be prepared prior to preparation of the electrode, or provided as monomers to be cure-polymerized at the time of the curing of the electrode.. ... University Of Kentucky Research Foundation

Design and synthesis of metal oxide surfaces and interfaces with crystallographic control using solid-liquid-vapor etching and vapor-liquid-solid growth

The present invention provides integrated nanostructures comprising a single-crystalline matrix of a material a containing aligned, single-crystalline nanowires of a material b, with well-defined crystallographic interfaces are disclosed. The nanocomposite is fabricated by utilizing metal nanodroplets in two subsequent catalytic steps: solid-liquid-vapor etching, followed by vapor-liquid-solid growth. ... University Of Kentucky Research Foundation

Method and system for identification of metabolites

A method and system is provided for mass spectrometry for identification of a specific elemental formula for an unknown compound which includes but is not limited to a metabolite. The method includes calculating a natural abundance probability (nap) of a given isotopologue for isotopes of non-labelling elements of an unknown compound. ... University Of Kentucky Research Foundation

01/11/18 / #20180009741

Bishydrazone-based antifungal agents

Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.. ... University Of Kentucky Research Foundation

12/14/17 / #20170355942

Cyclic photobioreactor and method for biofilm control

. . The invention herein describes a novel photobioreactor (pbr) system for culturing algae. The pbr system utilizes vertical transparent tubes that can be cyclically filled with an algae culture. ... University Of Kentucky Research Foundation

12/07/17 / #20170349899

Fungal chromosome-end knockoff strategy

Non-toxigenic fungal strains, and methods of making and use thereof, are provided and have utility as endophytes in forage crops, and as strains that can outcompete toxigenic strains in forage and food crops.. . ... University Of Kentucky Research Foundation

11/30/17 / #20170343530

Lipid bilayer-integrated spp1 connector protein nanopore and spp1 connector protein variants for use as lipid bilayer-integrated nanopore

A conductive channel-containing membrane includes a membrane layer, and a spp1 connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which conductance can occur when an electrical potential is applied across the membrane. A method of sensing a molecule, such as a polypeptide or nucleic acid molecule, makes use of the conductive channel-containing membrane. ... University Of Kentucky Research Foundation

11/16/17 / #20170331111

Fluorinated coal derived carbons and electrodes for use in battery systems and similar

An electrode including fluorinated and surface defluorinated coal is described, as well as methods of producing such and employing such within an electrical system. The coal in the electrodes is fluorinated at an amount of between 0.3 and 1.4. ... University Of Kentucky Research Foundation

10/26/17 / #20170304227

Vesicular monoamine transporter-2 ligands and their use in the treatment of psychostimulant abuse

The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse and withdrawal therefrom comprising administering at least one n-phenylalkyl amphetamine derivative and pharmaceutical compositions comprising at least one n-phenylalkyl amphetamine derivative to an individual in need thereof.. . ... University Of Kentucky Research Foundation

10/05/17 / #20170283270

Novel graphene-like si2bn material and method of making thereof

This application relates to monolayers of si2bn or c2bn, arranged in a graphiticized hexagonal arrangement. Each si/c atom has a si/c, b, and n nearest neighbor, while each b (n) has two si/c's and one n (b) as nearest neighbors. ... University Of Kentucky Research Foundation

10/05/17 / #20170281751

Equine disease model for herpesvirus neurologic disease and uses thereof

The present invention relates to an in vivo equine disease model for equine herpesvirus-1 neurological disease comprising a horse having a low pre-exposure level of herpesvirus-specific ctl precursors and/or is approximately 20 years of age or older wherein the horse is experimentally infected with a neuropathogenic strain of equine herpesvirus or a mutant thereof. The invention includes a method of preparing an in vivo equine disease model for equine herpesvirus-1 neurological disease comprising obtaining a horse that possesses low pre-infection levels of ehv-1 specific ctl precursors and/or is approximately 20 years of age or older and inoculating the horse intranasally with an effective infecting amount of a neuropathogenic strain of ehv-1. ... University Of Kentucky Research Foundation

08/17/17 / #20170232380

Method of development and use of catalyst-functionalized catalytic particles to increase the mass transfer rate of solvents used in acid gas cleanup

The present invention relates to methods for improving carbon capture using entrained catalytic-particles within an amine solvent. The particles are functionalized and appended with a co2 hydration catalyst to enhance the kinetics of co2 hydration and improve overall mass transfer of co2 from an acid gas.. ... University Of Kentucky Research Foundation

08/10/17 / #20170226072

1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepines, and 1,3-disubstituted pyrrolidine compounds

The present invention is directed to 1,4-disubstituted piperidines, 1,4-disubstituted piperazines, 1,4-disubstituted diazepanes, and 1,3-disubstituted pyrrolidine compounds and their use.. . ... University Of Kentucky Research Foundation

08/03/17 / #20170222151

Water processable n-type organic semiconductor

The present invention concerns a water-processable n-type semiconductor comprised of polyvinylpyrrolidone (pvp), carbon nanotubes (cnts) and poly(ethyleneimine) (pei). The semiconductors are prepared by providing pvp and cnts in a hydrophilic slurry and dispersing therein small amounts of pei.. ... University Of Kentucky Research Foundation

08/03/17 / #20170216763

Co2 mass transfer enhancement of aqueous amine solvents by particle additives

The present invention relates to methods for improving carbon capture by providing particles within an amine solvent. The particles provide for increased turbulence at the interface between the counter-flowing gas and solvent, which allows for increased amine and carbamate salt diffusion between the liquid film and bulk.. ... University Of Kentucky Research Foundation

07/27/17 / #20170214096

Low temperature liquid metal batteries for energy storage applications

The present invention relates to a molten metal battery of liquid bismuth and liquid tin electrodes and a eutectic electrolyte. The electrodes may be coaxial and coplanar. ... University Of Kentucky Research Foundation

06/22/17 / #20170175122

Rna-based compositions and adjuvants for prophylactic and therapeutic treatment

The present invention is directed towards an artificial rna nanostructure comprising multiple external strands of rna, each external strand comprising about 40-50 nucleotides; one internal strand of rna comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a prna three-way junction (3wj) motif at each vertex of the nanostructure. Such nanostructure can be provided in a composition together with an adjuvant for use in inducing the production of high affinity neutralizing antibodies or inhibitory antibodies, inducing the production of cytokines, inducing an immune response in a subject, or a combination thereof.. ... University Of Kentucky Research Foundation

06/22/17 / #20170173108

Amidated dopamine neuron stimulating peptides for cns dopaminergic upregulation

The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (gdnf) peptides (or “amidated dopamine neuron stimulating peptides (adns peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.. . ... University Of Kentucky Research Foundation

06/15/17 / #20170165241

Compositions and methods of modulating 15-pgdh activity

Compounds and methods of modulating 15-pgdh activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-pgdh activity and/or prostaglandin levels include 15-pgdh inhibitors and 15-pgdh activators described herein.. . ... University Of Kentucky Research Foundation

06/01/17 / #20170155164

Liquid phenothiazine catholytes for non-aqueous redox flow batteries

Highly soluble, liquid phenothiazines containing methoxy-terminated ether and oligoether substituents are disclosed with high diffusion coefficients and robust performance in electrochemical measurements, which can be synthesized in one step from commercially-available starting materials, thereby circumventing previous synthetic limitations.. . ... University Of Kentucky Research Foundation

04/06/17 / #20170098818

Solvent-free dry powder-coating method for electrode fabrication

Electrostatic dry powder spray processes are disclosed for making battery electrodes. The electrodes made by dry powder coating processes are conventional lithium ion battery electrodes and unconventional electrodes of gradient in composition and structure, large thicknesses, free-standing, and flexible.. ... University Of Kentucky Research Foundation

03/30/17 / #20170089906

Biomarkers for ovarian cancer

The present invention provides protein-based biomarkers and biomarker combinations that am useful in qualifying ovarian cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as ovarian cancer, ovarian cancer of low malignant potential, benign ovarian disease or other malignant condition. ... University Of Kentucky Research Foundation

03/02/17 / #20170055512

Microfabricated surfaces for the physical capture of insects

Novel devices and methods of capturing, controlling and preventing infestation of insects using microfabricated surfaces are provided. In particular, a mechanism of insect capture inspired by the microstructures of the leaf surfaces of plants and the key features of those surfaces with respect to the capture and control of pests have been determined and engineered into a variety of microfabricated surfaces capable of reproducing the effectiveness of these physical capture methods.. ... University Of Kentucky Research Foundation

02/23/17 / #20170051199

Proppant for use in hydraulic fracturing to stimulate a well

A proppant for use in hydraulic fracturing to stimulate a well is provided. The proppant is fly ash particles having a mean particle size (d50) of between 45 μm and 150 μm and a size distribution defined by (d10)≦5 μm and (d98)≦250 μm.. ... University Of Kentucky Research Foundation








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