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University Of Louisville Research Foundation Inc patents


Recent patent applications related to University Of Louisville Research Foundation Inc. University Of Louisville Research Foundation Inc is listed as an Agent/Assignee. Note: University Of Louisville Research Foundation Inc may have other listings under different names/spellings. We're not affiliated with University Of Louisville Research Foundation Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Louisville Research Foundation Inc-related inventors


Methods for providing optimized neurostimulation

Disclosed herein are methods for neurostimulation therapy for spinal cord injury. More particularly, the present invention relates to methods for neurostimulation therapy for spinal cord injury. ... University Of Louisville Research Foundation Inc

Sync pulse detector

Disclosed herein are devices and methods used with neurostimulation therapy for spinal cord injury. More particularly, embodiments of the present invention relate to a sync pulse detector and methods for synchronizing signals from an implanted neurostimulator with measured physiological responses and other data.. ... University Of Louisville Research Foundation Inc

Atrial appendage closure device and related methods

An atrial appendage closure device is provided that includes an occluding portion having a distal surface and a proximal surface opposite the distal surface, the occluding portion being moveable between a retracted position and a deployed position such that, in the deployed position, the occluding portion is configured to provide a seal between a left atrial appendage and a left atrium of a heart. An anchoring portion is operably connected to the occluding member with the anchoring portion being moveable between a retracted position and a deployed position. ... University Of Louisville Research Foundation Inc

High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury

Methods comprising applying electrical stimulation to patients in conjunction with physical training are described.. . ... University Of Louisville Research Foundation Inc

Methods for applying epidural electrical stimulation

Embodiments of the present invention relate to methods for applying epidural electrical stimulation to improve motor function or physiological responses in paralyzed individuals. More particularly, the present invention relates to methods for creating and applying specific configurations of epidural stimulation to assist or cause a patient to perform a complex motor function or to mitigate one or more secondary consequences of paralysis including, but not limited to, cardiovascular, respiratory, bladder, temperature and sexual dysfunction.. ... University Of Louisville Research Foundation Inc

Substituted benzoxazepine for cancer therapy

Implementations of the present invention include a compound and methods for inhibiting karyopherin beta 1 activity by administering to a patient in need thereof a therapeutically effective amount of a substituted benzoxazepine. The compound of formula ii, 9-[(1-methylpiperidin-3-yl)methoxy]-4-[(6-methylpyridin-2-yl)methyl]-7-(5-methylthiophen-2-yl)-3,5-dihydro-2h-1,4-benzoxazepine or one of its salts, inhibits the import of protein and transcription factors, such as nfat and p65/nfkb into the nucleus of a cell, and thus has anti-cancer effects enabling the compound to be used for cancer treatment.. ... University Of Louisville Research Foundation Inc

Selective pfkfb4 inhibitors for the treatment of cancer

Methods and pharmaceutical compositions for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (pfkfb4) and the treatment of cancer are described.. . ... University Of Louisville Research Foundation Inc

Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents

A composition comprises an anti-nucleolin agent conjugated to nanoparticles, and optionally containing gadolinium. Furthermore, a pharmaceutical composition for treating cancer comprises a composition including an anti-nucleolin agent conjugated to nanoparticles, and a pharmaceutically acceptable carrier. ... University Of Louisville Research Foundation Inc

Exosomal compositions and methods for the treatment of disease

An exosomal composition is provided that comprises a therapeutic agent encapsulated by an exosome. The therapeutic agent can be a phytochemical agent, a chemotherapeutic agent, or a stat3 inhibitor. ... University Of Louisville Research Foundation Inc

Method for operating a linear compressor

A method for operating a linear compressor includes establishing a set of predictors, and establishing a model for an estimated head clearance of the linear compressor with the set of predictors. Coefficients of the model for the estimated head clearance of the linear compressor may also be established. ... University Of Louisville Research Foundation Inc

Nanoparticles for drug delivery

The invention provides nanoparticles, methods for making nanoparticles, and methods for using nanoparticles.. . ... University Of Louisville Research Foundation Inc

Milk-derived microvesicle compositions and related methods

A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. ... University Of Louisville Research Foundation Inc

Computer aided diagnostic system for classifying kidneys

A computer aided diagnostic system and automated method to classify a kidney. Image data for a medical scan that includes image data of a kidney may be received. ... University Of Louisville Research Foundation Inc

Method and device for detecting cellular targets in bodily sources using carbon nanotube thin film

A device and method detect cellular targets in a bodily source by utilizing a biofunctional pad comprised of a thin film of carbon nanotubes (cnt's). When antibodies are absorbed by the cnt's, cellular targets having markers matching the antibodies may be detected in a bodily source placed upon the biofunctional pad by measuring the conductivity of the thin film using conductive contacts electrically coupled to the thin film, as the binding of the receptors in the cellular targets to the antibodies changes the free energy in the thin film. ... University Of Louisville Research Foundation Inc

06/07/18 / #20180153917

Compositions and methods for reducing oxidative damage

Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. ... University Of Louisville Research Foundation Inc

05/31/18 / #20180147198

Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancer

Provided herein is a method of treating cancer and stimulating anti-tumor immunity in a subject in need thereof, the method including administering to the subject a synergistic, therapeutically effective amount of a pfkfb3 inhibitor, such as pfk-158, in combination with an immune checkpoint inhibitor. Also provided is a method of synergistically increasing activity of an immune checkpoint inhibitor, the method including administering to a subject in need thereof a combination therapy including pfk-158 and the immune checkpoint inhibitor. ... University Of Louisville Research Foundation Inc

05/24/18 / #20180140654

Compositions and methods for treatment of alcohol induced liver injury

Methods for treating alcohol induced liver injury include administering to a subject an effective amount of a ginger-derived nanoparticle. Methods for decreasing nuclear factor erythroid-2 related factor (nrf2) activation in a hepatocyte are also provided and include contacting the hepatocyte with an effective amount of a ginger-derived nanoparticle. ... University Of Louisville Research Foundation Inc

04/12/18 / #20180101640

System and method for personalized dosing of pharmacologic agents

A system and method for personalized dosing of a pharmacologic agent include: executing, using a processing device, a plurality of dosing regimen program modules to determine a respective plurality of dose sets in response to receiving, from an input device, a target response value for a patient; and executing, using the processing device, a dosing selection algorithm module, following executing the plurality of dosing regimen program modules and in response to receiving from the input device a response profile and a monitoring frequency of the patient, to determine a recommended dose set computed as a combination of the plurality of dose sets weighted by degrees of matching computed using fuzzy sets and the response profile.. . ... University Of Louisville Research Foundation Inc

03/29/18 / #20180088117

Micro-array devices for capturing cells in blood and methods of their use

The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a cnt device; allowing cells in the blood sample to differentially settle on the cnt device, and identifying and counting cells of preselected type in the blood sample.. ... University Of Louisville Research Foundation Inc

03/29/18 / #20180086749

Inhibitors of viruses

The present technology is directed to compounds, compositions, and methods to treat a viral infection. The compound is according to formula i or a solvate and/or pharmaceutically acceptable salt thereof. ... University Of Louisville Research Foundation Inc

03/15/18 / #20180070905

Accurate detection and assessment of radiation induced lung injury based on a computational model and computed tomography imaging

A system and computation method is disclosed that identifies radiation-induced lung injury after radiation therapy using 4d computed tomography (ct) scans. After deformable image registration, the method segments lung fields, extracts functional and textural features, and classifies lung tissues. ... University Of Louisville Research Foundation Inc

02/08/18 / #20180036232

Ophthalmic compositions and methods for reducing oxidative damage to an eye lens

Methods of reducing oxidative damage to an eye of a subject are provided. Aspects of the method include intravitreal injection an antioxidant composition consisting essentially of a non-reducing sugar or a hydrate thereof. ... University Of Louisville Research Foundation Inc

12/21/17 / #20170360476

Trocar for improved fluid pressure management during endoscopic surgery

A trocar for arthroscopy and other endoscopic surgeries is provided, including a diaphragm seal, in which the assembly as a whole provides adequate insufflation of the body compartment during a procedure, while limiting or eliminating the leakage of insufflation fluid from the rear of the trocar, thus maintaining adequate insufflation pressure management. The design, placement, and spacing associated with said diaphragm seal provides an enhanced interface between the diaphragm opening and a surgical instrument inserted through such opening to gain access to the body compartment of a surgical patient.. ... University Of Louisville Research Foundation Inc

12/07/17 / #20170348017

Open loop polypectomy system

Embodiments of this invention relate to endoscopic and laparoscopic surgical instruments. More specifically, embodiments of this invention relate to an open loop polypectomy system including a means for securely closing the loop. ... University Of Louisville Research Foundation Inc

11/09/17 / #20170321329

Solar hydrogen production from ambient water vapor electrolysis

Hydrogen gas as a power source is obtained from gaseous water, including seawater vapor existing abundantly at near-surface levels of the oceans or humid air over land. An integrated system of photovoltaic cells for capturing and harnessing solar energy is combined with a water vapor electrolysis system comprising an electrolyzer with an anode compartment and a cathode compartment separated by a proton exchange membrane. ... University Of Louisville Research Foundation Inc

10/12/17 / #20170292161

Methods and compositions for detecting colorectal neoplasias using micro rnas

Methods of detecting or predicting the presence of colorectal neoplasia are described based on the amounts of particular mirnas in plasma.. . ... University Of Louisville Research Foundation Inc

09/07/17 / #20170253758

Core-shell nanostructures and related inks, films and methods

Copper inks are provided that include a plurality of core-shell nanostructures, with each nanostructure including a copper core and a barrier metal shell, a diameter of less than about 500 nm, and a distinct boundary between the copper core and the barrier metal shell. Methods of forming a copper ink are further provided and include an initial step of synthesizing an amount of copper nanoparticles in an aqueous solution. ... University Of Louisville Research Foundation Inc

08/31/17 / #20170250030

Methods for forming a perovskite solar cell

A perovskite thin film and method of forming a perovskite thin film are provided. The perovskite thin film includes a substrate, a hole blocking/electron transport layer, and a sintered perovskite layer. ... University Of Louisville Research Foundation Inc

08/31/17 / #20170246809

Quality certification method for an additive manufacturing process

In a quality certification method, a digital, three-dimensional quality certificate (3dqc) is created by the manufacturer and is delivered to the customer along with the manufactured part. The data in the 3dqc can be viewed using a three-dimensional rendering system, such that the customer that review and confirm that certain process monitor values were within specification during the entire manufacturing process.. ... University Of Louisville Research Foundation Inc

08/24/17 / #20170239298

Cardiac progenitor cells and methods of use therefor

Provided are pharmaceutical compositions that include a pharmaceutically acceptable carrier and isolated post-natal cardiac progenitor cells (cpcs) and/or progeny cells thereof that are ssea3-positive and c-kit-negative. Also provided are methods for preparing cells capable of repairing damaged myocardium, methods for isolating populations of ssea3-positive/c-kit-negative cpcs from cardiac tissue samples, methods for preparing an isolated cell population enriched in post-natal ssea3-positive/c-kit-negative cpcs, therapeutic methods for using the presently disclosed cells and populations of cells to treat subjects in need thereof, and cell cultures that contain the presently disclosed cells and populations of cells.. ... University Of Louisville Research Foundation Inc

08/10/17 / #20170224839

Nanoparticles for drug delivery

The invention provides therapeutic magnetic nanoparticles containing a therapeutic agent connected to a magnetic nanoparticle core through a stable functional group and a linker that can be induced to release the therapeutic agent from the core, through hydrolysis of the functional group. Also provided are methods for making nanoparticles, and methods for using nanoparticles.. ... University Of Louisville Research Foundation Inc

08/03/17 / #20170216285

Small molecule inhibitors for cancer therapy

Compounds, including quinoxaline derivatives of formula (i), for use in the treatment of cancer are described. In general, the compounds inhibit the import of proteins and transcription factors such as kpnα, ap-1, p65, nfat into the nucleus of a cell by inhibiting the nuclear import protein, kpnβ1. ... University Of Louisville Research Foundation Inc

06/29/17 / #20170184221

Bilayer microvalve arrays for pneumatic and fluidic applications

A strained bilayer film with reinforcing members is used to open and close gas flow outlets in a microvalve array. The bottom layer of the bilayer film is compressive and the top layer is tensile. ... University Of Louisville Research Foundation Inc

06/08/17 / #20170157389

Parylene-based microelectrode array implant for spinal cord stimulation

An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion positionable alongside the spinal cord that includes a plurality of first openings. ... University Of Louisville Research Foundation Inc

05/18/17 / #20170137892

Exosome-associated microrna as a diagnostic marker

The presently disclosed subject matter provides methods of diagnosis of cancer or adverse pregnancy outcomes in a subject by measuring amounts of one or more micrornas present in cancer-derived exosomes isolated from a biological sample from the subject.. . ... University Of Louisville Research Foundation Inc

05/11/17 / #20170128496

Methods and compositions to support transplanted tissue integration and inosculation with adipose stromal cells

The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (svf) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. ... University Of Louisville Research Foundation Inc

04/20/17 / #20170108499

Progenitor cells and methods for preparing and using the same

Provided are methods for isolating subpopulations of stem cells. In some embodiments, the presently disclosed methods include selecting subsets of cells that are positive for cd34 or sca-1, are further positive for one or more of fshr, lhcgr, prlr, ar, esrα, esrβ, and pgr; and are negative for each of cd45r/b220, gr-1, tcrαβ, tcrγδ, cd11b, and ter-119. ... University Of Louisville Research Foundation Inc

04/06/17 / #20170097352

Immunoglobulin-bound extracellular vesicles and uses thereof

Provided are methods of isolating igg-bound (e.g., igg-bound or protein g-recognized igg-bound) extracellular vesicles from a sample containing a biological fluid from a subject, where the igg (e.g., igg2 or protein g-recognized igg) is bound to an antigen present on the surface of the extracellular vesicle and the igg (e.g., igg2 or protein g-recognized igg) is an endogenous antibody. Also provided are methods of diagnosing a cancer in a subject that include detecting the presence of one or more tumor antigens in an isolated igg-bound (e.g., igg2-bound or protein g-recognized igg-bound) extracellular vesicle, and methods of treating a subject that include administering one or more cancer therapeutics to a subject having an igg-bound (e.g., igg2-bound or protein g-recognized igg-bound) extracellular vesicle that contains one or more tumor antigens.. ... University Of Louisville Research Foundation Inc

04/06/17 / #20170095562

Anti-nucleolin agent-conjugated nanoparticles

A composition comprises an anti-nucleolin agent conjugated to nanoparticles. The nanoparticles are non-magnetic, not iron oxide and not polyacrylamide. ... University Of Louisville Research Foundation Inc

03/30/17 / #20170089645

Heat pipe augmented passive solar heating system

A heat pipe augmented passive solar space heating system modulates the temperature inside a building structure, particular during heating seasons when the ambient temperature is below levels customarily associated with adequate room comfort, and in some embodiments comprises a solar absorber, a heat pipe surrounding wholly or partially by insulation, the heat pipe having three main sections which are an evaporator at one end proximal to the solar absorber, a condenser at the other end proximal to an interior room being heated, and a rubber adiabatic section between those. Additional aspects such as a mechanical valve in the adiabatic section are disclosed to limit unwanted thermal gains when cooling is needed because the ambient temperatures already exceed room comfort.. ... University Of Louisville Research Foundation Inc

03/09/17 / #20170067057

Compositions and methods for treating cancer, inhibiting cell proliferation, and inducing cell death

Quadruplex-forming guanine-rich nucleic acid sequences are useful in compositions and methods for inhibiting cellular growth and proliferation and inducing cell death. Compositions for treating a patient are provided, including (i) a safe and effective amount of a sequence having at least 80% nucleic acid identity with a sequence selected from the group consisting of seq id no: 1, seq id no: 2, seq id no:3, seq id no: 4, seq id no: 5, seq id no: 6, seq id no: 7, seq id no: 8, seq id no: 9, seq id no:10, seq id no:11, seq id no:12 and combinations thereof, and (ii) a carrier, wherein the isolated oligonucleotide forms at least one quadruplex.. ... University Of Louisville Research Foundation Inc

03/02/17 / #20170056432

Cancer therapy using beta glucan and antibodies

The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble beta (1,3; 1,6) glucan (nsg) enhances the tumoricidal activity of the innate immune system by binding to the c3 complement protein receptor cr3. ... University Of Louisville Research Foundation Inc

03/02/17 / #20170056138

Methods for fabricating dental restorations

A method of fabricating a dental restoration is provided that includes the initial step of providing a powder of a dental material. An amount of a binder is then selectively deposited onto the powder of the dental material to produce an unfinished layer of the dental material. ... University Of Louisville Research Foundation Inc

02/09/17 / #20170035700

Coated edible plant-derived microvesicle compositions and methods for using the same

Compositions are provided that comprise a microvesicle derived from an edible plant. The microvesicles are coated with a plasma membrane derived from a targeting cell and can further be utilized to encapsulate a therapeutic agent. ... University Of Louisville Research Foundation Inc

02/02/17 / #20170032520

Computer aided diagnostic system for mapping of brain images

Systems, methods, and computer program products for classifying a brain are disclosed. An embodiment method includes processing image data to generate segmented image data of a brain cortex. ... University Of Louisville Research Foundation Inc

02/02/17 / #20170030892

Noninvasive detection of cancer originating in tissue outside of the lung using exhaled breath

Provided is a non-invasive method of detecting or screening for a cancer in a subject specimen originating in a tissue outside of the lung. The method includes detecting elevated levels of one or more carbonyl-containing volatile organic compounds (vocs) that are biomarkers for the cancer in exhaled breath from the subject specimen. ... University Of Louisville Research Foundation Inc

01/19/17 / #20170015712

Compositions and methods for treating, including preventing, parvovirus infections and related diseases

Some embodiments of the invention include inventive polypeptides (e.g., mutant vp2 proteins) and virus-like particles made from the inventive polypeptides. Other embodiments of the invention include compositions for treating (e.g., preventing) parvovirus (e.g., erythrovirus or parvovirus b19) infection and other diseases. ... University Of Louisville Research Foundation Inc

01/05/17 / #20170000825

Human facilitating cells

The present disclosure relates to human facilitating cells (hfc), and methods of isolating, characterizing, and using such hfcs.. . ... University Of Louisville Research Foundation Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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