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University Of Maryland patents


Recent patent applications related to University Of Maryland. University Of Maryland is listed as an Agent/Assignee. Note: University Of Maryland may have other listings under different names/spellings. We're not affiliated with University Of Maryland, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Maryland-related inventors


All-elastomer 3-axis contact resistive tactile sensor arrays and micromilled manufacturing methods thereof

At least one tactile sensor includes an insulating layer and a conductive layer formed on the surface of the insulating layer. The conductive layer defines at least one group of flexible projections extending orthogonally from the surface of the insulating layer. ... University Of Maryland

System and method for irradiation therapy using voxel based functional measurements of organs at risk

A method and apparatus for irradiation therapy using voxel based function measurements of organs-at-risk (oar). The method includes determining size and location of each voxel of a plurality of voxels in a reference frame of a radiation device. ... University Of Maryland

Methods and systems for controlling magentic fields and magnetic field induced current

Methods and systems to control magnetic fields and magnetic field induced currents, and to provide stimulations within a patient's body, e.g.: deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. An array of magnetic coils is provided and positionable about a portion of a patient's body, and are configured to create a small region of a magnetic hole, or configured to create a small region of concentrated magnetic field strength, or their combination, and at depths within the patient's body in a focused region and sparing the surrounding tissues of the focused region, that have previously not been receptive to non-invasive tms methods, which are either focused but can affect only the surface and shadow areas, or that can reach certain depths but by doing so only through affecting large surface areas and deep tissue areas.. ... University Of Maryland

Method and apparatus to provide a virtual workstation with enhanced navigational efficiency

A method and apparatus are provided for enhancing a navigational efficiency of a virtual workstation. The method includes receiving a design space describing a desired arrangement of virtual monitors. ... University Of Maryland

Chemoenzymatic glycoengineering of antibodies and fc fragments thereof

The present invention provides for recombinant endo-s mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated glcnac-protein acceptor. Such recombinant endo-s mutants are useful for efficient glycosylation remodeling of igg1-fc domain to provide different antibody glycoforms carrying structurally well-defined fc n-glycans.. ... University Of Maryland

Layer-by-layer assembly of graphene oxide membranes via electrostatic interaction and eludication of water and solute transport mechanisms

A method for synthesizing a water purification membrane is presented. The method includes stacking a plurality of graphene oxide (go) nanosheets to create the water purification membrane, the stacking involving layer-by-layer assembly of the plurality of go nanosheets and forming a plurality of nanochannels between the plurality of go nanosheets for allowing the flow of a fluid and for rejecting the flow of contaminants. ... University Of Maryland

Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. . ... University Of Maryland

Separators for blood collection tubes

Sample collection tubes and methods of producing the same are provided. Contemplated collection tubes comprise a tube having a separator substance disposed therein. ... University Of Maryland

Road distance systems and methods

Various computational systems may benefit from enhanced systems for computing multiple network distance queries. For example, systems requiring high throughput of numerous network distance queries may benefit from systems and method that can utilize all-store and other distance oracles, including integrated architecture systems. ... University Of Maryland

Endolysins active against staphylococcus bacteria, pharmaceutical compositions, and methods relating thereto

The present invention relates to methods of treating or preventing a bacterial disease or infection, antibacterial compositions, and antibacterial surfaces, including isolated endolysin polypeptides from bacteriophage grcs.. . ... University Of Maryland

Methods of treating pancreatic cancer

Described herein are methods and compositions for the treatment of pancreatic cancer in a subject in need thereof. The pancreatic cancer may be resistant to other therapeutic regimens. ... University Of Maryland

Use of recombinant human activated protein c to enhance viability of transplant tissue

The present invention relates to the use of activated protein c (apc) to enhance the viability of transplant graft. In certain instances, the invention provides methods of ex vivo perfusion of transplant graft with a composition comprising apc.. ... University Of Maryland

Systems and methods using multi-wavelength single-pulse raman spectroscopy

The invention provides methods and apparatus comprising a multi-wavelength laser source that uses a single unfocused pulse of a low intensity but high power laser over a large sample area to collect raman scattered collimated light, which is then rayleigh filtered and focused using a singlet lens into a stacked fiber bundle connected to a customized spectrograph, which separates the individual spectra from the scattered wavelengths using a hybrid diffraction grating for collection onto spectra-specific sections of an array photodetector to measure spectral intensity and thereby identify one or more compounds in the sample.. . ... University Of Maryland

Apparatus and method for recording digital images and presenting 3d models of a body lumen

An apparatus including: a lumen scanner (260) configured to scan a body lumen and acquire data for rendering a 3d model of the body lumen. The lumen scanner includes: an optical sensor (240) configured to acquire images of the body lumen while the lumen scanner is disposed inside the body lumen; and a fluid nozzle (202) configured to direct fluid onto an area of the body lumen imaged by the optical sensor while the lumen scanner is disposed inside the body lumen.. ... University Of Maryland

05/10/18 / #20180125895

Cardiac stem cells for cardiac repair

Embodiments of the disclosure concern compositions and methods of use related to particular c-kit+ mesenchymal cells, including cardiac stem cells, obtained from a pediatric or neonatal individual. In specific embodiments, the cells, or conditioned medium or partial or total secretomes thereof, are provided in an effective amount to an individual in need thereof.. ... University Of Maryland

05/03/18 / #20180120873

Comfort units and systems, methods, and devices for use thereof

Despite otherwise uncomfortable conditions in a surrounding environment, a customizable microenvironment can be created around a user to maintain a comfortable temperature and/or humidity level using a comfort unit. For example, the environment may be an office building where conditions are out of the comfortable range to save on energy or for other reasons, a factory/shop environment that is poorly conditioned, or an outdoor location with little to no conditioning. ... University Of Maryland

05/03/18 / #20180118704

Compounds for treating parasitic infections

Compounds and compositions comprising them are provided. The compounds and compositions are useful for inhibiting transport of heme across membranes in parasitic heme auxotrophic organisms, thereby limiting their growth or killing the parasites.. ... University Of Maryland

05/03/18 / #20180117589

Generation and trapping of aqueous droplets in a microfluidic chip with an air continuous phase

The invention relates to a method and system for generating droplets of an aqueous solution on a microfluidic chip with an air continuous phase. Specifically, the droplet generator according to the present invention is integrated into a microfluidic chip to generate and introduce droplets of an aqueous solution into the microfluidic chip. ... University Of Maryland

04/19/18 / #20180105804

Novel methods for recovery of leaf proteins

A novel method for processing soluble plant leaf proteins is described. While leaf proteins are considered potentially the most abundant source of protein in nature, the lack of efficient processing techniques for leaf proteins has limited their commercial use. ... University Of Maryland

04/12/18 / #20180099038

Compositions and methods for producing bacterial conjugate vaccines

Longer chain antigenic o-polysaccharide chains for use as a hapten in conjugate vaccines can be produced in a controlled manner using recombinant gram-negative bacteria that overexpress native or heterologous genes of the wzz family, for example wzzb. Bacteria expressing a chosen wzz gene have modified o-polysaccharide chain lengths, allowing the bacteria to produce lipopolysaccharides having the longer o-polysaccharides. ... University Of Maryland

03/29/18 / #20180088114

Ultra-fast pathogen toxin detection assay based on microwave-accelerated metal-enhanced fluorescence

The present invention provides for a system and method to detect low levels of the anthrax protective antigen (pa) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (mef)-pa assay in combination with microwave-accelerated pa protein surface absorption. Microwave irradiation rapidly accelerates pa deposition onto the surface adjacent to deposited metallic particles and significantly speeding up the mef-pa assay and resulting in a total assay run time of less than 40 min with an analytical sensitivity of less than 1 pg/ml pa.. ... University Of Maryland

03/29/18 / #20180088008

Actively shaken in-situ passive sampling device

A vibrating platform for the deploying of passive sampling devices in sediments and other media to be sampled. The vibrating platform can greatly enhance the rate of mass transfer of analytes, such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls, into passive sampler material by disrupting the formation of a depletion layer in proximity of the passive sampler material.. ... University Of Maryland

03/29/18 / #20180086700

Inhibitors of the notch transcriptional activation complex and methods for use of the same

Disclosed herein are inhibitors of the notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of formula (i) and pharmaceutically acceptable salts thereof: formula (i), wherein the substituents are as described.. ... University Of Maryland

03/22/18 / #20180078234

Coaptation ultrasound devices and methods of use

Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with sufficient force so as to allow the operator to manually guide the member to its intended location. ... University Of Maryland

03/15/18 / #20180075591

Systems, devices, and methods for generating a social street view

Disclosed are systems, devices, and methods for creating a rendering of real-world locations with embedded multimedia elements. An exemplary method includes receiving image data of a real-world location, identifying geographic coordinates of the real-world location and/or a point of view from which the image data was acquired, acquiring multimedia elements relevant to the real-world location based on the geographic coordinates and/or the point of view, and creating a rendering of the image data with the multimedia elements embedded therein.. ... University Of Maryland

03/01/18 / #20180060485

Privacy-preserving similar patient query systems and methods

Method including securely calculating, by a processor in electrical communication with a genome registry, an edit-distance between a query private genome and a second private genome, and securely calculating, by the processor, a set difference size between the query genome and the second private genome are disclosed. Systems capable of performing similar patient queries while preserving privacy are also disclosed.. ... University Of Maryland

03/01/18 / #20180058319

Systems and methods for anti-phase operation of pulse combustors

A pulse combustor system for operating pulse combustors in anti-phase. The pulse combustor system includes two pulse combustors connected at their combustion chambers by a connecting tube. ... University Of Maryland

03/01/18 / #20180057562

Universal antibody-mediated biosensor

A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to detect target agents in a sample. The fusion protein has an extracellular antibody-binding domain that binds antibodies without regard to their binding specificity and a signaling domain that induces cellular activation upon antigen binding. ... University Of Maryland

02/15/18 / #20180045626

Particle separation and concentration using spiral inertial filtration

A spiral inertial filtration device is capable of high-throughput (1 ml/min), high-purity particle separation while concentrating recovered target particles by more than an order of magnitude. Large fractions of sample fluid are removed from a microchannel without disruption of concentrated particle streams by taking advantage of particle focusing in inertial spiral microfluidics, which is achieved by balancing inertial lift forces and dean drag forces. ... University Of Maryland

02/08/18 / #20180036320

Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens, in vitro biological activities, pharmacokinetics and antitumor activity

Described are steroidal c-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic vinylic “addition-elimination” substitution reaction of 3β-acetoxy-17-chloro-16-formylandrosta-5,16-diene or analogs thereof and benzoazole or pyrimidinoazole nucleophiles and methods having a palladium catalyzed cross-coupling reaction of 17-iodoandrosta-5,16-dien-3β-ol or analogs thereof with tributylstannyl diazines. ... University Of Maryland

02/01/18 / #20180033496

Systems, methods, and devices for inertial electrostatic confinement

A continuous electrode (ce) inertial electrostatic confinement (iec) device has particle paths radially extending from a central core region. Each particle path has a corresponding particle path aligned on an opposite side of the central core region. ... University Of Maryland

02/01/18 / #20180028646

Polyelectrolyte multilayers assembled from immune signal compounds

Immune-polyelectrolyte multilayers (ipems) that can be made entirely from immune signal compounds are provided. Ipems are formed from first layer of a first immune signal compound, and a second layer of the first immune signal compound or a second immune signal compound disposed on the first layer of the first immune signal compound. ... University Of Maryland

01/25/18 / #20180021414

Methods of regulating uptake and transcellular transport of leukocytes and therapeutics

Methods for controlling and regulating engulfment, uptake and/or transcellular transport at a stage following initial engagement of an agent to the endothelium are provided, based on the identification of cam-mediated endocytosis and the sphingomyelin/ceramide pathway as active steps in transcellular tem. Administration of regulators relating to the identified pathways, such as nhe1, sphingomyelinases, acid sphingomyelinase and ceramide, permit control and regulation of uptake and transcellular transport. ... University Of Maryland

01/18/18 / #20180020186

Systems and methods for integration of audiovisual components to central station monitoring

Systems and methods for integration of audiovisual components of central station monitoring are provided. At the outset, patient data from a central monitoring station is received at an audiovisual switcher. ... University Of Maryland

01/11/18 / #20180011249

Fiber-to-waveguide couplers with ultra high coupling efficiency and integrated chip waveguides including the same

An easy-to-fabricate and highly efficient single-mode optical fiber-to-single-mode optical waveguide coupler having relatively large horizontal and vertical alignment tolerances between the fiber and the waveguide coupler. The waveguide coupler also features ease of end-facet cleaving. ... University Of Maryland

01/11/18 / #20180011244

Generation of arbitrary optical filtering function using complex bragg gratings

A waveguide bragg grating includes a silicon substrate defining a length, a width and a depth and a silicon dioxide (sio2) cladding over the silicon substrate and encasing a silicon nitride (si3ni4) core extending along the length of the silicon substrate and defining a variable width and thickness; wherein the silicon nitride (si3ni4) core is configured as and functions as a complex bragg grating waveguide. The waveguide bragg grating is designed by determining a grating profile of the silicon nitride (si3ni4) core from a layer peeling algorithm and a layer adding algorithm; and mapping the grating profile to a 1-layer waveguide structure with varying width dimensions. ... University Of Maryland

01/11/18 / #20180010299

Super clear cellulose paper

Wood fibers possess natural unique hierarchical and mesoporous structures that enable a variety of new applications beyond their traditional use. For the first time we dramatically modulate the propagation of light through random network of wood fibers. ... University Of Maryland

01/04/18 / #20180005647

Multiple pitch extraction by strength calculation from extrema

An apparatus includes a function module, a strength module, and a filter module. The function module compares an input signal, which has a component, to a first delayed version of the input signal and a second delayed version of the input signal to produce a multi-dimensional model. ... University Of Maryland

12/21/17 / #20170363632

Biomarker kit for metastatic breast cancer prognosis and uses thereof

Provided herein are kits for detecting and quantifying the level of a metastatic cancer biomarker(s) in a patient. The kits may contain a detection and quantifying means, such as, biomarker specific antibodies. ... University Of Maryland

12/07/17 / #20170352061

Optimal social network ad allocation using hyperbolic embedding

Various computational systems may benefit from improvement in determining optimal allocation. For example certain social network advertisement systems may benefit from the use of hyperbolic embedding. ... University Of Maryland

11/30/17 / #20170342458

Biomass containment device

A biomass containment device (bcd) and methods of measuring microbial growth or enzyme activity in the presence of insoluble substrates using the bcd is described. The bcd is compatible with microbial growth and enzyme assays, is sterilizable, is reusable, and the size can be varied to fit any container.. ... University Of Maryland

11/23/17 / #20170338522

Interfacial layers for solid-state batteries and methods of making same

One or more interfacial layers in contact with a solid-state electrolyte and hybrid electrolyte materials. Interfacial layers comprise inorganic (e.g., metal oxides and soft inorganic materials) or organic materials (e.g., polymer materials, gel materials and ion-conducting liquids). ... University Of Maryland

11/23/17 / #20170336509

Projectile position measurement using non-linear curve fitting

An electronic home plate provides assistance to an umpire in determining whether a pitch results in a “strike” or a “ball.” the home plate is implemented with leds producing discrete pulses of infrared light beams extending vertically. As a moving ball intersects the pulses, light from the pulses is scattered and incident on photodetectors embedded in the home plate, producing a series of data points. ... University Of Maryland

11/16/17 / #20170332468

Laser-driven high repetition rate source of ultrashort relativistic electron bunches

A laser-plasma-based acceleration system includes a focusing element and a laser pulse emission directing a laser beam to the focusing element to such that laser pulses transform into a focused beam and a chamber defining a nozzle having a throat and an exit orifice, emitting a critical density range gas jet from the exit orifice for laser wavelengths ranging from ultraviolet to the mid-infrared. The critical density range gas jet intersects the focused beam at an angle and in proximity to the exit orifice of the nozzle to define a point of intersection between the focused beam and the critical density range gas jet. ... University Of Maryland

11/16/17 / #20170327427

Phosphorus extraction and recovery system (pears)

Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.. ... University Of Maryland

11/16/17 / #20170326345

Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds

A sprayable polymeric foam hemostat for both compressible and non-compressible (intracavitary) acute wounds is disclosed. The foam comprises hydrophobically-modified polymers, such as hm-chitosan, or other amphiphilic polymers that anchor themselves within the membrane of cells in the vicinity of the wound. ... University Of Maryland

11/16/17 / #20170326169

Advanced functional biocompatible polymeric matrix containing nano-compartments

The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. ... University Of Maryland

11/09/17 / #20170322081

Tunable near-infrared emitters and methods

The present invention relates to near-infrared quantum emitters, and in particular carbon nanostructures with chemically incorporated fluorescent defects, and methods of synthesizing near-infrared emitting nanostructures.. . ... University Of Maryland

10/26/17 / #20170303958

Self-sealing cannula

The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. ... University Of Maryland

10/12/17 / #20170295014

Method and apparatus for authenticating device and for sending/receiving encrypted information

Methods and apparatuses for authenticating communication devices and securely transmitting and/or receiving encrypted voice and data information. A biometric scanner, for example a fingerprint scanner, is utilized for authenticating the communication device and for generating the encryption key. ... University Of Maryland

10/12/17 / #20170291930

Histatin-5 based synthetic peptides and uses thereof

Provided herein are synthetic peptides or synthetic fragments thereof based on a histatin-5 peptide, for example with a sequence dshakrhhgykrkfhekhhshrgy (seq id no: 1). The synthetic peptides or synthetic fragments have at least one substituted amino acid that is arginine and/or leucine to increase resistance to proteolytic degradation by a microbe, such as a fungus. ... University Of Maryland

10/05/17 / #20170283486

Stable immunogen based on inner domain of hiv-1 gp120 for inducing immunity against hiv

Stable immunogens comprising portions of the inner domain (id) of the human immunodeficiency virus (hiv-1) gp120 protein are provided. These id immunogens selectively present the gp120 c1/c2 region in its cd4-bound state within a minimal structure. ... University Of Maryland

09/28/17 / #20170278431

Central pressurized cadaver model

Provided are methods for creating a pressurized cadaver model used for surgical procedure training. In the method the internal jugular veins, common carotid arteries, brachial arteries, superficial femoral arteries and femoral veins thereof of a cadaver are exposed. ... University Of Maryland

09/28/17 / #20170276666

Multi-functional fluid flow device

The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal end of the elongate body, at least one well outlet port positioned at the distal end of the elongate body, at least one conduit connecting the at least one source fluid inflow port to the at least one well inlet port, and at least one conduit connecting the at least one waste fluid outflow port to the at least one well outlet port.. ... University Of Maryland

09/21/17 / #20170266181

Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity

Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (ar), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including prostate cancer, castration resistant prostate cancer, bladder cancer, pancreatic cancer, hepatocellular carcinoma, benign prostatic hyperplasia (bph), kennedy's disease, androgenetic alopecia, breast cancer, androgen-insensitive syndrome, and spinal and bulbar muscular atrophy.. ... University Of Maryland

09/14/17 / #20170263935

Protection layers for metal anodes

A protection layer is formed on a highly-reactive substantially-pure metal anode to a thickness of between 1 nm and 200 nm, inclusive, using atomic layer deposition (ald). The ald protection layer allows the conduction of ions of the metal of the anode therethrough but suppresses electron transport therethrough. ... University Of Maryland

09/14/17 / #20170258464

Method and apparatus for transapical procedures on a mitral valve

Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. ... University Of Maryland

08/31/17 / #20170247653

Compositions and methods for collecting algae

The invention relates to compositions containing bacillus sp., optionally with magnetite, useful in methods for collecting algae. The invention also relates to methods for collecting algae by contacting algae and bare maghemite and compositions thereof.. ... University Of Maryland

08/31/17 / #20170246477

System and method for optimizing a treatment plan for irradiation therapy using multi-criteria optimization (mco)

A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes defining a single objective function based on a plurality of objective functions that are each associated with a plurality of tissue types within a subject, upper and lower bounds for each objective function and a plurality of apertures. ... University Of Maryland

08/31/17 / #20170246177

Methods of treating age-related symptoms in mammals and compositions therefor

A method of alleviating age-related symptoms in a mammal, which comprises a step of administering to a mammal in need thereof, an effective amount of a composition containing an effective amount of at least methylene blue.. . ... University Of Maryland

08/10/17 / #20170226181

Soluble cd80 as a therapeutic to reverse immune suppression in cancer patients

The present invention provides for a therapeutic cancer treatment using a soluble cd80 fusion protein that binds to pdl1 and inhibits pdl1-pd1 interactions thereby overcoming pdl1-induced immune suppression and restoring t cell activation.. . ... University Of Maryland

08/10/17 / #20170224779

Methods for treating cardiovascular dysfunction and improving fluid homeostasis with a peptide hormone

The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition by administering an ela peptide or fusion protein to a subject in need. The invention relates to fusion proteins of fc-ela-32 and fc-ela-21 that exhibit improved properties for use as therapeutic agents, e.g. ... University Of Maryland

08/03/17 / #20170216479

Compositions comprising textured patterns and methods of using the same

The invention provides method of guiding unidirectional movement of a cell comprising exposing the cell to a surface comprising an asymmetric, three-dimensional pattern of one or a plurality of topographical elements for a time period sufficient to bias actin polymerization within the cell. The invention also provides methods of inducing directional movement of a cell, and methods of harnessing an actin wave within a cell. ... University Of Maryland

07/27/17 / #20170211120

Pathogen identification in complex biological fluids

Provided herein are methods for rapidly identifying a microbe, such as a pathogen, from a biological sample including, blood, urine, wound effluent, stool, serum, and bronchoalveolar lavage fluid. The method comprises obtaining the sample from the subject and performing a spectrometric analysis of the lipids in the microbe to obtain a profile. ... University Of Maryland

07/27/17 / #20170211012

Method of extracting lipids from microbes

Improved methods for extracting lipid-containing molecules from microbes are disclosed. The methods utilize selected surfactants for extraction of lipids and lipopolysaccharides from microbes, such as bacteria and fungi. ... University Of Maryland

07/27/17 / #20170209864

Methods and systems for processing particles

Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.. ... University Of Maryland

07/27/17 / #20170209605

Carbohydrate functionalized catanionic surfactant vesicles for drug delivery

Carbohydrate functionalized catanionic vesicles that include a glycoconjugate and/or peptidoconjugate for vaccination or drug delivery, methods for forming these, and methods of using these.. . ... University Of Maryland

07/20/17 / #20170202968

Novel composition of matter for delivering lipid-soluble materials, and a method for producing it

This invention describes a novel composition of matter describing a complex comprising leaf protein and a lipophilic substance(s), along with the method of producing it. Delivery of lipid-soluble materials into the body is challenging because they are generally highly insoluble in water and very subject to oxidative degradation. ... University Of Maryland

07/20/17 / #20170202752

Protein-repellent dental materials and use thereof in dental applications

The present invention provides protein-repellent dental materials that can be widely applied in a variety of dental applications. The protein-repellent dental materials of the invention include dental primers, dental adhesives, dental resins, dental composites, dental bonding systems and the like, as well as dental cements, dental sealants, dental bases and dental liners, each of which is protein-repellent and each of which comprises a protein-repellent agent. ... University Of Maryland

07/20/17 / #20170202536

System and method for assessment of cardiac stroke volume and volume responsiveness

Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (lvot vti), and venous measurements of the internal jugular vein. ... University Of Maryland

07/13/17 / #20170198329

Device and methods of using device for detection of aminoacidopathies

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of amino acids with the use of a reaction surface comprising one or a plurality of metabolic enzymes or functional fragments thereof, but wherein the reaction surface does not comprise an electrode or electrically conductive support. In some embodiments, the biosensor comprises use of a thermophilic bacterial metabolic enzyme immobilized or attached to the reaction surface.. ... University Of Maryland

07/13/17 / #20170197087

System, apparatus and method for transient electric field detection and display

Disclosed are systems, devices and methods for detecting and measuring tms-induced electrical fields. In accordance with certain aspects of an embodiment of the invention, a tms sensor probe is provided having a field detector, a first electrical connection connecting the field detector to either a power source or a processor, and a second electrical connection connecting the field detector to a processor. ... University Of Maryland

07/13/17 / #20170196957

Recombinant t cell receptor ligand compositions and methods for treatment of prostate cancer

Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a mhc molecule including covalently linked first and second domains, wherein the first domain is an mhc class ii β1 domain and the second domain is an mhc class ii α1 domain, wherein the amino terminus of the α1 domain is covalently linked to the carboxy terminus of the β1 domain, and a prostate specific antigen peptide covalently linked to the first domain. ... University Of Maryland

06/29/17 / #20170186595

Active stabilization of ion trap radiofrequency potentials

Disclosed are improved methods and structures for actively stabilizing the oscillation frequency of a trapped ion by noninvasively sampling and rectifying the high voltage rf potential at circuit locations between a step-up transformer and a vacuum feedthrough leading to the ion trap electrodes. We use this sampled/rectified signal in a feedback loop to regulate the rf input amplitude to the circuit. ... University Of Maryland

06/29/17 / #20170184614

Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease

In sporadic alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of alzheimer's disease, which has remained elusive. ... University Of Maryland

06/29/17 / #20170184609

Human exhaled aerosol droplet biomarker system and method

A system and method for detecting a biomarker in exhaled breath condensate nanodroplets comprises noninvasively collecting exhaled breath condensate nanodroplets of a subject, and analyzing said nanodroplets utilizing immuno-quantitative polymerase chain reaction to detect one or more target biomarkers.. . ... University Of Maryland

06/29/17 / #20170184568

Microtentacle imaging in patient tumor samples

The present invention provides a method for imaging microtentacles on isolated, living, non-adherent primary tumor cells from a cancer subject comprising: i) obtaining one or more living, non-adherent primary tumor cells that has been isolated from a solid tumor from the subject; and ii) imaging the one or more living, non-adherent primary tumor cells and detecting the microtentacles.. . ... University Of Maryland

06/29/17 / #20170181972

Microfluidic liposome synthesis, purification and active drug loading

Microfluidic methods and systems are provided for continuous flow synthesis and active loading of liposomes, which include a liposome formation region configured to form a population of liposomes and a microdialysis region downstream from the liposome formation region and configured to form a transmembrane gradient for active drug loading of the liposomes. Microfluidic methods and systems for high throughput production of liposomes are also provided featuring high aspect ratio microchannels.. ... University Of Maryland

06/22/17 / #20170176318

System and method of label-free cytometry based on brillouin light scattering

The present invention relates to a method and system for a label-free cell analysis based on brillouin light scattering techniques. Combined with microfluidic technologies according to the present invention, brillouin spectroscopy constitutes a powerful tool to analyze physical properties of cells in a contactless non-disturbing manner. ... University Of Maryland

06/22/17 / #20170174620

Linked diaryl compounds with anticancer properties and methods of using the same

Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. ... University Of Maryland

06/22/17 / #20170174577

Nutrient extraction and recovery device for isolation and separation of target products from animal produced waste streams

The present invention provides for nutrient extraction and recovery devices that use the donnan membrane principle (dmp) to cause spontaneous separation of dissolved ions along electrochemical potential gradients, wherein anions and cations such as h2po4−, hpo42−, po43−, mg2+, ca2+, nh4+, and k+ are moved from manure containing waste streams through cation and anion exchange membranes into a recovery stream thereby precipitating target compounds including but not limited to struvite, potassium struvite and hydroxyapatite.. . ... University Of Maryland

06/22/17 / #20170173129

Local engineering of the lymph node environment to promote immune tolerance

A method of inducing specific immune tolerance to myelin in an individual is provided. The method includes introducing directly into a lymph node of the individual an effective amount of a composition that contains a myelin antigen, a biodegradable material and at least one tolerogenic agent. ... University Of Maryland

06/22/17 / #20170172119

Targeted genome editing in zygotes of domestic large animals

A method is provided of targeted genome editing of an animal using site specific homologous integration. A composition comprising a single stranded oligonucleotide or double stranded nucleic acid molecule comprising a nucleic acid molecule of interest and sequences flanking a target locus cleavage site is injected into the zygote of an animal along with a nuclease and a guide nucleic acid molecule that targets the nuclease to a target locus. ... University Of Maryland

06/15/17 / #20170168392

Multicolor photolithography materials and methods

The present invention relates to photoresist compositions comprising a base resin such as a monomer capable of radical polymerization upon photoinitiation, and photoinitiator molecules such as a diketone, and multicolor photolithography methods. Photoresist compositions comprise photoinitiator molecules that are exposed to a first radiation source, thereby exciting the photoinitiator molecules from a ground state to a pre-activated state. ... University Of Maryland

06/15/17 / #20170168048

Plasmonic substrates for metal-enhanced fluorescence based sensing, imaging and assays for cells

Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. ... University Of Maryland

06/15/17 / #20170166929

Method of converting marine fish waste to biomethane

Methods employed for the discovery, enrichment, and characterization of a marine consortium of fermentative and methanogenic microorganisms developed from the solid waste digestor of a fully contained, land-based, marine recirculating aquaculture system are described. The methanogenic microbial consortium discovered is capable of reducing over 90% of marine fish waste in an aquaculture system to biomethane and carbon dioxide at saline concentrations found in marine aquaculture. ... University Of Maryland

06/08/17 / #20170156690

Techniques for suppression of motion artifacts in medical imaging

Techniques for suppression of motion artifacts in medical imaging include obtaining projections at different times within a time interval from a medical imaging system operating on a subject. A stationary projection is determined for a first subset of the projections in which a signal source and detector array of the imaging system are in a first configuration relative to the subject. ... University Of Maryland

06/01/17 / #20170155169

Ceramic ion conducting structures and methods of fabricating same, and uses of same

Ceramic ion-conducing structures are disclosed. The structures can be in the form of a single layer or multilayer structures. ... University Of Maryland

06/01/17 / #20170152318

Methods and compositions for modulation of blood-neural barrier

Methods and compositions for modulating blood-neural barrier (bnb) for the treatment of cns conditions such as edema, and for increased drug delivery efficacy across the bnb. The present invention further relates to improved tpa treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the pdgf signaling pathway. ... University Of Maryland

05/18/17 / #20170137431

Molecular containers and methods of making and using same

Acyclic cb[n]-type compounds, methods of making such compounds, and uses of the compounds. For example, these compounds can be used as nanocontainers to solubilize pharmaceutical agents. ... University Of Maryland

05/18/17 / #20170135699

Apparatus and method for placement of device along wall of a body lumen

An apparatus (100) includes: a expandable structure (140) formable into three dimensional shapes including a range of diameters (d) and corresponding lengths (l); a movable component (106) moveable between a range of positions (124, 126) effecting the range of diameters; and a mechanical linkage (110) disposed between the movable component and the expandable structure. The expandable structure is configured to fit inside a working channel (204) of an endoscope (202) when the expandable structure is collapsed. ... University Of Maryland

05/11/17 / #20170132354

Methods and apparatuses for assessing high temperature bonding systems and bonded substrates therefrom

Methods and apparatuses for assessing the behavior of high temperature bonding systems such as sinter joint models of virtual interconnect microstructures via simulations that analyze sinter joint model properties include defining a plurality of sinter joint objects in a virtual interconnect microstructure, each sinter joint object having a type and a size, and determining a location of individual sinter joint objects with respect to one another in a virtual joint space to create a sinter joint model. The type is at least one of an intermetallic compound, a void, and a metal particle. ... University Of Maryland

05/11/17 / #20170129031

Methods and apparatuses for high temperature bonding controlled processing and bonded substrates formed therefrom

Methods and apparatuses for controlled processing of high temperature bonding systems via devices to control heating and cooling systems of a high temperature heating bonding includes use of a sinter fixture device including a plate surface, that is shaped to contact and conform to a contacting surface of a tlps substrate assembly, and a plurality of channels below the plate surface within a base body of the sinter fixture device shaped to receive heating and cooling elements. A first set of the one or more channels includes a plurality of cross-channels, a cooling medium inlet, and a cooling medium outlet, which cross-channels, cooling medium inlet, and cooling medium outlet are in fluid communication with one another. ... University Of Maryland

05/04/17 / #20170121758

Device and methods of using device for separation of bacteria from complex samples

The present disclosure relates to devices and systems for separating motile pathogenic bacterial cells from samples. The disclosure also provides for methods of determining whether a sample is contaminated by pathogenic bacteria. ... University Of Maryland

04/27/17 / #20170112723

Nanostructured antibacterial and remineralizing dental bonding agents and dental bonding systems

The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.. ... University Of Maryland

03/30/17 / #20170089995

Magnetic resonance 2d relaxometry reconstruction using partial data

An approach is presented to recontruct image data for an object using a partial set of magnetic resonance (mr) measurements. A subset of data points in a data space representing an object are selected (e.g. ... University Of Maryland

03/23/17 / #20170079296

Methods for treating plants or fruits

Methods for treating plants or fruits, involving contacting the plants or fruits with a solvothermal prepared metal-organic framework which releases at least one gas (e.g., ethylene) to treat the plants or fruits.. . ... University Of Maryland

03/09/17 / #20170066136

All-elastomer 3-axis contact resistive tactile sensor arrays and micromilled manufacturing methods thereof

At least one tactile sensor includes an insulating layer and a conductive layer formed on the surface of the insulating layer. The conductive layer defines at least one group of flexible projections extending orthogonally from the surface of the insulating layer. ... University Of Maryland

03/02/17 / #20170064478

Simultaneous solution for sparsity and filter responses for a microphone network

Placement of microphones and design of filters in a microphone network are solved simultaneously. Using filterbanks with multiple sub-channels for each microphone, the design of the filter response is solved simultaneously with placement. ... University Of Maryland

03/02/17 / #20170058040

Chemoenzymatic glycoengineering of antibodies and fc fragments thereof

The present invention provides for recombinant endo-s mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated glcnac-protein acceptor. Such recombinant endo-s mutants are useful for efficient glycosylation remodeling of igg1-fc domain to provide different antibody glycoforms carrying structurally well-defined fc n-glycans.. ... University Of Maryland

02/23/17 / #20170051278

Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human lmna

Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon lmna-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced lmna mrna isoforms that encode progerin.. . ... University Of Maryland

02/23/17 / #20170049880

Infectious laryngotracheitis virus (iltv) vaccine using recombinant newcastle disease virus vector

In this study, for the first time, protective efficacy of gd against iltv challenge was evaluated. Immunization with recombinant newcastle disease virus expressing iltv gd induced a higher level of neutralizing antibodies and offered complete protection to chickens against lethal iltv challenge. ... University Of Maryland

01/26/17 / #20170026836

Attribute-based continuous user authentication on mobile devices

Various devices and systems may benefit from convenient authentication. For example, certain mobile devices may benefit from attribute-based continuous user authentication. ... University Of Maryland

01/26/17 / #20170021187

Methods and systems for controlling magnetic fields and magnetic field induced current

The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and systems. In accordance with certain aspects of an embodiment, an array of magnetic coils is provided and positionable about a portion of a patient's body. ... University Of Maryland

01/26/17 / #20170020892

Use of negative modulators of gaba receptors containing alpha5 subunits as fast acting antidepressants

Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of gabaa receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of gabaa receptors, such as a partial inverse agonist of a gabaa receptor comprising an alpha5 subunit.. ... University Of Maryland

01/19/17 / #20170014415

Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. . ... University Of Maryland

01/12/17 / #20170013213

Turbulence-free camera system and related method of image enhancement

A turbulence-free ccd camera system with nonclassical imaging resolution, for applications in long-distance imaging, such as satellite and aircraft-to-ground based distant imaging, utilizing an intensity-fluctuation correlation measurement of thermal light. The proposed camera system has the following advantages over classic imaging technology: (1) it is turbulence-free; (2) its spatial resolution is mainly determined by the angular diameter of the light source. ... University Of Maryland

01/05/17 / #20170000931

Para-xylene films and therapeutic uses thereof

The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and 95 degrees (e.g., to prevent adhesion formation). ... University Of Maryland








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