Real Time Touch



new TOP 200 Companies filing patents this week

new Companies with the Most Patent Filings (2010+)




Real Time Touch

University Of Massachusetts patents


Recent patent applications related to University Of Massachusetts. University Of Massachusetts is listed as an Agent/Assignee. Note: University Of Massachusetts may have other listings under different names/spellings. We're not affiliated with University Of Massachusetts, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Massachusetts-related inventors


Microfluidic devices and methods of manufacture and use thereof

This invention provides microfluidic devices with graphene films as architectural materials and methods of fabrication and use thereof in x-ray analysis.. . ... University Of Massachusetts

Transgenic expression of dnasei in vivo delivered by an adeno-associated virus vector

The disclosure relates to compositions and methods for aav-mediated delivery of a nuclease to a subject. In some embodiments, the nuclease is dnase i. ... University Of Massachusetts

High strength polyisobutylene polyurethanes

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea, or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer, wherein the soft segment includes a polyisobutylene macrodiol and/or diamine. Additionally disclosed is a method of forming a polyisobutylene-based thermoplastic urethane, comprising the steps of (a) reacting a polyisobutylene macrodiol and/or diamine with a diisocyanate to form a first reaction mixture; (b) combining a metal catalyst and a chain extender with the first reaction mixture to create a second reaction mixture, a molar ratio of the metal catalyst to the diisocyanate being greater than 0.0:1 and less than or equal to 0.4:1; and (c) reacting the second reaction mixture for a period of time sufficient to form the polyisobutylene-based thermoplastic urethane.. ... University Of Massachusetts

Devices and methods for optical pathology

Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. ... University Of Massachusetts

Membrane and droplet-interface bilayer systems and methods

Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.. ... University Of Massachusetts

Application of the extrema distortion method to optimize control signals

A system is described that observes a signal from a subject of interest, converts the signal to an electrical representation, uses the electrical representation to compute a synthetic control signal, and applies the synthetic control signal to control some aspect of operation of the subject. The procedure used to generate the synthetic control signal involves subjecting the electrical representation of the observed signal to random noise, allowing the extrema of the electrical representation to move, and obtaining a converged solution as the synthetic control signal.. ... University Of Massachusetts

Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended sirna

The present invention provides methods of enhancing the efficacy and specificity of rnai using single or double blunt-ended sirna. The invention also provides single and double-blunt ended sirna compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. ... University Of Massachusetts

Genetically modified non-human animals and methods relating to complement dependent cytotoxicity

The present invention relates generally to genetically modified non-human animals and immunodeficient non-human animals characterized by restored complement-dependent cytotoxicity, as well as methods and compositions for assessment of therapeutic antibodies in the genetically modified immunodeficient non-human animals. In specific aspects, the present invention relates to immunodeficient non-obese diabetic (nod), a/j, a/he, akr, dba/2, nzb/bin, b10.d2/osn and other mouse strains genetically modified to restore complement-dependent cytotoxicity which is lacking in the unmodified immunodeficient mice. ... University Of Massachusetts

Stabilized polymeric nanocapsules, dispersions comprising the nanocapsules, and methods for the treatment of bacterial biofilms

A nanocapsule includes a liquid hydrophobic care including an essential oil, and a shell encapsulating the core. The shell includes a copolymer having repeating units of formula (i) and (ii) wherein x, l1, r1, r2, y, and p are as described herein. ... University Of Massachusetts

Sensors and methods for capture, killing, and release of bacteria

There is provided a renewable sensor for sensing or selectively capturing a targeted bacteria in a fluid. The renewable sensor includes a surface, the surface includes a substrate, a biologically or bacterially non-adhesive feature disposed on or in functional proximity to at least a portion of the substrate; and an adhesive elements disposed on or in functional proximity to the non-adhesive feature, a flow channel in operative contact with the surface; and a detector configured to detect the targeted cell type captured on the surface. ... University Of Massachusetts

In vivo production of small interfering rnas that mediate gene silencing

The invention provides engineered rna precursors that when expressed in a cell are processed by the cell to produce targeted small interfering rnas (sirnas) that selectively silence targeted genes (by cleaving specific mrnas) using the cell's own rna interference (rnai) pathway. By introducing nucleic acid molecules that encode these engineered rna precursors into cells in vivo with appropriate regulatory sequences, expression of the engineered rna precursors can be selectively controlled both temporally and spatially, i.e., at particular times and/or in particular tissues, organs, or cells.. ... University Of Massachusetts

Monomers and polymers for functional polycarbonates and poly(ester-carbonates) and peg-co-polycarbonate hydrogels

The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. ... University Of Massachusetts

Catheter assemblies

A catheter assembly for transferring fluid into and out of a ventricle in the brain is disclosed. The catheter assembly include a sheath permanently installed in the brain, a catheter removably disposed in the sheath, and a connector. ... University Of Massachusetts

Polymers and polymeric assemblies for peptide and protein encaosulation and release, and methods thereof

The invention provides polymers and polymeric nanogels that stably encapsulate peptides and proteins, which are controllably released upon degradable of the nano-structures in response to specific microenvironment, and compositions and methods of preparation and use thereof.. . ... University Of Massachusetts

05/24/18 / #20180140465

Negative pressure wound closure device

The present invention relates to wound closure devices, systems and methods. Embodiments of the invention facilitate closure of the wound by preferentially contracting under negative pressure to provide for movement of the surrounding tissues. ... University Of Massachusetts

05/17/18 / #20180134866

Flexible functionalized ceramic-polymer based substrates

Flexible substrates including a polymer selected from a thermoplastic polymer, a thermoset polymer, and/or a polymer blend, and ferroelectric perovskite-type oxide particles dispersed in the polymer, where the ferroelectric perovskite-type oxide has a dielectric constant that varies with applied voltage. The flexible substrates can be used in tunable electronics.. ... University Of Massachusetts

05/17/18 / #20180134845

Polymeric nanogels with degradable backbones and from gras components, and compositions and methods thereof

The invention generally relates to novel polymers and polymeric nanogels having biodegradable polymeric backbones, and compositions and methods of preparation and use thereof, for example, as guest-host polymer nano-assemblies and nano-delivery vehicles, which offer utilities in diverse fields including drug delivery, diagnostics and specialty materials.. . ... University Of Massachusetts

05/17/18 / #20180134157

Efficient control of fuel consumption in cars

A system that includes an accelerometer configured to measure acceleration of a vehicle, a gyroscope configured to measure orientation of the vehicle, a memory having computer readable instructions, and a processor for executing the computer readable instructions. The computer readable instructions include performing at intervals: receiving acceleration data from the accelerometer; receiving orientation data from the gyroscope; combining the acceleration data and the orientation data to generate speed fluctuation and slope data for the vehicle; and transmitting the fluctuation and slope data to a controller of the vehicle. ... University Of Massachusetts

05/10/18 / #20180125791

Polymer nanocapsules for protein delivery

A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of formula (i) (i) wherein x, l1, r1, and y are as described herein. ... University Of Massachusetts

05/10/18 / #20180125763

Preparation and use of silver sulfadiazine-immobilized fillers

Silver sulfadiazine-immobilized inorganic fillers are described, and their synthesis is presented. The fillers are believed to have utility in dental composites and dental adhesives to achieve potent, long-term, and none-leaching antimicrobial effects.. ... University Of Massachusetts

05/03/18 / #20180120267

Distributed fiber sensor

In an embodiment, a sensor comprises a waveguide comprising a photoacoustic generation element disposed on the waveguide, the photoacoustic generation element comprising a photoabsorptive material; and a sensing element comprising an optical acoustic wave detector. In another embodiment, a sensing system comprises the sensor and a laser. ... University Of Massachusetts

04/19/18 / #20180109239

Piezoelectric transducer device with resonance region

According to one configuration, an acoustical device includes a piezoelectric substrate and at least one curved electrode. Material on a surface of the piezoelectric substrate defines boundaries of a resonance region. ... University Of Massachusetts

04/12/18 / #20180100249

Polymer nanofibers from electrospinning of complex coacervates, and compositions and methods thereof

The invention provides novel polymer nanofiber or microfiber mats or membranes and methods for their preparation via an aqueous, one-step polyelectrolyte complexation and electrospinning of complex coacervates.. . ... University Of Massachusetts

04/05/18 / #20180094264

Aav treatment of huntington's disease

Aspects of the disclosure relate to compositions and methods useful for treating huntington's disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial mirnas) targeting the huntingtin gene (htt) and methods of treating huntington's disease using the same.. ... University Of Massachusetts

04/05/18 / #20180094263

Oligonucleotide compounds for targeting huntingtin mrna

This disclosure relates to novel huntingtin targets. Novel oligonucleotides for the treatment of huntington's disease are also provided.. ... University Of Massachusetts

04/05/18 / #20180092420

Add-on impact energy absorbing pad structure for outside of military and sport helmets

A flocked helmet cover pad (fhcp) attachable add-on to a helmet cover includes a central hub and multiple appendages attached to the central hub. The appendages are shaped and arranged to provide additional impact energy absorption properties for a helmet.. ... University Of Massachusetts

03/29/18 / #20180091961

Smart case

The present invention relates to a cell phone case, particularly to a multifunction back cover for a cell phone case, wherein the back cover has an rechargeable power source connected to a microcontroller and an emergency notification button used to trigger a variety of functional responses in cooperation with the application mode of the cell phone, wherein said microcontroller is in electronic communication with said emergency notification button.. . ... University Of Massachusetts

03/29/18 / #20180087110

Compositions and methods for xi chromosome reactivation

In some aspects, the disclosure relates to the reactivation of inactive x chromosomes (xi). In some embodiments, the disclosure provides compositions and methods for the reactivation of inactive x chromosomes. ... University Of Massachusetts

03/22/18 / #20180078634

Virus-like particle compositions and vaccines against epstein-barr virus infection and disease

. . The present invention relates to prophylactic and/or therapeutic vaccines that contain newcastle disease virus (ndv) virus-like particles (vlps) comprising one or more epstein-barr virus (ebv) antigens. In one embodiment, the invention provides a recombinant virus-like particle (vlp) comprising, in operable combination, a) newcastle disease virus (ndv) matrix (m) protein, and b) one or more epstein-barr virus (ebv) antigens. ... University Of Massachusetts

03/15/18 / #20180072901

Ferroelectric nanocomposite based dielectric inks for reconfigurable rf and microwave applications

A novel ferroelectric ink comprising multiphase barium strontium titanate (bst) in a polymer composite is described. The ink can be employed using direct-ink writing techniques to print high dielectric constant, low loss, and electrostatically-tunable dielectrics on substrates. ... University Of Massachusetts

03/01/18 / #20180059875

System and methods for cuing visual attention

A system and methods for cuing visual attention using one or more sensory cues. Sensory cues, such as visual and touch cues, are used to determine an area neglected by a user and presented on a screen display to cue the user to direct his/her attention to that neglected area. ... University Of Massachusetts

03/01/18 / #20180055777

Hydrogel beads with self-regulating microclimate ph properties

A composition includes a hydrogel bead in an external matrix, the hydrogel bead having an at least partially crosslinked gelling polymer, the hydrogel bead having encapsulated therein a functional agent, and a buffering agent having low water solubility, wherein at least a portion of the buffering agent is in solid form in the hydrogel bead.. . ... University Of Massachusetts

02/22/18 / #20180049826

System and method for robotic surgical intervention in a magnetic resonance imager

A system and method for image guided assisted medical procedures using modular units, such that a controller, under the direction of a computer and imaging device, can be utilized to drive and track low cost, purpose specific manipulators. The system utilizes modular actuators, self tracking, and linkages. ... University Of Massachusetts

02/15/18 / #20180044635

Surface-modified macrophages for cell-based delivery

A population of isolated mammalian macrophages, the cell surface of which is chemically modified to comprise a molecule that comprises an imaging agent or a therapeutic agent or a molecule that binds to an imaging agent or a therapeutic agent, and methods of making and using the modified macrophages are provided.. . ... University Of Massachusetts

02/15/18 / #20180043025

Protein transduction domains mimics

The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.. ... University Of Massachusetts

02/15/18 / #20180042998

Targeting gdf6 and bmp signaling for anti-melanoma therapy

The invention features methods of treating melanoma by modulating an activity of gdf6 in melanoma cells. In one aspect, the methods involve downregulating an activity of gdf6, for example, by using an anti-gdf6 binding molecule, such as an inactivating antibody. ... University Of Massachusetts

02/15/18 / #20180042991

Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression

The present invention relates to recombinant glut1 adeno-associated viral vector (raav) constructs and related methods for restoring glut1 expression in glut1 deficient mammals. In certain embodiments, the raav further comprises a chicken β-actin promoter wherein the raav is capable of crossing the blood-brain barrier (bbb). ... University Of Massachusetts

02/08/18 / #20180037877

Compositions and methods for transient delivery of nucleases

The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated aav capsid proteins having terminally grafted nucleases and isolated nucleic acids encoding the same. ... University Of Massachusetts

02/08/18 / #20180036713

Porous materials, methods of manufacture thereof and articles comprising the same

Disclosed herein is a porous material comprising a biopolymer functionalized with a carbon dioxide capturing moiety; where the biopolymer is in the form of a foam or an aerogel having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter. Disclosed herein too is a method comprising functionalizing a biopolymer with a carbon dioxide capturing moiety; dissolving the biopolymer in an aqueous solution to form a first solution; reducing the temperature of the first solution to below the freezing point of the aqueous solution; displacing the aqueous solution with a first solvent that has a lower surface tension than a surface tension of the aqueous solution; and drying the first solvent to produce a porous biopolymer having a bulk density of 500 grams per cubic meter to 2500 grams per cubic meter.. ... University Of Massachusetts

02/01/18 / #20180032768

Systems and methods for asymmetric backscatter communications

Systems and methods for backscatter communications are provided that employ a backscatter reader to transmit a carrier signal to multiple backscatter tags having heterogeneous hardware and specifications. In response to receiving the carrier, the tags encode data into the received signal and, concurrently, transmit their respective backscattered signal to the reader. ... University Of Massachusetts

01/25/18 / #20180025074

Analogy finder

A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. ... University Of Massachusetts

01/25/18 / #20180023094

Recombinant aav variants and uses thereof

The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. ... University Of Massachusetts

01/25/18 / #20180022831

Nanoparticle-protein complex for intracellular protein delivery

Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. ... University Of Massachusetts

01/18/18 / #20180016719

Fiber surface finish enhanced flocked impact force absorbing structure and manufacturing

Embodiments of fiber surface finish enhanced flocked surface impact force absorbing structure include a plurality of flock fibers disposed on a substrate, a surface coating applied to the plurality of flock fibers, and in another embodiment, a divider fabric bonded to the tops of flock fibers.. . ... University Of Massachusetts

01/11/18 / #20180013022

Backside configured surface plasmonic structure for infrared photodetector and imaging focal plane array enhancement

The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (qdips) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.. ... University Of Massachusetts

12/28/17 / #20170373892

Systems and methods for backscatter communication

Systems and methods for wireless communication are provided. The systems and methods employ a backscatter tag that is configured to shift an incident carrier signal received by the tag to a different frequency band and then transmitting the frequency-shifted carrier signal to a receiver. ... University Of Massachusetts

12/28/17 / #20170369882

Fully stabilized asymmetric sirna

Provided herein are self-delivering oligonucleotides that are characterized by efficient risc entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.. . ... University Of Massachusetts

12/28/17 / #20170368643

Preparation and application of pb-free nanosolder

The preparation and use of particulate metallic solder alloy having particles of a single chemical composition is described. The particles of the particulate metallic solder alloy have a bimodal size distribution in which particles in a smaller size range have a largest dimension that is smaller than a smallest dimension of particles in a larger size range of the bimodal distribution. ... University Of Massachusetts

12/28/17 / #20170368099

Cancer immunotherapy

Methods of providing populations of nkt and/or γδ t cells, and their use, e.g., in therapies such as cancer immunotherapy.. . ... University Of Massachusetts

12/21/17 / #20170362269

Novel neisseria gonorrhoeae therapeutic based on cmp-nonulosonate sugars

N. Gonorrhoeae has become resistant to almost every conventional antibiotic. ... University Of Massachusetts

12/07/17 / #20170349911

Cns targeting aav vectors and methods of use thereof

The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to cns tissue, and compositions comprising the same, and methods of use thereof in some aspects, the invention provides methods and compositions for treating cns-related disorders.. . ... University Of Massachusetts

12/07/17 / #20170348362

Anthelmintic probiotic compositions and methods

Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a recombinant bacterium expressing a crystal protein such as a bacillus thuringiensis crystal protein (cry). ... University Of Massachusetts

11/23/17 / #20170336564

Ultralow-energy electro-optical logic and nxn switching by resonant on-chip nanobeam waveguide networks

An ultralow-energy electro-optical 2×2 cross-bar switch comprises an identical pair of semiconductor nanobeams that are incorporated in the central arms of a waveguided mach-zehnder interferometer. Each nanobeam includes a one dimensional “lattice” of holes along the nanobeam axis that defines a resonant cavity whose fundamental mode is the operating wavelength of the switch. ... University Of Massachusetts

11/23/17 / #20170335315

Mapping of genomic interactions

The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.. ... University Of Massachusetts

11/23/17 / #20170333490

Targeting epigenetic regulators using a bacterial delivery system

One embodiment provides an attenuated salmonella strain comprising a lysis gene or cassette operably linked to an intracellularly induced salmonella promoter. In one embodiment, the promoter is a promoter for one of the genes in salmonella pathogenicity island 2 type iii secretion system (spi2-t3ss) selected from the group spic/ssab, ssef, sseg, ssei, ssej, ssek1, ssek2, sifa, sifb, pipb, pipb2, sopd2, gogb, ssel, stec, ssph1, ssph2, or sirp. ... University Of Massachusetts

11/23/17 / #20170333363

Polymers and polymeric nanogels with hydrophilics encapsulation and release capabilities and methods thereof

The invention provides ph- or redox-responsive and charge-neutral polymeric nanogels that stably encapsulate a biomolecule at one ph or redox condition and then release it at a different ph or redox condition, and compositions and methods of preparation and use thereof.. . ... University Of Massachusetts

11/16/17 / #20170331096

Electrical insulation layer and battery device

An electrical insulation layer including microparticles and having a mesoporous structure; and a battery device including a cathode, an anode, an electrical insulation layer including microparticles and having a mesoporous structure, the electrical insulation layer being arranged between the anode and the cathode, and an ion conductive composition.. . ... University Of Massachusetts

11/16/17 / #20170327843

Mouse model of alpha-one antitrypsin (aat) deficiency

Transgenic non-human animals, e.g., rodents, e.g., mice comprising genomic mutations that inactive all of the serpinla genes and thus lack any functional serpina1 genes. As a result of the genomic mutations, the animals express no hepatic or circulatory aat protein. ... University Of Massachusetts

11/16/17 / #20170327822

Rna interference mediating small rna molecules

Double-stranded rna (dsrna) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as rna interference (rnai). Using a drosophila in vitro system, we demonstrate that 19-23 nt short rna fragments are the sequence-specific mediators of rnai. ... University Of Massachusetts

11/16/17 / #20170326071

Yeast cell wall particles for receptor-targeted nanoparticle delivery

The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to trapping nanoparticles either on the surface or inside a yeast glucan particles, for example, yeast glucal particles. ... University Of Massachusetts

10/26/17 / #20170306403

Molecular diagnosis of fshd by epigenetic signature

The present invention includes methods of determining whether an individual in need thereof has, or is at risk of developing, facioscapulohumeral muscular dystrophy (fshd).. . ... University Of Massachusetts

10/26/17 / #20170306189

High capacity easy release extended use adhesive devices

The invention provides novel devices, systems, designs, materials and fabrication methods that enable high-load capacity, easy release, and suitable for extended/repeated use in a variety of applications.. . ... University Of Massachusetts

10/26/17 / #20170306084

Deoxybenzoin containing flame retardant polymer compositions

The present invention relates to specific deoxybenzoin containing flame retardant polyesters and flame retardant thermoplastic polymer molding compositions comprising deoxybenzoin containing flame retardant polyesters as well as their preparation and use for producing moldings, fibers or foils.. . ... University Of Massachusetts

10/26/17 / #20170304428

Compositions and methods for increasing immunogenicity of glycoprotein vaccines

The present invention relates to the microbial immunogens engineered to bear α-gal epitope(s) for induction of potent humoral and cellular immune responses when administered to subjects having anti-gal antibodies. In one embodiment, the present invention provides compositions and methods for propagating influenza virus in human, ape, old world monkey or bird cells that have been engineered to express an α1,3galactosyltransferase (α 1,3gt) gene to produce virions bearing hemagglutinin molecules containing α-gal epitopes, to increase the immunogenicity of the influenza virus. ... University Of Massachusetts

10/05/17 / #20170282147

Nanostructured apparatus and methods for producing carbon-containing molecules as a renewable energy resource

. . Nanostructured arrays having a metal catalyst (e.g., cobalt) are irradiated with light to initiate the an artificial photosynthetic reaction resulting in the formation of carbon-containing molecules, for example, long chained hydrocarbons or amino acids. A nanostructure having one or more structural elements having a high aspect ratio can formed over a substrate and are placed in contact with water and a carbon-containing source (e.g., carbon dioxide, bicarbonate, methane). ... University Of Massachusetts

10/05/17 / #20170281838

Negative pressure wound closure devices and methods

Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of non-planar wounds such as amputation wounds. The devices and methods utilize a collapsing structure and negative pressure to cause the shaped wound to preferentially close. ... University Of Massachusetts

09/28/17 / #20170276643

Coulometric microfluidic sensors using a silver band electrode, and methods thereof

The invention provides novel microfluidic coulometric sensors having a silver (ag) band electrode longitudinally placed in a microchannel affording visual readout suitable for the naked eye, and methods of fabrication and applications thereof.. . ... University Of Massachusetts

09/14/17 / #20170263385

Hydrophilic conjugated polymers, and methods of preparation and use thereof

. . The invention provides novel hydrophilic conjugated polymers, e.g., hydrophilic poly(arylene vinylenes) or pavs, and preparation thereof, and methods and devices for their application in photovoltaics, and the resulting improved solar cells.. . ... University Of Massachusetts

09/14/17 / #20170260351

Porous material and methods of making and of using the same

In an embodiment, a porous material comprises a base polymer having a continuous pore structure. In another embodiment, a method of making the porous material comprises reacting a base polymer with a degradable polymer with a crosslinker in the presence of a solvent and/or reacting a base polymer and a degradable polymer with a crosslinker in the presence of the solvent; removing the solvent to form a phase separated material; and removing the degradable polymer to form the porous material.. ... University Of Massachusetts

09/14/17 / #20170258892

Compositions and methods to treat aids

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against hiv are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different hiv envelope glycoproteins. ... University Of Massachusetts

09/14/17 / #20170258796

Methods and compositions to reduce oxidative stress

The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. ... University Of Massachusetts

08/24/17 / #20170241982

Multi-well quartz crystal microbalance mass and viscoelastic sensor

In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. ... University Of Massachusetts

08/24/17 / #20170239377

Molecular probes for multimodality imaging and tracking of stem cells

The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (nir) dye for optical imaging, and (c) a radionuclide for pet or spect imaging. ... University Of Massachusetts

08/24/17 / #20170238660

High capacity easy release extended use adhesive closure devices

Unique designs, devices, systems, materials and fabrication methods are provided including adhesive closure devices that are easily released and are suitable for extended/repeated use in a variety of applications.. . ... University Of Massachusetts

08/17/17 / #20170233517

Amphiphilic graft copolymers

A novel amphiphilic graft copolymer is described. A process to make amphiphilic graft copolymers via grafting either poly(ethylene oxide) or polylactide side chains onto an eva platform using oxo-anion ring-opening polymerization chemistry is also described. ... University Of Massachusetts

08/17/17 / #20170231905

Methods of inhibiting cataracts and presbyopia

Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.. ... University Of Massachusetts

08/17/17 / #20170231587

Apparatus and method for x-ray-based breast imaging

The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.. . ... University Of Massachusetts

08/10/17 / #20170226193

Anti-ospa antibodies and methods of use

The invention provides anti-ospa antibodies and methods of using the same.. . ... University Of Massachusetts

08/03/17 / #20170219503

Apparatus and method for x-ray phase contrast imaging

An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. ... University Of Massachusetts

08/03/17 / #20170216450

Crosslinked polymer nano-assemblies and uses thereof

The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. ... University Of Massachusetts

07/27/17 / #20170209625

Zwitterionic hydrogels for delivery of biomolecules

The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. ... University Of Massachusetts

07/06/17 / #20170193339

Feature type spectrum technique

. . Sensors are used to generate sample set data representing objects in a sample set. A computer system analyzes the sample set data to determine the frequencies with which features in a feature set are observed in the objects in the sample set. ... University Of Massachusetts

07/06/17 / #20170191893

Optical fiber pressure sensor with uniform diaphragm and method of fabricating same

An optical fiber sensor can be used to measure pressure with high sensitivity and fine resolution. As a cavity at the end of the sensor expands or contracts, the spectrum of a beam reflected from the end of fiber shifts, producing a change linked to pressure exerted on the sensor. ... University Of Massachusetts

07/06/17 / #20170191039

Recombinant aavs having useful transcytosis properties

The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capab- lities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. ... University Of Massachusetts

07/06/17 / #20170188823

Eye tracker system and methods for detecting eye parameters

An improved eye tracker system and methods for detecting eye parameters including eye movement using a pupil center, pupil diameter (i.e., dilation), blink duration, and blink frequency, which may be used to determine a variety of physiological and psychological conditions. The eye tracker system and methods operates at a ten-fold reduction in power usage as compared to current system and methods. ... University Of Massachusetts

06/29/17 / #20170184730

Detectors, system and method for detecting ionizing radiation using high energy current

Detectors, a system and a method for detecting ionizing radiation are provided. In some aspects, a detector includes a first layer comprising a first conducting material, and a second layer comprising a second conducting material, wherein at least one of the first layer and second layer is configured to produce secondary particles upon irradiation by an ionizing radiation. ... University Of Massachusetts

06/29/17 / #20170183741

Treating chronic myelogenous leukemia (cml)

Methods for treating chronic myeloid leukemia (cml), e.g., bcr-abl inhibitor imatinib mesylate (im)-resistant cml, using combination treatments, e.g., combined treatment with a bcr-abl inhibitor, e.g., im, and a mek inhibitor, e.g., trametinib.. . ... University Of Massachusetts

06/29/17 / #20170183686

Exosomal loading using hydrophobically modified oligonucleotides

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.. ... University Of Massachusetts

06/29/17 / #20170182220

Degradable hydrogel with predictable tuning of properties, and compositions and methods thereof

The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner is achieved via a simple but versatile hydrogel platform that allows formulation of hydrogels with predictable disintegration time from within 2 days to >250 days yet comparable macroscopic physical properties.. ... University Of Massachusetts

06/29/17 / #20170181952

Botulinum nanoemulsions

The embodiment described herein are related nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. ... University Of Massachusetts

06/22/17 / #20170179391

Organic photovoltaic devices and methods thereof

The invention provides a novel fabrication method to produce solar cells using water-based inks that can be readily used in roll-to-roll processing, ink-jet printing and other large-scale fabrication processes. The invention also provides opv devices with significantly improved efficiency. ... University Of Massachusetts

06/22/17 / #20170172411

Methods and systems for reducing irritability in infants

Systems and methods according to the present concepts reduce irritability in infants, such as infants suffering from neonatal abstinence syndrome (nas) or colic. According to one embodiment, a method for reducing irritability in an infant includes determining one or more physiological measurements from an infant. ... University Of Massachusetts

06/15/17 / #20170166927

Isolation of novel aav's and uses thereof

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant aav (raav) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a mirna.. ... University Of Massachusetts

06/15/17 / #20170166925

Recombinant aav vectors useful for reducing immunity against transgene products

The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.. . ... University Of Massachusetts

06/15/17 / #20170165377

Isolation of novel aav's and uses thereof

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant aav (raav) to an animal having at least one transgene that expresses a small interfering nucleic acid or at least one binding site for a mirna.. ... University Of Massachusetts

06/15/17 / #20170165116

Negative pressure wound closure devices and methods

Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of amputation wounds. The devices and methods utilize a compression structure and negative pressure to cause the amputation wound to preferentially close from the deepest portion of the wound to the shallowest portion.. ... University Of Massachusetts

06/08/17 / #20170157243

Manf as a regulator of immune system function

Methods and compositions for enhancing an immunological response by administering an immunogenic composition comprising an effective amount of a manf family protein or fragment thereof and an antigen to a subject. Also, methods and compositions for decreasing an immune response by inhibiting or antagonizing the activity of a manf family protein.. ... University Of Massachusetts

05/18/17 / #20170137558

Polyisobutylene-based polyurethanes

An elastomeric polymer, comprising (1) a hard segment in the amount of 10% to 60% by weight of the elastomeric polymer, wherein the hard segment includes a urethane, urea or urethaneurea; and (2) a soft segment in the amount of 40% to 90% by weight of the elastomeric polymer. The soft segment comprises (a) at least 2% by weight of the soft segment of at least one polyether macrodiol, and/or at least one polycarbonate macrodiol; and (b) at least 2% by weight of the soft segment of at least one polyisobutylene macrodiol and/or diamine.. ... University Of Massachusetts

05/18/17 / #20170135972

Methods of inhibiting cataracts and presbyopia

Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a bifunctional molecule comprising a substituted or unsubstituted amine, succinimide, carboxylic acid, isocyanate, isothiocyanate, sulfonyl chloride, aldehyde, carbodiimide, acyl azide, anhydride, fluorobenzene, carbonate, n-hydroxysuccinimide ester, imidoester, epoxide or fluorophenyl ester covalently linked to a molecular bristle. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.. ... University Of Massachusetts

05/18/17 / #20170135646

Hyperspectral imaging for prediction of skin injury after exposure to thermal energy or ionizing radiation

The invention provides hyperspectral imaging-based methods that enable effective, efficient and non-invasive detection and characterization of thermal and ionizing radiation exposure in tissue. The methods allow for complete visualization and quantification of oxygenation and perfusion changes in thermal burn or ionizing radiation impacted skin and enables rapid identification of individuals exposed to such exposures and allows early prediction of extent of injury in normal tissue after exposure.. ... University Of Massachusetts

05/11/17 / #20170133525

Infrared absorption by crystalline silicon, compositions and methods thereof

The invention provides a novel method for fabrication of ir-absorbing silicon substrate in ambient atmosphere without the need for special background gases, and compositions and methods of preparation and use thereof.. . ... University Of Massachusetts

05/11/17 / #20170133163

Perovskite-containing solar cells comprising fulleropyrrolidine interlayers

Perovskite-containing solar cells are described herein. An inverted perovskite solar includes an anode substrate, a photoactive layer including a perovskite, a hole transport layer disposed between the anode substrate and the photoactive layer, an electron transport layer, a metal cathode layer, and an interlayer disposed between the electron transport layer and the metal cathode layer. ... University Of Massachusetts

05/04/17 / #20170122963

Method for the comparison of protein higher order structures

Some aspects of the disclosure include methods for comparing the higher order structures (hos) of proteins using covalent labeling agents which allow for the direct comparison of changes in the hos of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the hos of a protein therapeutic has spontaneously changed during storage. ... University Of Massachusetts

05/04/17 / #20170120295

High aspect ratio nanostructures and methods of preparation

Metal nanomaterials and nano structures may be formed via shearing force in the presence of a reactant.. . ... University Of Massachusetts

04/27/17 / #20170114340

Raav-based compositions and methods for treating amyotrophic lateral sclerosis

The invention relates to inhibitory nucleic acids and raav-based compositions, methods and kits useful for treating amyotrophic lateral sclerosis.. . ... University Of Massachusetts

04/20/17 / #20170110642

Folded multi-layered 2-d van der waals materials as efficient thermoelectric converters, and methods thereof

The invention provides thermoelectric devices based on folded, multi-layered nanomembranes prepared from 2-dimensional van der waals materials, and compositions and methods of preparation and use thereof.. . ... University Of Massachusetts

04/13/17 / #20170101738

Method for preparation of cellulose nanocrystals and nanofibrils

. . A method for producing nanocellulose is described herein. The method includes contacting a cellulosic material with an oxidizing agent, and a compound selected from the group consisting of an alkali metal bromide, an alkali metal iodide, an alkali metal fluoride, an alkali metal chloride, or a combination thereof, in an aqueous solution to provide an oxidized cellulose mixture. ... University Of Massachusetts

04/13/17 / #20170101645

Compositions and methods for modulating dysferlin expression

Aspects of the disclosure relate to methods of altering rna splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a dysf gene having a mutation that results in defective splicing.. ... University Of Massachusetts

04/13/17 / #20170101640

Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)

The present invention relates to mir145, mir132, mir212, and the genes or gene products regulated by these mirnas. Mir145 is downregulated in cells infected with hcmv. ... University Of Massachusetts

04/06/17 / #20170096664

Spinal muscular atrophy (sma) treatment via targeting of smn2 splice site inhibitory sequences

The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named iss-n1 (for “intronic splicing silencer”), located in the smn2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the smn2 iss-n1 site in the smn2 pre-mrna, thereby modulating the splicing of smn2 pre-mrna to include exon 7 in the processed transcript. ... University Of Massachusetts

04/06/17 / #20170096121

Retrofit seat belt system

Systems and methods for installing retrofit seat belt systems with structural support for the lap and shoulder belts, while at the same time providing a low cost solution. In particular, some, or all of the loads, as required, are shared by an added support structure connected rigidly to a structural base, e.g., of a bus or other vehicle, via a base plate. ... University Of Massachusetts

04/06/17 / #20170095578

Ct scans using gadolinium-based contrast agent

A method of diagnosing a condition of a living subject that uses gadoxeate disodium as a contrast agent for making images such as ct scans of the biliary tree and related anatomical structures. The method uses x-ray radiation generated with excitation voltages in the range of 70 kv to 140 kv. ... University Of Massachusetts

03/23/17 / #20170084764

Backside configured surface plasmonic structure for infrared photodetector and imaging focal plane array enhancement

The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (qdips) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.. ... University Of Massachusetts

03/23/17 / #20170081664

Targeting hepatitis b virus (hbv) host factors

Described herein are methods of identifying host factors that modulate hepatitis b virus (hbv) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating hbv infections by targeting those factors. Zinc finger, cchc domain containing 14 (zcchc14) is an exemplary host factor.. ... University Of Massachusetts

03/09/17 / #20170068725

Analogy finder

A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. ... University Of Massachusetts

03/09/17 / #20170067821

Fourier domain terahertz coherence tomography (tct)

A single-shot terahertz imaging system including an interferometer and a terahertz spectrometer. The interferometer includes a beam splitter configured to receive input terahertz radiation and output first terahertz radiation and second terahertz radiation, a sample configured to reflect the first terahertz radiation, and a mirror configured to reflect the second terahertz radiation. ... University Of Massachusetts

03/09/17 / #20170065720

Compositions and methods for delivering agents to the central nervous system

The invention in some aspects provides compounds useful for targeting bacterial infections. In some embodiments, the compounds comprise a transferrin receptor ligand covalently linked to a bactericidal agent. ... University Of Massachusetts

02/23/17 / #20170053079

System and methods for scoring data to differentiate between disorders

A clinical scoring system and methods that effectively and efficiently utilizes a number of different data sources to determine a diagnosis of patient conditions. The score is compared to a spectrum of scores in order to identify between disorders, such as inflammatory bowel disease (ibd) and irritable bowel syndrome (ibsd) or gastroesophageal reflux disease (gerd) and functional dyspepsia.. ... University Of Massachusetts

02/23/17 / #20170051283

Rna interference for the treatment of gain-of-function disorders

The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, huntington's disease (hd). The present invention utilizes rna interference technology (rnai) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.. ... University Of Massachusetts

02/23/17 / #20170050991

Substituted angular bistetracenes and substituted angular bisoligoacenes and electronic devices made with same

We report the synthesis and characterization of novel bistetracenes, an unconventional, linearly extended conjugated core with eight fused rings. Also described are bisoligoacenes. ... University Of Massachusetts

02/23/17 / #20170049113

Nanoparticle-stabilized microcapsules, dispersions comprising nanoparticle-stabilized microcapsules, and method for the treatment of bacterial biofilms

A stabilized microcapsule includes a liquid hydrophobic core including an essential oil and an aromatic monoaldehyde, and a shell encapsulating the core, the shell including a plurality of amino-functionalized inorganic nanoparticles. Also disclosed is a dispersion including a plurality of the stabilized microcapsules. ... University Of Massachusetts

02/16/17 / #20170047520

Functional interlayers of fullerene derivatives and applications in organic solar cells

The invention provides novel materials, methods and designs to enable improved power conversion efficiencies of organic photovoltaics (opvs). In particular, the invention provides novel materials and interlayers for polymer-based solar cells. ... University Of Massachusetts

02/16/17 / #20170043024

Bioactive conjugates for oligonucleotide delivery

Provided herein are self-delivering oligonucleotides that are characterized by efficient risc entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.. . ... University Of Massachusetts

02/09/17 / #20170036241

Methods and formulations for durable superhydrophic, self-cleaning, and superhydrophobic polymer coatings and objects having coatings thereon

An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring micro/nanoparticle and at least another group that results in hydrophobicity. The hierarchical structuring micro/nanoparticles are dispersed in the liquid silane. ... University Of Massachusetts

02/09/17 / #20170035837

Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)

The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising sipa. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of p-gp and/or p53. ... University Of Massachusetts

02/09/17 / #20170035691

Food matrices and methods of making and using

A method of these teachings for designing foods in order to improve the bioavailability of orally administered bioactive agents, the method including designing a food matrix, the food matrix not having bioactivity above its normal nutritional function, that increases bioavailability of a predetermined pharmaceutical or nutraceutical by at least one of facilitating the release and solubilization of bioactive agents in the predetermined pharmaceutical or nutraceutical, altering the absorption of lipophilic bioactive agents in the predetermined pharmaceutical or nutraceutical when co-ingested, or interfering with chemical transformations that occur within gastrointestinal tract (git) or after absorption; the food matrix being co-ingested with the predetermined pharmaceutical or nutraceutical or ingested at a specified time soon before or after the pharmaceutical or nutraceutical.. . ... University Of Massachusetts

02/02/17 / #20170029838

Plant biomass yield increase by modified swam1 gene expression

Provided herein are plants and methods to increase plant biomass, for example, a transgenic plant, plant cell, plant part or seed, wherein the transgenic plant, plant cell, plant part or seed comprises a heterologous promoter which increases expression of swam1, other genes related to swam1, or gnrf, as compared to a non-transgenic plant.. . ... University Of Massachusetts

02/02/17 / #20170028103

Compositions and methods for surface mineralization

The invention provides novel compositions and methods of surface mineralization for metallic or ceramic implants and devices and the resulting enhancement of properties and performance in skeletal tissue engineering, orthopedic applications and dental care. The novel approach utilizes zwitterionic brushes (e.g., of poly(sulfobetaine methacrylate) or psbma) covalently grafted on the surface of titanium or its alloy substrates (e.g., ti6al4v) to promote surface-mineralization of hydroxyapatite with enhanced surface mineral coverage and mineral-substrate interfacial adhesion. ... University Of Massachusetts

01/19/17 / #20170014547

Amphiphilic degradable polymers for immobilization and sustained delivery of biomolecules

The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can be achieved. ... University Of Massachusetts

01/12/17 / #20170009090

Ferroelectric nanocomposite based dielectric inks for reconfigurable rf and microwave applications

A novel ferroelectric ink comprising multiphase barium strontium titanate (bst) in a polymer composite is described. The ink can be employed using direct-ink writing techniques to print high dielectric constant, low loss, and electrostatically-tunable dielectrics on substrates. ... University Of Massachusetts








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



###

This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. Freshpatents.com is not affiliated or associated with University Of Massachusetts in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for University Of Massachusetts with additional patents listed. Browse our Agent directory for other possible listings. Page by FreshPatents.com

###