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University Of Miami patents


Recent patent applications related to University Of Miami. University Of Miami is listed as an Agent/Assignee. Note: University Of Miami may have other listings under different names/spellings. We're not affiliated with University Of Miami, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Miami-related inventors


Diagnostic transcriptomic biomarkers in inflammatory cardiomyopathies

Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.. . ... University Of Miami

Method for in vivo expansion of t regulatory cells

Compositions specific for tnf-receptor superfamily member 25 (tnfrsf25, dr3) modulate the immune re-sponse by regulating t regulatory cells.. . ... University Of Miami

Modulating uracil-dna glycosylase and uses thereof

The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (aid)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-dna glycosylase (ung) inhibitor, or a composition comprising the inhibitor, and a pharmaceutically acceptable carrier, to a subject having pathogenic cells expressing aid, uracil-dna glycosylase (ung) and mismatch repair pathway (mmr). Also provided are kits comprising an ung inhibitor, methods of stratifying a subject having an aid-associated disease, uses and compositions for use of the ung inhibitor.. ... University Of Miami

Portable plasmonic system for disease detection

A plasmonic photoconductor sensing platform is provided. The plasmonic photoconductor sensing platform includes an insulating substrate; a semiconducting film placed on top of the insulating substrate; two metal contacts placed at least in part on the semiconducting film to enforce an electric field; a plurality of plasmonic nanostructures deposited on the semiconducting film and physically separated from metal contacts; an insulating layer, the insulating electrically isolating the plasmonic nanostructures from semiconductor; at least one energy source; and at least one microfluidic channel disposed on the insulating layer.. ... University Of Miami

Method and system for three-dimensional thickness mapping of corneal micro-layers and corneal diagnoses

Techniques for improved diagnosis, treatment, and monitoring of corneal pathologies use enhanced mapping of the cornea or corneal regions, to develop three-dimensional mapping of corneal thickness, while retaining particular corneal micro-layer thickness data. Anterior and posterior surface identifications, along with surface apex determinations, are used for registration of segmentation of these micro-layers. ... University Of Miami

Cancer treatment and diagnosis

The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of sting or cgas in the cell; and selecting a therapy for the cancer based on the functional activity of the sting or cgas in the cell. Also provided, if the functional activity of sting and/or cgas is determined to be defective in the cell, the therapy selected is one that is effective at killing sting-deficient and/or cgas-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.. ... University Of Miami

Transcriptomic biomarker of myocarditis

Molecular signatures that function as very sensitive diagnostic biomarker for myocarditis, heart disease and disorders thereof, are identified.. . ... University Of Miami

Methods and compositions for converting non-endocrine pancreatic tissue into insulin-producing cells

Compositions and methods are provided for generating islet-like cell clusters. The methods include culturing a whole non-islet pancreatic cell discard or cells sorted therefrom with an effective amount of a molecule having bone morphogenetic protein (bmp) activity (e.g., a bmp polypeptide). ... University Of Miami

Methods and compositions for the treatment of epidermolysis bullosa

The present invention provides compositions and methods for treating epidermolysis bullosa.. . ... University Of Miami

Vaccine compositions and methods of use thereof

Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, sirna, rna or dna to papcs or mhc class ii positive cells (e.g. Tumor cells). ... University Of Miami

Sting (stimulator of interferon genes), a regulator of innate immune responses

Novel molecules termed sting which include nucleic acids, polynucleotides, oligonucleotides, peptides, mutants, variants and active fragments thereof, modulate innate and adaptive immunity in a subject. Sting compositions are useful for the treatment of an immune-related disorder, including treating and preventing infection by modulating immunity.. ... University Of Miami

Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists, and immunotoxins

This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. Tnfr25 agonists disclosed herein have an anti-inflammatory and healing effect. ... University Of Miami

Dendrimer conjugates for coating cells

The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.. ... University Of Miami

Kits and methods for pathogen detection

Kits and methods for detecting pathogens without the need for laboratory equipment are disclosed. The kits and methods described herein allow for near-room temperature amplification of pathogen polynucleotides in a biological sample in a one-compartment reaction vessel. ... University Of Miami

02/01/18 / #20180031733

Biodegradable oceanic drifter tracking device

A water body drifter device for tracking movement of a fluid is disclosed. The drifter may include a floater assembly having a toroid shaped buoy fixedly connected to a floater head disposed interiorly to the toroid shaped buoy, the floater head having a recess and a cap sealably attached to the recess for housing a network-enabled controller. ... University Of Miami

02/01/18 / #20180028477

Treatment of cardiac remodeling and other heart conditions

The present disclosure provides novel methods for treating cardiac remodeling and heart conditions using specific compounds, as well as compositions, and pharmaceutical formulations. In some embodiments, the compounds may inhibit acetylation of mef2 transcription factors.. ... University Of Miami

12/07/17 / #20170349878

Cell culture media

A cell culture medium comprising adenosine triphosphate; a carrier protein; cholesterol, linoleic acid, and lipoic acid; glutathione; at least one nucleotide salvage pathway precursor base; phosphoethanolamine; selenium; transferrin; triiodothyronine; all-trans-retinoic acid (atra) and vitamin c; zinc, magnesium, and copper; an agent that increases intracellular camp; epidermal growth factor (egf); hydrocortisone; insulin; and charcoal stripped fetal bovine serum, wherein said cell culture medium is substantially free, if not entirely free, of vitamin d, androgenic hormones, androgenic ligands, estrogenic hormones, estrogenic ligands, and/or androgenic receptors.. . ... University Of Miami

10/12/17 / #20170291817

Purification of carbon nanotubes via selective heating

The present invention provides methods for purifying a layer of carbon nanotubes comprising providing a precursor layer of substantially aligned carbon nanotubes supported by a substrate, wherein the precursor layer comprises a mixture of first carbon nanotubes and second carbon nanotubes; selectively heating the first carbon nanotubes; and separating the first carbon nanotubes from the second carbon nanotubes, thereby generating a purified layer of carbon nanotubes. Devices benefiting from enhanced electrical properties enabled by the purified layer of carbon nanotubes are also described.. ... University Of Miami

09/07/17 / #20170252976

Apparatus, system, and method for 4-dimensional molecular printing

A method and apparatus for 4-dimensional printing are disclosed. The apparatus includes a polymer pen array translatable in three axes, a light source for illuminating the polymer pen array, a reactive surface disposed opposite the polymer pen array, and a flow-through microfluidic cell having a reactive chamber in fluid communication with influx and outflux conduits. ... University Of Miami

08/17/17 / #20170233448

Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use

Various methods and compositions are provided which can be employed to modulate the immune system. Compositions include a fusion protein comprising: (a) a first polypeptide comprising interleukin-2 (il-2) or a functional variant or fragment thereof; and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of interleukin-2 receptor alpha (il-2rα) or a functional variant or fragment thereof, and wherein the fusion protein has il-2 activity. ... University Of Miami

08/10/17 / #20170226218

Method for in vivo expansion of t regulatory cells

Compositions specific for tnf-receptor superfamily member 25 (tnfrsf25, dr3) modulate the immune response by regulating t regulatory cells.. . ... University Of Miami

08/03/17 / #20170216240

Methods for modulating iks channel activity

Disclosed herein are methods of using polyunsaturated fatty acids and derivatives thereof (“pufas”) to modulate iks channels to treat conditions associated with a disruption in iks channel activity, such as cardiac arrhythmias. In particular, disclosed herein are negatively charged pufas having decreased pka values, which can activate (i.e., open) iks channels, and positively charged pufas that can inhibit (i.e., close) iks channels.. ... University Of Miami

07/06/17 / #20170191058

Perforin 2 defense against invasive and multidrug resistant pathogens

Perforin-2 (p2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, mycobacteria smegmatis, m. Avium, salmonellae, mrsa (drug resistant stapholococci), e. ... University Of Miami

04/20/17 / #20170107277

Methods of modulating inflammasome activity to treat inflammatory conditions

Compositions and methods for reducing inflammation in the central nervous system (cns) of a mammal that has been subjected to a stroke, traumatic injury to the cns such as traumatic brain injury (tbi), spinal cord injury (sci), or having an autoimmune or cns disease have been developed. The compositions and methods described herein include antibodies that specifically bind to at least one component (e.g., asc, nalp1) in a mammalian inflammasome (e.g., the nalp1 inflammasome) and have use as treatments for sci, tbi, stroke, and autoimmune and cns diseases in a mammal. ... University Of Miami

03/23/17 / #20170082625

Method and system for microfilter-based capture and release of cancer associated cells

A slotted microfilter is coated with a phase changeable material having a hydrophobic state under a first temperature and a hydrophilic state under a second temperature. An example coating material is poly(n-isopropylacrylamide) (“pipaam”). ... University Of Miami

03/23/17 / #20170080027

Expanded utility of red-cell derived microparticles (rmp) for treatment of bleeding

Red blood cell membrane derived microparticles (rmp) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as universal hemostatic agents. Effective rmp are produced from red blood cells using a high-pressure extrusion membrane shear process. ... University Of Miami

03/16/17 / #20170074849

A test strip for melamine detection

Described here is a test strip for detection of melamine, comprising: a support configured for capillary flow of a fluid sample from a first end of the support to a second end of the support that is downstream from the first end; a conjugation pad disposed adjacent to the first end of the support and including nanoparticles configured for suspension in the sample flowing past the conjugation pad, the nanoparticles configured to produce a colorimetric effect when exposed to melamine; and a test portion downstream of the conjugation pad and including a molecular recognition agent immobilized on the support and having an affinity for melamine.. . ... University Of Miami

03/09/17 / #20170065233

Image guided small animal stereotactic radiation treatment system

A dual, imaging and radiation system provides for finely aligned movement of a subject through the use of a computer controlled mounting stage having separate, non-gantry translational and rotational controllable movement. The system cycles a subject tissue between a treatment position where radiation doses are applied and an imaging position where high-quality computed tomography (ct) imaging is performed. ... University Of Miami

01/05/17 / #20170003303

Innate immune proteins as biomarkers for cns injury

The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the serverity of central nervous system injury in a patient are disclosed. ... University Of Miami








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