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University Of South Florida patents


Recent patent applications related to University Of South Florida. University Of South Florida is listed as an Agent/Assignee. Note: University Of South Florida may have other listings under different names/spellings. We're not affiliated with University Of South Florida, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of South Florida-related inventors


Systems and methods for diagnosing tumors in a subject by performing a quantitative analysis of texture-based features of a tumor object in a radiological image

An example method for diagnosing tumors in a subject by performing a quantitative analysis of a radiological image can include identifying a region of interest (roi) in the radiological image, segmenting the roi from the radiological image, identifying a tumor object in the segmented roi and segmenting the tumor object from the segmented roi. The method can also include extracting a plurality of quantitative features describing the segmented tumor object, and classifying the tumor object based on the extracted quantitative features. ... University Of South Florida

Method of repairing damaged blood-spinal cord barrier (bscb)

The disclosure provides methods of administering a composition comprising human bone marrow cd34+ (hbm34+) cells to a mammal in need thereof, whereby vascular damage in the blood-central nervous system barrier (b-cns-b), such as in the blood-spinal cord barrier, of the mammal is repaired. The disclosure also provides a method of treating amyotrophic lateral sclerosis (als) in a mammal by administering a composition comprising human bone marrow cd34+ cells (hbm34+).. ... University Of South Florida

Exo-s-mecamylamine formulation and use in treatment

A pharmaceutical composition includes a therapeutically effective amount of exo-s-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-r-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. ... University Of South Florida

Compositions and methods for the treatment of tauopathies

Disclosed herein are compositions and methods for treating tauopathies such as alzheimer's disease (ad). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. ... University Of South Florida

Bone fusion systen

A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. ... University Of South Florida

Bone fusion system

A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. ... University Of South Florida

Methods and materials for detection, diagnosis and management of ovarian cancer

The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female patient. The proteins were identified using proteomics analyses of plasma samples obtained preoperatively from ovarian cancer patients versus those of healthy control women. ... University Of South Florida

Gas-inflatable personal flotation devices

In one embodiment, a personal flotation device that can be worn by a user includes an inflation system including an inflatable bladder and a gas-generating component, the gas-generating component being configured to generate gas using a chemical reaction and inject the generated gas into the bladder to inflate it, and an inflation control system configured to control activation of the gas-generating component.. . ... University Of South Florida

Coaxial semiconductive organic nanofibers and electrospinning fabrication thereof

A coaxial nanocomposite including a core, which includes fibers of a first organic polymer, and a shell, which includes fibers of a second organic polymer, the first polymer and the second polymer forming a heterojunction.. . ... University Of South Florida

Electrodeposition of al-ni alloys and al/ni multilayer structures

A method for electrodepositing aluminum and nickel using a single electrolyte solution includes forming a mixture comprising nickel chloride and an organic halide, adding aluminum chloride to the electrolyte solution in an amount at which the mixture becomes an acidic electrolyte solution, providing a working electrode and a counter electrode in the acidic electrolyte solution, and applying a waveform to the counter electrode using cyclic voltammetry to cause aluminum and nickel ions to be deposited on the working electrode.. . ... University Of South Florida

Detecting threats in big data platforms based on call trace and memory access patterns

A runtime attack can be detected on a big data system while processes are executed on various computing devices. A behavior profile can be maintained for tasks or processes running on different computing devices. ... University Of South Florida

Three-dimensional fibrous scaffolds for cell culture

Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (peg-pla) and a poly(lactic-co-glycolic acid) (plga). Also provided are methods for using the three-dimensional scaffolds described herein.. ... University Of South Florida

Methods and compositions related to kras inhibitors

Stapled peptides and methods of using them to inhibit the kras/raf interaction are disclosed herein.. . ... University Of South Florida

Tools and methods for distributed spatial control of swarms via multiplex information networks

A method and system for distributed spatial control of a formation of vehicles includes receiving at a first formation vehicle via a peer-to-peer communication interface, direction of travel and formation density information that indicate a course of travel for the first vehicle while travelling as a member of the formation of vehicles. The peer-to-peer formation density information indicates a distance to maintain from other neighboring formation vehicles. ... University Of South Florida

06/14/18 / #20180164050

Thermoelectric flow cloaking via metamaterials

A thermoelectric cloak including an inner region and an external medium. The inner region has a cloaking effect and is simultaneously invisible from both heat and electric charge fluxes; and heat, electric currents, and gradients in the external medium are unaltered by the cloaking effect of the inner region.. ... University Of South Florida

05/31/18 / #20180152229

Low complexity flexible beam-width for directional modulation

Method and system for transmitting a directionally modulated data stream via an antenna array. A first signal processing circuitry receives a data symbol of a first data stream, maps the first data stream to a specified number of sub-beams based on a stream beam-width assignment, assigns a direction angle for transmission of the data stream, and transmits in parallel, for each of the specified number of sub-beams, an instance of the data symbol to a second signal processing circuitry. ... University Of South Florida

05/31/18 / #20180146973

Power morcellation in a protected environment

A power morcellation system, apparatus, and methodology. Structurally, the device includes a sturdy, pliable (e.g., able to be inserted and retracted through a 10-15 mm morcellator port), distensible, waterproof/watertight retaining bag/pouch/carrier to be deployed into the pelvic cavity of the subject. ... University Of South Florida

05/17/18 / #20180139081

Cyclic prefix-aligned generalized and n-continuous orthogonal frequency division multiplexing

A wireless transmit/receive unit (wtru) may combine an alignment component with an fdm based symbol to produce a signal such that it is aligned to a duration of a cp of the fdm based symbol at a receiver upon reception. A component may be added to one or more subcarriers of the alignment signal to reduce peak-to-average ratio (papr) of the signal.. ... University Of South Florida

05/17/18 / #20180132893

Laparoscopic tool with obturator

A laparoscopic device with obturator. The device facilitates extraction of specimens from a female subject's abdominal cavity through the subject's vagina by also facilitating the suturing of a mesh to the anterior and posterior walls of the subject's vagina. ... University Of South Florida

05/17/18 / #20180132786

Prosthesis and orthosis slip detection sensor and method of use

A device and method for measuring prosthetic or orthotic slip is presented. An optical sensor device is attached to the prosthesis or orthosis and measures the amount of relative motion between the prosthetic socket and the residual limb surface or between the orthosis and the affected body part. ... University Of South Florida

05/10/18 / #20180131089

Mm-wave wireless channel control using spatially adaptive antenna arrays

System and method for determining a position of an antenna array for optimal wireless communication. The system includes a spatially adaptive and beam-steering antenna array configured to control a wireless communications path between a first element and a second element based on a determination of wireless channel gain.. ... University Of South Florida

05/10/18 / #20180127700

Cell culture substrate for rapid release and re-plating

The invention pertains to devices and methods for rapid release of a patterned tissue module. The invention pertains to a device comprising a substrate and a pattern of shape-memory polymer fabricated upon the substrate, wherein the shape-memory polymer is converted to a deformed state by exposure to an external stimulus, for example, a change in temperature, ph, ionic strength, solvent, salt, surfactant, or an electric or magnetic field. ... University Of South Florida

05/10/18 / #20180126034

Osteoconductive and osteoinductive implant for augmentation, stabilization, or defect reconstruction

Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or allogenic bone material, or similar compound.. . ... University Of South Florida

04/19/18 / #20180104358

Modified ube3a gene for a gene therapy approach for angelman syndrome

Angelman syndrome (as) is a genetic disorder occurring in approximately one in every 15,000 births. It is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. ... University Of South Florida

04/12/18 / #20180099071

Intracorporal ultra high purity calcium sulfate cast mixed with antimicrobials for the treatment of penile implant infections

The present invention includes a method for treating penile implant infections that uses a synthetic high-purity calcium sulfate mixed with antimicrobials, which is capable of providing prolonged exposure of antimicrobials to the infection site and capable of acting as an intracorporal filler preventing fibrosis and loss of phallic length. The technique is especially useful for high-risk patients, and provides another medium for which antimicrobial agents can be delivered to a surgical infection site while at the same time acting as a filler, preventing fibrosis, and loss of the space. ... University Of South Florida

04/12/18 / #20180098718

Orientation invariant gait matching

Aspects of gait matching are described herein. In one embodiment, a method of gait matching includes identifying a gait cycle timing in a data sequence captured by an inertial sensor, splitting the data sequence into a gait cycle segment, resampling the gait cycle segment, and estimating a rotation matrix for the resampled gait cycle segment. ... University Of South Florida

04/05/18 / #20180092916

Methods of treating disease-induced ataxia and non-ataxic imbalance

. . Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity.. ... University Of South Florida

04/05/18 / #20180092751

Bone fusion system

A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screw includes a threaded distal piece fixedly attached connected to an inner post. ... University Of South Florida

03/29/18 / #20180085139

Minimally invasive laparoscopic tissue removal device

A minimally invasive laparoscopic tissue removal device, namely a morcellator. The device includes, from proximal end to distal end, a handle, handle guard, elongate sheath, and mouth, finally terminating in a safety tip. ... University Of South Florida

03/22/18 / #20180078615

Use of ccl2 to inhibit abnormal uterine bleeding

The present invention concerns compositions and methods for inhibition of abnormal uterine bleeding (aub), such as that associated with use of long-acting progestin-only contraceptives (lapcs). An aspect of the invention concerns compositions comprising chemokine (c-c motif) ligand 2 (ccl2), or a biologically active fragment thereof, which may administered to subjects for inhibition of aub. ... University Of South Florida

03/22/18 / #20180078595

Inhibition of formation of amyloid b-protein fibrils using cactus mucilage extracts

Alzheimer' s disease (ad) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of amyloid β-protein (aβ) into plaques. Cactus mucilage extracted from opuntia ficus-indica was analyzed in disturbing the aggregation pathway of amyloid β-protein (aβ) fibrils and α-synuclein. ... University Of South Florida

03/01/18 / #20180057511

Organic anion lithium ionic cocrystal compounds and compositions

A cocrystal having the formula lix.am, or a solvate or hydrate thereof, wherein x is a conjugate base of an organic acid, m is a neutral organic molecule, and a is from 0.5 to 4, pharmaceutical compositions comprising such cocrystals, cocrystal solvates, or cocrystal hydrates, and methods of preparing such cocrystals, cocrystal solvates, or cocrystal hydrates, and such pharmaceutical compositions.. . ... University Of South Florida

02/22/18 / #20180051055

Toll-like receptor 2 ligands and methods of making and using thereof

Disclosed are monoacylated toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for tlr2 relative to a known potent diacylated agonists, but only −½ the bioactivity. ... University Of South Florida

02/08/18 / #20180037768

Cutin-like materials with advanced functionalities and methods of manufacture

Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (clms) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. ... University Of South Florida

02/08/18 / #20180036529

System and method for electroporation controlled by electrical impedance measurements

The present invention provides a system and method for measuring the impedance of one more target cells before and after an electroporation protocol has been applied to the cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.. ... University Of South Florida

02/01/18 / #20180028488

Treating and/or preventing insulin-resistance related weight gain

Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (acpd).. . ... University Of South Florida

01/25/18 / #20180021456

Self-assembled targeted inclusion complexes for drug delivery

Inclusion complexes are provided containing a targeted carrier non-covalently associated with an active agent. The targeted carrier includes an inclusion host that binds the active agent or a binding partner attached to the active agent. ... University Of South Florida

01/18/18 / #20180016482

Encapsulation of thermal energy storage media

In one embodiment, a method for depositing metal on a polymer surface, the method includes coating the polymer surface with a binding metal to render the polymer surface solvophillic and/or hydrophilic and depositing a further metal on the binding metal-coated polymer surface.. . ... University Of South Florida

01/18/18 / #20180016171

Systems and methods for treating dilute wastewater

In one embodiment, a dilute wastewater treatment system includes a separation subsystem configured to receive dilute wastewater and separate it into a product stream containing a low concentration of organic material and a reject stream containing a high concentration of organic material, and a conversion subsystem configured to receive the reject stream from the separation subsystem and anaerobically treat the reject stream to break down the organic material and separate it from water within the reject stream.. . ... University Of South Florida

01/18/18 / #20180014866

Bone fusion system

A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. ... University Of South Florida

01/11/18 / #20180012748

Systems and methods for bubble based ion sources

The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, an ion channel, an electrode, and/or any other components. The ion source can include a container at least partially comprising a solvent or solution, a bubble generator coupled to the container configured to generate a plurality of bubbles within the solvent, and/or any other component. ... University Of South Florida

01/11/18 / #20180008564

Method of treating colorectal cancers using a pkc inhibitor

The subject invention pertains to methods of treating colorectal cancer by administering an atypical pkc inhibitor. The inhibitors of apkc useful in the methods of the instant invention include acpd, ica-1, dnda and ζ-stat. ... University Of South Florida

01/04/18 / #20180002706

Methods and compositions for cloning into large vectors

Provided herein are methods of cloning into vectors.. . ... University Of South Florida

01/04/18 / #20180002413

Inflammatory disease diagnosis and methods of treatment using lipopolysaccharide-responsive beige-like anchor

Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine cascade is highly redundant and multiple cytokines are involved in inflammation. Targeting a critical common regulator of inflammatory effectors is desirable. ... University Of South Florida

01/04/18 / #20180001298

Metal oxide-based biocompatible hybrid sorbent for the extraction and enrichment of catecholamine neurotransmitters and related compounds, and method of synthesis

The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a zro2 polypropylene oxide based sol-gel. ... University Of South Florida

01/04/18 / #20180000761

Methods for making catechin derivatives

Disclosed herein are methods for making a catechin derivative, or a salt thereof. The methods can include: contacting an alcohol protected aromatic aldehyde and a triphenyl phosphonium ylide to make an alcohol protected aromatic olefin; hydrogenating the alcohol protected aromatic olefin to make alcohol protected aromatic compound; and deprotecting the alcohol protected aromatic compound to make the catechin derivative.. ... University Of South Florida

12/07/17 / #20170348336

Method of treating melanoma using an inhibitor of an atypical protein kinase c

The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of pkc-ζ and/or pkc-ι. Non-limiting examples of an inhibitor of pkc-ζ and/or pkc-ι include ica-1 and acpd. ... University Of South Florida

11/16/17 / #20170328900

Methods and materials for capture antibody targeted fluorescent in-situ hybridization (cat-fish)

The subject invention concerns materials and methods for detecting a target cell in a population. Methods of the invention comprise internally labeling cells via fluorescence in situ hybridization (fish) using probes that target rrna, followed by binding of capture antibodies targeted (cat) for specific cell surface epitopes on the target cells. ... University Of South Florida

10/05/17 / #20170283873

Supervised learning methods for the prediction of tumor radiosensitivity to preoperative radiochemotherapy

Disclosed is a gene expression panel that can predict radiation sensitivity (radiosensitivity) of a tumor in a subject. A method of predicting radiation sensitivity is provided that is based on cellular clonogenic survival after 2 gy (sf2) for 48 cell lines. ... University Of South Florida

10/05/17 / #20170283344

Systems and methods for producing liquid fuels from landfill gases

In some embodiments, a system for producing liquid fuel from landfill gas includes a tri-reformer that receives landfill gas and produces synthesis gas having a h2:co ratio of approximately 2:1, and a fischer-tropsch synthesis (fts) reformer that receives the synthesis gas from the tri-reformer and produces liquid fuel.. . ... University Of South Florida

10/05/17 / #20170281665

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof

This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. . ... University Of South Florida

09/28/17 / #20170273963

Pharmaceutical compounds and use of same in cancer and tauopathies

Disclosed are compounds of formula (i)-(v): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. ... University Of South Florida

09/21/17 / #20170266148

Compositions and methods for producing elevated and sustained ketosis

Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/l), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance in a short period of time. ... University Of South Florida

09/14/17 / #20170263355

Magneto-dielectric polymer nanocomposites

In accordance with the present invention, novel superparamagnetic magneto-dielectric polymer nanocomposites are synthesized using a novel process. The tunability of the dielectric/magnetic properties demonstrated by this novel highly-viscous solvent-free polymer nanocomposite that is amenable to building 3d electromagnetic structures/devices by using processes such as 3d printing, compression molding or injection molding, when an external dc magnetic field is applied, exceeds what has been previously reported for magneto-dielectric polymer nanocomposite materials.. ... University Of South Florida

09/14/17 / #20170258940

Transgenic mouse model for conditional fkbp51 expression and related methods

The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human fkbp51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome of the animal, comprising a nucleotide sequence encoding a tetracycline transactivator (tta) operably linked to a promoter; wherein the tta is expressed upon activation of the promoter and binds the tetracycline response element, thereby causing expression of fkbp51. ... University Of South Florida

09/07/17 / #20170257364

Systems and methods for authentication using authentication votes

A system and method of authentication is described. In operation, an authenticator computing device receives a request to access a resource from a requesting user. ... University Of South Florida

08/24/17 / #20170240880

Arginine deiminase gene therapy for disordered proteins

The invention relates to compositions comprising arginine deiminase and their use in a method of reducing aggregation of disordered protein in a subject.. . ... University Of South Florida

08/17/17 / #20170237439

Wide operating level shifters

Aspects of wide operating range level shifter designs are described. One embodiment includes a level shifter configured to receive an input signal in a first voltage domain and generate an output signal in a second voltage domain, a pulse generator configured to generate a pulse in response to sensing a rise transition on the input signal, and a droop circuit configured to decouple at least a portion of the level shifter from the second voltage domain in response to the pulse. ... University Of South Florida

08/17/17 / #20170232055

Methods of synthesizing gamma-aapeptides, gamma-aapeptide building blocks, gamma-aapeptide libraries, and gamma-aapeptide inhibitors of alpha-beta40 aggregates

Embodiments of the present disclosure provide for γ-aapeptides, γ-aapeptide building blocks, methods of making γ-aapeptides and libraries of γ-aapeptides, methods of screening the γ-aapeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-aapeptides that are inhibitors of aβ peptide aggregation, methods of inhibiting and disassembling aβ peptide aggregation, methods of inhibiting the toxicity of aβ aggregates towards n2a neuroblasotma cells, as well as methods and compounds for treating alzheimer's disease.. ... University Of South Florida

08/10/17 / #20170225969

Porous organic polymers for binding heavy metals

Compositions containing a porous organic polymer and a heavy metal chelating moiety are provided for binding heavy metals, for example in remediation and purification. The compositions can be stable and recyclable. ... University Of South Florida

08/10/17 / #20170224724

Ionic cocrystal of lithium, lispro, for the treatment of fragile x syndrome

The invention relates to a pharmaceutical composition comprising an ionic co-crystal (icc) of lithium with salicylic acid and 1-proline (lispro). The pharmaceutical composition can further comprise an anti-inflammatory agent, for example, salicylic acid. ... University Of South Florida

08/03/17 / #20170219564

Three-dimensional fibrous scaffolds for cell culture

Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (peg-pla) and a poly(lactic-co-glycolic acid) (plga). Also provided are methods for using the three-dimensional scaffolds described herein.. ... University Of South Florida

08/03/17 / #20170216337

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof

This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.. . ... University Of South Florida

07/27/17 / #20170214532

Magnetic memory physically unclonable functions

A magnetic random access memory (mram) physically unclonable function (puf) device that uses the geometric variations in magnetic memory cells to generate a random puf response is described herein. Within the mram, one or more magnetic memory cells can be used for the puf. ... University Of South Florida

07/20/17 / #20170202902

Conjugates for immunotherapy

The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a t cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. ... University Of South Florida

07/20/17 / #20170202848

Afobazole nanoparticles formulation for enhanced therapeutics

A novel nanoparticle drug composition and method of use thereof is presented herein. The nanoparticle drug composition is comprised of at least one nanoparticle carrier, formed from the conjugation of plga and. ... University Of South Florida

07/20/17 / #20170202659

Reversible anchoring devices

In one embodiment, a reversible anchoring device includes a base having a threaded shaft and an internal passage that extends through the base along a longitudinal direction of the base and a cap having a top surface, a bottom surface, a threaded circular opening formed in the bottom surface adapted to thread onto the threaded shaft of the base, and a suture opening that extends from the top surface of the cap to the threaded circular opening through which a suture can pass.. . ... University Of South Florida

07/13/17 / #20170196948

Methods, antibodies, and vaccines utilizing epitopes of alpha synuclein for treatment of parkinsons disease

The present invention pertains to a dendritic cell-based vaccine against rh-α-syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, preventing, and/or vaccinating against parkinson's disease (pd), or symptoms thereof.. . ... University Of South Florida

07/06/17 / #20170189490

Methods of treating cognitive impairment

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (flt3) ligand, interleukin-6 (il-6), macrophage migration inhibitory factor (mif), interleukin-1 (il-1), interleukin-3 (il-3), erythropoietin (epo), vascular endothelial growth factor a (vegf-a), hypoxia-inducible transcription factor (hif-1alpha), insulin like growth factor-1 (igf-1), tumor necrosis factor (tnf), granulocyte colony-stimulating factor (g-csf), granulocyte/macrophage colony-stimulating factor (gm-csf), macrophage colony-stimulating factor (m-csf), stem cell factor (scf), darbepoetin (aranesp), and metalloproteinases, to an animal or person in need of treatment.. ... University Of South Florida

07/06/17 / #20170188554

Animal model for studying complex human diseases

The invention concerns a non-human animal model useful for modeling complex human diseases; compositions comprising cell populations from the animal model having different genotypes for the same gene; methods for producing the animal model; and methods for studying a phenotype using an animal model or compositions of the invention.. . ... University Of South Florida

06/29/17 / #20170185697

Systems and methods for designing kinetic shapes

In one embodiment, a kinetic shape is designed by determining an applied force to be applied to an object that is to incorporate the kinetic shape, determining a reactive force that is desired to be produced in response to the applied force, inputting the applied force and the reactive force into a kinetic shape equation, and solving the equation to obtain the kinetic shape.. . ... University Of South Florida

06/29/17 / #20170181983

Exo-s-mecamylamine formulation and use in treatment

A pharmaceutical composition includes a therapeutically effective amount of exo-s-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-r-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. ... University Of South Florida

06/22/17 / #20170174726

Stabilized peptoid-peptide hybrids and uses thereof

The current invention pertains to stabilized peptoids or peptoid-peptide hybrids. The peptoids or peptoid-peptide hybrids are stabilized by side chain-side to side chain linkages and/or backbone cyclization. ... University Of South Florida

06/22/17 / #20170173216

Collagen scaffolds, medical implants with same and methods of use

The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. ... University Of South Florida

06/22/17 / #20170173049

Withacnistin compounds for treatment of cancer

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of stat3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing one or more withacnistin compounds, or a pharmaceutically acceptable salt or derivative thereof. ... University Of South Florida

06/22/17 / #20170172969

Methods of sustaining dietary ketosis and its effects on lipid profile

The ketogenic diet (kd) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mm) without need for dietary restriction. ... University Of South Florida

06/22/17 / #20170172418

Standardized oral health assessment and scoring using digital imaging

System and methodology objectively capture clinical data on oral health and provide standardized scoring for quantifying oral health. The process of capturing clinical data is based on use of an intraoral camera with imaging software that has the capacity to capture digital images of all tooth surfaces. ... University Of South Florida

06/08/17 / #20170157571

Electrospun cactus mucilage nanofibers

Novel electrospun nanofibers and nanofibrous membranes, methods of manufacturing the same, and methods of using the same are provided. The nanofibers include a cactus mucilage, such as mucilage from opuntia ficus-indica. ... University Of South Florida

05/18/17 / #20170140672

Radial arm model with mesh

A radial arm model in combination with a two-way mesh to permit puncturing, dissection/transection, and suturing of the underlying simulation vessels. The current invention also includes a method of training for such a procedure using said model, along with a method of fabricating or manufacturing such a model.. ... University Of South Florida

05/18/17 / #20170137812

Compositions and methods for modulating myeloid derived suppressor cells

Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microrna 142, an amount of microrna 223 or an amount of microrna 142 and an amount of micro rna 223 to the subject in need thereof.. . ... University Of South Florida

04/20/17 / #20170108829

Systems and methods for performing self-interference incoherent digital holography

In one embodiment, a self-interference incoherent digital holography system including a light sensor and a diffractive filter configured to receive light from an object to be holographically imaged and generate holographic interference patterns on the light sensor. A self-interference incoherent digital holography system comprising: a light sensor; and a diffractive filter configured to receive light from an object to be holographically imaged and generate holographic interference patterns on the sensor.. ... University Of South Florida

04/20/17 / #20170106019

Compositions and methods for mitigating drug resistant bacteria

The current invention is a broad-based remediation mechanism against mrfs and includes nanotechnology formulations and methodologies that may be used to develop novel mitigation strategies against certain drug resistant bacterial strains. In an embodiment, the current invention relates to mitigation of drug resistant bacteria from nosocomial infections, for example in hospitals and in food animals. ... University Of South Florida

04/13/17 / #20170101439

Gamma-aa-peptide stat3/dna inhibitors and methods of use

Stat3 hyperphosphorylation, dimerization and dna binding are required for its ability to contribute to malignant transformation. As such, stat3 has been recognized as a promising target for cancer therapy. ... University Of South Florida

04/13/17 / #20170100506

Protease resistant growth factor formulations for chronic wound healing

A formulation and method of treating chronic wounds is presented. The formulation uses two different fusion peptides, one of which incorporates an elastase resistant peptide, to preserve the bioactivity of different functional peptides and growth factors in chronic wounds.. ... University Of South Florida

03/23/17 / #20170082602

Systems and methods for analyzing liquids

In one embodiment, an optical spectroscopy probe includes an optical fiber having a distal tip and a microfluidic filtering chamber attached to the distal tip of the optical fiber, the chamber comprising a microfluidic membrane adapted to enable liquid to enter the chamber but prevent particles from entering the chamber.. . ... University Of South Florida

03/23/17 / #20170081635

Tumor-infiltrating lymphocytes for adoptive cell therapy

Disclosed are compositions and methods for ex vivo expansion of tumorinfiltrating lymphocytes for use in adoptive cell therapy (act). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumorinfiltrating lymphocytes for use in act. ... University Of South Florida

03/23/17 / #20170081225

Portable wastewater treatment systems

In one embodiment, a portable wastewater treatment system includes an anaerobic reactor in which organic material within the wastewater can be broken down, a membrane filter that receives wastewater from the anaerobic reactor and filters the water to produce permeate, and a small shipping container in which the reactor and the membrane filter are contained.. . ... University Of South Florida

03/23/17 / #20170080007

Effective treatment of esophageal adenocarcinoma using triciribine and related compounds

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.. . ... University Of South Florida

03/16/17 / #20170071496

Radiologically identified tumor habitats

Virtually every cancer patient is imaged with ct, pet or mri. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. ... University Of South Florida

03/09/17 / #20170067005

Concentrically baffled reactors and systems that incorporate them

In one embodiment, a concentrically baffled reactor includes an outer housing that defines an interior space, an inlet through which material can be delivered into the interior space, an outlet through which material can be removed from the interior space, and multiple concentric baffles within the interior space that define multiple concentric reactor zones through which the material can sequentially flow to the outlet.. . ... University Of South Florida

03/09/17 / #20170065643

Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers

Blood brain barrier (bbb) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether bbb permeation in the chronic stage of the disease still facilitates the entry of stem cells from the periphery to the injured brain. ... University Of South Florida

03/02/17 / #20170062072

Physically unclonable function based on domain wall memory and method of use

A system and method for providing a physically unclonable function (pfu) is described. In operation, the method includes applying a domain wall shift pulse challenge to a plurality of nanowires of a domain wall memory (dwm) array, wherein the nanowires of the domain wall memory (dwm) array have process induced variations, resulting in pinning potentials which affect the velocity of the domain walls along the length of the nanowires. ... University Of South Florida

03/02/17 / #20170060417

Magnetic coprocessor and method of use

A magnetic system for solving a quadratic optimization problem by associating each of a plurality of variables of a quadratic optimization problem with a nanomagnet of a nanomagnet array, driving the nanomagnets of the nanomagnet array to an excited state, allowing the nanomagnets of the nanomagnet array to enter a relaxed state after being driven to an excited state, wherein the nanomagnets magnetically couple with one another in the relaxed state to minimize the total magnetic coupling energy of the nanomagnet array, and sensing a magnetic coupling of the nanomagnets of the nanomagnet array to solve the quadratic optimization problem.. . ... University Of South Florida

03/02/17 / #20170058002

Gamma-aapeptides with potent and broad-spectrum antimicrobial activity

The present invention is directed to a novel class of antimicrobial agents called γ-aapeptides. The current invention provides various categories of γ-aapeptides, for example, linear γ-aapeptides, cyclic γ-aapeptides, and lipidated γ-aapeptides. ... University Of South Florida

03/02/17 / #20170056337

Antibacterial s-heterosubstituted disulfides

Synthetically-derived s,s-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including staphylococcus aureus, methicillin-resistant staphylococcus aureus and francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.. ... University Of South Florida

02/23/17 / #20170050946

Antimicrobials from an epigenetics based fungal metabolite screening program

Novel antimicrobial compounds and associated methods of development are presented herein.. . ... University Of South Florida

02/16/17 / #20170044225

Amyloid precursor protein (app) based β-secretase inhibitor peptides, and methods of use

The present invention provides fusion peptides, compositions, methods and kits for treating, reducing the risk of, lessening the severity of, preventing, or delaying the onset of amyloid-related disorders, such as alzheimer's disease and hiv associated neurocognitive impairment.. . ... University Of South Florida

02/16/17 / #20170042927

Effective treatment of ovarian cancer using triciribine and related compounds

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.. . ... University Of South Florida

02/09/17 / #20170039892

Synthetic vaginal cuff model and method of simulating vaginal cuff closure

A vaginal cuff surgical model and methods of manufacture and use thereof. The model includes a body (resembling a vaginal cuff) and appendages (resembling uterosacral ligaments) extending from the body. ... University Of South Florida

01/26/17 / #20170022540

Bioink for three-dimensional biomaterial printing

A method of creating “bioink” has been proposed, which increases the shelf-life and transportability of biological materials for use in bioprinting applications. The current invention also contemplates a composition of biomaterials admixed with trehalose to dehydrate the biomaterials for preservation and transportation. ... University Of South Florida

01/26/17 / #20170020826

Stabilization of alcohol intoxication-induced cardiovascular instability

The present invention concerns use of an agent that increases sphingosine-1-phosphate (s1p) receptor activity, such as s1p, or an s1p receptor agonist, for treatment of alcohol-intoxicated subjects will help stabilize blood pressure and improve resuscitation efforts in alcohol-intoxicated subjects, including alcohol-intoxicated trauma patients. Another aspect concerns a kit for stabilization of alcohol-intoxicated subjects, comprising an agent that increases s1p receptor activity.. ... University Of South Florida

01/19/17 / #20170019284

Joint physical layer security and papr mitigation in ofdm sytems

Systems and methods for securing orthogonal frequency division multiplexing (ofdm) transmission of data are discussed herein. Transceivers can sense the signal strength of frequencies on an ofdm wireless channel. ... University Of South Florida

01/19/17 / #20170018308

Mtj-based content addressable memory

Embodiments of the subject invention provide a three transistor, two domain-wall-based magnetic tunnel junction cam cell (3t-2dw-mtj cam). A four transistor, two magnetic tunnel junction ternary cam cell (4t-2mtj tcam) is also provided. ... University Of South Florida

01/05/17 / #20170004868

Robust slope detection technique for sttram and mram sensing

Slope detection systems and methods are provided that monitor magnetic tunnel junction (mtj) resistance switching. A low-overhead, sample-and-hold circuit can be used. ... University Of South Florida

01/05/17 / #20170002317

Conversion of non-neuronal cells into neurons

The subject invention concerns materials and methods for conversion of non-neuronal cells into neurons. The subject invention also concerns methods for screening drugs and other compounds for activity in treating alzheimer's disease using neuronal cells produced using the subject invention. ... University Of South Florida

01/05/17 / #20170000785

Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use

The subject invention concerns materials and methods for treating depression, stress disorders, such as ptsd, anxiety disorders, and/or a neurodegenerative disease or condition in a person or animal. In one embodiment, a person or animal in need of treatment is administered one or more compounds or drugs, or a composition comprising the one or more compounds or drugs, that inhibit fkbp51 activity or function. ... University Of South Florida

01/05/17 / #20170000754

Ketone supplements for treatment of angelman syndrome

The invention concerns a method of treating angelman syndrome (as) in a subject, comprising inducing ketosis in the subject by administering a therapeutically effective amount of a ketone ester, such as an r,s-1,3-butanediol acetoacetate ester, wherein administration of the ketone ester elevates the blood ketone level in the subject. Other aspects of the invention include a method of increasing cognitive function and/or motor function in a subject with as; and a method of decreasing seizures and increasing the latency to seize in a subject with as.. ... University Of South Florida

01/05/17 / #20170000630

Universal multi-branch endograft

The present invention provides endovascular stent graft conversion devices, systems and related methods that are particularly useful in aortic aneurysm repair, such as, but not limited to, thoraco-abdominal aortic aneurysm (taaa) repair. The endovascular stent graft conversion device provided by the present invention comprises a graft segment comprising a first end and a second end, wherein the first end is adapted for engaging a limb of an endograft device, and wherein the second end comprises three or more graft branches extending therefrom.. ... University Of South Florida

01/05/17 / #20170000612

Osteoconductive and osteoinductive implant for augmentation, stabilization, or defect reconstruction

Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or allogenic bone material, or similar compound.. . ... University Of South Florida








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