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University Of Southern California patents


Recent patent applications related to University Of Southern California. University Of Southern California is listed as an Agent/Assignee. Note: University Of Southern California may have other listings under different names/spellings. We're not affiliated with University Of Southern California, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Southern California-related inventors


 new patent  Received signal strength transformation method to achieve better indoor radio frequency localization

A method for localizing a mobile device in a physical space based on radio signals received from transmitters in the physical space includes a step of transforming a received signal strength vector to produce a transformed received signal strength vector. Sequence based localization is performed on the transformed rss vector with a different ideal sequence centroid table.. ... University Of Southern California

 new patent  Surface projection tool for multi-axis additive manufacturing

Methods, systems, and devices including a light guide tool for multi-axis additive manufacturing. The light guide tool includes a tubular light guide. ... University Of Southern California

Excited state management

Arrangements and techniques for providing organic emissive layers are provided, in which the emissive layer includes a first dopant having a dissociative energy level. A second dopant in the emissive layer provides a solid state sink energy level, to which doubly excited excitons and/or polarons may transition instead of to the dissociative energy level, thereby decreasing the undesirable effects of transitions to the dissociative energy level.. ... University Of Southern California

Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer

A mechanism of monoamine oxidases (maos) driven epithelium-to-mesenchymal transition (emt) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing maos in cancer cells. ... University Of Southern California

Monoamine oxidase inhibitors and methods for treatment and diagnosis of prostate cancer

A method of treating prostate cancer in a subject with biochemically recurrent prostate cancer is provided. The method includes administering to a subject in need thereof an effective amount of a pharmaceutical composition that includes phenelzine.. ... University Of Southern California

G protein-coupled receptors incorporated into rehydrated polymer vesicles retain functionality

A g protein coupled receptor (gpcr) is incorporated in polymeric giant unilamellar protein vesicles (pgups). By utilizing an agarose rehydration technique, the gpcr is inserted in the biased, physiological orientation with the c-terminus cytosolic and n-terminus extracellular. ... University Of Southern California

Screen printing systems and techniques for creating thin-film transistors using separated carbon nanotubes

A method of fabricating a thin film transistor, the method includes applying a first ink containing metallic particles to a first screen mask, and using the first screen mask to deposit the first ink to form a source electrode and a drain electrode on a substrate bearing a layer of carbon nanotubes (cnt). The method includes applying a second ink containing a dielectric material to a second screen mask, and using the second screen mask to deposit the second ink to form a layer of the dielectric material on the layer of cnt between the source electrode and the drain electrode. ... University Of Southern California

Methods for analyzing the interaction between a target protein and a ligand

Provided is a method for simultaneously determining both [l]0 and kd values of a ligand for a target protein. In one embodiment, the present technology involves performing quantitative equilibrium immunoassays at two different concentrations of the target and fitting the data to simultaneously determine kd and [l]0. ... University Of Southern California

Smooth muscle electrical stimulation based on entrainment of intracellular calcium ion oscillations

Methods, systems, and apparatus for electrically stimulating a smooth muscle. The method includes generating a continuous pulse train signal having pulses and pulse intervals between the pulses, the pulses and the pulse intervals being generated at a pulse frequency. ... University Of Southern California

Compositions and methods for modified nutrient delivery

This disclosure provides a microencapsulated capsule or microparticle comprising a nutrient-filled core encapsulated in an enteric coating. The microparticles are useful in the treatment of a variety of disorders when ingested or administered to a subject in need thereof. ... University Of Southern California

Data encoding and channel hopping using orbital angular momentum modes

Methods, systems, and devices for data encoding and channel hopping. The system includes a signal source for providing a signal. ... University Of Southern California

Methods and related kits for treating and regenerating tooth pulp and periapical tissues in a mammal

In one embodiment, a method of regenerating tooth pulp in a mammal is provided. The method comprises removing at least a portion the existing tooth pulp of a mammal and adding amelogenin protein to the existing tooth pulp of the mammal to regenerate tooth pulp in a mammal. ... University Of Southern California

Methods to treat neurological diseases

Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered c9orf72 protein activity. ... University Of Southern California

Lithium-ion mixed conductor membrane improves the performance of lithium-sulfur battery and other energy storage devices

A lithium ion mixed conduction membrane includes an optional polymeric binder and a partially lithiated ion conductive material having lithium ion conductivity and electrical conductivity dispersed within the polymeric binder that is capable of improving the performance and cycle life of lithium-sulfur rechargeable batteries and other batteries exhibiting the polysulfide shuttle. One or more lithium ion conduction membranes are placed between the positive and negative electrodes, or adjacent to the negative electrode of a battery and in particular, of a lithium sulfur battery.. ... University Of Southern California

06/07/18 / #20180158552

Interpretable deep learning framework for mining and predictive modeling of health care data

A method for creating an interpretable model for healthcare predictions includes training, by a deep learning processor, a neural network to predict health information by providing training data, including multiple combinations of measured or observed health metrics and corresponding medical results, to the neural network. The method also includes determining, by the deep learning processor and using the neural network, prediction data including predicted results for the measured or observed health metrics for each of the multiple combinations of the measured or observed health metrics based on the training data. ... University Of Southern California

05/31/18 / #20180148789

Methods for treating and assessing tumor invasion and metastasis

Provided herein are methods, such as diagnostic methods, for evaluating a tissue sample, such as a biopsy or cytology specimen of a subject to determine a likelihood of metastasis, a risk of tumor or cancer occurrence, or combinations thereof and provided herein are methods, such as a screening method, for determining the efficacy of a drug in reducing cell invasiveness. Also provided are methods of treatment, drugs, primers, and kits.. ... University Of Southern California

05/31/18 / #20180148508

Masking chimeric antigen receptor t cells for tumor-specific activation

The invention is directed to a masked chimeric antigen receptor, comprising: (a) a masking peptide; (b) one or more antigen-specific targeting domains; (c) an extracellular spacer domain; (d) a transmembrane domain; (e) at least one co-stimulatory domain; and (f) an intracellular signaling domain. The mcars are activated upon cleavage of the masking peptide.. ... University Of Southern California

05/31/18 / #20180147156

Therapeutic compositions comprising monoterpenes

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. ... University Of Southern California

05/24/18 / #20180146195

Method and device for processing a video signal by using an adaptive separable graph-based transform

The present invention provides a method for decoding a video signal using an adaptive separable graph-based transform, comprising the steps of: receiving a transform index for a target block from the video signal, wherein the transform index indicates a graph-based transform to be applied to the target block; deriving a graph-based transform kernel corresponding to the transform index; and decoding the target block based on the graph-based transform kernel.. . ... University Of Southern California

05/24/18 / #20180143180

System and method for determining tumor invasiveness

A method of determining invasion potential of a tumor cell includes exposing a tumor cell to an activity sensor; after exposing the tumor cell to the activity sensor, stimulating the tumor cell to cause a response in the cell that is reported by the activity sensor; detecting the level of response after stimulation of the tumor cell; and determining the invasion potential of the tumor cell based on the response. A system for determining the invasion potential of a tumor cell includes a sample stage that supports the tumor cell; a stimulator that focuses energy on the tumor cell to stimulate the tumor cell; and an imaging apparatus that observes an effect of the beam on the tumor cell.. ... University Of Southern California

05/24/18 / #20180142213

Pancreatic stromal progenitor cells

This disclosure relates to pancreatic stromal progenitor cells. This disclosure also relates to isolation of pancreatic stromal progenitor cells. ... University Of Southern California

05/17/18 / #20180136019

Fault detection system utilizing dynamic principal components analysis

Methods and systems for detecting a fault in a data set from an industrial process are disclosed. One method includes forming a first data matrix at a data processing framework from time-series training data, and performing a principal component pursuit on the first data matrix to form an uncorrupted, unscaled matrix and a sparse matrix in the memory, and scaling the uncorrupted, unscaled matrix to form an uncorrupted scaled matrix. ... University Of Southern California

05/17/18 / #20180133336

Targeting macula densa cells as a new therapeutic approach for kidney disease

There is no specific cure for chronic kidney disease (ckd), which affects one in every ten adults. The unmet medical need has created significant interest in regenerative therapeutic approaches. ... University Of Southern California

05/10/18 / #20180127785

Optimized gene editing utilizing a recombinant endonuclease system

Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded dna, for which knock-ins are notoriously inefficient for relying on random integration of homologous dna sequences into the break site by repair proteins. ... University Of Southern California

05/03/18 / #20180118831

Car t-cells for the treatment of b7-h4 expressing solid tumors

Car cells and antibodies targeting human b7-h4 expressed on many human cancers including but not limited to breast ovarian, and renal cancers are described as a new method of cancer treatment. It is proposed that b7-h4 car cells are safe and effective in patients and can be used to treat human tumors expressing the b7-h4 surface protein.. ... University Of Southern California

04/19/18 / #20180104281

High telmerase activity bone marrow mesenchymal stem cells, methods of producing the same and pharmaceuticals and treatment methods based thereon

Disclosed are isolated human bone marrow mesenchymal stem cells having high telomerase activity (tbmmscs). Also disclosed are isolated human cd34+ bone marrow mesenchymal stem cells. ... University Of Southern California

04/05/18 / #20180097249

Materials for high-performance aqueous organic redox flow batteries

. . Quinones and related compounds for use in flow batteries are provided. Many of these compounds are found to mitigate the effects of crossover in a flow battery. ... University Of Southern California

03/29/18 / #20180088645

Digital signal transition counters for digital integrated circuits

A digital integrated circuit comprising may include a digital sensor circuit that converts binary bit patterns of wires in a sub-circuit over a given time into a single integer value that represents the total activity of a sub-circuit, and a digital data processing circuit that receives multiple activity integer values from multiple digital sensors in multiple sub-circuits and logically combines the values or uses a lookup table to output a single integer value that represents the total activity of a larger sub-circuit.. . ... University Of Southern California

03/29/18 / #20180086746

Heteroatom containing deoxyuridine triphosphatase inhibitors

Provided herein are dutpase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions in a method of treating cancer. The dutpase inhibitors disclosed contain a uracil isostere in the molecule represented by a 2,6-diketopiperazine moiety. ... University Of Southern California

03/29/18 / #20180085571

Implanted electrical lead for pacemaker

An open coiled pacemaker lead is provided that has improved structural stability and functional life in vivo. The open coiled lead includes an electrically conductive material that is coated or covered by a thin layer of electrically insulative material. ... University Of Southern California

03/15/18 / #20180075161

Extensible automatic query language generator for semantic data

Systems and methods for querying a semantic data set are described. The semantic data set is defined by an ontology that represents a graphical relationship among data included in the semantic data set. ... University Of Southern California

03/08/18 / #20180066064

Biotherapeutics targeting gpr158 for cancer

Prostate cancer (pca) is typically associated with genetic alterations involving androgen sensitivity and the androgen receptor (ar). Described herein is the expression, molecular regulation, subcellular localization and functional role of a g-protein coupled receptor, gpr158, wherein different four human pca cell lines with variable alterations in the ar result in various degrees of androgen-responsiveness, androgen-sensitivity and ar expression. ... University Of Southern California

03/08/18 / #20180064829

Fluorescent bisphosphonate analogs

Fluorescent probes based on n-heterocyclic bisphosphonates or their phosphonocarboxylate analogues are provided. The probes have variable spectroscopic properties, bone mineral binding affinities, and pharmacological activities. ... University Of Southern California

02/22/18 / #20180049411

Generation of an inducible pericyte-specific cre mouse model

Pericytes are mural cells of brain capillaries that degenerate in multiple neurological disorders. Pericytes regulate neurovascular functions, but their role in the adult brain and disease is still poorly understood because of the lack of adequate pericyte-specific experimental models. ... University Of Southern California

02/15/18 / #20180044278

Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases

This disclosure provides compounds, pharmaceutical compositions, and methods of use for the prevention and treatment of inflammatory diseases or degenerative diseases including neurodegenerative diseases. Embodiments of the present disclosure provide compounds related to very long chain polyunsaturated fatty acids, pharmaceutical compositions containing the provided compounds, and methods of treating a subject with a condition or disease using provided compounds or pharmaceutical compositions.. ... University Of Southern California

02/08/18 / #20180039154

Monolithically integrated large-scale optical phased array

An optical device includes a row of optical units, each of the optical units comprising an antenna element and an associated phase shifting element, a first optical power splitter optically coupled to a first optical input/output element, and a first plurality of boundary adjustment elements. In the optical phased array, each of the first plurality of boundary adjustment units optically couples the first optical power splitter to different sub-rows of the row of optical units, and each of the plurality of boundary adjustment elements include a sub-row amplitude adjustment element and a sub-row phase adjustment element.. ... University Of Southern California

02/08/18 / #20180039153

Two-dimensional optical phased array

An optical device includes an array of unit optical elements. Each of the unit optical elements includes a plurality of amplitude adjustment (aa) elements, each of the plurality of aa elements configured for processing one of different phases of an optical signal; an optical antenna, and a combining mechanism for optically coupling the plurality of aa elements to the optical antenna. ... University Of Southern California

02/01/18 / #20180034556

Systems and techniques for communication using combined orbital angular momentum and multiple-input-multiple-output processing

. . A system includes a transmitter with multiple transmit devices each having an oam multiplexer that converts multiple input signals into an oam beam. Each transmit device outputs a coaxial group of orthogonal oam beams. ... University Of Southern California

02/01/18 / #20180030042

Methods, compounds, and compositions for the treatment of angiotensin-related diseases

Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders, including cardiovascular diseases, metabolic diseases, gastrointestinal diseases, renal diseases, inflammatory/autoimmune diseases, neurological diseases, bone marrow diseases and cancer. In particular, the invention provides compounds, methods and compositions for the treatment of metabolic diseases and disorders, such as diabetes mellitus, diabetes-related cardiovascular disorders, diabetes-related dermal ulcerations, diabetes related hypertension, and diabetes-related ophthalmic diseases.. ... University Of Southern California

02/01/18 / #20180028790

Sheath for maintaining position in a pericardial space

The present invention provides a novel design for sheaths intended for medical procedures. The sheath includes structures that anchor the sheath in a cavity or space when deployed but are at the same time retractable such that the sheath can be removed without tearing the tissue defining the space.. ... University Of Southern California

01/25/18 / #20180020926

Real-time imaging system for monitoring and control of thermal therapy treatments

Methods and systems of monitoring and controlling thermal therapy treatments. One method includes determining, with an electronic processor, a propagation constant for a plurality of waveports. ... University Of Southern California

01/18/18 / #20180016148

Redox sorting of carbon nanotubes

. . A method of separating and extracting carbon nanotubes, the method includes introducing the carbon nanotubes into a two-phase system that includes a first component and a second component, the first component being different from the second component. The method includes introducing a chemical agent into the two-phase system, mixing the chemical agent and the carbon nanotubes in the two-phase system, removing the first component to extract a first portion of the carbon nanotubes contained in the first component after the mixing, replenishing the two-phase system with fresh first component, and extracting a second portion of the carbon nanotubes contained in the fresh first component. ... University Of Southern California

01/04/18 / #20180004915

Generating performance assessment from human and virtual human patient conversation dyads during standardized patient encounter

An artificial intelligence machine may quickly generate a comprehensive virtual patient interview database based on limited input from a case author. The comprehensive virtual patient interview database may include a list of topics and a set of items. ... University Of Southern California

01/04/18 / #20180000421

Multi-sensor platform for diagnosing catheter status

A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material. A multi-sensor system may include a catheter that has lumen, is flexible, is made of a polymer, and has a circular cross section that has an outer diameter of no more than 0.5 cm; and one or more sensors that sense multiple characteristics of material flowing within the lumen, including at least two of the following: flow rate, pressure, and composition of the material.. ... University Of Southern California

12/28/17 / #20170369191

Instrument lander utilizing a cubesat platform for in situ exploration of asteroids and comets

Methods, systems, and apparatus for designing, constructing and using instrument landers for in situ exploration of small solar system bodies, such as asteroids and comets. In one aspect, a lander includes a cubesat-style platform; instrument packaging, wherein the cubesat-style platform and the instrument packaging are configured and arranged for an uncontrolled descent, hopping landing on a surface of a body in a solar system, where a descending trajectory for the lander is designed based on gravitational force and solar radiation, with no lander-based propulsion; and a mobility mechanism configured and arranged to self-orient the lander on the surface of the body in the solar system.. ... University Of Southern California

12/21/17 / #20170364362

Nested quantum annealing correction

Systems and methods of processing using a quantum processor are described. A method includes obtaining a problem hamiltonian and defining a nested hamiltonian with a plurality of logical qubits by embedding a logical kn representing the problem hamiltonian into a larger kc×n, where n represents a number of the logical qubits and c represents a nesting level defining the amount of hardware resources for the nest hamiltonian. ... University Of Southern California

12/14/17 / #20170354736

Use of alginate formulation for intraincisional drug delivery

Described herein are compositions of alginate formulations and their use for treating incisional wounds, such as intra-incisional application.. . ... University Of Southern California

11/30/17 / #20170346376

Energy harvester with self-assembled liquid bearing

A vibration energy harvester that converts kinetic energy to electrical energy. The vibration energy harvester includes an electrically conductive coil array, a magnetic array and a self-assembled liquid bearing. ... University Of Southern California

11/30/17 / #20170342577

Nanoelectrodes for water splitting

In various embodiments, the invention teaches a method for water splitting with much higher efficiency than previous methods. By decreasing the distance between two electrodes to nanometer scale, even shorter than the electric field screening length, the external power required for water splitting is significantly reduced.. ... University Of Southern California

11/30/17 / #20170342063

Blockers of the growth hormone receptor in disease prevention and treatment

Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human gh, ghr, stat5, socs, igf-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.. ... University Of Southern California

11/16/17 / #20170328194

Autoencoder-derived features as inputs to classification algorithms for predicting failures

The invention relates to using autoencoder-derived features for predicting well failures (e.g., rod pump failures) using a machine learning classifier (e.g., a support vector machine (svms)). Features derived from dynamometer card shapes are used as inputs to the machine learning classifier algorithm. ... University Of Southern California

11/16/17 / #20170325709

Method for improved dynamic contrast enhanced imaging using tracer-kinetic models as constraints

Tracer kinetic models are utilized as temporal constraints for highly under-sampled reconstruction of dce-mri data. The method is flexible in handling any tk model, does not rely on tuning of regularization parameters, and in comparison to existing compressed sensing approaches, provides robust mapping of tk parameters at high under-sampling rates. ... University Of Southern California

11/16/17 / #20170325493

Fasting mimicking diet (fmd) as an immunoregulatory treatment for gastrointestinal autoimmune/inflammatory diseases

A method for treating autoimmune and/or inflammatory diseases includes a step of identifying a subject having a gastrointestinal autoimmune/inflammatory disease. A fasting mimicking diet (fmd) is administered to the subject for a first time period.. ... University Of Southern California

11/09/17 / #20170322166

Black phosphorus gas sensor

The inventors experimentally demonstrated no2 gas sensing performance of multilayer black phosphorous (bp) field effect transistors. The bp sensors were sensitive to no2 concentration down to 5 ppb making them comparable in sensitivity to the best 2d material based sensors. ... University Of Southern California

10/26/17 / #20170310334

Wideband nyquist vco-based analog-to-digital converter

. . An analog-to-digital converter may convert an analog signal into digital codes representative of the changing level of the analog signal. An analog high pass filter may receive and continuously differentiate the analog signal. ... University Of Southern California

10/26/17 / #20170307902

3d printing with variable voxel sizes based on optical filter

A three-dimensional printing approach based on stereolithography with variable printing resolutions to solve the trade-off between throughput and resolution. In this technology, the variable fabrication resolutions are achieved by switching light wavelength. ... University Of Southern California

10/26/17 / #20170304764

Regenerative adsorbents of modified amines on nano-structured supports

The invention relates to regenerative, solid sorbent for adsorbing carbon dioxide from a gas mixture, with the sorbent including a modified polyamine and a nano-structured solid support. The modified polyamine is the reaction product of an amine and an aldehyde. ... University Of Southern California

10/05/17 / #20170281756

Compositions and methods to selectively block pain induced by cold

Tissue injury prompts the release of a number of proalgesic molecules that induce acute and chronic pain by sensitizing pain-sensing neurons (nociceptors) to heat and mechanical stimuli. In contrast, many proalgesics have no effect on cold sensitivity, or can inhibit cold-sensitive neurons and diminish cooling-mediated pain-relief (analgesia). ... University Of Southern California

09/28/17 / #20170279739

Predictive network system and method

A proactive networking system and method is disclosed. The network anticipates the user demands in advance and utilizes this predictive ability to reduce the peak to average ratio of the wireless traffic and yield significant savings in the required resources to guarantee certain quality of service (qos) metrics. ... University Of Southern California

09/28/17 / #20170273793

Assembly of layered monetite-chitosan nanocomposite and its transition to organized hydroxyapatite

A multilayer structure that functions as a bone replacement material includes a plurality of organic matrix layers such that each organic matrix layer includes chitosan and a dicarboxylic acid. The multilayer structure also includes a plurality of calcium phosphate-containing layers wherein each calcium phosphate-containing layer is interposed between a pair of organic matrix layers. ... University Of Southern California

09/21/17 / #20170272171

Phase-sensitive regeneration without a phase-locked loop using brillouin amplification

Methods, systems, and apparatus for phase-sensitive regeneration of a signal without a phase-locked loop and using brillouin amplification. The system for phase-sensitive regeneration includes a data channel, one or more pumps and a mixing stage. ... University Of Southern California

09/21/17 / #20170265755

Iglass: infrared thermography for learning thermoregulation performance

An infrared thermography based technique is described for monitoring an individual's thermoregulation performance and thermal comfort level through measuring the skin temperature on several points the face as the face has a high density of blood vessels and it is typically not covered by clothing. This technique allows for continuous monitoring during normal daily activities and instantaneous identification of thermoregulation performance and thermal comfort. ... University Of Southern California

09/14/17 / #20170260592

Next generation rna-sequencing and long non-coding rna in glioblastoma multiforme

Lncrnas are emerging as important oncogenic drivers in many cancers, but comprehensive, agnostic studies to identify key lncrnas involved in gbm are lacking. Described herein are new lncrna involved in gliomagenesis and prognosis, elucidating the biological functions of these relatively unknown biological actors and opening new therapeutic avenues for therapeutic development.. ... University Of Southern California

09/14/17 / #20170258810

Agents, compositions and methods for enhancing neurological function

Neuro-enhancing agents, compositions and methods are disclosed herein. Preferred neuro-enhancing agents of the present invention include progesterone and metabolites of progesterone, such as 3α-hydroxy-5α-pregnan-20-one (thp). ... University Of Southern California

09/14/17 / #20170258409

Synchronized multi-module pulsed arterial spin labeled magnetic resonance imaging

A magnetic resonance imaging system may include a magnet, gradient coils, an rf pulse transmitter, an rf receiver that receives mr signals from tissue that has been exposed to rf pulses, gradient fields, and a magnetic field, and a computer that includes a processor. The computer may have a configuration that: causes the rf pulse transmitter and gradient coils to emit multiple labeling pulses at predetermined labeling times directed to blood in a subject; causes the rf pulse transmitter, gradient coils, and magnet to generate mr signals directed to tissue at one or more spatial locations within the subject that receives the blood; causes the rf receiver to receive mr signals emitted by the tissue at predetermined imaging times; generates an image of the tissue based on the received mr signals; repeats the foregoing four actions one or more times; and generates information indicative of perfusion within the tissue based on the generated images.. ... University Of Southern California

08/17/17 / #20170232053

Drug combinations and methods to stimulate embryonic-like regeneration to treat diabetes and other diseases

Stem cell-based therapies can potentially reverse organ dysfunction and diseases but the removal of impaired tissue and reactivation of the program leading to organ regeneration pose major challenges. In mice, a four-day fasting mimicking diet (fmd) induces a step-wise expression of sox17 and pdx-1, resembling that observed during pancreatic development and followed by ngn3-driven generation of insulin-producing β-cells. ... University Of Southern California

08/03/17 / #20170216364

Apoptotic bodies

. . This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. ... University Of Southern California

07/13/17 / #20170196221

Method of cryopreservation of stem cell-derived retinal pigment epithelial cells on polymeric substrate

Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.. ... University Of Southern California

06/29/17 / #20170187060

Inexpensive metal-free organic redox flow battery (orbat) for grid-scale storage

. . A flow battery includes a positive electrode, a positive electrode electrolyte, a negative electrode, a negative electrode electrolyte, and a polymer electrolyte membrane interposed between the positive electrode and the negative electrode. The positive electrode electrolyte includes water and a first redox couple. ... University Of Southern California

06/22/17 / #20170172967

Benzo lipoxin analogues

. . Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation.. ... University Of Southern California

06/08/17 / #20170163451

Systems and techniques for communication using multiple-input-multiple-output processing of orbital angular momentum modes

A system includes a transmitter having a first transmit device having a first transmit antenna and a first oam multiplexer designed to receive two input signals and to convert the input signals to orthogonal oam beams. The first transmit antenna is designed to transmit a first output signal that includes the oam beams. ... University Of Southern California

06/08/17 / #20170162876

Coating particles

A method includes combining a coating material and an uncoated particulate core material in a solution having a selected ionic strength. The selected ionic strength promotes coating of the uncoated particulate core material with the coating material to form coated particles; and the coated particles can be collected after formation. ... University Of Southern California

06/01/17 / #20170151610

Inserting inhibitor to create part boundary isolation during 3d printing

A 3d printing system may print a desired 3d object. A fusible powder may fuse when subjected to a fusing condition. ... University Of Southern California

05/18/17 / #20170141434

High efficiency iron electrode and additives for use in rechargeable iron-based batteries

An iron electrode and a method of manufacturing an iron electrode for use in an iron-based rechargeable battery are disclosed. In one embodiment, the iron electrode includes carbonyl iron powder and one of a metal sulfide additive or metal oxide additive selected from the group of metals consisting of bismuth, lead, mercury, indium, gallium, and tin for suppressing hydrogen evolution at the iron electrode during charging of the iron-based rechargeable battery. ... University Of Southern California

05/04/17 / #20170121719

Dereplication strain of aspergillus nidulans

Modified fungal strains having deleted gene clusters are provided. The modified fungal strains include a. ... University Of Southern California

05/04/17 / #20170119748

Methods, compounds, and compositions for the treatment of musculoskeletal diseases

This invention provides methods, compounds and compositions for the treatment of musculoskeletal disease, muscle dysfunction, muscle-wasting disease or disorder, including hereditary myopathy, neuromuscular disease, muscular dystrophy, muscular atrophy, drug-induced myopathy, and related disease, disorder or condition that causes a decrease in muscle strength, comprising the use of heterocyclic non-peptidic compounds that act as mas agonists and/or mimics of angiotensin 1-7.. . ... University Of Southern California

04/27/17 / #20170113002

Adaptive brain-machine interface system for anesthesia delivery

A system for controlling a state of anesthesia of a patient. The system includes a neural sensor configured to be coupled to a patient and generate an output signal indicative of neural activity of the patient; and an electronic processor. ... University Of Southern California

04/13/17 / #20170100054

Electrical impedance spectroscopy measurement based on concentric bipolar microelectrode sensor

A portion of a concentric bipolar microelectrode sensor is attached to an inflatable balloon of a catheter. Another portion of the concentric bipolar microelectrode sensor is also attached to a body of the catheter. ... University Of Southern California

04/06/17 / #20170096630

Compact subnanosecond high voltage pulse generation system for cell electro-manipulation

Disclosed are methods and systems for subnanosecond rise time high voltage (hv) electric pulse delivery to biological loads. The system includes an imaging device and monitoring apparatus used for bio-photonic studies of pulse induced intracellular effects. ... University Of Southern California

03/09/17 / #20170065691

Brain cancer immunotherapy

The invention describes immunotherapies for treating various cancers in nervous system, particularly brain cancer. In various embodiments, the method may comprise: obtaining a tumor tissue from the subject; preparing a tumor cell lysate from the tumor tissue; isolating an immune cell from the subject; priming the immune cell against the tumor cell lysate. ... University Of Southern California

02/09/17 / #20170038267

Portable polarimetric fiber stress sensor system for visco-elastic and biomimetic material analysis

An all-optical fiber sensor apparatus includes a light source and an in-line fiber polarizer that polarizes light received from the light source. The in-line fiber polarizer outputs light in a first polarization state which is directed to a polarization-maintaining fiber. ... University Of Southern California

02/09/17 / #20170035094

Methods and diets to protect against chemotoxicity and age related illnesses

A method of improving longevity and/or alleviating a symptom of aging or preventing age related diseases is provided. The method includes a step in which the subject's average and type of daily protein intake, igf-i, and igfbp1 levels, and risk factors for overall mortality, cancer and diabetes are determined. ... University Of Southern California

02/09/17 / #20170035093

Methods and formulations promoting tissue/organ regeneration, longevity and healthspan

A method includes a step of identifying a subject in need of diet modification; and administering a first diet to the subject for a first time period. The first diet provides 4.5 to 7 kilocalories per pound of subject for a first day and 3 to 5 kilocalories per pound of subject per day for a second to fifth day of the first diet. ... University Of Southern California

02/02/17 / #20170029371

Mao inhibitors and their conjugates as therapeutics for the treatment of brain cancer

A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's near-infra-red dye monoamine oxidase inhibitor (nmi), and mhi 148-clorgyline, and their salt thereof. ... University Of Southern California

02/02/17 / #20170027217

Autoimmunity and multiple sclerosis treatment

A method for alleviating a symptom of multiple sclerosis or other autoimmune or inflammatory disease includes a step of identifying a subject having multiple sclerosis or other autoimmune diseases. A fasting mimicking diet is administered to the subject for a first predetermined time period, the fasting mimicking diet providing less than 50% of the subject's normal caloric intake. ... University Of Southern California

01/19/17 / #20170015730

Polypeptide compositions with type vii collagen fibronectin type iii-like repeats and treatment methods for wound closure and healing

. . Disclosed are compositions and methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one or more functional fragments or variants thereof. ... University Of Southern California

01/12/17 / #20170007737

Amelogenin-chitosan hydrogel for dentin hypersensitivity

A method to regrow a protective layer over exposed/demineralized dentin that includes a step of identifying a subject having exposed/demineralized dentin. The demineralized dentin is contacted with a remineralization composition that includes an amelogenin and derived peptides, a chitosan, water, and a sufficient amount of a ph adjusting component such that the composition has a ph greater than about 6.0 such that dentinal tubules are occluded with apatite crystals and enamel is regrown on the dentinal tubules.. ... University Of Southern California

01/05/17 / #20170000183

Fasting condition as dietary treatment of diabetes

A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. ... University Of Southern California








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