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University Of Tennessee Research Foundation patents


Recent patent applications related to University Of Tennessee Research Foundation. University Of Tennessee Research Foundation is listed as an Agent/Assignee. Note: University Of Tennessee Research Foundation may have other listings under different names/spellings. We're not affiliated with University Of Tennessee Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Tennessee Research Foundation-related inventors


Catalyst for low temperature emission control and methods for using same

The invention provides a composite catalyst containing a first component and a second component. The first component contains a ternary mixed metal oxide. ... University Of Tennessee Research Foundation

Tunable thin liquid/gas diffusion layers for electrolyzers

A liquid/gas diffusion layer (lgdl) 112 for use in a proton exchange membrane electrolyzer cell 100 includes a planar body 120 having first and second surfaces 128, 130 that are separated by a body thickness 126. The body defines 120 a plurality of straight-through, non-interconnected, pores 122 extending through the body thickness 126, between the first and the second surfaces 128, 130. ... University Of Tennessee Research Foundation

Lpa2 receptor-specific benzoic acid derivatives

Disclosed is a five-feature pharmacophore model of lpa2 receptor specific agonists. Compounds may be identified as agonists of the lpa2 receptor using the five-feature pharmacophore model.. ... University Of Tennessee Research Foundation

Ternary metal halide scintillators

Metal halide scintillators are described. More particularly, the scintillators include tl and/or in-based ternary metal halides, such as those of the formulas a2bx4 and ab2x5, wherein a is an alkali metal, such as li, na, k, rb, cs or any combination thereof; b is an alkali earth metal, such as be, mg, ca, sr, ba or any combination thereof; x is a halide, such as cl, br, i, f or any combination thereof; some or all of a has been replaced by tl and/or in, and some or all of b has been replaced by another dopant, such as eu, ce, tb, yb, and pr. ... University Of Tennessee Research Foundation

Power system disturbance location determination based on rate of change of frequency

A method for determining a location of a disturbance in a power system is provided. The method includes receiving data from a plurality of sensors distributed across the power system; determining, with one or more processors, for each sensor, an extremum of the data corresponding to the sensor; interpolating, with the one or more processors, the extrema; and presenting, on one or more display units, a location corresponding to a global maximum of the interpolated extrema as the location of the disturbance. ... University Of Tennessee Research Foundation

Magnetic field based wireless gmd/emp-e3 impact monitoring device

A system and methods for monitoring an impact of geomagnetic disturbances (gmds) or an e3 component of electromagnetic pulses (emp-e3), involving a transducer generating a transduced signal in response to a magnetic field of a current carrying element of a transmission line. The transduced signal reflects harmonic characteristics of the current carrying element, and is amplified and filtered, then digitally converted. ... University Of Tennessee Research Foundation

Compounds for treatment of cancer

The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.. . ... University Of Tennessee Research Foundation

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel 3-amino propanamide selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

Sarms and method of use thereof

This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as duchenne muscular dystrophy and becker muscular dystrophy and in improving or preserving lung function and cardiac function in a subject suffering from duchenne muscular dystrophy.. . ... University Of Tennessee Research Foundation

Ternary metal halide scintillators

Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas a2bx4 and ab2x5, wherein a is an alkali metal, such as li, na, k, rb, cs or any combination thereof; b is an alkali earth metal, such as be, mg, ca, sr, ba or any combination thereof; and x is a halide, such as cl, br, i, f or any combination thereof. ... University Of Tennessee Research Foundation

Memory cell comprising coupled josephson junctions

Methods and apparatus are disclosed for operating a memory cell formed from the plurality of coupled josephson junctions. The memory cell is configured such that applying an electrical signal to the junctions can cause at least one, but not all, of the junctions to change their respective phase states. ... University Of Tennessee Research Foundation

Dual-frequency mode transmitter for wireless power transfer

A transmitter for wireless power transfer is provided. The transmitter includes an input port, a first transmission port, a second transmission port, an inverter, and a controller. ... University Of Tennessee Research Foundation

Methods and compositions for preventing and treating tooth erosion

An oral composition is provided comprising crosslinked polyvinylpyrrolidone (pvp) and xylitol. The xylitol and the crosslinked pvp are in a ratio of about 5:1, and the oral composition is in the form of a lozenge or lollipop. ... University Of Tennessee Research Foundation

Additive manufacturing methods using aluminum-rare earth alloys and products made using such methods

Described herein are additive manufacturing methods and products made using such methods. The alloy compositions described herein are specifically selected for the additive manufacturing methods and provide products that exhibit superior mechanical properties as compared to their cast counterparts. ... University Of Tennessee Research Foundation

03/15/18 / #20180071242

Substituted acylanilides and methods of use thereof

This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter alia, a muscle wasting disease and/or disorder such as muscular dystrophies including duchenne muscular dystrophy and becker muscular dystrophy.. . ... University Of Tennessee Research Foundation

01/18/18 / #20180019483

Redox flow battery with increased-surface-area electrode and asymmetric electrolyte concentration

A flow battery having stable electrochemical performance is provided. The flow battery includes a separator disposed between a positive electrode and a negative electrode, a first flow plate to distribute a positive electrolyte to the positive electrode, and a second flow plate to distribute a negative electrolyte to the negative electrode. ... University Of Tennessee Research Foundation

01/18/18 / #20180018358

Method and apparatus for constructing a neuroscience-inspired artificial neural network with visualization of neural pathways

A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic artificial neural network array and a neural network array of electrodes associated with neural tissue such as a brain, the method and apparatus having a special purpose display processor. The special purpose display processor outputs a display over a period of selected reference time units to demonstrate a neural pathway from, for example, one or a plurality of input neurons through intermediate destination neurons to an output neuron in three-dimensional space. ... University Of Tennessee Research Foundation

12/28/17 / #20170369900

Scn plants and methods for making the same

The invention relates to genes which may be utilized for resistance to soybean cyst nematode. More specifically the present disclosure relates to identification of gene(s) that can confer upon a soybean plant resistance to soybean cyst nematode (scn) and methods to use these loci and genes to obtain soybean strains that are resistant to scn.. ... University Of Tennessee Research Foundation

12/28/17 / #20170368003

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (sard) compounds including heterocyclic anilide rings and their synthetic precursors, r-isomers, and non-hydroxylated and/or non-chiral propanamides, and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

12/21/17 / #20170360927

Diagnosing and treating iga nephropathy

Provided are methods of diagnosing iga nephropathy in a subject. Optionally, the methods comprise isolating an igg from the subject and determining whether the igg binds to a galactose-deficient iga1. ... University Of Tennessee Research Foundation

11/16/17 / #20170326530

Surface-functionalized polyolefin fibers and their use in methods for extracting metal ions from liquid solutions

A fiber useful in the absorption of metal ions from aqueous solutions, the fiber comprising a polyolefin backbone having a diameter of at least 1 micron and having covalently appended on its surface halogen atoms and vinyl-addition polymeric grafts functionalized with metal-binding groups, such as at least one functional group selected from carboxylate, keto, aldo, amino, imino, nitrile, amido, oxime, amidoxime, imide dioxime, and hydroxamate groups. The vinyl-addition polymeric grafts may also be further functionalized with hydrophilic groups different from the metal-binding groups, wherein the hydrophilic groups may be selected from carboxylate, sulfone, sulfonate, phosphonate, alkylammonium, iminium, amide, pyrrolidone, and polyalkyleneglycol groups. ... University Of Tennessee Research Foundation

11/09/17 / #20170319444

Methods and compositions for preventing and treating tooth erosion

Methods and compositions are provided for reducing, treating or preventing dental erosion in a patient in need of such treatment, the methods and compositions comprising administering a therapeutically effective amount of an alkalinizing agent and a re-mineralizing agent to the teeth.. . ... University Of Tennessee Research Foundation

10/12/17 / #20170290846

In situ gelling form for long-acting drug delivery

The present invention relates to an injectable polymer matrix drug delivery system comprising a biodegradable polymer, a solvent or a combination of solvents, and an active pharmaceutical ingredient.. . ... University Of Tennessee Research Foundation

10/05/17 / #20170281807

Targeting immunotherapy for amyloidosis

Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. ... University Of Tennessee Research Foundation

09/21/17 / #20170267722

Inhibitory peptides of viral infection

Disclosed are methods of treating and/or inhibiting a viral infection in a subject. The methods include administering a therapeutically effective amount of heparin-binding peptide. ... University Of Tennessee Research Foundation

08/31/17 / #20170247834

Comprehensive process for selectively separating lignocellulosic biomass into purified components with high yield

A comprehensive process for treating lignocellulosic biomass in order to separate the biomass into its component parts, the process comprising: a) contacting the lignocellulosic biomass with a first solvent for a period of time and at a first temperature at a severity in the range of about 2 to about 4 to remove extractive components and a portion of ash from the biomass; b) contacting the biomass from step (a) with a second solvent, and optional catalyst, at a second temperature at a severity in the range of about 1 to 5 to remove hemicelluloses and additional ash from the biomass; and c) separating the biomass from step (b) into a lignin product and a cellulose product by contacting the biomass from step (b) with a third solvent at a severity in the range of about 1.5 to 5 to provide a spent liquor product and a solid fraction containing cellulose.. . ... University Of Tennessee Research Foundation

08/24/17 / #20170240506

Selective androgen receptor modulator and methods of use thereof

This invention provides substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject including, inter alia, a muscle wasting disease and/or disorder such as duchenne muscular dystrophy or becker muscular dystrophy.. . ... University Of Tennessee Research Foundation

08/10/17 / #20170226086

Compounds for treatment of cancer

The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. Melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.. ... University Of Tennessee Research Foundation

08/03/17 / #20170218265

Intrinsic and activated a4bx6 scintillators

Mixed halide scintillation materials of a first general formula a4b(1-y)myx′6(1-z)x″6z and a second general formula a(4-y)bmyx′6(1-z)x″6z are disclosed. In the general formulas, a is an alkali metal, b is an alkali earth metal, and x′ and x″ are two different halogen atoms. ... University Of Tennessee Research Foundation

07/27/17 / #20170209202

System and method for harmonic control of dual-output generators

A dual-output generator is configured to output two or more waveforms at different frequencies. In particular, the dual-output generator is configured to provide low-frequency output, which may be suitable for ultrasonic surgical instruments, and a high-frequency output, which may be suitable for electrosurgical instruments, while reducing the amplitude of all remaining frequencies other than the two selected low and high frequencies to about zero.. ... University Of Tennessee Research Foundation

07/27/17 / #20170208730

Flex roller-crimper for improved management and termination of cover crops and other plant material

Herein is described an agricultural device that can include a frame; and a plurality of roller-crimping devices supported by the frame arranged in at least one row oriented in a direction that is transverse to a direction of travel of the agricultural device. Each of the plurality of roller-crimping devices having an exterior surface configured to at least partially crush stems of residual plant matter, and being individually movably mounted to the frame such that each of the plurality of roller-crimping devices will move at least vertically with respect to the frame when subjected to a temporary increase in resistance caused by an encounter with a non-uniform region in the field.. ... University Of Tennessee Research Foundation

07/06/17 / #20170191029

Methods for improvement of semen quality

A method for improving quality of a mammalian semen sample includes providing an insoluble carrier carrying at least one ligand that binds to an indicator of impaired sperm membrane integrity and/or motility, or the insoluble carrier carrying at least one molecule capable of binding to the at least one ligand, and contacting the semen sample and the insoluble carrier to provide a bound sperm cell population and an unbound sperm cell population, the insoluble carrier may be a plurality of beads each carrying the at least one ligand or the at least one molecule. The indicator may be associated with one or both of impaired sperm acrosome and impaired sperm plasma membrane integrity. ... University Of Tennessee Research Foundation

07/06/17 / #20170190969

Ternary metal halide scintillators

Metal halide scintillators are described. More particularly, the scintillators include doped (e.g., europium-doped) ternary metal halides, such as those of the formulas a2bx4 and ab2x5, wherein a is an alkali metal, such as li, na, k, rb, cs or any combination thereof; b is an alkali earth metal, such as be, mg, ca, sr, ba or any combination thereof; and x is a halide, such as cl, br, i, f or any combination thereof. ... University Of Tennessee Research Foundation

06/29/17 / #20170186518

Iron nitride magnetic material including coated nanoparticles

The disclosure describes techniques for forming nanoparticles including fe16n2 phase. In some examples, the nanoparticles may be formed by first forming nanoparticles including iron, nitrogen, and at least one of carbon or boron. ... University Of Tennessee Research Foundation

06/29/17 / #20170183440

Multigraft copolymer superelastomers by emulsion polymerization

Multigraft copolymers having various structures, e.g., comb and centipede structures, can be prepared from emulsion copolymerization of monomers and macromonomers. The emulsion copolymerization can be initiated by a thermally activated radical initiator or a redox initiation system. ... University Of Tennessee Research Foundation

06/15/17 / #20170166526

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

06/01/17 / #20170153682

Transient stability simulation and operation of power systems

Systems and methods for simulating and operating a power system following a contingency are provided. Semi-analytic solutions (sass) for the power system state variables may be derived offline for a plurality of contingencies. ... University Of Tennessee Research Foundation

05/18/17 / #20170137374

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel 3-amino propanamide selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

05/11/17 / #20170130236

Methods of plant transformation using transformable cell suspension culture and uses thereof

The subject invention pertains to a method of rapidly transforming a plant with a gene of interest. The method of the current invention comprises the steps of a) preparing a bacterial culture, wherein the bacterial culture comprises a vector containing the gene of interest, b) producing a plant cell suspension culture from the plant, c) contacting the plant cell suspension culture with the bacterial culture to produce a plant cell transformed with the gene of interest from the plant cell suspension culture, and e) producing a plant from the plant cell transformed with the gene of interest. ... University Of Tennessee Research Foundation

04/20/17 / #20170108493

Methods for detecting a biomarker by alternating current electrokinetics

Methods are described for detecting pathogens, infectious diseases, and physiological conditions by quantifying change of impedance over time of when a biological sample is applied onto a lab-on-a-chip. The lab-on-a-chip utilizes alternating-current electrokinetic (acek) phenomena such that molecules move or are carried in an electric field generated by the application of an electrical signal of predetermined magnitude and frequency to an electrode array of the lab-on-a-chip.. ... University Of Tennessee Research Foundation

04/06/17 / #20170095446

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

03/23/17 / #20170081396

Treatment and prophylaxis of amyloidosis

Methods useful for effecting prophylaxis or treatment of amyloidosis, including aa amyloidosis and al amyloidosis, by administering peptides comprising neoepitopes, such as aa fragments from a c-terminal region of aa, and antibodies specific for neoepitopes of aggregated amyloid proteins, for example, antibodies specific for the c-terminal region of aa fibrils. Antibodies for inhibition of formation and/or increasing clearance of amyloid deposits in a patient thus effecting prophylaxis or treating amyloid disease.. ... University Of Tennessee Research Foundation

03/02/17 / #20170058196

Mixed halide scintillators for radiation detection

Mixed halide scintillation materials of the general formula ab(1-y)myx′wx″(3-w), where 0≦y≦1, 0.05≦w≦1, a may be an alkali metal, b may be an alkali earth metal, and x′ and x″ may be two different halogen atoms, and of the general formula a(1-y)bmyx′wx″(3-w), where 0≦y≦1, 0.05≦w≦1, a maybe an alkali metal, b may be an alkali earth metal, and x′ and x″ are two different halogen atoms. The scintillation materials of formula (1) include a divalent external activator, m, such as eu2+ or yb2+. ... University Of Tennessee Research Foundation

03/02/17 / #20170057930

Compounds for treatment of cancer

The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.. . ... University Of Tennessee Research Foundation

03/02/17 / #20170057898

Novel glycerol dehydration methods and products thereof

Methods and systems for suppressing coking in dehydration reactions catalyzed by solid acids. Dehydration reactions catalyzed by one or more solid acid catalysts can be performed in the presence of a super critical carbon dioxide medium which prevents or minimizes coking of the solid acid catalysts. ... University Of Tennessee Research Foundation

02/23/17 / #20170050921

Selective androgen receptor degrader (sard) ligands and methods of use thereof

This invention provides novel 3-amino propanamide selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, androgenic alopecia or other hyperandrogenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (ar-fl) including pathogenic or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

02/02/17 / #20170029370

Selective androgen receptor degrader (sard) ligands and methods of use thereof

. . This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (sard) compounds, pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other ar-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, kennedy's disease, amyotrophic lateral sclerosis (als), abdominal aortic aneurysm (aaa), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (ar-fl) including pathogenic and/or resistance mutations, ar-splice variants (ar-sv), and pathogenic polyglutamine (polyq) polymorphisms of ar in a subject.. . ... University Of Tennessee Research Foundation

01/19/17 / #20170016940

Universal grid analyzer

Embodiments of the present invention may provide a device for monitoring electric power at the distribution level. The device may include an analog-to-digital converter (adc) to convert an input signal into digital samples at time intervals, a receiver to generate a pulse-per-second (pps) signal, an oscillator to generate an oscillator signal, and a data processor coupled to the adc, the receiver, and the oscillator. ... University Of Tennessee Research Foundation

01/19/17 / #20170016068

Single nucleotide polymorphisms (snp) and association with resistance to immune tolerance induction

This application discloses methods, systems and kits for correlating the presence or absence of certain nucleic acid sequences within a population with the ability to create immune tolerance in that same population. Tolerance can be induced by solo or repeated administration of antigen, including soluble antigens administered either intravenously or sublingually. ... University Of Tennessee Research Foundation

01/19/17 / #20170014371

Sarms and method of use thereof

This invention is directed to substituted acylanilide compounds and uses thereof in treating muscular dystrophies such as duchenne muscular dystrophy and becker muscular dystrophy and in improving or preserving lung function and cardiac function in a subject suffering from duchenne muscular dystrophy.. . ... University Of Tennessee Research Foundation

01/19/17 / #20170014370

Sarms and method of use thereof

This invention is directed to substituted acylanilide compounds and uses thereof in improving or preserving lung function and cardiac function in a subject suffering from duchenne muscular dystrophy.. . ... University Of Tennessee Research Foundation

01/12/17 / #20170007559

Compositions and methods for protecting colonic epithelial barrier function

Disclosed are compositions and methods for treating or preventing colonic barrier dysfunction in a human by administering to the human in need thereof a pharmaceutically effective amount of an lpa2 receptor agonist or n-acetyl l-cysteine.. . ... University Of Tennessee Research Foundation

01/05/17 / #20170005170

Semiconductor composition containing iron, dysprosium, and terbium

An amorphous semiconductor composition includes 1 to 70 atomic percent iron, 15 to 65 atomic percent dysprosium, 15 to 35 atomic percent terbium, balance x, wherein x is at least one of an oxidizing element and a reducing element. The composition has an essentially amorphous microstructure, an optical transmittance of at least 50% in at least the visible spectrum and semiconductor electrical properties.. ... University Of Tennessee Research Foundation








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