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Vanderbilt University patents


Recent patent applications related to Vanderbilt University. Vanderbilt University is listed as an Agent/Assignee. Note: Vanderbilt University may have other listings under different names/spellings. We're not affiliated with Vanderbilt University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "V" | Vanderbilt University-related inventors


Thermal volatilization of orco agonists

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. ... Vanderbilt University

Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1

In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor m1 (machr m1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

Transient electronics using thermoresponsive materials

A composite element and methods of fabrication thereof are provided. The composite element can include a binder material and one or more electrical traces supported by the binder material, where a composition of the binder material is a thermoresponsive material and where each of the one or more electrical traces comprises an interconnected network of nanoparticles.. ... Vanderbilt University

Characterizing gastro-intestinal disease

A method for characterizing a gastro-intestinal disease in a subject involves comparing ratios of expression levels of genes in a biological sample from a subject to references, wherein the gastro-intestinal disease is characterized based on a difference in the ratios of the expression values of genes in the biological sample from the subject as compared to the references.. . ... Vanderbilt University

System and methods for removing impurities from phosphogypsum and manufacturing gypsum binders and products

Methods and systems that remove impurities from phosphogypsum (pg), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, pg is reacted with a chloride solution in an acidic environment under mechanical manipulation and/or heat followed by galvanic and/or zeolite absorption removal of impurities.. ... Vanderbilt University

Multifunctional degradable nanoparticles with control over size and functionalities

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. ... Vanderbilt University

Dexterous surgical manipulator and method of use

A surgical manipulator includes an internal working end having an internal joint, and an external control interface linked to the internal working end for controlling the internal working end. The external control interface includes at least one lever defining a grip volume for a surgeon's hand when gripping and operating the at least one lever, and an external joint linked to the internal joint for controlling the internal joint. ... Vanderbilt University

Nanofiber electrode and method of forming same

A method of forming an electrode for an electrochemical device includes mixing at least a first amount of a catalyst and a second amount of an ionomer or an uncharged polymer to form a liquid mixture; delivering the liquid mixture into a metallic needle having a needle tip; applying a voltage between the needle tip and a collector substrate positioned at a distance from the needle tip; and extruding the liquid mixture from the needle tip at a flow rate such as to generate electrospun fibers and deposit the generated fibers on the collector substrate to form a mat comprising a porous network of fibers, where each fiber has a plurality of particles of the catalyst distributed thereon.. . ... Vanderbilt University

Aqueous polyglycidol synthesis with ultra-low branching

Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures

Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

Chimeric dengue virus e glycoproteins comprising mutant domain i and domain ii hinge regions

The present invention provides compositions and methods of use comprising a chimeric dengue virus e glycoprotein comprising a dengue virus e glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus e glycoprotein domain i and domain ii hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus e glycoprotein backbone.. . ... Vanderbilt University

Free solution measurement of molecular interactions by backscattering interferometry

Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry. In one aspect, the invention relates to method and systems for detecting molecular interaction between analytes in free-solution wherein the analytes are label-free and detection is performed by back-scattering interferometry. ... Vanderbilt University

Substituted imidazopyridine and triazolopyridine analogs as positive allosteric modulators of muscarinic acetylcholine receptor m1

In one aspect, the invention relates to substituted imidazopyridine and triazolopyridine analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor m1 (machr m1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the disclosed compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

Spool and body architectures for three-position directional control valves

A directional-control valve is typically comprised of a valve spool that slides linearly within a valve body. The valve body typically includes five internal ports, which are covered or exposed as the spool slides within the body. ... Vanderbilt University

04/19/18 / #20180104010

Biomechanical model assisted image guided surgery system and method

A method for image guided surgery includes obtaining intraoperative locations including intraoperative fiducial locations for a non-rigid structure and intraoperative rigid structure locations for associated rigid structures, estimating a gravity deformation for the non-rigid structure based on a first rigid registration for preoperative fiducial locations in a computer model relative to the intraoperative fiducial locations and a second rigid registration for the preoperative rigid structure locations for a rigid structure in the computer model with respect to the intraoperative rigid structure locations, modifying the preoperative fiducial locations using first rigid registration and the gravity deformation, determining a third rigid registration for the modified fiducial locations relative to the intraoperative fiducial locations, calculating a non-rigid transformation for the computer model using the volumetric gravity field deformation and first boundary conditions from errors in the third rigid registration, and displaying image data for the non-rigid structure modified to undergo the non-rigid transformation.. . ... Vanderbilt University

04/05/18 / #20180092359

Binary compositions as disruptors of orco-mediated odorant sensing

In one aspect, the invention relates to binary compositions that disrupt orco-mediated odorant sensing. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in organisms that express orco receptors such as airborne insects, e.g., mosquitoes, and ticks. ... Vanderbilt University

03/29/18 / #20180086776

Positive allosteric modulators of the muscarinic acetylcholine receptor m4

Disclosed herein are substituted 8-aminothieno[3,2-e][1,2,4]triazolo[4,3-b]pyridazine-7-carboxamide compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor m4 (machr m4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.. ... Vanderbilt University

03/29/18 / #20180086767

Wdr5 inhibitors and modulators

Described are compounds that disrupt the wdr5-mll1 protein-protein interaction, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating disorders and conditions in a subject.. . ... Vanderbilt University

03/29/18 / #20180085475

Composition and method for detecting hypoxia

A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible on-off fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. ... Vanderbilt University

03/22/18 / #20180080570

Organ on chip integration and applications of the same

A rotary planar peristaltic micropump (rppm) includes an actuator having a shaft engaged with a motor such that activation of the motor causes the shaft to rotate, and a bearing assembly engaged with the shaft. The bearing assembly has a bearing cage defining a plurality of spaced-apart openings thereon, and a plurality of rolling-members accommodated in the plurality of spaced-apart openings of the bearing cage, such that when the shaft rotates, the plurality of rolling-members of the bearing assembly rolls along a circular path. ... Vanderbilt University

03/22/18 / #20180079802

Antibody-mediated neutralization of chikungunya virus

The present disclosure is directed to antibodies binding to and neutralizing chikungunya virus (chikv) and methods for use thereof.. . ... Vanderbilt University

03/22/18 / #20180078607

Alphaa-crystallin mimetic peptides and uses thereof

This invention relates to αa-crystallin protein modulating compounds (e.g., phosphomimetic peptides), compositions comprising such modulating compounds, and their use as therapeutics for the treatment and prevention of conditions involving neurodegeneration and neuroinflammation.. . ... Vanderbilt University

03/15/18 / #20180072674

Negative allosteric modulators of metabotropic glutamate receptor 2

Described are negative allosteric modulators of metabotropic glutamate receptor 2 (mglu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, alzheimer's disease, or autism spectrum disorders in a subject.. . ... Vanderbilt University

03/08/18 / #20180064749

Conjugation of lipophilic albumin-binding moiety to rna for improved carrier-free in vivo pharmacokinetics and gene silencing

Provided herein are compounds and methods for gene silencing. The compound includes a rna directly conjugated to an albumin-binding group. ... Vanderbilt University

03/01/18 / #20180057491

Isoquinoline amide and isoquinoline amide-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

03/01/18 / #20180057490

Benzomorpholine and benzomorpholine-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

03/01/18 / #20180055913

Recombinant collagen iv surrogates and uses thereof

The disclosure describes compositions that mimic certain structural and functional characteristics of collagen iv. Additionally provided are methods for the recombinant production of said compositions and particular methods of use.. ... Vanderbilt University

03/01/18 / #20180055811

Methods of treating an overweight subject

The invention generally relates in part to methods of effecting weight loss and/or improving glucose tolerance in a patient in need thereof, comprising administering a metap2 inhibitor.. . ... Vanderbilt University

02/22/18 / #20180053298

Methods and systems for three-dimensional real-time intraoperative surgical margin evaluation of tumor tissues

A method of evaluating a surgical margin of tumor tissues of a living subject includes acquiring images of a specimen of the tumor tissues; calculating a three-dimensional (3d) morphological surface of the specimen from the acquired images and displaying the 3d morphological surface; obtaining, from the 3d morphological surface, a plurality of specimen locations to cover a surface of the specimen; acquiring optical data at each specimen location; evaluating a margin status of the specimen at each specimen location to either positive or negative based on the acquired optical data; and displaying the margin status of the specimen on the 3d morphological surface of the specimen with morphological orientations.. . ... Vanderbilt University

02/22/18 / #20180050083

Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. ... Vanderbilt University

02/01/18 / #20180030105

Therapeutic compositions and methods for disorders associated with neuronal degeneration

Disclosed are isolated mutant erythropoietin (epo) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including such peptides and nucleic acids. The mutant epo peptides are unique in that they include a substitution at amino acid position number 76, such as a glutamic acid for arginine substation at position 76. ... Vanderbilt University

02/01/18 / #20180028501

Positive allosteric modulators of the muscarinic acetylcholine receptor m4

Disclosed herein are thieno[3,2-e][1,2,4]triazolo[1,5-a]pyridin-6-amine, thieno[3,2-e][1,2,4]triazolo[4,3-a]pyridin-3-amine, and imidazo[1,2-a]thieno[3,2-e]pyridin-3-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor m4 (machr m4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.. ... Vanderbilt University

02/01/18 / #20180028440

Milrinone composition and method for administering same

Embodiments of the present invention include inhalable composition, comprising milrinone or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable carrier, an excipient, a surfactant; the composition being capable of being administered by inhalation.. . ... Vanderbilt University

01/25/18 / #20180022746

Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

01/25/18 / #20180022745

Isoquiniline and napthalene-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

01/25/18 / #20180022744

Benzothiazole and benzisothiazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

01/25/18 / #20180022712

Negative allosteric modulators of metabotropic glutamate receptor 3

Described are negative allosteric modulators of metabotropic glutamate receptor 3 (mglu3), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, cognitive disorders, schizophrenia, alzheimer's disease, or cancer in a subject.. . ... Vanderbilt University

01/25/18 / #20180021312

Benzoisoxazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mglur4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.. . ... Vanderbilt University

01/25/18 / #20180020935

Intravenous access device detecting intravenous infiltration and in-vein placement

Aspects of the invention relates to systems and methods for monitoring an intravenous (iv) line functionality of an iv device. In one embodiment, the system includes an iv catheter to be inserted into the vein of the living subject, at least one pressure sensor in fluid communication with the iv catheter to acquire peripheral venous signals; and a processing device. ... Vanderbilt University

01/04/18 / #20180005391

System and method for correcting data for deformations during image-guided procedures

Systems and methods for collecting and processing physical space data for use while performing an image-guided surgical (igs) procedure are provided. The system and method includes obtaining a computer model of a non-rigid structure of interest in a patient and performing a rigid alignment of the computer model and surface data in a patient space associated with at least a portion of the non-rigid structure. ... Vanderbilt University

01/04/18 / #20180005381

Image segmentation via multi-atlas fusion with context learning

Systems and methods are provided for segmenting tissue within a computed tomography (ct) scan of a region of interest into one of a plurality of tissue classes. A plurality of atlases are registered to the ct scan to produce a plurality of registered atlases. ... Vanderbilt University

12/28/17 / #20170373434

Multi-platform modular device

A multi-platform modular device including a plurality of platforms or modules. Each module implements a different function and can be connected to another module via a plurality of magnetic contacts. ... Vanderbilt University

12/28/17 / #20170369505

Positive allosteric modulators of the muscarinic acetylcholine receptor m4

Disclosed herein are tricyclic compounds, including pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine-8-amine, pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4-amine, pyrazino[2′,3′:4,5]thieno[3,2-d]pyrimidin-4-amine, pyrido[3′,2′:4,5]furo[3, 2-d]pyrimidin-4-amine, and pyrimido[4′,5′:4,5]furo[2,3-c]pyridazin-8-amine compounds, which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor m4 (machr m4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.. ... Vanderbilt University

12/21/17 / #20170364630

Identification of cellular antimicrobial drug tablets through interactome analysis

A method of identifying a promising cellular antiviral or bacterial toxin drug target is described including: 1) providing a plurality of potential antiviral or bacterial toxin drug targets; 2) generating an interactome including the potential drug targets using a systems-biology computational method; and 3) analyzing the interactome to identify one or more promising antiviral or bacterial toxin drug targets. New indications for older drugs identified using this method are also described.. ... Vanderbilt University

12/07/17 / #20170348398

Compositions and methods for decreasing blood glucagon levels

Disclosed are improved compositions and methods for decreasing blood glucagon levels. As disclosed herein, l-glutamine is a selective stimulator of α-cell proliferation generated when glucagon signaling is interrupted. ... Vanderbilt University

11/30/17 / #20170340614

Compositions and methods of treating muscular dystrophy with thromboxane-a2 receptor antagonists

The present invention is directed to methods of treating and/or ameliorating muscular dystrophy and/or treating cardiomyopathy in muscular dystrophy patients by administration of a therapeutically effective amount of a thromboxane a2 receptor antagonist.. . ... Vanderbilt University

11/23/17 / #20170333520

Compositions and methods for the treatment of disorders involving epithelial cell apoptosis

The present invention provides therapeutic and prophylactic compositions for use in treating and preventing disorders involved epithelial cell apoptosis, such as gastrointestinal disorders (e.g., inflammatory bowel disease, crohn's disease or ulcerative colitis) in a subject, such as a human patient.. . ... Vanderbilt University

11/23/17 / #20170333222

Systems and method for volitional control of jointed mechanical device based on surface electromyography

Systems and methods for controlling a weight bearing member having at least one powered joint are provided. A system includes a velocity reference module for receiving myoelectric control signals from a user during a non-weight bearing mode for the powered joint and generating a velocity reference for the powered joint based on the myoelectric control signals. ... Vanderbilt University

11/23/17 / #20170332919

Device and method for hemorrhage detection and guided resuscitation and applications of same

Aspects of the invention relates to systems and methods for detecting volume status, volume overload, dehydration, hemorrhage and real time assessment of resuscitation, as well as organ failure including but not limited cardiac, renal, and hepatic dysfunction, of a living subject using non-invasive vascular analysis (niva). In one embodiment, a non-invasive device, which includes at least one sensor, is used to acquire vascular signals from the living subject in real time. ... Vanderbilt University

11/16/17 / #20170325787

Phantom design for testing of doppler ultrasound function

A doppler phantom includes a first reservoir, a second reservoir, a fluid line coupling the first and second reservoirs, a pressure line coupling the first and second reservoirs, and a tissue mimicking material surrounding at least the fluid line. The phantom can be positioned in first and second positions, where the first reservoir defines an elevated reservoir and the second reservoir defines a lower reservoir in the first position, where the second reservoir defines the elevated reservoir and the first reservoir defines the lower reservoir in the second position. ... Vanderbilt University

11/09/17 / #20170319611

Methods and compositions comprising akt inhibitors and/or phospholipase d inhibitors

Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase d inhibitors and/or akt therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

10/05/17 / #20170283387

Metabolism probes for therapy and diagnosis

Novel 2-substituted glutamylanides useful as modulators of asct2 inhibitors. Compounds of the present invention can be used to treat patients suffering from diseases caused or influenced by abnormal asct2 transporter dysfunction.. ... Vanderbilt University

10/05/17 / #20170281453

Movement assistance device

A apparatus includes an a exoskeleton system with a plurality of sensors for generating signals indicating a current motion and a current arrangement of at least the exoskeleton system, a hip segment, and at least one lower limb. The lower limb includes thigh and shank segments for coupling to a lateral surface of a user's leg. ... Vanderbilt University

09/21/17 / #20170265950

Dexterous wrists

A rotatable wrist connecting a gripper tool to the distal end of a positioning shaft. The rotatable wrist includes a wrist hub that is non-rotatably connected to the distal end of the shaft. ... Vanderbilt University

09/14/17 / #20170258771

Compositions and methods of treating cardiac fibrosis with ifetroban

The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.. . ... Vanderbilt University

09/07/17 / #20170253617

Substituted 5-membered heterocyclic analogs as protease activated receptor 4 (par-4) antagonists

Embodiments of the invention include compounds and compositions thereof to inhibit protease activated receptor-4. Also described are methods of preparation of compositions and methods for treating diseases related to thrombotic disorders by administration of the composition.. ... Vanderbilt University

08/31/17 / #20170250431

Polymer solution, fiber mat, and nanofiber membrane-electrode-assembly therewith, and method of fabricating same

In one aspect of the present invention, a fiber mat is provided. The fiber mat includes at least one type of fibers, which includes one or more polymers. ... Vanderbilt University

08/31/17 / #20170247366

Substituted 4-alkoxypicolinamide analogs as mglur5 negative allosteric modulators and methods of making and using the same

Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mglur5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

08/31/17 / #20170246149

Compositions and methods for treating microbial infections

Embodiments of the presently-disclosed subject matter include activators of hssrs that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting s. ... Vanderbilt University

08/31/17 / #20170245889

Movement dampening system for a surgical tool

A movement dampening system for a surgical tool. The system includes a height-adjustable base positionable adjacent to a surgical site on a patient. ... Vanderbilt University

08/31/17 / #20170245741

Hydro-jet endoscopic capsule and methods for gastric cancer screening in low resource settings

Systems and methods are provided for controlling lateral movement of a medical capsule system. A capsule housing is configured to be inserted into an anatomical structure of a patient. ... Vanderbilt University

08/24/17 / #20170238841

Oral end tidal carbon dioxide probe for diagnosing pulmonary arterial hypertension

This disclosure concerns improved capabilities for evaluating pulmonary arterial hypertension (pah). A system and method of evaluating pah in a subject may include measuring end tidal partial pressure of exhaled carbon dioxide in the subject, wherein the measurement is made orally using described systems or devices. ... Vanderbilt University

08/03/17 / #20170220850

System for interpretation of image patterns in terms of anatomical or curated patterns

Imaging mass spectrometry (ims) has become a prime tool for studying the distribution of biomolecules in tissue. Although ims data sets can become very large, computational methods have made it practically feasible to search these experiments for relevant findings. ... Vanderbilt University

08/03/17 / #20170219721

Gamma ray spectroscope for determining a composition of an asteroid or the regolith of the asteroid

Disclosed and described herein are embodiments and methods of use of a gamma ray spectroscope. In one aspect the gamma ray spectroscope comprises a scintillator for receiving radiation and a solid-state photomultiplier for detecting and amplifying light emitted by the scintillator in response to the received radiation, wherein an electrical output signal is provided by the photomultiplier that is proportional to the received radiation.. ... Vanderbilt University

07/27/17 / #20170208809

Compositions for inhibition of insect sensing

In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitoes. ... Vanderbilt University

07/20/17 / #20170205377

Apparatus and methods for probing a material as a function of depth using depth-dependent second harmonic generation

A method for non-invasively probing at least one physics property of a solid material. In one embodiment, the method has the steps of splitting a photon beam into a first photon beam and a second photon beam, exposing the solid material to the first photon beam to generate a coherent acoustic phonon wave in the solid material at time t, and exposing the solid material to the second photon beam at a time t+Δt, where t+Δt≧t, to generate corresponding second harmonic generation signals, where from the corresponding second harmonic generation signals, the at least one physics property of the solid material is determinable.. ... Vanderbilt University

07/20/17 / #20170204195

Anti-factor xi monoclonal antibodies and methods of use thereof

Compositions and methods for inhibiting thrombosis without compromising hemostasis are described. Compositions include anti-factor xi monoclonal antibodies (aximabs) capable of binding to an epitope on the heavy chain of human fxi, particularly the a3 domain of the heavy chain of human fxi. ... Vanderbilt University

07/06/17 / #20170190717

Compounds and methods for inhibition of hedgehog signaling and phosphodiesterase

Compounds and compositions, and methods of use thereof, are provided and have utility in inhibiting hedgehog signaling and/or phosphodiesterase-4 activity.. . ... Vanderbilt University

06/29/17 / #20170182659

Systems and methods for safe compliant insertion and hybrid force/motion telemanipulation of continuum robots

Methods and systems are described for controlling movement and an applied force at the tip of the continuum robot that includes a plurality of independently controlled segments along its length. An estimated force at the tip of the continuum robot is determined based on measurements of loads and positions of each segment. ... Vanderbilt University

06/22/17 / #20170177967

Methods for automatic segmentation of inner ear anatomy in post-implantation ct and applications of same

A method for automatic segmentation of intra-cochlear anatomy in post-implantation ct image of bilateral cochlear implant recipients includes coarsely segmenting a labyrinth with a labyrinth surface chosen from a library of inner ear anatomy shapes; creating a target specific asm for each of the labyrinth and the sois using a set of inner ear anatomy surfaces selected from the library of inner ear anatomy shapes such that the set of inner ear anatomy surfaces has the smallest dissimilarity quantity with the coarsely localized labyrinth surface in the post-implantation ct image; refining the coarsely segmented labyrinth surface by performing an asm-based segmentation of the labyrinth using the target-specific asm of the labyrinth to obtain a segmented labyrinth; and fitting the points of the target-specific asm of the sois to their corresponding points on the segmented labyrinth to segment the sois in the post-implantation ct image.. . ... Vanderbilt University

06/22/17 / #20170174689

Substituted indole mcl-1 inhibitors

The present invention provides for compounds that inhibit the activity of an anti-apoptotic bcl-2 family member myeloid cell leukemia-1 (mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of mcl-1 protein.. ... Vanderbilt University

06/22/17 / #20170172595

Surgical grasper

A surgical grasper includes a first handle arm, a second handle arm pivotally coupled to the first handle arm, a tool body pivotally coupled to both the first handle arm and the second handle arm, a first jaw member pivotally coupled to the tool body, a second jaw member pivotally coupled to the tool body, a first tension element coupled to both the first handle arm and to the first jaw member, a second tension element coupled to both the second handle arm and to the second jaw member, and a lock that locks relative movement between the first and second handle arms. Rotational movement of the first and second handle arms generates correlated rotational movement of the first and second jaw members.. ... Vanderbilt University

06/15/17 / #20170168054

Methods and systems for predicting response to immunotherapies for treatment of cancer

A method of detecting cell membrane expression of an mhc molecule in a subject, a method of treating cancer in a subject with an immunotherapeutic agent, and an mhc complex are provided. The method of detecting cell membrane expression of an mhc molecule includes obtaining a tumor cell sample from a subject, and detecting cell membrane expression of the mhc molecule by contacting the tumor cell sample with an antibody targeting the mhc molecule and detecting binding between the mhc molecule and the antibody. ... Vanderbilt University

06/15/17 / #20170166710

Polycarbonate containing compounds and methods related thereto

Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The crosslinked polycarbonates can be prepared from allyl or epoxy polycarbonates. ... Vanderbilt University

06/15/17 / #20170164934

Method and device for extracting multiple tissue samples

A multipurpose tissue sampling device is provided for extracting at least one tissue sample from a tissue sampling site. An outer sheath has a cutting surface and an outer sheath lumen extending from an outer sheath proximal end to an outer sheath distal end. ... Vanderbilt University

06/08/17 / #20170157400

Methods and systems for customizing cochlear implant stimulation and applications of same

One aspect of the invention provides a method for customizing cochlear implant stimulation of a living subject. The cochlear implant includes an electrode array having a plurality of electrodes implanted in a cochlea of the living subject. ... Vanderbilt University

06/01/17 / #20170153218

Methods of detecting sulfur-containing compounds

Methods of detecting a sulfur-containing compound in a sample are described, for example using nmr-sabre hyperpolarization of the sulfur-containing compounds in the sample. The methods can comprise, for example, contacting a sample comprising a sulfur-containing compound with parahydrogen and a catalyst to form a mixture. ... Vanderbilt University

05/18/17 / #20170135675

Adaptive clutter demodulation for ultrasound imaging

Systems and methods for adaptive clutter demodulation in ultrasound imaging are provided. The method includes obtaining a plurality of beamformed radiofrequency (rf) lines representing an ultrasound scan and computing displacements between adjacent ones of the plurality of beamformed rf lines. ... Vanderbilt University

05/11/17 / #20170129889

Substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m1

In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor m1 (machr m1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

05/11/17 / #20170128055

Method and device for extracting multiple tissue samples

A multipurpose tissue sampling device is provided for extracting at least one tissue sample from a tissue sampling site. An outer sheath has a cutting surface and an outer sheath lumen extending from an outer sheath proximal end to an outer sheath distal end. ... Vanderbilt University

05/04/17 / #20170119924

Poly(thioketal-urethane) scaffolds and methods of use

A biodegradable scaffold, a low-molecular weight thioketal, and a method of forming a biodegradable scaffold are provided. The biodegradable scaffold includes a thioketal and an isocyanate, where the thioketal is linked to the isocyanate to form the scaffold. ... Vanderbilt University

05/04/17 / #20170119715

Therapeutic methods employing nitric oxide precursors

Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase i phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase i polymorphism. By analyzing genomic dna or amplified genomic dna, or amplified cdna derived from mrna, it is possible to type a human carbamyl phosphate synthetase i with regard to the human carbamyl phosphate synthetase i polymorphism, for example, in the context of diagnosing and treating hepatic veno-occlusive disease (hvod) associated with bone marrow transplants.. ... Vanderbilt University

04/20/17 / #20170105623

Intra-operative use of fluorescence spectroscopy and applications of same

In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining raman data from light scattered from the illuminated tissues, finding raman signatures corresponding to thyroid or parathyroid tissues from the obtained raman data, and identifying the thyroid or parathyroid tissues from the corresponding raman signatures.. ... Vanderbilt University

04/13/17 / #20170100454

Compositions and methods for targeting nuclear import shuttles and treating inflammatory disorders

The present invention relates to compositions and methods for treating autoimmune, microbial, metabolic, neoplastic, and posttraumatic diseases mediated by inflammation in a subject. Compositions and methods including at least one importin beta-selective nuclear transport modifier (ntm) and/or at least one importin alpha-selective ntm, and/or at least one importin alpha-specific ntm, and/or at least one inhibitor of importin alpha and importin beta complex formation may be administered to a subject to modulate the transport of transcription factors, mediated by nuclear import adaptors, into the nucleus of a cell resulting in a decrease or abrogation of inflammation.. ... Vanderbilt University

04/13/17 / #20170100264

Coordinating operation of multiple lower limb devices

Systems and methods for operating autonomous lower limb devices, including at least one adjustable joint and configured for at least supporting a body are provided. A method includes collecting real-time sensor information associated with the autonomous lower limb device. ... Vanderbilt University

04/06/17 / #20170095668

Multichannel biphasic signal generator circuit

A circuit includes first and second current control sub-circuits connected in series between a dc supply voltage node and a reference voltage node and third and fourth current control sub-circuits connected in series between the dc supply voltage node and the reference voltage node. The circuit also includes a dc/dc converter with a first input terminal coupled to the first load node between the first and second current control sub-circuits, a second input terminal coupled to a second load node between the third and fourth current control sub-circuits, a first output terminal, and a second output terminal. ... Vanderbilt University

04/06/17 / #20170095299

Concentric tube robot

A robotic surgical apparatus includes at least two tubes having a nested, concentric configuration with an inner tube positioned in an outer tube. The tubes are configured to deliver surgical therapy. ... Vanderbilt University

03/30/17 / #20170091411

Systems and methods for serial treatment of a muscular-skeletal deformity

Systems and methods for establishing a serial treatment plan to correct a muscular-skeletal deformity of a subject are described herein. A method can include receiving an image of a portion of the subject's body having the muscular-skeletal deformity, processing the image of the portion of the subject's body to establish a quantitative measure of the muscular-skeletal deformity, and determining a therapeutic state to correct the muscular-skeletal deformity. ... Vanderbilt University

03/23/17 / #20170082836

Telecentric lens assembly providing a collimated light space

Systems and methods for imaging a target are provided. A system includes a detector and a substantially bitelecentric lens assembly positioned between the detector and the target. ... Vanderbilt University

03/23/17 / #20170082606

High-throughput, multi-omics approach to determine and validate de novo global mechanisms of action for drugs and toxins

The present disclosure provides for rapid identification of mechanism of action (moa) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.. ... Vanderbilt University

03/23/17 / #20170081625

Interconnections of multiple perfused engineered tissue constructs and microbioreactors, multi-microformulators and applications of the same

The invention relates to a system of fluidic valves and pumps and associated fluidic channels integratable into a bio-object microfluidics module. The module can include input and output buses; upstream and downstream interconnection bus control valves (cvs) coupled to the input and output buses, respectively. ... Vanderbilt University

03/09/17 / #20170067906

Pre-coated surfaces for imaging biomolecules

Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. ... Vanderbilt University

02/16/17 / #20170043136

Torque device

A device for manipulating a wire includes a first structure and a second structure pivotably mounted with respect to each other so as to define respective facing surfaces configured for alternating between a closed position and at least one open position, where each of the respective facing surfaces includes one or more detent elements and one or more tooth elements extending therefrom. In the device, the tooth elements of the first structure and the second structure are in an interlocking and overlapping arrangement in at least the closed position. ... Vanderbilt University

02/16/17 / #20170042964

Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. ... Vanderbilt University

02/16/17 / #20170042869

Methods for limiting acute kidney injury

Method of limiting development of acute kidney injury (aki) and treating aki using pyridoxamine are described, together with methods for monitoring efficacy of pyridoxamine therapy.. . ... Vanderbilt University

02/09/17 / #20170039822

Dynamic alarm system for reducing alarm fatigue

A dynamic alarm system that can assess the background noise in a clinical environment with sub-minute time sampling and change the alarm output to a desired signal-to-noise ratio (snr) below ambient noise (negative snr) to minimize clinician fatigue and ameliorate deleterious patient outcomes, while preserving clinician performance.. . ... Vanderbilt University

02/09/17 / #20170036883

Apparatus and method for moving an elongate rod

An apparatus for moving an elongate rod longitudinally and rotationally, and a method of moving the elongate rod longitudinally and rotationally, are provided. A translation member has a first translation member end held relatively stationary and a longitudinally spaced second translation member end which is selectively movable longitudinally with respect to the first translation member end via actuation of the translation member. ... Vanderbilt University

02/02/17 / #20170030903

Low resource method and device for detecting analytes

Systems and methods are described for isolation, separation and detection of a molecular species using a low resource device for processing of samples. Methods include isolation, separation and detection of whole cells.. ... Vanderbilt University

01/26/17 / #20170023547

Chemical threat assessment by rapid molecular phenotyping

Systems and methods for characterizing the cellular response of one or more animal cells to a chemical agent are described. The method includes the steps of: exposing one or more animal cells to a chemical agent; generating data representing an altered molecular phenotype of the one or more animal cells after exposure to the chemical agent using a multi-omic analysis; providing the data representing the altered molecular phenotype to a system comprising a processor; using the system to compare the data representing the altered molecular phenotype with data representing a normal molecular phenotype of the one or more animal cells; and using the system to output a characterization of the cellular response of the one or more animal cells to the chemical agent based on the results of comparing the data.. ... Vanderbilt University

01/26/17 / #20170022216

Substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs as positive allosteric modulators of the muscarinic acetylcholine receptor m4

In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor m4 (machr m4); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

01/26/17 / #20170022173

Substituted 4-benzyl-3,4-dihydro-2h-benzo[b][1,4]oxazine-2carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor m1

In one aspect, the invention relates to n-substituted 3,4-dihydro-benzo[£][1,4]oxazine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor m1 (machr m1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... Vanderbilt University

01/26/17 / #20170022070

System and methods for removing impurities from phosphogypsum and manufacturing gypsum binders and products

Methods and systems that remove impurities from phosphogypsum (pg), including from radium and heavy metal salts, and produce gypsum binders and products. In one embodiment, pg is reacted with a chloride solution in an acidic environment under mechanical manipulation and/or heat followed by galvanic and/or zeolite absorption removal of impurities.. ... Vanderbilt University

01/26/17 / #20170020894

Bile acid receptor agonism for treating addiction

Compositions and methods for treating addiction in a subject are disclosed. In particular, compositions and methods for treating addiction to a dopaminergic psychostimulant are disclosed. ... Vanderbilt University

01/12/17 / #20170008937

Compositions and methods for treating or preventing clostridium infection

Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. ... Vanderbilt University

01/12/17 / #20170007723

Fluorocoxib a loading into ros-responsive nanoparticles

Disclosed are compositions that comprise a cyclooxygenase-2-selective therapeutic and/or diagnostic agent having a therapeutic and/or diagnostic agent conjugated to a nsaid drug; and a ros-responsive nanoparticle. Methods of making and using these compositions for drug encapsulation and delivery are also disclosed.. ... Vanderbilt University








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