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Vrije Universiteit Brussel patents


Recent patent applications related to Vrije Universiteit Brussel. Vrije Universiteit Brussel is listed as an Agent/Assignee. Note: Vrije Universiteit Brussel may have other listings under different names/spellings. We're not affiliated with Vrije Universiteit Brussel, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "V" | Vrije Universiteit Brussel-related inventors


Single domain antibodies capable of modulating bace activity

Described are single domain antibodies with a specificity for bace1. More specifically, described are single variable-domain antibodies derived from camelids that bind to bace1 and are capable of inhibiting the activity of bace1. ... Vrije Universiteit Brussel

Front-end module comprising an ebd circuit, telecommunication device comprising the front-end module and method for operatingthem

The present disclosure relates to a front-end module for a telecommunication device with an ebd circuit comprising a hybrid transformer for coupling via a transmit port to the telecommunication device transmitting a first frequency transmit signal, to an antenna, via a receive port to the telecommunication device receiving a second frequency receive signal, and to a tunable impedance circuit. In a first configuration the ebd circuit is configured to isolate the transmit port from the receive port at the first frequency, and the fem comprises a first filter at the transmit port for attenuating the transmit signal with a predetermined amount at the second frequency. ... Vrije Universiteit Brussel

High-performance liquid chromatography

A chromatographic column assembly is described, comprising a channel and a flow inducer. The channel comprises an inlet for receiving a sample liquid and an outlet, and is adapted for separating the sample liquid into components when the sample liquid flows through the channel in an axial direction from the inlet to the outlet. ... Vrije Universiteit Brussel

Hydrogel-forming peptides

Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.. ... Vrije Universiteit Brussel

Standard cell having vertical transistors

The disclosed technology generally relates to semiconductor devices, and more particularly to a standard cell semiconductor device comprising transistors having vertical channels and a common gate. In one aspect, a standard cell semiconductor device comprises a substrate, a unit cell having a first transistor and a second transistor, a gate layer common to the first and second transistor, and a set of routing tracks for contacting the first and second transistor. ... Vrije Universiteit Brussel

Static random access memory cell

The disclosed technology generally relates to semiconductor memory devices, and more particularly to a static random access memory (sram) device. One aspect of the disclosed technology is a bit cell for a static random access memory (sram) comprising: a first and a second vertical stack of transistors arranged on a substrate. ... Vrije Universiteit Brussel

Sensor for monitoring freezing status of products

A sensor system for sensing a level of frozenness of a predetermined product comprises at least one emission antenna for directing electromagnetic radiation with at least one frequency within a frequency range of 0.1 ghz to 10 thz to a product and at least one receiver for receiving said electromagnetic radiation after transmission through or reflection from said product. The sensor system furthermore comprises at least one data processing unit for determining a level of frozenness based on said received electromagnetic radiation and taking into account dielectric properties of the predetermined product based on a physical-mathematical model of the product or calibration data.. ... Vrije Universiteit Brussel

Characterization of multilayer structures

A method for determining characteristics of a layer-based structure comprises repetitively irradiating the layer-based structure with a transient continuous wave electromagnetic radiation and capturing as a function of time a transient part of the reflection or transmission of the transient continuous wave electromagnetic radiation reflected at or transmitted through the different interfaces of layer-based structure. The method furthermore comprises deriving from the transient part of the reflected or transmitted transient continuous wave electromagnetic radiation as function of time information regarding different contributions in the transient part of the reflected or transmitted transient continuous wave electromagnetic radiation stemming from the reflections at different interfaces of the layer-based structure and determining from said information at least geometric information and/or electromagnetic properties of the different layers of the layer based structure. ... Vrije Universiteit Brussel

Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and its use in vaccination

We provide new methods of in vitro or in vivo enhancing the t-cell stimulatory capacity of human dcs and the use thereof in cancer vaccination. The method includes the introduction of different molecular adjuvants to human dcs by contacting or modifying them with mrna or dna molecule(s) encoding cd40l, and cd70 or constitutively active tilr4 (catlr4).. ... Vrije Universiteit Brussel

Optimized liver-specific expression systems for fviii and fix

The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor ix or factor viii transgenes, methods employing these expression cassettes and vectors and uses thereof. The present invention is particularly useful for applications using liver-directed gene therapy, in particular for the treatment of hemophilia a and b.. ... Vrije Universiteit Brussel

Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response

The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (vhh) or a functional fragment thereof, wherein said vhh or a functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor, e.g. Her2. ... Vrije Universiteit Brussel

Polar transmitter and method for generating a transmit signal using a polar transmitter

A polar transmitter provided for transmitting a phase/frequency modulated and amplitude modulated transmit signal and a method for generating a transmit signal using a polar transmitter are described. An example polar transmitter comprises a phase locked loop for generating a phase/frequency modulated precursor of the transmit signal. ... Vrije Universiteit Brussel

Endotracheal tube for mechanical ventilation

The present invention relates generally to medical devices, methods, and kits. More particularly, the present invention relates to improved endotracheal tubes or patient ventilation tubes which prevent the leakage of proximal secretions to the distal airways.. ... Vrije Universiteit Brussel

Semiconductor device with stacked layout

The disclosed technology generally relates to semiconductor devices, and more particularly to semiconductor devices having a stacked arrangement, and further relates to methods of fabricating such devices. In one aspect, a semiconductor device comprises a first memory device and a second memory device formed over a substrate and at least partly stacked in a vertical direction. ... Vrije Universiteit Brussel

11/30/17 / #20170346493

Dtc-based pll and method for operating the dtc-based pll

The disclosure provides a phase locked loop, pll, for phase locking an output signal to a reference signal. The pll comprises a reference path providing the reference signal to a first input of a phase detector, a feedback loop providing the output signal of the pll as a feedback signal to a second input of the phase detector, a controllable oscillator generating the output signal based on at least a phase difference between reference and feedback signal, a digital-to-time converter, dtc, delaying a signal that is provided at one of the first and second input, a delay calculation path for calculating a dtc delay value. ... Vrije Universiteit Brussel

11/30/17 / #20170342379

In vitro maturation of a mammalian cumulus oocyte complex

The present invention relates to a composition and method for assisted reproductive technology in mammals. In particular, the present invention provides compositions and methods for in vivo maturation of an immature cumulus oocyte complex (coc), thereby enhancing the embryology outcome.. ... Vrije Universiteit Brussel

10/05/17 / #20170283470

Mutant csgg pores

The invention relates to mutant forms of the outer membrane located lipoprotein csgg, in particular, modifications at one or more of positions tyr51; asn55; and phe56. The invention also relates to analyte detection and characterisation using said mutant csgg.. ... Vrije Universiteit Brussel

09/28/17 / #20170276883

Optical fiber connection system including optical fiber alignment device

A self-centering structure (300) for aligning optical fibers (308) desired to be optically coupled together is disclosed. The self-centering structure (300) including a body (310) having a first end (312) and a second end (314). ... Vrije Universiteit Brussel

08/10/17 / #20170226493

Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose

Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.. . ... Vrije Universiteit Brussel

07/13/17 / #20170199443

Systems for nonlinear optical wave-mixing

A system for conversion or amplification using quasi-phase matched nonlinear optical wave-mixing includes a first radiation source for providing a pump radiation beam, a second radiation source for providing a signal radiation beam, a bent structure for receiving the pump radiation beam and the signal radiation beam, and an outcoupling radiation propagation portion for coupling out an idler radiation beam generated in the bent structure. A radiation propagation portion of the bent structure is made of a uniform three-dimensional material at least partly covered by a two-dimensional or quasi-two-dimensional material layer and has a dimension taking into account the spatial variation of the nonlinear optical susceptibility along the radiation propagation portion as experienced by radiation traveling along the bent structure for obtaining quasi-phase matched nonlinear optical wave-mixing in the radiation propagation portion. ... Vrije Universiteit Brussel

06/29/17 / #20170187510

Telecommunications device comprising an electrical balance duplexer and method for balancing the electrical balance duplexer

The present disclosure relates to a telecommunications device. The telecommunications device includes an electrical balance duplexer connected to an output node of a transmission path, an input node of a receive path, an antenna, and a tunable impedance. ... Vrije Universiteit Brussel

06/15/17 / #20170166870

Human hepatic 3d co-culture model and uses thereof

The invention in general relates to human hepatic 3d co-culture models, more in particular 3d spheroid co-cultures of human hepatocyte-like cells and hepatic stellate cells. Furthermore, the invention provides a method for obtaining such co-cultures, as well as the use of said co-cultures in the identification of pro-fibrotic and/or anti-fibrotic compounds.. ... Vrije Universiteit Brussel

06/15/17 / #20170165088

A prosthesis or orthosis comprising a hinge joint system for functionally assisting, enhancing and/or replacing a hinge joint of a human or animal subject

A prosthesis or orthosis having a movement controlling mechanism (mcm) including a first mcm part, a second mcm part and one or more intermediate elements and biasing mechanism which, in a contacting mode of operation of the mcm, bias the intermediate elements against a mcm part. When a relative torque or force is applied in a blocking sense (u) transmission of torque is allowed and, on the other hand, when a torque or force is applied in the opposite sense (v) non-blocking relative movement is allowed. ... Vrije Universiteit Brussel

06/08/17 / #20170160285

Methods to select for agents that stabilize protein complexes

The application relates to the field of structural biology. More specifically, the disclosure relates to methods for the identification and characterization of biomolecular tools allowing the selective recognition and/or stabilization of distinct conformational states of protein complexes, including transient protein-protein interactions and protein-nucleic acid complexes. ... Vrije Universiteit Brussel

06/01/17 / #20170151537

Mixing of fluids

A micro-reactor system for contacting fluids is described. The system comprises a first microfluidic channel structure for guiding a first fluid to at least one output nozzle thus generating a first sub-flow, a second microfluidic channel structure for guiding a second fluid to at least a second output nozzle thus generating a second sub-flow, said first output nozzle being aligned with said second output nozzle and arranged for contacting the first sub-flow and the second sub-flow. ... Vrije Universiteit Brussel

01/26/17 / #20170026022

Telecommunications device comprising an ebd circuit, a tunable impedance network and a method for tuning a tunable impedance network

A system having a tunable impedance network and a method of tuning a tunable impedance network are disclosed. In one aspect, a telecommunications device comprises an electrical-balance duplexer (ebd) circuit coupled to at least one output node of a transmit path (txin), an antenna, and at least one input node of a receive path (rxout), wherein the ebd circuit is configured to isolate the transmit path from the receive path by signal cancellation, and a balancing network (zbal) as part of the ebd circuit. ... Vrije Universiteit Brussel

01/05/17 / #20170000881

Enhancing the t-cell stimulatory capacity of human antigen presenting cells in vitro and in vivo and its use in vaccination

We provide new methods of in vitro or in vivo enhancing the t-cell stimulatory capacity of human dcs and the use thereof in cancer vaccination. The method includes the introduction of different molecular adjuvants to human dcs by contacting or modifying them with mrna or dna molecule(s) encoding cd40l, and cd70 or constitutively active tlr4 (catlr4).. ... Vrije Universiteit Brussel








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