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Wake Forest University Health Sciences patents


Recent patent applications related to Wake Forest University Health Sciences. Wake Forest University Health Sciences is listed as an Agent/Assignee. Note: Wake Forest University Health Sciences may have other listings under different names/spellings. We're not affiliated with Wake Forest University Health Sciences, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "W" | Wake Forest University Health Sciences-related inventors


Bioscaffolds for formation of motor endplates and other specialized tissue structures

Provided herein are scaffolds and methods useful to promote the formation of functional clusters on a tissue, for example, motor endplates (meps) or a component thereof on skeletal muscle cells or tissue, as well as the use of scaffolds so produced for repairing a tissue injury or defect.. . ... Wake Forest University Health Sciences

Vascular territory segmentation using mutual clustering information from image space and label space

Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional weighted cbf territory map of color-coded source artery locations using an automated vascular segmentation process to identify source locations using mutual connectivity in both image and label space.. . ... Wake Forest University Health Sciences

Vascular cast-based scaffolds and methods of making the same

The present application relates to biomimetic three-dimensional (3d) scaffolds, constructs and methods of making the same. The three-dimensional scaffold can include a sacrificial internal cast and a durable external scaffold material, wherein the durable external scaffold material comprises a biocompatible material which completely surrounds the sacrificial internal cast and wherein the sacrificial internal cast be removed to yield a branching 3d network of hollow, vessel-like tubes that substantially mimics a native tissue or organ.. ... Wake Forest University Health Sciences

Muscle tissue regeneration using muscle fiber fragments

The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. ... Wake Forest University Health Sciences

Bioenergetic profiling of circulating blood cells and systems, devices, and methods relating thereto

The invention relates generally to systems and methods of bioenergetic profiling, uses thereof, and systems and devices relating thereto. In particular, methods of the invention are useful in assessing wellness, particularly in elderly subjects. ... Wake Forest University Health Sciences

Methods and compositions for correlating genetic markers with prostate cancer risk

The present invention provides methods of assessing an individual subject's risk of developing prostate cancer, comprising: a) analyzing a nucleic acid sample obtained from the subject and determining a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; and b) calculating a cumulative relative risk (crr) for the subject based on the genotype determined in step (a). A crr of greater than 1.00 identifies a subject as having an increased risk of developing prostate cancer and also can identify a subject who is a candidate for early psa screening, prostate biopsy and/or chemoprevention.. ... Wake Forest University Health Sciences

Neural progenitor cell differentiation

Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions. ... Wake Forest University Health Sciences

Antibodies against human and canine il-13ra2

Provided herein are monoclonal antibodies that specifically bind il-13ra2 with cross-reactivity in humans and canines. Also provided are methods of use of the antibodies in the treatment and monitoring of cancers.. ... Wake Forest University Health Sciences

Methods of treating cancerous tissue

In one aspect, methods of treating cancerous tissue are described herein. In some embodiments, a method of treating cancerous tissue comprises inducing necrotic cell death in cancer stem cells in vivo during hyperthermic treatment of the tissue, wherein inducing necrotic cell death comprises positioning nanoparticles adjacent to the cancer stem cells and irradiating the nanoparticles with electromagnetic radiation resulting in membrane damage to the cancer stem cells.. ... Wake Forest University Health Sciences

Directed stem cell recruitment

The invention is directed to methods of inducing cell recruitment and tissue regeneration at a target site in a subject. It is also based, in part, on the discovery that a subject's own biologic resources and environmental conditions can be used for in situ tissue regeneration and thereby reduce or eliminate the need for donor cell procurement and ex vivo manipulation of such donor cells. ... Wake Forest University Health Sciences

Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same

The present invention is based, in part, on flagellin adjuvant used to enhance immune responses directed against streptococcus pneumoniae, in particular, to enhance immune responses to polypeptide antigens (e.g., pspa) and capsular polysaccharide from s. Pneumoniae. ... Wake Forest University Health Sciences

Devices that allow for rapid change out of endotracheal (et) tubes and related methods

Tracheal tube devices include: (a) a mouthpiece sized and configured to allow an endotracheal tube to extend outwardly therefrom; and (b) a handle holding a cutting member. The mouthpiece can include at least one outwardly projecting substantially rigid short tube. ... Wake Forest University Health Sciences

Stem cells from urine and methods for using the same

Provided herein are stem cells and methods for producing a culture of stem cells from urine. The stem cells may be differentiated into an osteogenic, chondrogenic, adipogenic, endothelial, neurogenic or myogenic lineage. ... Wake Forest University Health Sciences

Methods of predicting predisposition to or risk of kidney disease

Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (fsgs) or hypertensive end-stage kidney disease (eskd) or both in a human subject. The methods include detecting the presence of at least one single nucleotide polymorphism (snp) in an apol1 gene, such as the c-terminal exon of an apol1 gene. ... Wake Forest University Health Sciences

04/05/18 / #20180093016

Tissue-engineered bowel constructs

Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells and neural progenitor cells can be seeded on a mold with a surface texture that induces longitudinal alignment of the intestinal smooth muscle cells and co-cultured until an innervated aligned smooth muscle sheet is obtained. ... Wake Forest University Health Sciences

01/04/18 / #20180002394

Multi-level specific targeting of cancer cells

A compound comprising, in combination: a cell surface binding ligand or internalizing factor, such as an il-13rα2 binding ligand; at least one effector molecule (e.g., one, two, three or more effector molecules); optionally but preferably, a cytosol localization element covalently coupled between said binding ligand and said at least one effector molecule; and a subcellular compartment localization signal element covalently coupled between said binding ligand and said at least one effector molecule (and preferably with said cytosol localization element between said binding ligand and said subcellular compartment localization signal element). Methods of using such compounds and formulations containing the same are also described.. ... Wake Forest University Health Sciences

01/04/18 / #20180000743

Modified alginate hydrogels for therapeutic agents, their preparation and methods thereof

A novel chemically modified alginate hydrogel has been developed which combines an aromatic compound with a carbohydrate, where the aromatic compound is one or more amines combined with an alginate. The chemical structure of alginate is modified using different amines and different methods, including: (1) covalently bonding aminoethyl benzoic acid to the alginate backbone, and (2) oxidizing the vicinal diol in the alginate chain to an aldehyde before coupling to aminoethyl benzoic acid. ... Wake Forest University Health Sciences

12/28/17 / #20170368743

Integrated organ and tissue printing methods, system and apparatus

A method of making an organ or tissue comprises: (a) providing a first dispenser containing a structural support polymer and a second dispenser containing a live cell-containing composition; (b) depositing a layer on said support from said first and second dispenser, said layer comprising a structural support polymer and said cell-containing composition; and then (c) iteratively repeating said depositing step a plurality of times to form a plurality of layers one on another, with separate and discrete regions in each of said layers comprising one or the other of said support polymer or said cell-containing composition, to thereby produce provide a composite three dimensional structure containing both structural support regions and cell-containing regions. Apparatus for carrying out the method and composite products produced by the method are also described.. ... Wake Forest University Health Sciences

12/28/17 / #20170368242

Devices and methods for treating spinal cord tissue

The present invention provides devices and methods that treat damaged spinal cord tissue, such as spinal tissue damaged by disease, infection, or trauma, which may lead to the presence of swelling, compression, and compromised blood flow secondary to interstitial edema.. . ... Wake Forest University Health Sciences

12/14/17 / #20170354763

Multi-layer skin substitute products and methods of making and using the same

Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e., on the opposite side thereof as the first layer, so that the second layer is sandwiched between the first and third layers when the first layer is present), the third layer comprising live mammalian keratinocytes and live mammalian melanocytes in combination in a third hydrogel carrier.. ... Wake Forest University Health Sciences

12/14/17 / #20170354691

Co-encapsulation of live cells with oxygen-generating particles

Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.. ... Wake Forest University Health Sciences

11/23/17 / #20170333177

Bioreactor system and method of enhancing functionality of muscle cultured in vitro

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.. . ... Wake Forest University Health Sciences

10/26/17 / #20170307598

Tissue-mimicking hydrogel compositions for biofabrication

An extrudable hydrogel composition useful for making a three-dimensional organ construct includes a cross-linkable prepolymer, a post-deposition crosslinking group, optionally, an initiator that catalyzes the reaction between the prepolymer and said the crosslinking group; live cells (e.g., plant, animal, or microbial cells), optionally at least one one growth factor, and optionally water to balance. Methods of using the same and products so made are also described.. ... Wake Forest University Health Sciences

10/26/17 / #20170304433

Vaccine compositions and methods of use to treat neonatal subjects

The presently disclosed subject matter relates to the fields of pharmacology and medicine, and provides vaccine compositions and methods of use, particularly influenza compositions and methods of use to treat neonatal subjects.. . ... Wake Forest University Health Sciences

10/12/17 / #20170291017

Subdural drainage catheter with self contained mechanism for restoration of flow following catheter obstruction

A subdural drainage device includes a subdural drainage housing defining a drainage passageway. The drainage passageway has a a subdural drainage device includes a subdural drainage housing defining a drainage passageway. ... Wake Forest University Health Sciences

10/12/17 / #20170290950

Synthesis and use of poly(glycerol-sebacate) films in fibroblast growth regulation

Wound repair materials and methods of using the same to inhibit excess fibrosis are disclosed.. . ... Wake Forest University Health Sciences

08/24/17 / #20170239332

Regeneration of inner ear cells

The invention provides compositions and methods for treating or preventing hearing loss in a subject. The method comprises administering to the subject in need thereof, at least myc or an agent that increases the expression of myc in an inner ear organ, or associated neural structures, of the subject so as to treat or prevent the hearing loss.. ... Wake Forest University Health Sciences

08/10/17 / #20170227430

Compositions and methods for clearing a biological sample

The disclosure provides improved materials and methods for optically clearing biological tissue that is subsequently used for deep tissue imaging analysis. Also provided is a description of a microscopic image acquisition methodology in which imagery of intact tissues are acquired to rapidly acquire microscopy data on a whole-organ scale to maximize cost effectiveness for biological microscopy and minimize time spent performing such analysis.. ... Wake Forest University Health Sciences

07/20/17 / #20170203004

Amniotic membrane powder and its use in wound healing and tissue engineering constructs

The present invention includes compositions and methods for wound healing and tissue regeneration. The compositions of the present invention comprise amniotic membrane powder. ... Wake Forest University Health Sciences

06/01/17 / #20170152568

Methods and compositions for determining indication for prostate biopsy

The present invention provides a method of identifying a subject for whom a prostate biopsy is indicated, comprising: a) determining, from a nucleic acid sample obtained from the subject, a genotype for the subject at a plurality of biallelic polymorphic loci, wherein each of said plurality has an associated allele and an unassociated allele, wherein the genotype is selected from the group consisting of homozygous for the associated allele, heterozygous, and homozygous for the unassociated allele; b) calculating a genetic risk score (grs) for the subject based on the genotype determined in step (a); and c) analyzing the grs of the subject in combination with a prostate specific antigen (psa) level of the subject to identify a prostate cancer detection rate for the subject, whereby a prostate cancer detection rate of greater than or equal to a reference value identifies the subject as a subject for whom a prostate biopsy is indicated.. . ... Wake Forest University Health Sciences

06/01/17 / #20170151435

Methods and devices for improving cognitive function

The present invention provides methods and devices for improving cognitive function. In some embodiments, cognitive function is improved by detecting neuronal activity in the ca3 region of a patient's hippocampus and stimulating the ca3 region of the patient's hippocampus responsive to the neuronal activity detected.. ... Wake Forest University Health Sciences

04/20/17 / #20170107483

Method of producing in vitro testicular constructs and uses thereof

A cell composition composed of spermatogonial stem cells, sertoli cells, leydig cells and optionally peritubular cells, is provided, as is a culture composition, artificial testicular construct, hydrogel composition, and device containing the same. A method for using the device as a physiologically relevant in vitro model of human testicular function to screen compounds for pharmacological or toxicological activity is also provided.. ... Wake Forest University Health Sciences

04/20/17 / #20170106050

Methods of treating incontinence and other sphincter deficiency disorders

A method of treating a sphincter deficiency disorder (e.g., incontinence; gastrointestinal disorders) is carried out by administering stromal cell-derived factor 1 (sdf-1) to a sphincter or sphincter complex, such as a urethral or gastrointestinal sphincter (e.g., a rectal sphincter) of the subject in a treatment-effective amount.. . ... Wake Forest University Health Sciences

04/06/17 / #20170095630

Oxygen port nasal cannula

A device for use in delivering oxygen to a human patient while measuring carbon dioxide exhaled from that patient, comprises: (a) a base member having an oxygen delivery inlet port and a carbon dioxide detection outlet port formed therein separate from the oxygen delivery port; (b) a flexible cannula extending from the base, the cannula having a proximal end portion, an intermediate portion, a distal end portion, a first lumen formed therein, and a second lumen separate from the first lumen formed therein, with the distal end portion connected to the base member, the first lumen in fluid communication with the oxygen delivery inlet port, and the second lumen in fluid communication with the carbon dioxide detection outlet port.. . ... Wake Forest University Health Sciences

04/06/17 / #20170095204

Oral apparatus with rigid sensor capture component for strong coupling to upper jaw

An oral apparatus comprising a sensor or a plurality of sensors is provided for accurately measuring mechanical forces associated with concussive and sub-concussive impacts to the head, especially as in sports.. . ... Wake Forest University Health Sciences

03/30/17 / #20170087548

Cell pathology tubes and associated cell processing methods

Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. ... Wake Forest University Health Sciences

03/30/17 / #20170087278

Methods for making a tissue engineered muscle repair (temr) construct in vitro for implantation in vivo

Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.. . ... Wake Forest University Health Sciences

03/23/17 / #20170082629

Diagnostic and prognostic markers for cancer

Compositions and methods useful for diagnosis and prognosis of cancer are provided.. . ... Wake Forest University Health Sciences

03/23/17 / #20170082599

Selective analysis of modified biological molecules with solid-state nanopores

In one aspect, methods are described herein for the selective detection and quantitative analysis of biological molecule compositions. A method described herein comprises providing a mixture comprising biological molecules, such as dna, rna or proteins, complexed with a translocating agent, such as another dna or protein, and non-complexed biological molecules. ... Wake Forest University Health Sciences

03/16/17 / #20170072150

Halotherapy devices and methods

Devices and methods for administering halotherapy are provided for treating respiratory or skin conditions. Variations include a portable devices as well as stationary devices suitable for administering therapy in permanent settings (e.g., in the home).. ... Wake Forest University Health Sciences

03/16/17 / #20170071972

Method of treating peripheral neuropathies and motor neuron diseases

A composition comprising a molecule for use in the delivery of the molecule to the peripheral nervous system (pns) and/or to the central nervous system (cns), wherein the composition is administered by regional infusion.. . ... Wake Forest University Health Sciences

03/09/17 / #20170067059

Methods and compositions for treatment of chlamydial infection and related diseases and disorders

The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with chlamydial infection in a subject.. . ... Wake Forest University Health Sciences

02/09/17 / #20170035551

Bioreactor system and method of enhancing functionality of muscle cultured in vitro

A method of producing organized skeletal muscle tissue from precursor muscle cells in vitro comprises: (a) providing precursor muscle cells on a support in a tissue media; then (b) cyclically stretching and relaxing the support at least twice along a first axis during a first time period; and then (c) optionally but preferably maintaining the support in a substantially static position during a second time period; and then (d) repeating steps (b) and (c) for a number of times sufficient to enhance the functionality of the tissue formed on the support and/or produce organized skeletal muscle tissue on the solid support from the precursor muscle cells.. . ... Wake Forest University Health Sciences

01/19/17 / #20170014521

Pharmaceutical compositions for high-capacity targeted delivery

Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, the aptamer selectively binds a protein of interest such as an extracellular receptor protein of interest (e.g., a cancer cell extracellular receptor protein, which may be differentially expressed in some embodiments). ... Wake Forest University Health Sciences

01/05/17 / #20170000373

Methods, systems, and devices for assessing neuromuscular status of ligamentous and soft tissues

Systems, devices, and methods for neuromuscular testing of ligamentous or soft tissue structures in mammals provide information (e.g., emg feedback) about the status of neuromuscular function and reflex activity for, e.g., joint structures, in consideration of surgical or other procedures.. . ... Wake Forest University Health Sciences








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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