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Wisconsin Alumni Research Foundation patents


Recent patent applications related to Wisconsin Alumni Research Foundation. Wisconsin Alumni Research Foundation is listed as an Agent/Assignee. Note: Wisconsin Alumni Research Foundation may have other listings under different names/spellings. We're not affiliated with Wisconsin Alumni Research Foundation, we're just tracking patents.

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Capacitive touch sensor

A capacitive touch sensor is provided, the capacitive touch sensor includes a plate having an upper surface and lying in a plate plane. A generally planar, first electrode is spaced from the plate along an axis generally perpendicular to the upper surface of the plate. ... Wisconsin Alumni Research Foundation

Systems for generalizing non-uniform rational b-spline and application of systems

Systems and methods for generating approximations and other representations of data in a data set include a generalized non-uniform rational b-splines (nurbs) framework that facilitates optimized computer-generated representations having high accuracy and requiring less computing resources than previous frameworks capable of achieving similar accuracy. The framework includes a set of rational basis functions that define a mesh parametrization of the data set; these rational basis functions are based on the typical nurbs rational basis functions, but decoupled to provide discrete weights in each direction of a parametrized space. ... Wisconsin Alumni Research Foundation

Simplified compositions and methods for generating neural stem cells from human pluripotent stem cells

Simplified methods and compositions for directed differentiation of human pluripotent stem cells into neural stem cells are described. Methods and compositions for deriving neural stem cells from human pluripotent stem cells under defined, xeno-free conditions are also described.. ... Wisconsin Alumni Research Foundation

Synthesis of diindolylmethanes and indolo[3,2-b]carbazoles, compounds formed thereby, and pharmaceutical compositions containing them

Described is a method to make diindolylmethanes and indolyl/pyrrolylmethanes, the method includes the steps of contacting an ether comprising an arylpropargyl moiety and an amine-protected, substituted or unsubstituted aniline moiety with a substituted or unsubstituted indol or a substituted or unsubstituted pyrrole, in the presence of a metal-containing catalyst, for a time and at a temperature to cause an annulation/arylation cascade reaction that yields a diindolylmethane or a indolyl/pyrrolylmethane. The resulting compounds are effective to modulate activity of arylhydrocarbon receptors, to inhibit activity of pcsk9, and to stimulate secretion of glucagon-like peptide 1 in mammals.. ... Wisconsin Alumni Research Foundation

Magnetization state control method and magnetization state control device

A magnetization state control method for a variable magnetization machine, the method includes generating a flux linkage vector while changing a magnetization state of the variable magnetization machine such that a trajectory of the flux linkage vector has a curved clockwise trajectory on a dq-axis plane and a magnitude of the flux linkage vector temporally changes, with the dq-axis plane being a synchronous reference frame with a d-axis pointing in a direction of a permanent magnet flux and a q-axis being 90 degrees ahead of the d-axis in a rotational direction of a rotor.. . ... Wisconsin Alumni Research Foundation

Converter control with reduced link capacitor

A controller controls power between a source and a load with a link capacitor. (a) a switch vector is selected based on load and source values, a capacitor voltage value, and a switch state selection mode. ... Wisconsin Alumni Research Foundation

Permanent magnet synchronous motor

A permanent magnet synchronous motor includes a stator, a rotor rotatable relative to the stator, and a magnetic structure with a low coercive force magnet and a high coercive force magnet that are arranged magnetically in series with respect to each other to define a pole-pair of the permanent magnet synchronous motor. A magnetization level of the low coercive force magnet is changeable by a stator current pulse such that a stator magnetomotive force at a rated current is equal to or larger than a product of a magnetic field strength for fully magnetizing the low coercive force magnet and a thickness of the low coercive force magnet.. ... Wisconsin Alumni Research Foundation

Engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same

The invention generally relates to engineered prephenate dehydrogenases and arogenate dehydrogenases and methods of using the same. More specifically, the invention relates in part to compositions including engineered prephenate dehydrogenases (pdh) polypeptides and engineered arogenate dehydrogenase (adh) polypeptides with altered substrate preferences and tyrosine sensitivities and methods of using the same.. ... Wisconsin Alumni Research Foundation

Reconfigurable, application-specific computer accelerator

A reconfigurable hardware accelerator for computers combines a high-speed dataflow processor, having programmable functional units rapidly reconfigured in a network of programmable switches, with a stream processor that may autonomously access memory in predefined access patterns after receiving simple stream instructions. The result is a compact, high-speed processor that may exploit parallelism associated with many application-specific programs susceptible to acceleration.. ... Wisconsin Alumni Research Foundation

Intra-mammary teat sealant formulation and method of using same to reduce or eliminate visual defects in aged cheeses

Described is an intra-mammary teat sealant and a corresponding method of forming a physical barrier in the teat canal of a non-human animal for prophylactic treatment of mammary disorders during the animal's dry period. The method includes the step of infusing a teat seal formulation including a metal salt in a glyceride-containing gel base into the teat canal of the animal. ... Wisconsin Alumni Research Foundation

Visible detection of microorganisms

. . Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/ml. ... Wisconsin Alumni Research Foundation

Enhanced throughput mineral coatings for optimization of stem cell behavior

Disclosed are methods for cell transfection and regulating cellular behavior. More particularly, the present disclosure relates to methods of non-viral cell transfection and regulating cellular behavior using mineral coatings that allow for the enhanced transfection of cells. ... Wisconsin Alumni Research Foundation

Production of polyhydroxyalkanoates with a defined composition from an unrelated carbon source

Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an r-specific enoyl-coa hydratase gene, a pha polymerase gene, a thioesterase gene, and an acyl-coa-synthetase gene. ... Wisconsin Alumni Research Foundation

Bismuth-based chloride-storage electrodes

Bismuth-based, chloride-storage electrodes and rechargeable electrochemical cells incorporating the chloride-storage electrodes are provided. Also provided are methods for making the electrodes and methods for using the electrochemical cells to remove chloride ions from a sample. ... Wisconsin Alumni Research Foundation

07/19/18 / #20180200251

Methods for treating cognitive deficits associated with fragile x syndrome

Provided herein are methods of treating a cognitive deficit, including cognitive deficits associated with a fmr1 genetic defect. More particularly, provided herein are methods in which an effective amount of a mdm2-p53 pathway inhibitor is administered to a subject afflicted with at least one cognitive deficit, whereby administration of the inhibitor improves, enhances, or rescues at least one cognitive deficit in the subject.. ... Wisconsin Alumni Research Foundation

07/05/18 / #20180187227

Rna-mediated gene assembly from dna oligonucleotides

. . The present invention is directed to methods and materials for rna-mediated gene assembly from oligonucleotide sequences. In some embodiments, the oligonucleotides used for gene assembly are provided in an array format. ... Wisconsin Alumni Research Foundation

07/05/18 / #20180185278

Compositions containing preen oil and methods of use thereof

Described herein are methods of use of purified preen oil, food and feed compositions containing purified preen oil, food and feed additives containing purified preen oil, and pharmaceutical compositions containing purified preen oil. Methods include treatment of chronic joint inflammation in humans and animals by orally administering purified preen oil. ... Wisconsin Alumni Research Foundation

06/28/18 / #20180182911

Hybrid tandem solar cells with improved tunnel junction structures

Tandem solar cells comprising two or more solar cells connected in a solar cell stack via pn diode tunnel junctions and methods for fabricating the tandem solar cells using epitaxial lift off and transfer printing are provided. The tandem solar cells have improved tunnel junction structures comprising a current tunneling layer integrated between the p and n layers of the pn diode tunnel junction that connects the solar cells.. ... Wisconsin Alumni Research Foundation

06/28/18 / #20180177856

Immunogenic compositions against tuberculosis

Methods of preparing mutants of mycobacterium tuberculosis with one or more disrupted genes are presented, where the disrupted genes include ctpv, rv0990c, rv0971c, and/or rv0348. Compositions containing mutants with attenuated virulence and pathogenesis, which are capable of stimulation of an immune response against tuberculosis, are described. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180176739

Navigation system tracking high-efficiency indoor lighting fixtures

A system for identifying the location of a mobile device uses signatures of standard room lighting derived from the frequency spectrum of light fluctuations associated with driver circuitry of that lighting. Improved sensitivity (frequency and dynamic range) are provided by using a pair of dedicated photodetectors which may deduce a one-dimensional angular location of a light source by comparing the signals developed by two photodetectors having different angular sensitivities.. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180175396

Perovskite compounds for stable, high activity solid oxide fuel cell cathodes and other applications

Solid oxide fuel cells (sofcs) are provided. A sofc may comprise a cathode, an anode, and a solid oxide electrolyte between the anode and the cathode, wherein the cathode comprises a perovskite compound. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180172977

Optical phase shifter

A optical phase shifter is provided for adjusting an optical phase of light propagating therethrough along an optical axis. The optical phase shifter includes first and second transparent slides defining a cavity therebetween. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180172598

Packaging and methods for detecting exposure of a perishable good to an elevated temperature

Nanoreactors comprising a metal precursor in a carrier are provided. In some embodiments, upon exposure to heat, the metal precursor forms nanoparticles that can be detected, e.g., by detecting a color change in the nanoreactor and/or by detecting the number and/or size and/or size distribution and/or shape of the nanoparticles. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180170889

Simplified structural mimetics of aips as quorum sensing inhibitors

Compounds that regulate quorum sensing in staphylococcal bacteria and in particular in staphylococcus aureus are provided. Compounds are described in formulas i, ii, iii, iv, v and vi herein. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180170755

Mixed oxygen and organic compound treatment for functionalizing oxygen onto the surface of boron nitride

Improved methods of synthesizing oxygen-functionalized boron nitride (o—bn) are disclosed. In the disclosed methods, boron nitride (bn) in any form is contacted with a gaseous composition or compositions that include oxygen and an organic compound, such as, but not limited to, a hydrocarbon.. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180169224

Tlr agonists for reducing activation-induced pd-1 expression on t cells and methods of use

The present invention is directed toward methods of increasing the immune response to an antigen using tlr1/2 agonist and/or tlr7 agonist in combination with a t cell activating treatment, for example, a vaccine. In some aspects, the present invention provides methods of enhancing an anti-tumor response comprising administering at least one tlr1/2 agonist and/or at least one tlr7 agonist in combination with an immunotherapeutic agent.. ... Wisconsin Alumni Research Foundation

06/21/18 / #20180169185

Syndecan peptides and polypeptides as inhibitors of vascular endothelial growth factor receptor-2 (vegfr2) and very late antigen-4 (vla-4)

The disclosure provides for peptides from syndecan 1 and methods of use therefor. These peptides can inhibit vla-4 interaction with vegfr2, thereby preventing tumor cell growth and tissue invasion.. ... Wisconsin Alumni Research Foundation

06/14/18 / #20180162901

Method for facilitating extraction of a fraction from a biological sample

A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. ... Wisconsin Alumni Research Foundation

06/07/18 / #20180159391

Salient pole, wound field, synchronous machine with enhanced saliency

A rotor for a salient pole, wound field, synchronous machine includes a rotor core, a plurality of pole bodies, and a field winding. Each pole body of the plurality of pole bodies includes a pole core, a pole shoe, and a single flux barrier. ... Wisconsin Alumni Research Foundation

06/07/18 / #20180155732

Constructs and methods for genome editing and genetic engineering of fungi and protists

Provided herein are constructs for genome editing or genetic engineering its fungi or protists, methods of using the constructs and media for use in selecting cells. The construct include a polynucleotide encoding a thymidine kinase operably connected to a promoter, suitably a constitutive promoter; a polynucleotide encoding an endonuclease operably connected to an inducible promoter; and a recognition site for the endonuclease. ... Wisconsin Alumni Research Foundation

06/07/18 / #20180153924

Compositions and methods for aquaculture

Methods and compositions for increasing the growth rate of a prey fish are described. A method includes contacting the prey fish with a water-soluble growth promoting factor in an amount effective to increase the growth rate of the prey fish. ... Wisconsin Alumni Research Foundation

06/07/18 / #20180153849

Multi-drug combinations that act as potent radiosensitizers

Provided is a method of treatment including administering to lung, brain or esophageal cancer cells an effective amount of radiation in conjunction with a micelle composition that includes an effective amount of paclitaxel, and one or both of 17-aag, and rapamycin, wherein the micelle includes poly(ethylene glycol)-block-poly(lactic acid) (peg-b-pla).. . ... Wisconsin Alumni Research Foundation

05/31/18 / #20180147272

Vaccine candidates against johne's disease

A composition and method for immunizing a mammal infected with mycobacterium are disclosed. The genes gcpe, psta, kdpc, papa2, impa, umaa1, fabg2_2, aceab, mbth2, lpqp, map0834c, cspb, lipn, or map1634 of m. ... Wisconsin Alumni Research Foundation

05/31/18 / #20180147171

Trans10:cis12 isomer of conjugated linoleic acid as a therapeutic and preventative agent for hypertension specific to pregnancy

Described herein are compositions and methods for the use of t10:c12 conjugated linoleic acid to reduce hypertension in pregnant women. Advantageously, by reducing blood pressure, the compositions will also reduce the risk of pre-term birth. ... Wisconsin Alumni Research Foundation

05/24/18 / #20180142215

Artificial transcription factors and uses thereof

The present invention relates to artificial transcription factors (atfs) that alter gene expression, including inducing pluripotency in cells or promoting the conversion of cells to specific cell fates. In particular, provided herein is a zinc-finger based atf library that can be screened in cells by looking for expression of a specific gene (e.g., reporter expression), monitoring for cell surface markers or morphology, or via functional assays.. ... Wisconsin Alumni Research Foundation

05/24/18 / #20180142207

Induction of arterial-type of hemogenic endothelium (ahe) and enhancement of t cell production from pscs through overexpression of ets factors or modulating mapk/erk signalling pathways

The present invention is a method of creating a population of hemogenic endothelial cells with arterial specification and enhanced t cell potential. In one embodiment, the method uses ets transgene induction at the mesodermal stage of differentiation. ... Wisconsin Alumni Research Foundation

05/24/18 / #20180140557

Unimolecular nanoparticles for efficient delivery of therapeutic rna

A unimolecular nanoparticle, a composition thereof, and methods of use thereof that includes 1) a dendritic polymer having a molecular weight of about 500-120,000 da and terminating in hydroxyl, amino or carboxylic acid groups; 2) cationic polymers attached to at least a majority of the terminating groups of the dendritic polymer via a ph-sensitive linker, wherein each cationic polymer comprises a polymeric backbone attached to cationic functional groups and to weakly basic groups by disulfide bonds, wherein the molar ratio of cationic functional groups to weakly basic groups ranges from 1:1-5:1, and has a molecular weight from about 1,000-5,000 da; and 3) poly(ethylene glycol) attached to a plurality of cationic polymers and having a terminal group selected from a targeting ligand, oh, o-alkyl, nh2, biotin, or a dye, wherein the terminal group of at least one poly(ethylene glycol) is having a molecular weight of about 1,000-15,000 da.. . ... Wisconsin Alumni Research Foundation

05/17/18 / #20180136215

Epithelial quantitation of histologically normal prostate tissue predicts the presence of cancer in tissue biopsies

A method of detecting the presence of a prostate cancer in a human subject comprising the steps of (a) obtaining a histologically normal prostate tissue sample from the patient and (b) quantifying the epithelial percentage of the tissue, wherein an epithelial percentage greater than 39% indicates the presence of prostate cancer or a prostate cancer field defect.. . ... Wisconsin Alumni Research Foundation

05/17/18 / #20180135136

Unbiased dna methylation markers define an extensive field defect in histologically normal prostate tissues associated with prostate cancer: new biomarkers for men with prostate cancer

A method of detecting the presence of a prostate cancer field defect in a human subject comprising the step of (a) obtaining genomic dna from the human subject and (b) quantitating methylation in at least one target region selected from the group consisting of pla2g16, cav1, evx1, mcf2l, fgf1, ncr2 and wnt2 and ext1 and spag4 target, wherein significant methylation changes indicate the presence of prostate cancer or a prostate cancer field defect, wherein the change is relative to tissue from a second human subject who does not have prostate cancer.. . ... Wisconsin Alumni Research Foundation

05/17/18 / #20180132777

Apparatus for assessing human balance capability

An apparatus with one or more force plates senses of center-of-pressure and force-angle in the sagittal plane for a standing individual to provide an indication of balance capability based on the deduced functional relationship between center-of-pressure and force-angle within a limited band of frequencies. In one embodiment this relationship may be expressed as an intersection point of the force vectors with respect to the individual's center-of-mass.. ... Wisconsin Alumni Research Foundation

05/10/18 / #20180127784

Synthetic yeast cells and methods of making and using the same

. . Methods of making synthetic yeast cells by mating together two diploid (or higher ploidy) yeast species or hybrids to generate multi-ploid yeast hybrids are provided herein. The synthetic yeast cells made by this process and kits for performing the process are also provided.. ... Wisconsin Alumni Research Foundation

05/10/18 / #20180125345

Otoscope providing low obstruction electronic display

An otoscope provides a circular display allowing a compact housing providing improved simultaneous viewing of the display and the patient's ear for improved positioning and stabilization of the otoscope. A recorded image may be rotationally corrected, and non-image data displayed on the screen may be rotationally corrected with the use of an inclinometer.. ... Wisconsin Alumni Research Foundation

05/03/18 / #20180122910

High quality vanadium dioxide films

Layers of high quality vo2 and methods of fabricating the layers of vo2 are provided. The layers are composed of a plurality of connected crystalline vo2 domains having the same crystal structure and the same epitaxial orientation.. ... Wisconsin Alumni Research Foundation

05/03/18 / #20180121564

High-speed graph processor

A computer architecture for graph processing employs a high-bandwidth memory closely coupled to independent processing elements for searching through a graph using a first set of processing elements operating simultaneously to determine neighbors to a current frontier and second processing elements operating simultaneously to determine a next frontier, this process being repeated to search through graph nodes.. . ... Wisconsin Alumni Research Foundation

05/03/18 / #20180119104

Generating vasculogenic cell populations

The present invention relates generally to methods and compositions useful for therapeutic vascular tissue engineering. In particular, the present invention provides methods for generating substantially pure populations of vasculogenic cells from human mesenchymal progenitors, and methods and compositions for clinical applications in the field of regenerative medicine.. ... Wisconsin Alumni Research Foundation

05/03/18 / #20180119098

Methods of maintaining, expanding, and differentiating neuronal subtype specific progenitors

Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.. ... Wisconsin Alumni Research Foundation

05/03/18 / #20180116603

System for characterizing brain condition

A sensitive measure of brain condition simultaneously evaluates multiple measurements of water diffusion in brain tissue combined so as to correct for covariance between the different data types of the multipoint measurements and compares the multipoint measurements to a corresponding multipoint measure representing normal brain tissue to provide a distance indicating a likelihood of atypical brain conditions.. . ... Wisconsin Alumni Research Foundation

04/19/18 / #20180105940

Electrochemical and photoelectrochemical reduction of furfurals

Electrochemical cells and photoelectrochemical cells for the reduction of furfurals are provided. Also provided are methods of using the cells to carry out the reduction reactions. ... Wisconsin Alumni Research Foundation

04/12/18 / #20180101983

Singularity reduction in quadrilateral meshes

Systems and methods for modifying and generating quadrilateral meshes for computer graphic structures include obtaining a polygon mesh representing a computer graphic structure, the polygon mesh comprising a plurality of polygonal faces and a plurality of singularities, determining, based on a first singularity of the plurality of vertices, selecting, based on one or more characteristics of the patch, a first minimum singularity template (mst) of a plurality of msts each representing a corresponding quadmesh that has three or fewer singularities, and replacing, within the polygon mesh, the patch with the first mst.. . ... Wisconsin Alumni Research Foundation

04/12/18 / #20180100910

Method for correcting phase offsets in quantitative chemical shift encoded magnetic resonance imaging

Systems and methods for correcting phase errors in chemical shift encoded data are described. The technique is self-calibrated, without the need for specialized calibration data, and therefore may enable fat and iron quantification using data from clinical and research sites that do not have specialized pulse sequences.. ... Wisconsin Alumni Research Foundation

04/12/18 / #20180099870

Degradable conjugated polymers for the selective sorting of semiconducting carbon nanotubes

Conjugated polymers composed of bi-pyridine units linked to 9,9-dialkyl fluorenyl-2,7-diyl units via imine linkages along the polymer backbone are provided. Also provided are semiconducting single-walled carbon nanotubes coated with the conjugated polymers and methods of sorting and separating s-swcnts from a sample comprising a mixture of s-swcnts and metallic single-walled carbon nanotubes using the conjugated polymers.. ... Wisconsin Alumni Research Foundation

04/05/18 / #20180096743

Duplex accident tolerant coating for nuclear fuel rods

A method is described for forming duplex layers including an interlayer and a corrosion resistant boundary layer on a nuclear fuel rod cladding tube for use in a water cooled nuclear reactor. The method includes forming, by thermal deposition or physical vapor deposition, on the exterior of a substrate, an inner interlayer with mo, ta, w or nb or other particles, and forming, by thermal deposition or physical vapor deposition, on the interlayer, an outer corrosion resistant layer with particles selected from the group consisting of cr, a cr alloy, and combinations thereof. ... Wisconsin Alumni Research Foundation

04/05/18 / #20180095773

State extractor for middlebox management system

A method of automatically identifying state information in different middlebox programs first identifies relevant program portions by expanding outward from a packet processing loop to statements dependent either by control or data dependency on that packet processing loop. Persistent variables in the statements are then collected and optionally winnowed by whether they are “used” or modified by those statements. ... Wisconsin Alumni Research Foundation

04/05/18 / #20180094247

Adsorptive membranes for trapping viruses

A disposable, virus-trapping membrane, and a corresponding method to remove viruses from solution are described. The membrane includes a disposable, micro-porous filter membrane and a ligand immobilized on the membrane. ... Wisconsin Alumni Research Foundation

04/05/18 / #20180094246

Primed cardiac progenitors and methods for making and using same

An improvement to the giwi protocol for differentiating human pluripotent cells to developmentally mature cardiomyocytes includes a step of activating innate immunity in mesoderm stage cells in the in vitro differentiation culture. When the mesoderm cells, which are precursors to cardiac progenitor cells, are primed by exposure to an activator of innate immunity, a population of cardiomyocytes is generated that is more developmentally mature than is generated in the giwi protocol without the primed step. ... Wisconsin Alumni Research Foundation

04/05/18 / #20180094245

Methods for cardiac fibroblast differentiation of human pluripotent stem cells

Methods for generating high-yield, high-purity cardiac fibroblasts are described. Differentiation methods comprising chemically defined culture conditions and methods for in vitro maintenance of human pluripotent stem cell-derived cardiac fibroblasts are also provided.. ... Wisconsin Alumni Research Foundation

03/29/18 / #20180091261

Differential mimo transceiver

A receiver detects a plurality of information symbols. A first signal and a second signal are received from a first transmitted signal and a second transmitted signal, respectively, transmitted by a first plurality of antennas and received by a second plurality of antennas connected to the receiver. ... Wisconsin Alumni Research Foundation

03/29/18 / #20180087074

Microorganisms and methods for producing pyruvate, ethanol, and other compounds

Microorganisms comprising modifications for producing pyruvate, ethanol, and other compounds. The microorganisms comprise modifications that reduce or ablate activity of one or more of pyruvate dehydrogenase, 2-oxoglutarate dehydrogenase, phosphate acetyltransferase, acetate kinase, pyruvate oxidase, lactate dehydrogenase, cytochrome terminal oxidase, succinate dehydrogenase, 6-phosphogluconate dehydrogenase, glutamate dehydrogenase, pyruvate formate lyase, pyruvate formate lyase activating enzyme, and isocitrate lyase. ... Wisconsin Alumni Research Foundation

03/29/18 / #20180087073

Use of bacteriocin-producing ethanologens in biofuel production

An ethanologen for producing biofuel from one or more carbohydrates and reducing lactate and acetate production in a biofuel manufacturing process. The ethanologen is made by introducing into the ethanologen one or more exogenous genes required for production of a bacteriocin. ... Wisconsin Alumni Research Foundation

03/29/18 / #20180086813

Peptides that inhibit syndecan-1 activation of vla-4 and igf-1r

A fusion peptides with sequences derived from the extracellular domain of syndecan-1 that inhibits vla-4 and igf-1r signaling are disclosed. The fusion peptides include an igf-1r-binding segment having the amino acid sequence lpagegpkegeavvlpevepgltareq (seq id no:1) and a vla-4-binding segment having the amino acid sequence sequence dftfetsgenta (seq id no:2).. ... Wisconsin Alumni Research Foundation

03/29/18 / #20180085748

Device and method to facilitate the prepackaging, handling and use of small volumes of fluids

A device and method are provided to facilitate the handling of a volume or fluid. The device includes an elongated tube having an open first end and a second end. ... Wisconsin Alumni Research Foundation

03/22/18 / #20180080912

Method of detection of volatile organic compounds using liquid crystals that form a blue phase; and device for stabilization and thickness control of liquid crystal films

Methods and compositions for detecting a targeted analyte, such as volatile organic compound (vocs), are disclosed. Specifically, a cholesteric liquid crystal composition comprising a nematic liquid crystal and a chiral dopant transitions to a liquid crystal blue phase or undergoes other optical changes when in contact with a sample containing the analyte. ... Wisconsin Alumni Research Foundation

03/22/18 / #20180079149

Support structure constrained topology optimization for additive manufacturing

Systems and methods for generating designs of objects for additive manufacturing (am) include a topological optimization framework that facilitates optimized computer generated designs requiring significantly reduced support structures. Towards this end, the concept of ‘support structure topological sensitivity’ is introduced. ... Wisconsin Alumni Research Foundation

03/15/18 / #20180073033

Genes that improve tolerance to lignocellulosic toxins when overexpressed in yeast and methods of use in biofuel production

The present invention provides isolated gene sequences useful in increasing lignocellulosic toxin tolerance in yeast. Such engineered yeast are useful in methods of biofuel production, particularly ethanol production. ... Wisconsin Alumni Research Foundation

03/08/18 / #20180068848

Low dielectric constant (low-k) dielectric and method of forming the same

A method of forming a low dielectric constant (low-k) dielectric is disclosed. The method includes providing a substrate and forming a dielectric including porogens over the substrate. ... Wisconsin Alumni Research Foundation

03/08/18 / #20180065945

Synthesis of novel analogs of diptoindonesin g, compounds formed thereby, and pharmaceutical compositions containing them

Disclosed are unnatural analogs of diptoindonesin g, methods to make the analogs, pharmaceutical compositions containing the analogs, and methods of using the analogs to inhibit neoplastic cell growth.. . ... Wisconsin Alumni Research Foundation

03/01/18 / #20180059325

Optical fiber thermal property probe

An optical fiber sensor extends coaxially with a controllable heater to provide high-resolution axial measurement of thermal properties such as thermal convection of the surrounding, heat removal by either conduction or convection may be used to deduce material height in a tank, or velocity of flow when coupled with localized heating, or other aspects of the material based on thermal conductivity.. . ... Wisconsin Alumni Research Foundation

03/01/18 / #20180057949

Electrochemical reductive amination of furfural-based molecules

Electrochemical cells for the reductive amination of furfural-based molecules are provided. Also provided are methods of using the electrochemical cells to carry out the electrochemical reductive amination reactions. ... Wisconsin Alumni Research Foundation

03/01/18 / #20180057808

Methods and systems for isolating and identifying nucleic acid from a plurality of microorganisms and viruses

The disclosure relates to laboratory and bioinformatics methods for isolating, detecting, and characterizing microbes in biological samples using metagenomic approaches.. . ... Wisconsin Alumni Research Foundation

03/01/18 / #20180055856

Combination of low dose 2-methylene-19-nor-(20s)-1alpha, 25-dihydroxyvitamin d3 and calcimimetics to treat secondary hyperparathyroidism

Disclosed are pharmaceutical compositions and methods of combination therapy that include or utilize low doses of 2-methylene-19-nor-(20s)-1α,25-dihydroxyvitamin d3 and a calcimimetic to treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.. . ... Wisconsin Alumni Research Foundation

03/01/18 / #20180055795

Siderophore-polymer conjugates for increasing bacterial sensitivity to antibiotics

The present technology provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., pseudomonas, p. Aeruginosa, acinetobacter, and a. ... Wisconsin Alumni Research Foundation

03/01/18 / #20180055075

Compositions and methods of preserving meat substitutes

The disclosure provides for compositions and methods for the preservation of meat substitutes containing plant heme protein. In particular, small molecules that can fit in the unique heme pocket of plant heme proteins are provided to stabilize and preserve meat substitutes the products.. ... Wisconsin Alumni Research Foundation

02/22/18 / #20180052693

Computer architecture with synergistic heterogeneous processors

. . A computer architecture employs multiple special-purpose processors having different affinities for program execution to execute substantial portions of general-purpose programs to provide improved performance with respect to a general-purpose processor executing the general-purpose program alone.. . ... Wisconsin Alumni Research Foundation

02/22/18 / #20180052445

Homogenization of material properties in additively manufactured structures

A method for estimating a material characteristic of an article includes receiving a material property tensor having an associated reference direction. A tool path model of an additive manufacturing process for manufacturing the article is received. ... Wisconsin Alumni Research Foundation

02/22/18 / #20180052182

Methods for predicting glucoregulatory dysfunction

This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals at risk for glucoregulatory dysfunction.. . ... Wisconsin Alumni Research Foundation

02/22/18 / #20180050338

Deformable well and method

A deformable well structure for a microtiter plate and method are provided. The deformable well structure includes a sample container defining a well for receiving a sample therein. ... Wisconsin Alumni Research Foundation

02/15/18 / #20180045645

Methods and systems for transmission and detection of free radicals

The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from free radical interaction with a target molecule.. . ... Wisconsin Alumni Research Foundation

02/15/18 / #20180044390

Compositions and methods for improving resistance to breakage and eggshell strength

Described herein are fgf-23 epitope peptides, methods of producing antibodies in laying hens by injecting the peptides, and methods of improving resistance to eggshell breakage and/or increasing eggshell strength by administering an fgf-23 epitope peptide to a laying hen.. . ... Wisconsin Alumni Research Foundation

02/15/18 / #20180043562

Knife blade edge serrations and method therefor

Various aspects of the present disclosure are directed toward blades having serrations, and methods for forming the serrations. As may be implemented in accordance with one or more embodiments, laser light is scanned across a surface of a knife blade in which the laser light is intersected with an edge thereof. ... Wisconsin Alumni Research Foundation

02/15/18 / #20180043011

Pi3-kinase inhibition and lag-3 checkpoint blockade as a combination therapy for cancer

This disclosure provides methods of treating cancer comprising administering at least one pi3k inhibitor and at least one lag-3 checkpoint inhibitor. Suitable compositions are also disclosed.. ... Wisconsin Alumni Research Foundation

02/15/18 / #20180042899

Method of treating transplant rejection and autoimmune diseases

A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of su-5416 is disclosed.. . ... Wisconsin Alumni Research Foundation

02/15/18 / #20180042844

Perivascular drug delivery system

The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle. ... Wisconsin Alumni Research Foundation

02/08/18 / #20180041737

Apparatus for augmenting human vision

. . The functional effect of having additional color-sensing cone types in the human eye is implemented by an encoding of some spectral information differently for the left and right eyes. This different encoding for identical features seen by the left and right eyes is interpreted as a perceptively different feature by the human brain, allowing additional spectral information to be conveyed through the limited tristimulus sensitivity of the human eye.. ... Wisconsin Alumni Research Foundation

02/08/18 / #20180040806

Flexible compact nanogenerators based on mechanoradical-forming porous polymer films

Power generators that incorporate porous electric generation layers composed of mechanoradical-forming polymers are provided. Also provided are methods for using the generators to convert mechanical energy into and electrical signal to power electronic devices. ... Wisconsin Alumni Research Foundation

02/08/18 / #20180037925

Multi-color reporter cells for detecting hiv-1

Disclosed are methods to measure the extent of viral infection and methods to measure latent viral reservoir in cells harboring or suspected of harboring such a reservoir.. . ... Wisconsin Alumni Research Foundation

02/08/18 / #20180036542

Adaptor to allow electrogram visualization and pacing from temporary epicardial wires

A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ecg monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. ... Wisconsin Alumni Research Foundation

02/01/18 / #20180030115

Collagen mimics

Novel collagen mimics are disclosed with a tripeptide unit having the formula (xaa-yaa-gly)n, where one of the positions xaa or yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the xaa or yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. ... Wisconsin Alumni Research Foundation

01/25/18 / #20180025902

High throughput semiconductor deposition system

. . . . A reactor for growing or depositing semiconductor films or devices. The reactor may be designed for inline production of iii-v materials grown by hydride vapor phase epitaxy (hvpe). ... Wisconsin Alumni Research Foundation

01/25/18 / #20180025794

Spray methods for coating nuclear fuel rods to add corrosion resistant barrier

A method is described herein for coating the substrate of a component for use in a water cooled nuclear reactor to provide a barrier against corrosion. The method includes providing a zirconium alloy substrate; and coating the substrate with particles selected from the group consisting of metal oxides, metal nitrides, fecral, fecraly, and high entropy alloys. ... Wisconsin Alumni Research Foundation

01/25/18 / #20180025793

Cold spray chromium coating for nuclear fuel rods

A method is provided for coating the substrate of a component, such as a zirconium alloy cladding tube, for use in a water cooled nuclear reactor under normal operating conditions and under high temperature oxidation conditions. The method includes heating a pressurized carrier gas to a temperature between 200° c. ... Wisconsin Alumni Research Foundation

01/25/18 / #20180021427

H3 influenza a virus

The invention provides an isolated h3 equine influenza a virus, as well as methods of preparing and using the virus, and genes or proteins thereof.. . ... Wisconsin Alumni Research Foundation

01/18/18 / #20180018796

System and method for high-temporal resolution, time-resolved cone beam ct angiography

. . . . A system and method for reconstructing an image using a cone-beam computed tomography (ct) imaging system includes acquiring data from a subject with the ct imaging system using a limited scan range that is less than 360 degrees. The process also includes reconstructing at least one image of the subject having a first temporal resolution from the data acquired, performing a temporal deconvolution of the at least one image using a finite temporal window to generate at least one image of the subject with a second temporal resolution that is greater than the first temporal resolution, and subtracting the at least one image of the subject with the second temporal resolution and a mask image of the subject to generate a time-resolved ct angiogram of the subject.. ... Wisconsin Alumni Research Foundation

01/18/18 / #20180015126

Generation of uniform hepatocytes from human embryonic stem cells by inhibiting tgf-beta and methods of maintaining hepatic cultures

This disclosure relates generally to new methods of maintaining the expression of hepatic genes in human hepatocytes and method for maintaining the functional hepatic enzyme activity of primary hepatocytes in culture. The disclosure also encompasses new methods of deriving a population of pure hepatocytes without selecting or sorting the cells from the cultured pluripotent cells.. ... Wisconsin Alumni Research Foundation

01/18/18 / #20180015107

Use of homosalate and octyl salicylate to treat multiple sclerosis

A method of treating an ms patient with homosalate, octyl salicylate, or a combination is disclosed.. . ... Wisconsin Alumni Research Foundation

01/11/18 / #20180013358

Cellulose composite-structured triboelectric generator and method

A triboelectric generator and method are provided. The triboelectric generator includes a first electrode having an inner surface and an outer surface and a second electrode having an inner surface and an outer surface. ... Wisconsin Alumni Research Foundation

01/11/18 / #20180013083

Floating evaporative assembly of aligned carbon nanotubes

High density films of semiconducting single-walled carbon nanotubes having a high degree of nanotube alignment are provided. Also provided are methods of making the films and field effect transistors (fets) that incorporate the films as conducting channel materials. ... Wisconsin Alumni Research Foundation

01/11/18 / #20180010138

Oxygen-responsive bacterial gene switch

The invention provided herein relates to sequence determinants that elicit certain levels of gene expression and methods for obtaining engineered ligand-responsive gene switches comprising these sequence determinants. More particularly, the invention provided herein relates to molecular building blocks (i.e., discrete nucleotide sequences), synthetic ligand-responsive gene switches comprising an assembly of these molecular building blocks, and methods of using synthetic ligand-responsive gene switches as customizable and controllable expression systems and sensors.. ... Wisconsin Alumni Research Foundation

01/11/18 / #20180010129

Compositions and methods to promote erythropoiesis

Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of exosc10, such as inhibitory nucleic acid molecules, produce an increase in red blood cell production in the individual.. ... Wisconsin Alumni Research Foundation

01/11/18 / #20180010124

Induction of hemogenic endothelium from pluripotent stem cells by forced expression of transcription factors

Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hpscs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hpscs of a combination of transcription factors as described herein.. . ... Wisconsin Alumni Research Foundation

01/04/18 / #20180006493

High power transfer through load-supporting bearings

A system for power transfer to a movable platform makes use of a capacitive interface in moving elements of load-supporting bearings for power transfer. Tank circuits associated with each bearing increase power transfer by reducing effective impedance of the small bearing capacitances.. ... Wisconsin Alumni Research Foundation

01/04/18 / #20180005766

Conductive textiles and related devices

A conductive textile is provided comprising a textile substrate comprising a network of one or more threads, each thread comprising one or more fibers, the one or more threads arranged to define a plurality of pores and a plurality of intersections distributed throughout the textile substrate, and a conductive polymer coating on a surface of the textile substrate, wherein the textile substrate is characterized by a porosity which is sufficiently high to achieve a substantially maximum conductivity for the conductive textile. The conductive textile may be incorporated into a variety of electronic devices, including solar cells.. ... Wisconsin Alumni Research Foundation

01/04/18 / #20180002755

Single nucleotide polymorphisms associated with bull fertility

Single nucleotide polymorphic sites of the bovine map1b, ppp1r11, and ddx4 genes are associated with improved bull fertility as measured by e.g. Sire conception rates. ... Wisconsin Alumni Research Foundation

01/04/18 / #20180002318

Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and method of using them

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. ... Wisconsin Alumni Research Foundation

01/04/18 / #20180000437

Fluoroscopy system resolving slowly evolving conditions

A fluoroscopy machine allows programming of a frame rate in the range of multiple seconds per frame and then displays the images at a higher rate in a loop in the radiological theater so as to impart an improved sense of motion to a human observer of a slow physiological processes captured by fluoroscopic studies.. . ... Wisconsin Alumni Research Foundation

12/28/17 / #20170369462

Modulation of bacterial quorum sensing with synthetic ligands

The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. ... Wisconsin Alumni Research Foundation

12/28/17 / #20170367672

System and method for accelerated, time-resolved imaging

A system and method for reconstructing a series of images of a subject includes acquiring medical image data from the subject with a medical imaging system and reconstructing a series of images of the subject from the acquired medical image data set. The reconstructing includes enforcing general adherence to a non-patient-specific signal model that describes a dependency of image intensity values on at least one variable that is associated with a physical or physiological property by constraining reconstruction of individual images in the series of images using the non-patient-specific model. ... Wisconsin Alumni Research Foundation

12/21/17 / #20170363513

Combustion gas sensor assembly for engine control

An optical sensor for sensing combustion products avoids fouling and damage to optical components by using a “windowless” design in which an air curtain through an orifice provides a constantly refreshing transparent shield protecting the optical components from corrosive combustion gases and resisting the accumulation of particulates that might otherwise foul a static window.. . ... Wisconsin Alumni Research Foundation

12/21/17 / #20170360317

Wireless vibrometer with antenna array

A wireless vibrometer employs an antenna array to significantly boost the signal-to-noise ratio of faint received signals twin small objects vibrating at acoustic frequencies. This technique may be used to provide an improved physiological monitor (such as a pulse detector) or for long-range eavesdropping using the emitted power from a cell phone or the like.. ... Wisconsin Alumni Research Foundation

12/14/17 / #20170356901

T cell-bound cytokine assay for antigen-specific tolerance

In vitro methods for detecting and measuring an antigen-specific regulatory t cell response are described. In particular, there is provided, for example, a method of detecting a change in surface expression of particular t cell markers in t cells obtained from the subject as a way to detect induced immune suppression in response to exposure to a particular antigen or plurality of antigens.. ... Wisconsin Alumni Research Foundation

12/14/17 / #20170356829

Method and device for containing expanding droplets

A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. ... Wisconsin Alumni Research Foundation

12/14/17 / #20170355748

Method for the design of fibrillar collagen-mimetic peptide self-assemblies

Novel synthetic human scale collagen triple helices assemblies are disclosed. Methods of making self-assembling collagen mimetic peptides that self-assemble into human scale collagen are also disclosed.. ... Wisconsin Alumni Research Foundation

12/14/17 / #20170354964

Non-displasive pipette

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. ... Wisconsin Alumni Research Foundation

12/14/17 / #20170354730

High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs

The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as mdck cells, or in eggs.. . ... Wisconsin Alumni Research Foundation

12/14/17 / #20170354725

Combinatorial androgen deprivation with an androgen receptor vaccine

It is disclosed herein methods of treating prostate cancer comprising administering to the subject the combination of androgen deprivation therapy (adt) and a vaccine directed against the androgen receptor or a fragment of the androgen receptor. Also disclosed are methods of increasing the efficacy of androgen deprivation therapy in a subject with prostate cancer comprising administering to the subject an effective amount of a vaccine against the androgen receptor or fragments thereof wherein the method inhibits, delays or reduces the growth of the prostate cancer and/or the development of castration-resistant prostate cancer.. ... Wisconsin Alumni Research Foundation

12/07/17 / #20170350951

System and method for chemical shift magnetic resonance imaging using magnetization transfer

A system and method is provided for producing a map of a static magnetic field (b0) of a magnetic resonance imaging system. The method includes forming a first dataset by acquiring, with the mri system, a first plurality of different echo signals occurring at a respective plurality of different echo times. ... Wisconsin Alumni Research Foundation

12/07/17 / #20170348278

Ecteinamycin, compositions and uses thereof

An isolated or synthesized compound of formula i and salts thereof are provided. A compound isolated from actinomadura and having a chemical formula of c38h60o12 is also provided. ... Wisconsin Alumni Research Foundation

12/07/17 / #20170348118

Prosthetic manipulator and method therefor

Various aspects of the present disclosure characterize apparatuses and/or methods as may be implemented with a variety of prosthetic components and applications. As may be consistent with one or more embodiments described herein, respective manipulators are operable and/or operate to manipulate a prosthetic foot component about respective (e.g., separate) axes. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170346558

Spatial location indoors using standard fluorescent fixtures

A system for identifying the location of the mobile device uses standard fluorescent light fixtures commonly found in indoor environments and detects minor variations in the light output of those fixtures caused by normal manufacturing variation. These variations are catalogued as identifying fingerprints together with location of the light fixtures to provide for navigation.. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170342574

Nitroxyl-mediated oxidation of lignin and polycarboxylated products

Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on β-o-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170342502

Biomarkers for breast cancer and methods of use thereof

Described herein is the use of agouti signaling protein (asip), in addition to certain other melanocortin signaling network (msn) genes, as prognostic and predictive biomarkers for the progression of breast cancer. In particular, the novel biomarkers can be used to determine if a female breast cancer patient is at risk of progressing to metastatic disease and thus also be used to direct treatment of the patient.. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170342441

Hepatocyte based insulin gene therapy for diabetes

A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first, second or third vector, wherein the first vector comprises a promoter enhancer, glucose inducible regulatory elements, a liver-specific promoter, a gene encoding human insulin with modified peptidase and an albumin 3′utr and lacks an hgh intron, wherein the second vector comprises an hgh intron, glucose inducible regulatory elements, a liver-specific promoter, a gene encoding human insulin with modified peptidase site and an albumin 3′utr and lacks a promoter enhancer, wherein the third vector comprises an hgh intron, glucose inducible regulatory elements, a liver-specific promoter, a gene encoding human insulin with modified peptidase site, an albumin 3′utr and a promoter enhancer and observing the patient's insulin levels, wherein the patient's insulin levels are controlled.. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170342219

Polycarboxylated compounds and compositions containing same

Methods of selectively modifying lignin, polycarboxylated products thereof, and methods of deriving aromatic compounds therefrom. The methods comprise electrochemically oxidizing lignin using stable nitroxyl radicals to selectively oxidize primary hydroxyls on β-o-4 phenylpropanoid units to corresponding carboxylic acids while leaving the secondary hydroxyls unchanged. ... Wisconsin Alumni Research Foundation

11/30/17 / #20170341300

Additive manufacturing process continuous reinforcement fibers and high fiber volume content

An additive printer dispenses filament having high volume content of axial reinforcing fibers impregnated with a partially cured thermoset material. Partial curing provides sufficient mechanical integrity for high-density fiber support and retention while maintaining tackiness necessary to allow layer by layer additive construction. ... Wisconsin Alumni Research Foundation

11/23/17 / #20170338750

Electrostatic rotating-machine employing dielectric substrates with surface conductors

. . An electrostatic rotating electrical machine employs axially extending electrically conductive electrodes on a rotor interacting with a corresponding set of axially extending electrodes on a stator, where the electrodes are supported at an outer surface of a dielectric sleeve which continues beneath the electrodes to provide a robust support and to minimize electrode weight.. . ... Wisconsin Alumni Research Foundation

11/23/17 / #20170336390

Methods, systems, and compositions for studying solvent accessibility and three-dimensional structure of biological molecules

This disclosure provides methods, systems, and compositions of matter for studying solvent accessibility and three-dimensional structure of biological molecules. A plasma can be used to generate marker radicals, which can interact with a biological molecule and mark the solvent-accessible portions of the biological molecule.. ... Wisconsin Alumni Research Foundation

11/23/17 / #20170335398

Method to predict likelihood of inherited peripheral neuropathy in mammals

Methods and kits for diagnosing propensity to exhibit acquired peripheral neuropathy in dogs are described. The methods and kits test dogs for presence of a single-nucleotide polymorphism (snp) tigrp2p18586_rs8746233. ... Wisconsin Alumni Research Foundation

11/23/17 / #20170335130

Azlactone based thermally crosslinkable polymer coating for controlling cell behavior

Random copolymers, crosslinked thin films of the random copolymers and cell culture substrates comprising the crosslinked thin films are provided. Also provided are methods of making and using the copolymers, thin films and substrates. ... Wisconsin Alumni Research Foundation

11/23/17 / #20170334953

Mosquitocidal xenorhabdus, lipopeptide and methods

Provided is a bacterial strain which produces a family of mosquitocidal toxins, xenorhabdus mt, on deposit with the american type culture collection, pta-6826, insecticidal compositions comprising the mosquitocidal toxin(s) produced by xenorhabdus mt, a mosquitocidal toxin preparation prepared from spent culture medium, whole culture or cells or a mixture thereof, of xenorhabdus mt and method of insect control, especially mosquito control. Also provided are microbial compounds (same as mosquitocidal toxins) compositions comprising them and use in formulating therapeutic and other antimicrobial compositions, and methods of use for inhibiting microbial growth and for treating infection.. ... Wisconsin Alumni Research Foundation

11/16/17 / #20170329741

Graphic processor unit with improved energy efficiency

A gpu architecture employs a crossbar switch to preferentially store operand vectors in a compressed form allowing reduction in the number of memory circuits that must be activated during an operand fetch and to allow existing execution units to be used for scalar execution. Scalar execution can be performed during branch divergence.. ... Wisconsin Alumni Research Foundation

11/16/17 / #20170327517

Boronic acid inhibitors of hiv protease

Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly hiv protease inhibitors which are boronated to enhance activity or to enhance entry into cells. Compounds, prodrugs and salts thereof of this invention contain phenylboronate groups, in particular p-b(oh)2-phenyl groups, benzoxaborole groups or borono-pyridyl groups or analogous groups in which the boronate group is protected. ... Wisconsin Alumni Research Foundation

11/16/17 / #20170326159

Methods of use to orally and topically treat acne and other skin conditions by administering a 19-nor containing vitamin d analog with or without a retinoid

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin d analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(s)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(s)-2-methylene-1α,25-dihydroxyvitamin d3, 2-methylene-1α,25-dihydroxy-(17e)-17(20)-dehydro-19-nor-vitamin d3, 2-methylene-19-nor-(24r)-1α,25-dihydroxyvitamin d2, 2-methylene-(20r,25s)-19,26-dinor-1α,25-dihydroxyvitamin d3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20r)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20s)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20s)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20s)-1α-hydroxyvitamin d3, 2-methylene-18,19-dinor-(20s)-1α,25-dihydroxyvitamin d3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof. ... Wisconsin Alumni Research Foundation

10/26/17 / #20170303887

Head mounted microphone array for tinnitus diagnosis

A three-dimensional, head mounted microphone array is employed to isolate and analyze intracranial sound sources such as may provide for objective tinnitus. The microphone array allows a region of interest within the patient's head to be isolated for the detection of sounds and allows episodic sounds to be automatically identified as to location. ... Wisconsin Alumni Research Foundation

10/12/17 / #20170290901

Global gene regulators (ggr) as vaccine candidates against paratuberculosis

Described herein is a mycobacterium mutant, comprising at least one mutation in at least one gene sequence encoding global gene regulators (ggrs) selected from the group consisting of sigh, sigl, sige, ecf-1, and mixtures thereof, wherein the ggr gene is at least partially inactivated. Described herein also is a vaccine based on the mutant and a method of differentiating between subjects that have been infected with mycobacterium and subjects that have not been infected with mycobacterium or have been vaccinated with a mycobacterium vaccine.. ... Wisconsin Alumni Research Foundation

10/12/17 / #20170290852

Micelle formulations of amphotericin b

The present technology relates generally to micelle formulations of amphotericin b that optionally include 5-fluorocytosine and methods of preparing such formulations. Methods of treating fungal infections with the present compositions are also provided.. ... Wisconsin Alumni Research Foundation

10/05/17 / #20170288586

Variable magnetization machine controller

A variable magnetization machine control system comprising a controller configured to adjust a d-axis current waveform and a q-axis current waveform in accordance with an operating condition of a variable magnetization machine to generate an adjusted d-axis current waveform and an adjusted q-axis current waveform that provide a driving voltage to drive the variable magnetization machine at a predetermined speed while maintaining the driving voltage below a predetermined maximum magnitude.. . ... Wisconsin Alumni Research Foundation

10/05/17 / #20170285042

Gas-phase purification for accurate isobaric tag-based quantification

Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.. ... Wisconsin Alumni Research Foundation

10/05/17 / #20170283812

Method of creating industrial streptomyces with capability to grow on cellulosic polysaccharide substrates

A heterologous gene cassette useful for creating streptomyces species with enhanced capability of growing on a cellulosic polysaccharide substrate, wherein the cassette comprises at least two members of the following categories: a) a gh6 gene, b) an aa10 gene, c) a gh48 gene, d) a gh5 gene and e) either (i) a gh9 gene, (ii) a gh9 gene and a gh12 gene, or (iii) a gh12 gene is disclosed.. . ... Wisconsin Alumni Research Foundation

10/05/17 / #20170283774

Methods for efficient derivation of human motor neurons from diverse spinal regions

Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.. . ... Wisconsin Alumni Research Foundation

10/05/17 / #20170283772

Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells

Methods for generating functional brain microvascular endothelial cells (bmecs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional bmecs under chemically defined culture conditions are provided. ... Wisconsin Alumni Research Foundation

10/05/17 / #20170281741

Peptide and method for reducing the phosphate requirement and excretiion from farm animals

Disclosed are methods of altering metabolism of phosphate in a livestock via an antibody. The methods involve the development of an antibody against fgf-23 for the purpose of reducing phosphate excretion by an animal.. ... Wisconsin Alumni Research Foundation

10/05/17 / #20170281737

Universal platform for targeting therapies to treat neurological diseases

The present invention provides a universal delivery platform of functional, heterologous compounds to specific cells using toxins modified to include a heterologous compound. In one embodiment, the toxin is an ab5 toxin. ... Wisconsin Alumni Research Foundation

10/05/17 / #20170281643

Compounds and methods for modulating frataxin expression

The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula a-l-b, wherein -l- is a linker; a- is a brd4 binding moiety; and -b is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.. ... Wisconsin Alumni Research Foundation

09/28/17 / #20170279392

Variable magnetization machine controller

A variable magnetization machine control system comprising a controller configured to generate a reversely rotating d-axis/q-axis current vector trajectory during a change in a magnetization state of a variable magnetization machine to drive the variable magnetization machine at a predetermined speed while maintaining the driving voltage below a predetermined maximum magnitude.. . ... Wisconsin Alumni Research Foundation

09/28/17 / #20170279322

Permanent magnet synchronous motor

A permanent magnet synchronous motor includes a stator with a stator winding, a rotor with a rotor core rotatable relative to the stator, and a magnetic structure with at least one permanent magnet mounted to the rotor core. The magnetic structure produces a magnetic flux that flows between different magnetic poles of the magnetic structure through a main magnetic flux path that passes through the stator winding of the stator via an air gap and a leakage magnetic flux path that is located within the rotor core about an end portion of the permanent magnet near the air gap. ... Wisconsin Alumni Research Foundation

09/28/17 / #20170279148

Charge transfer mediator based systems for electrocatalytic oxygen reduction

Disclosed are systems for the electrocatalytic reduction of oxygen, having redox mediator/redox catalyst pairs and an electrolyte solution in contact with an electrode. The redox mediator is included in the electrolyte solution, and the redox catalyst may be included in the electrolyte solution, or alternatively, may be in contact with the electrolyte solution. ... Wisconsin Alumni Research Foundation

09/28/17 / #20170275643

Extending juvenility in grasses

The present invention relates to compositions and methods for modulating the juvenile to adult developmental growth transition in plants, such as grasses (e.g. Maize). ... Wisconsin Alumni Research Foundation

09/21/17 / #20170270424

Method of estimating program speed-up in highly parallel architectures using static analysis

The amount of speed-up that can be obtained by optimizing the program to run on a different architecture is determined by static measurements of the program. Multiple such static measurements are processed by a machine learning system after being discretized to alter their accuracy vs precision. ... Wisconsin Alumni Research Foundation

09/21/17 / #20170269179

System and method for controlling undesired magnetic field effects in magnetic resonance imaging

A system and method are provided for determining a spatial distribution of susceptibility in a subject using a magnetic resonance imaging (mri) system. The method includes directing the mri system to acquire imaging data from an imaging volume within a subject, wherein the imaging volume is subject to both background fields (bb) originating outside the imaging volume and local fields (bl) originating from tissue within the imaging volume. ... Wisconsin Alumni Research Foundation

09/21/17 / #20170269089

Methods for detection and treatment of colorectal cancer

This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.. . ... Wisconsin Alumni Research Foundation

09/21/17 / #20170266318

Hydrogel microspheres containing peptide ligands for growth factor regulation in blood products

Vascular endothelial growth factor vegf-sequestering hydrogel microspheres that have been prepared to selectively bind vegf from blood products are disclosed herein. In one particular embodiment, the microspheres bind vegf as part of an intra-operative process such that the growth factor can be removed from the blood products before the products are used in a clinical procedure.. ... Wisconsin Alumni Research Foundation








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