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Yale University patents


Recent patent applications related to Yale University. Yale University is listed as an Agent/Assignee. Note: Yale University may have other listings under different names/spellings. We're not affiliated with Yale University, we're just tracking patents.

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Neurotherapeutic nanoparticle compositions comprising leukemia inhibitory factor

There are provided compositions and methods for treatment of neurodegeneative diseases and cns injury. The compositions a pharmaceutically acceptable carrier solution; and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a neural stem cell and wherein the nanoparticles further comprise factors such as leukaemia inhibitory factor (lif); xav939 and/or one or more of: brain-derived neurotrophic factor (bdnf) or an agonist thereof; epidermal growth factor (egf) or an agonist thereof; glial cell-derived neurotrophic factor (gdnf) or an agonist thereof; retinoic acid and derivatives thereof; ciliary neurotrophic factor (ctnf) or an agonist thereof; and wnt5a. ... Yale University

Compositions and methods of using tyrosine kinase inhibitors

The present invention provides compositions and methods of inhibiting tyrosine phosphorylation. In one aspect, a composition comprising a low-dosage tyrosine kinase inhibitor, where the low-dosage tyrosine kinase inhibitor decreases tyrosine phosphorylation, is provided. ... Yale University

(--)-huperzine a processes and related compositions and methods of treatment

The invention provides (1) processes for making substantially-pure (−) huperzine a and substantially-pure (−) huperzine a derivatives; (2) compositions useful in making substantially-pure (−) huperzine a and substantially-pure (−) huperzine a derivatives; and (3) methods of treating or preventing neurological disorders using substantially-pure (−) huperzine a and substantially-pure (−) huperzine a derivatives.. . ... Yale University

Humanized anti-dkk2 antibody and uses thereof

The present invention relates to the discovery that inhibition of dickkopf2 (dkk2) increases cd8+ cytotoxic t lymphocyte (ctl) activity, attenuates tumor, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of a humanized anti-dkk2 antibody, methods for providing anti-tumor immunity in a subject, methods of stimulating a t cell mediated immune response to a cell population or a tissue and suppressing tumor in a subject. ... Yale University

Environmentally sensitive compositions and methods of use thereof

An environmentally sensitive membrane binding polypeptide, ph (low)-sensitive membrane peptide (phlip) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.. . ... Yale University

Genotype-guided dosing of opioid receptor agonists

Provided herein, in some aspects, are methods of dosing opioid receptor agonists for treatment of opioid dependence and pain management.. . ... Yale University

Differentiation of human ips cells to human alveolar type ii via definitive endoderm

The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction of stem cells into definitive endoderm to generate anterior foregut endoderm from pluripotent cells. The anterior foregut endoderm cells can then be differentiated into an alveolar epithelial type ii cell.. ... Yale University

System and method for generating biological tissue

The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. ... Yale University

Novel cell-penetrating compositions and methods using same

The invention includes an isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell. The invention also includes a transport construct in which a transport peptide is linked to a cargo moiety to be delivered into a cell. ... Yale University

Dickkopf2 (dkk2) inhibition suppresses tumor formation

The present invention relates to the discovery that inhibition of dickkopf2 (dkk2) increases cd8+ cytotoxic t lymphocyte (ctl) activity, attenuates tumor angiogenesis, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of dkk2 gene depleting agent, methods for providing anti-tumor immunity and anti-tumor angiogenesis in a subject, methods of stimulating a t cell mediated immune response to a cell population or a tissue and suppressing tumor angiogenesis in a subject. ... Yale University

Vehicles for controlled delivery of different pharmaceutical agents

A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. ... Yale University

Modular particulars for immunotherapy

Nanoparticulate compositions are disclosed. The nanoparticulate compositions typically include at least one, preferably two or more, active agent(s), one of which is an immunomodulatory compound, loaded into, attached to the surface of and/or enclosed within a delivery vehicle. ... Yale University

Wireless josephson bifurcation amplifier

A wireless josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor q and participation ratio p of the amplifier. The device may be fabricated on a chip and mounted in a waveguide. ... Yale University

Device and method for obtaining immuno-stimulatory antigen-presenting cells

The present invention relates to methods for producing immuno-stimulatory antigen-presenting cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.. ... Yale University

07/12/18 / #20180193529

Compositions and methods for promoting patency of vascular grafts

Methods for increasing the patency of biodegradable, synthetic vascular grafts are provided. The methods include administering one or more cytokines and/or chemokines that promote outward tissue remodeling of the vascular grafts and vascular neotissue formation. ... Yale University

07/12/18 / #20180193470

Egfr proteolysis targeting chimeric molecules and associated methods of use

The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (rtk) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an e3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. ... Yale University

07/05/18 / #20180186785

Proteolysis targeting chimera compounds and methods of preparing and using same

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. ... Yale University

06/28/18 / #20180179601

Fluorescence amplification method for forward genetic discovery of factors in human mrna degradation

The present invention provides systems and methods for performing forward genetic screens in cells and methods of treating disease through inhibiting targets identified in a forward genetic screen as involved in a pathway associated with the disease. The invention involves the use of multiple tandem fluorescent reporter molecules separated by cleavage sites under the control of a single promoter to enhance the fluorescent readout from a cell screen.. ... Yale University

06/28/18 / #20180179183

Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides

The present disclosure relates to bifunctional compounds, which find utility as modulators of rapidly accelerated fibrosarcoma (raf, such as c-raf, a-raf and/or b-raf; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a von hippel-lindau, cereblon, inhibitors of apotosis proteins or mouse double-minute homolog 2 ligand which binds to the respective e3 ubiquitin ligase and on the other end a moiety which binds the target protein raf, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. ... Yale University

06/28/18 / #20180179176

Biaryltriazole inhibitors of macrophage migration inhibitory factor

The present disclosure describes biaryl triazole compounds, as well as their compositions and methods of use. The compounds inhibit the activity of macrophage migration inhibitory factor and are useful for the treatment of diseases, e.g., inflammatory diseases and cancer.. ... Yale University

06/28/18 / #20180177901

Evaluation of presence of and vulnerability to atrial fibrillation and other indications using matrix metalloproteinase-based imaging

The invention provides, in some embodiments, methods relating to assessing increased risk of developing atrial fibrillation (af), and/or the likelihood of responding to particular af therapies using imaging agents comprising an mmp inhibitor linked to an imaging moiety. The invention further provides methods for evaluating the presence of the risk of developing other cardiovascular conditions and assessing the effectiveness of treatment or other intervention for such conditions by determining mmp levels.. ... Yale University

06/28/18 / #20180177688

Topical formulation of hyperbranched polyglycerol-coated particles thereof

Core-shell particles have a hydrophobic core and a shell formed of or containing hyperbranched polyglycerol (hpg). The hpg can be covalently bound to the one or more materials that form the core or coated thereon. ... Yale University

06/21/18 / #20180169192

Compositions and methods for modulating coagulation

The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of npp4.. . ... Yale University

06/14/18 / #20180163210

Compositions and methods for controlling vasculature

The invention relates to compositions and methods for reducing excessive vascular development and treat related disorders. In one aspect, the invention provides methods for treating, reducing or inhibiting vascular development in a subject in need thereof. ... Yale University

06/14/18 / #20180162813

Mif modulators

The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of mif expression and treat disorders associated with high or low levels of mif expression.. . ... Yale University

06/07/18 / #20180155332

Small molecule based antibody-recruiting compounds for cancer treatment

The present invention relates to chimeric (including bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds bind to the urokinase-type plasminogen activator receptor (upar) on the surface of a cancer cell, including a metastatic cancer cell, and consequently recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity (adcc) and/or complement dependent cytotoxicity (cdc) against a large number and variety of cancers, thus providing cancer cell death and an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer.. ... Yale University

05/31/18 / #20180152003

A method and device concerning iii-nitride edge emitting laser diode of high confinement factor with lattice matched cladding layer

Edge-emitting laser diodes having high confinement factors and lattice-matched, porous cladding layers are described. The laser diodes may be formed from layers of iii-nitride material. ... Yale University

05/17/18 / #20180138987

Wireless josephson parametric converter

A wireless josephson-junction-based parametric converter is described. The converter may be formed on a substrate with antennas that pump are configured to wirelessly receive pump, signal and idler frequencies and couple the received frequencies to the converter's circuitry. ... Yale University

05/10/18 / #20180128729

Label-free cellular manipulation and sorting via biocompatible ferrofluids

A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet. ... Yale University

05/10/18 / #20180126014

Compositions for enhancing delivery of agents across the blood brain barrier and methods of use thereof

Compositions and methods for improved delivery of active agents to the brain are provided. The compositions typically include a nanocarrier, such as a polymeric nanoparticle, liposome, or nanolipagel or are in the form of a conjugate. ... Yale University

05/03/18 / #20180119224

Identification of gene associated with reading disability and uses therefor

The present invention relates to identification of a human gene, dcdc2 (mim: 605755), associated with susceptibility for developing reading disability (rd), which is useful in identifying or aiding in identifying individuals at risk for developing rd, as well as for diagnosing or aiding in the diagnosis of rd.. . ... Yale University

05/03/18 / #20180117183

Fluorescent compound comprising a fluorophore conjugated to a ph-triggered polypeptide

The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.. ... Yale University

04/19/18 / #20180105854

Compositions and methods for making selenocysteine containing polypeptides

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element. ... Yale University

04/12/18 / #20180101642

52-gene signature in peripheral blood identifies a genomic profile associated with increased risk of mortality and poor disease outcomes in idiopathic pulmonary fibrosis

The clinical course of idiopathic pulmonary fibrosis (ipf) is difficult to predict. Described herein is a peripheral blood 52-gene expression signature useful to improve outcome prediction in ipf.. ... Yale University

03/29/18 / #20180085496

Ferromagnetic particles bound to polymeric implants

. . It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and magnetized. The magnetized materials are used to attract, capture, and/or retain magnetically labeled cells in the material in vivo. ... Yale University

03/22/18 / #20180080086

Fish panel for ctcl

Described herein are probes useful to detect gene copy number alterations of genes characteristic/indicative of cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, including probes specific to genes amplified or deleted in cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement; methods of detecting a (one or more) genetic abnormality, such as one or more gene copy number alteration (gcna), characteristic/indicative of cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, in a biological sample obtained from an individual; and methods of determining if an individual has cutaneous t cell lymphoma (ctcl), such as ctcl with blood involvement, or is likely to develop cutaneous t cell lymphoma (ctcl) with blood involvement.. . ... Yale University

03/08/18 / #20180069288

Techniques for coupling planar qubits to non-planar resonators and related systems and methods

According to some aspects, a quantum mechanical system is provided, comprising a resonator having a plurality of superconducting surfaces and configured to support at least one electromagnetic oscillation mode within a three-dimensional region, wherein the plurality of superconducting surfaces include a first superconducting surface that defines a first plane, and a physical qubit comprising at least one planar component that is planar within the first plane and borders the three-dimensional region.. . ... Yale University

03/08/18 / #20180066253

Methods and compositions for modifying endothelial cells

The present invention includes methods and compositions for modifying endothelial cells for improved vascular self-assembly. In some embodiments, the invention includes a modified endothelial cell and methods of generating and using the modified endothelial cell in a pharmaceutical composition. ... Yale University

03/08/18 / #20180064902

Method of correlating brain activity

The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner that minimally affects the experience itself. The present invention provides meditators the ability to enhance their control over their own brain activity, such as posterior cingulate cortex (pcc) activation. ... Yale University

03/08/18 / #20180064786

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.. ... Yale University

03/08/18 / #20180064648

Liposome structures and methods of use thereof

The present application relates to compositions comprising and methods of using a liposome comprising a phlip polypeptide, wherein a lipid bilayer of the liposome is substantially free of the phlip polypeptide.. . ... Yale University

03/01/18 / #20180057821

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.. ... Yale University

03/01/18 / #20180057820

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.. ... Yale University

03/01/18 / #20180055972

Particle conjugated prosthetic patches and methods of making and using thereof

Composite prosthetic patches with covalently bound particles for controlled drug release, and methods of making and using thereof, have been developed. The particles may encapsulate one or more therapeutic, prophylactic or diagnostic agent(s). ... Yale University

02/22/18 / #20180054165

Techniques for producing quantum amplifiers and related systems and methods

According to some aspects, a quantum circuit is provided including a plurality of non-linear circuit elements coupled together in series and in parallel, such that at least two of the circuit elements are coupled together in series and at least two of the circuit elements are coupled together in parallel, wherein the quantum circuit is configured to act as an amplifier.. . ... Yale University

02/08/18 / #20180040935

Josephson junction-based circulators and related systems and methods

According to some aspects, a circuit is provided comprising a plurality of josephson junctions arranged in series in a loop, at least one magnetic element producing magnetic flux through the loop, a plurality of superconducting resonators, each resonator coupled to the loop between a different neighboring pair of josephson junctions of the plurality of josephson junctions, a plurality of ports, each port coupled to at least one of the plurality of resonators at ends of the resonators opposite to ends at which the resonators are coupled to the loop, and at least one controller configured to provide input energy to each of the plurality of ports that causes the circuit to function as a circulator between the plurality of ports.. . ... Yale University

02/01/18 / #20180032895

Techniques for universal quantum control of quantum coherent states and related systems and methods

Some aspects are directed to a method of operating an apparatus, the apparatus comprising a first quantum system having a plurality of coherent quantum states, the first quantum system being coupled to a second quantum system, the method comprising providing an input energy signal to the second quantum system that stimulates energy transfer between the first quantum system and the second quantum system and that causes net dissipation of energy to be output from the second quantum system, wherein the input energy signal includes at least two components having different frequencies and each having an amplitude and a phase, and adiabatically varying the amplitude and the phase of the at least two components of the input energy signal to cause a change in one or more of the plurality of coherent quantum states of the first quantum system.. . ... Yale University

02/01/18 / #20180030517

Compositions and methods for identifying secretory antibody-bound microbes

The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof.. ... Yale University

02/01/18 / #20180030018

Myc g-quadruplex stabilizing small molecules and their use

Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes g-quadruplex dna in the promoter of the c-myc gene to the subject. ... Yale University

01/11/18 / #20180008705

Use of mif and mif pathway agonists

The present invention relates to novel methods and compositions for increasing ampk activity and glucose uptake comprising administering a macrophage migration inhibitory factor (mif) pathway agonist in a subject in need thereof. The invention also relates to methods for selecting a subject for treatment with an agonist of mif, identifying a subject at risk for developing a condition in which increased ampk activity is desirable, and for predicting whether a subject is susceptible to a condition in which increased ampk activity is desirable.. ... Yale University

01/11/18 / #20180008679

Compositions and methods of increasing longevity or treating cellular stress

The present invention includes methods and compositions for increasing longevity of a cell and increasing cellular resistance to stress. In certain embodiments, the invention includes a method to induce gene expression of a homolog of pachytene checkpoint 2 (pch-2) or bmk-1 gene. ... Yale University

01/11/18 / #20180008629

Compositions and methods for treating nlrp3 inflammasome-related diseases and disorders

The present invention provides compositions and methods for treating or preventing an nlrp3 immunosome-related disorder. In one embodiment, the method includes administering a therapeutically effective amount of a composition comprising at least one nlrp3 inflammasome inhibitor to a subject in need thereof.. ... Yale University

01/04/18 / #20180000911

Mosquito saliva protein malaria vaccine

The invention provides compositions and methods for preventing and treating infection by plasmodium sporozoites.. . ... Yale University

01/04/18 / #20180000465

Integrated painless bone marrow biopsy device

An apparatus and method for performing painless bone marrow biopsy that requires only a single procedural pass to the biopsy bone site is disclosed. The biopsy device combines dermatotomy, anesthesia and marrow specimen extraction functionality and inherently aligns the bone drilling site with the site of anesthetic delivery by incorporating a transport channel that may be used for anesthetic delivery, into the biopsy needle used for bone access and bone marrow sample retrieval. ... Yale University

12/21/17 / #20170360959

Formulations for targeted release of agents under low ph conditions and methods of use thereof

Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. ... Yale University

12/21/17 / #20170360775

Glutamate agents in the treatment of mental disorders

Methods of treating mental disorders, including anxiety disorders such as obsessive-compulsive disorder, are provided. The methods comprise administering an effective amount of a glutamate modulator to an individual in need thereof. ... Yale University

12/21/17 / #20170360724

Methods of preventing neurodegeneration of association cortex in a mammal

The present invention provides methods of preventing and/or reducing risk of neurodegeneration of association cortex, and/or inhibiting or reversing formation of phosphorylated tau or coxiv in the prefrontal cortex of a mammal in need thereof. In certain embodiments, the method comprises administering to the mammal a therapeutically effective amount of an α2a-adrenergic receptor agonist.. ... Yale University

12/14/17 / #20170356920

Methods and kits for detecting misfolded proteins

Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.. . ... Yale University

12/14/17 / #20170355755

Compositions and methods for modulating salm5 and hvem

The invention provides compositions and methods for regulating immune responses. In one embodiment, compositions of the invention include one or more salm5-hvem antagonists that are able to induce inflammation in the cns or an immune privileged tissue. ... Yale University

12/14/17 / #20170354719

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of npp1 or a mutant thereof, or a mutant npp4 modified to exhibit atp hydrolase activity similar to the hydrolase activity of npp1.. . ... Yale University

11/30/17 / #20170342088

Novel ulk1 inhibitors and methods using same

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ulk1-inhibiting pyrimidine, and a therapeutically effective amount of an mtor inhibitor.. . ... Yale University

11/30/17 / #20170340789

Cavo-arterial pump

The present invention provides an intravascular right ventricular assist device, i.e., the cavo-arterial pump (cap). Two prototypes of the cap were developed, including a direct drive cap and a magnetic drive cap, demonstrating the feasibility of providing adequate pulmonary support and the feasibility of using axial magnetic couplings for contactless torque transmission from the motor shaft to the pump impeller. ... Yale University

11/30/17 / #20170340714

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.. ... Yale University

11/30/17 / #20170340713

Compositions for treating pathological calcification conditions, and methods using same

The present invention includes compositions and methods for treating diseases or disorders associated with pathological calcification or pathological ossification. In certain embodiments, the diseases or disorders are selected from the group consisting of generalized arterial calcification of infancy (gaci), idiopathic infantile arterial calcification (iiac), ossification of the posterior longitudinal ligament (opll), hypophosphatemic rickets, osteoarthritis, calcification of atherosclerotic plaques, pxe, hereditary and non-hereditary forms of osteoarthritis, ankylosing spondylitis, hardening of the arteries occurring with aging, calciphylaxis resulting from end stage renal disease and progeria.. ... Yale University

11/23/17 / #20170333533

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of npp1 or a mutant thereof, or a mutant npp4 modified to exhibit atp hydrolase activity similar to the hydrolase activity of npp1.. . ... Yale University

11/23/17 / #20170333474

Drug therapy to inhibit chemotherapy-induced adverse effects and related pharmaceutical compositions, diagnostics, scrreening techniques and kits

The invention provides a method of treatment comprising reducing therapy-induced adverse effects (tiae), including chemotherapy-induced adverse effects (ciae), such as chemotherapy-induced peripheral neuropathy (cipn) and/or chemotherapy-induced cardiovascular adverse effects (cicae) in a subject being treated with a ciae-inducing anti-cancer active ingredient by co-administering to the subject a pharmaceutically effective amount of a ncs-1-protective composition. Related pharmaceutical compositions, diagnostics and screening techniques are also provided.. ... Yale University

11/16/17 / #20170326214

Cd4 t cells provide antibody access to immunoprivileged tissue

The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory cd4 t cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.. ... Yale University

11/16/17 / #20170325977

Endovascular graft defining internal lumens

An endovascular graft is provided that includes a stent structure adapted to move between a collapsed and a deployed configuration. An endovascular graft material is mounted with respect to the stent structure. ... Yale University

10/26/17 / #20170307614

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same

The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. ... Yale University

10/26/17 / #20170305948

Novel precatalyst scaffolds for cross-coupling reactions, and methods of making and using same

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. ... Yale University

10/05/17 / #20170281588

Compositions and methods for treating epithelial cancer

The present invention provides the eutomeric isomer of the compound of formula (i), or a salt or solvate thereof, which can be used to treat epithelial cancer in a subject. In certain embodiments, the compound of formula (i) can be used in combination with aicar and/or cisplatin.. ... Yale University

09/28/17 / #20170274054

Compositions and methods for modulating coagulation

The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of npp4.. . ... Yale University

09/28/17 / #20170274041

Reactivation of axon growth and recovery in chronic spinal cord injury

Disclosed are methods of treating chronic nervous system diseases or injuries, e.g., chronic spinal cord injury, using nogo receptor antagonists, including nogo receptor-1 (ngr1) polypeptides, nogo receptor-1 antibodies and antigen-binding fragments thereof, soluble nogo receptors and fusion proteins thereof, and polynucleotides. Also disclosed are methods of noninvasively monitoring axonal growth during and after treatment with an axonal growth promoting agent.. ... Yale University

09/28/17 / #20170274001

Compositions and methods for increasing red blood cells

The invention relates generally to a composition and method for increasing the frequency, amount, or presence of red blood cells in peripheral blood. In one embodiment, the invention comprises the inhibition of, or genetic modification of the genes encoding, one or more scavenger receptors. ... Yale University

09/28/17 / #20170273772

Assemblies and methodologies for the repair of hernias

An assembly for the repair of a hernia. The assembly includes an elongated shaft having a first end; a first holding member at least mostly positionable in the elongated shaft and a second holding member positionable in the elongated shaft; a coupler assembly having (i) a coupler for coupling the first holding member to the second holding member and (ii) a locking arrangement; a deployment assembly for deploying at least one of the first and second holding members out of the elongated shaft; a restrainer for restraining a portion of the coupler prior to the deployment of the second holding member out of the first end of the elongated shaft; wherein the coupler can be tensioned so as to pull the first holding member and the second holding member towards each other and the locking arrangement is lockable about the coupler. ... Yale University

09/21/17 / #20170266325

Compositions for nanoconfinement induced contrast enhancement and methods of making and using thereof

Multivalent ct or mr contrast agents and methods of making and using thereof are described herein. The agents contain a moiety, such as a polymer, that provides multivalent attachment of ct or mr contrast agents. ... Yale University

09/21/17 / #20170266119

Hyperbranched polyglycerol-coated particles and methods of making and using thereof

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. ... Yale University

09/07/17 / #20170252414

Compositions and methods for treating pathological calcification and ossification

The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of npp1 or a mutant thereof, or a mutant npp4 modified to exhibit atp hydrolase activity similar to the hydrolase activity of npp1.. . ... Yale University

08/31/17 / #20170251191

Systems, methods, and computer-readable media for ultra-high resolution 3d imaging of whole cells

One aspect of the invention provides a method for drift correction to correct a 3d point collection dataset to compensate for drift over time. The method includes: (a) separating the 3d dataset into n segments, wherein n>1; (b) for each of the n segments, reconstructing a volume image as a 3d histogram in which a count for each voxel in the histogram equals a number of localization estimates falling within the voxel; (c) performing 3d cross-correlation between pairs of the n segments; (d) identifying a correlation peak in a result of the 3d cross-correlation to determine a shift distance between pairs of the n segments; (e) solving an overdetermined system of shift distances to determine independent shifts; and (f) offsetting positions from a plurality of segments in the 3d point collection dataset with the independent shifts calculated in step (e) to correct for drift.. ... Yale University

08/31/17 / #20170248611

Method and panel for determining acute kidney injury

A method for determining the risk of acute kidney injury (aki) in a mammal following cardiac surgery is provided. The method comprises determining the sample value of il-6 or hfabp concentration, or the ratio of il-6 to il-10, in a biological sample from the mammal, either prior to cardiac surgery or within 6 hours following surgery; comparing the sample value to a corresponding reference value; and determining that the mammal is at risk of acute kidney injury following cardiac surgery if the sample value is greater than the corresponding reference value.. ... Yale University

08/24/17 / #20170242000

Calibration of nanostructure sensors

The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. ... Yale University

08/24/17 / #20170240908

Compositions and methods for biocontainment of microorganisms

Methods and strategies for introducing genetic safeguards into microorganisms, genetically modified organisms (gmo) including the safeguards, and methods of use thereof are provided. The genetic safeguards generally impart a low escape frequency, are robust, and are modular. ... Yale University

08/24/17 / #20170240648

Anti-erbb antibodies and methods of use thereof

Provided herein are compositions, methods and uses involving antibodies that bind to erbb, a receptor tyrosine kinase, and modulate the activity of erbb. Also provided are uses and methods for treating disorders, such as cancer, by administering to subject an antibody that binds to erbb.. ... Yale University

08/17/17 / #20170237234

A method for gan vertical microcavity surface emitting laser (vcsel)

Structures and methods for forming highly uniform and high-porosity gallium-nitride layers with sub-100-nm pore sizes are described. Electrochemical etching of heavily-doped gallium nitride at low bias voltages in concentrated nitric acid is used to form the porous gallium nitride. ... Yale University

08/17/17 / #20170233749

Site-specific incorporation of phosphoserine into proteins in escherichia coli

Nucleic acids encoding mutant elongation factor proteins (ef-sep), phosphoseryl-trna synthetase (seprs), and phosphoseryl-trna (trnasep) and methods of use in site specific incorporation of phosphoserine into a protein or polypeptide are described. Typically, seprs preferentially aminoacrylates trnasep with o-phosphoserine and the trnasep recognizes at least one codon such as a stop codon. ... Yale University

08/17/17 / #20170232027

Novel compositions and methods useful for treating or preventing liver diseases or disorders, and promoting weight loss

The invention includes a method of preventing or treating a toxic liver disease or disorder, such as but not limited to non-alcoholic steatohepatitis (nash), liver injury associated with or caused by alcohol consumption in a mammal afflicted with nash, alcoholic hepatitis, drug induced liver injury, primary sclerosing cholangitis, viral hepatitis, liver fibrosis, liver cirrhosis, and other toxic liver conditions, in a subject, such as a mammal. The invention also includes a method of promoting weight loss in a subject, such as a mammal. ... Yale University

08/10/17 / #20170226228

Compositions and methods to regulate renalase in the treatment of diseases and disorders

The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. ... Yale University

08/10/17 / #20170224617

Methods of treating inflammatory and autoimmune diseases and disorders

Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. ... Yale University

08/03/17 / #20170218036

Innate immune system modification for anticancer therapy

The present invention relates to the discovery of a role of the nuclear receptor retinoid-related orphan receptor gamma (rorgamma) in tumor suppression. The introduction and expression of rorgamma result in genes activation within innate immune cells that trigger recognition and suppression of tumor cells. ... Yale University

08/03/17 / #20170216416

Pigment epithelium-derived factor (pedf) and peptide derivatives thereof for use in osteoblast differentiation and bone growth

The present invention provides compositions and methods for differentiating a stem cell into an osteoblast or osteoblast progenitor cell. In certain embodiments, the invention may be used for promoting bone formation and increasing bone mass. ... Yale University

08/03/17 / #20170216244

Methods for treating diabetic nephropathy

The present invention provides methods for treating or preventing diabetic nephropathy and its related pathologies by inhibiting podocyte semaphorin3a (sema3a). The invention also provides a method for identifying or characterizing a compound useful for treating or preventing diabetic nephropathy.. ... Yale University

07/27/17 / #20170209570

Carbon nanotube compositions and methods of use thereof

Carbon nanotube (cnt)-based compositions for activating cellular immune responses are provided. The cnts function as high surface area scaffolds for the attachment of t cell ligands and/or antigens. ... Yale University

07/27/17 / #20170209489

Fast acting inhibitor of gastric acid secretion with enhanced activity

The present invention relates to the discovery that a hydrated salt form of zinc exhibits enhanced activity in reducing the acidity of gastric juice in a subject in need when compared to typical zinc salts. According to the invention, a zinc salt hydrate may be used alone or in combination with an additional zinc salt hydrate. ... Yale University

07/27/17 / #20170209079

Nanopatterned biosensor electrode for enhanced sensor signal and sensitivity

An electrode structure, which can be used as a biosensor, is provided that has non-random topography located on one surface of an electrode base substrate. The non-random topography of the electrode structure and the electrode base substrate of the electrode structure are of unitary construction and unitary composition and thus there is no interface is located between these elements of the electrode structure.. ... Yale University

06/22/17 / #20170175190

Circulating microrna as biomarkers for endometriosis

The invention includes compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one mirna that is associated with endometriosis.. . ... Yale University

06/22/17 / #20170174763

Nogo receptor-mediated blockade of axonal growth

Disclosed are ngr proteins and biologically active nogo (ligand) protein fragments. Also disclosed are compositions and methods for modulating the expression or activity of the nogo and ngr protein. ... Yale University

06/01/17 / #20170154759

Mass spectrometry imaging of benign melanocytic nevi and malignant melanomas

A method of differentiating benign melanocytic nevi from malignant melanomas is disclosed. The method generally includes subjecting a skin lesion sample from a patient to mass spectrometry to obtain a mass spectrometry protein profile. ... Yale University

05/18/17 / #20170140807

Circuitry for ferroelectric fet-based dynamic random access memory and non-violatile memory

Exemplary embodiments of the present disclosure are directed to circuitry for effective operation of ferroelectric-gated fet (fefet) memories. Exemplary embodiment of the present disclosure includes circuits and/or circuit blocks to facilitate memory refresh, error checking and correcting (ecc), reading and sensing memory cells, program and erase operations, and other control and periphery operations for fefet memory cell arrays.. ... Yale University

05/18/17 / #20170138950

Identification of cancer protein biomarkers using proteomic techniques

The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. ... Yale University

05/11/17 / #20170133826

Lateral electrochemical etching of iii-nitride materials for microfabrication

Conductivity-selective lateral etching of iii-nitride materials is described. Methods and structures for making vertical cavity surface emitting lasers with distributed bragg reflectors via electrochemical etching are described. ... Yale University

05/11/17 / #20170130228

Compositions and methods to activate or inhibit toll-like receptor signaling

The present invention includes compositions and methods of inhibiting or activating tlr7 signaling. In one aspect, a composition includes an inhibitor of tlr7 signaling is described, where the inhibitor of tlr7 signaling is a tlr7 inhibitory oligonucleotide, a tlr7 antibody, or a tlr7 antagonist. ... Yale University

05/11/17 / #20170128490

Method for obtaining globally activated monocytes

The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.. ... Yale University

05/04/17 / #20170121773

Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome

Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of hermansky pudlak syndrome (hps) and, e.g., pulmonary fibrosis in a subject. As described herein, subjects with hps who have, will develop, cor are most at risk or developing pulmonary fibrosis have elevated levels of chi3l1. ... Yale University

05/04/17 / #20170121454

Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery

Poly(amine-co-ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. ... Yale University

05/04/17 / #20170121321

Proteolysis targeting chimera compounds and methods of preparing and using same

The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or uncontrolled activation of a tyrosine kinase in a subject in need thereof. In certain embodiments, the compounds of the present invention comprise a tyrosine kinase inhibitor, a linker and a ubiquitin ligase binder. ... Yale University

05/04/17 / #20170120198

In situ formation of biocidal metal nanoparticles on thin-film composite reverse osmosis membranes for biofouling mitigation

The present invention relates to a method including reacting a solution of a salt of a biocidal metal with an active layer of water purification membrane, discarding the biocidal metal salt solution such that a thin layer of the biocidal metal salt solution remains on the membrane surface, reacting a reducing agent solution with the active layer of the membrane and the thin layer of the biocidal metal salt solution thereby forming a biocidal metal nanoparticle-modified membrane, removing the reducing agent solution, and rinsing the biocidal metal nanoparticle-modified membrane.. . ... Yale University

04/20/17 / #20170111046

Bootstrapping circuit and unipolar logic circuits using the same

Exemplary embodiments of the present disclosure are directed to a bootstrapping module and logic circuits utilizing the bootstrapping module to compensate for a weak high condition. The bootstrapping module can be implemented using transistors have a single channel type that is the same as the channel type of transistors utilized in the logic circuits such that a truly unipolar circuit can be realized while addressing the weak high problem of such unipolar circuits.. ... Yale University

04/20/17 / #20170107499

Compositions and methods for treating and preventing pancreatitis, renal injury and cancer

The present invention includes compositions and methods for detecting, treating and preventing renal and pancreatic diseases and disorders.. . ... Yale University

04/20/17 / #20170105956

Novel methods of treating or preventing fibrotic lung diseases

The invention includes a method of preventing or treating a fibrotic lung disease in a subject, comprising administering to the subject a thyroid hormone by inhalation and/or aerosolization. The invention further comprises compositions and kits comprising compositions useful within the invention.. ... Yale University

04/13/17 / #20170100428

Regulators of anaplastic lymphoma kinase and uses thereof

Provided herein are alk regulators for the treatment of diseases and disorders. For example, presented herein are alk regulators, e.g., alk activators, and methods of treatment and/or prevention of diseases, including neurodegenerative, neuromuscular and cognitive diseases or disorders, and methods of enhancing cognitive abilities using alk regulators, e.g., alk activators. ... Yale University

04/06/17 / #20170096415

Bifunctional molecules with antibody-recruiting and entry inhibitory activity against the human immunodeficiency virus

The present invention is directed to new bifunctional compounds and methods for treating hiv infections. The bifunctional small molecules, generally referred to as arm-hi's, function through orthogonal pathways, by inhibiting the gp120-cd4 interaction, and by recruiting anti-dnp antibodies to gp120-expressing cells, thereby preventing cell infection and spread of hiv. ... Yale University

03/30/17 / #20170087148

Tlr-agonist-conjugated antibody recruiting molecules (tlr-arms)

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (abt) moiety covalently bonded to a cell binding terminus (cbt) and toll-like receptor agonist (tlr) through a linker and a multifunctional connector group or molecule.. ... Yale University

03/16/17 / #20170073676

Treatment for conditions associated with fibrosis and collagen deposition

Methods, compositions, devices, and kits for treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition are provided. The method of treating and/or reducing the risk of developing a condition associated with fibrosis and/or collagen deposition in a subject includes administering an effective amount a mirna-762 inhibitor to the subject, wherein the subject is identified as having a risk of developing and/or a need for treatment of the condition associated with fibrosis and/or collagen deposition. ... Yale University

03/09/17 / #20170067887

System, device and method for high-throughput multi-plexed detection

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. ... Yale University

03/09/17 / #20170067874

Small-molecule hydrophobic tagging of fusion proteins and induced degradation of same

The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of the compounds to the transmembrane or intracellular protein induces proteasomal degradation of the transmembrane or intracellular protein. The present invention further includes a method of inducing proteasomal degradation of a transmembrane or intracellular protein. ... Yale University

03/09/17 / #20170067109

Assays for detecting wdr62 mutations

The present invention relates to compositions and methods for detecting mutations in wd repeat domain 62 (wdr62).. . ... Yale University

03/09/17 / #20170065719

Compounds and methods for the targeted degradation of bromodomain-containing proteins

The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a vhl ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. ... Yale University

03/02/17 / #20170056493

Virus like vesicles (vlvs) based vaccines to prevent or treat chronic hepatitis b virus (hbv) infection

The present invention relates to the discovery of compositions and methods for therapeutic immunization for treatment of chronic hepatitis b. Methods of the invention include a method generating an evolved high titer hybrid-hepatitis b virus (hbv) vector, methods of treating and/or preventing hbv, and methods of inducing a memory t and b cell immune response against hbv infection in a subject administered the vlv composition produced thereby. ... Yale University

02/23/17 / #20170051307

Evolution of high-titer virus-like vesicles for vaccine applications

The present invention relates to the discovery of a high titer hybrid-virus vector that gives rise to high titer virus like vesicles (vlvs) that can be used as a vaccine. The invention includes compositions and methods of generating an evolved hybrid-virus vector vaccine and selecting high titer vlvs, methods of treating and/or preventing or immunizing against, a specific disease or disorder, and methods of inducing a memory t cell and b cell immune response in a subject administered the vlv composition produced thereby. ... Yale University

02/23/17 / #20170049583

Multi-grasp prosthetic hand

The present invention provides a prosthetic hand capable of multiple grasp types. The prosthetic finger units are underactuated both within and between the finger units using a differential mechanism arrangement. ... Yale University

02/16/17 / #20170047220

Nitrogen-polar semipolar gan layers and devices on sapphire substrates

Methods and structures for forming epitaxial layers of semipolar iii-nitride materials on patterned sapphire substrates are described. Semi-nitrogen-polar gan may be grown from inclined c-plane facets of sapphire and coalesced to form a continuous layer of (2021) gan over the sapphire substrate. ... Yale University

02/02/17 / #20170033186

Method of obtaining planar semipolar gallium nitride surfaces

Methods and structures for forming flat, continuous, planar, epitaxial layers of semipolar iii-nitride materials on patterned sapphire substrates are described. Semipolar gan may be grown from inclined c-plane facets on a patterned sapphire substrate, and coalesced to form a continuous layer of semipolar iii-nitride semiconductor over the sapphire substrate. ... Yale University

02/02/17 / #20170029858

Compositions and methods for making selenocysteine containing polypeptides

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element. ... Yale University

02/02/17 / #20170027926

Compositions and methods of inhibiting histone deacetylases

The present invention provides compositions and methods for treating pulmonary hypertension. In one aspect, a method is included for increasing myocyte enhancer factor 2 (mef2) activity in an endothelial cell comprising exposing the cell to a class iia histone deacetylase inhibitor. ... Yale University

02/02/17 / #20170027140

Human sirpa transgenic animals and their methods of use

The invention relates generally to compositions and methods of using transgenic non-human animals expressing human sirpα that are engrafted with a human hematopoietic system. In various embodiments, the human hematopoietic system engrafted, human sirpα transgenic non-human animals of the invention are useful as systems for the in vivo evaluation of the growth and differentiation of hematopoietic and immune cells, for the in vivo assessment of an immune response, for the in vivo evaluation of vaccines and vaccination regimens, for in vivo production and collection of immune mediators, including human antibodies, and for use in testing the effect of agents that modulate hematopoietic and immune cell function.. ... Yale University

01/26/17 / #20170022337

Multiblock copolymer films, methods of making same, and uses thereof

A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. ... Yale University

01/26/17 / #20170021005

Compositions and methods for using salmonella typhi toxin to induce or enhance an immune response

The invention provides compositions and methods for using plta, pltb, cdtb, or a mutant thereof, in inducing or enhancing an immune response.. . ... Yale University

01/26/17 / #20170020508

Assemblies and methodologies for internal transfascial mesh fixation

An assembly for securing a mesh patch to a surface of a peritoneum layer of an abdominal wall. The assembly includes first and second holding members coupled by a suture. ... Yale University

01/19/17 / #20170014500

Compositions and methods of preparing leptospira

The present invention includes compositions and methods of preparing flagellar-coiling protein 1 (fcp1)-deficient leptospira bacterium. In one aspect, the invention includes an isolated, flagellar-coiling protein 1 (fcp1)-deficient leptospira bacterium. ... Yale University

01/12/17 / #20170007717

Duocarmycin adcs for use in treatment of endometrial cancer

The present invention relates to duocarmycin-containing antibody-drug conjugates (adcs) for use in the treatment of human solid tumours expressing her2, wherein the human solid tumour expressing her2 is endometrial cancer, in particular uterine serous carcinoma (usc). In particular, the present invention relates to duocarmycin-containing adcs for use in the treatment of endometrial cancer, notably usc, with her2 ihc 2− or 1+ and her2 fish negative tumour tissue status.. ... Yale University

01/05/17 / #20170002422

Novel methods of identifying patients responsive to immunotherapeutic strategies

The invention includes a method of determining whether a mammal's cancerous tumor is associated with a hypermutator phenotype (i.e., harboring a large number of mutations) for the dna polymerase epsilon (pole) gene as compared to normal cells. The invention further includes a method of selecting patients harboring an immunogenic tumor that is responsive to immunotherapy.. ... Yale University

01/05/17 / #20170002347

Compositions and methods for making selenocysteine containing polypeptides

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element. ... Yale University

01/05/17 / #20170000737

Hyperbranched polyglycerol-coated particles and methods of making and using thereof

Core-shell particles and methods of making and using thereof are described herein. The core is formed of or contains one or more hydrophobic materials or more hydrophobic materials. ... Yale University








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